Penggunaan Magnesium Sulfat untuk Menurunkan Angka Kejadian Cerebral Palsy pada Bayi Prematur

Herry Aktyar Matondang, Jusuf Sulaeman Effendi, Budi Handono, Andi Kurniadi

Abstract


Abstrak
Latar belakang: Magnesium Sulfat merupakan senyawa kimia yang sudah banyak terbukti manfaatnya pada kehamilan. Selain digunakan sebagai obat anti kejang, dan obat tokolitik pada kontraksi prematur, magnesium sulfat berperan banyak pada proses intraseluler, diantaranya sebagai agen vasodilator pembuluh darah otak, menurunkan reaksi inflamasi, seperti sitokin dan zat radikal bebas, serta mencegah masuknya ion kalsium kedalam sel.  Prematuritas merupakan masalah serius karena hampir sebagian besar dari neonatus yang berhasil hidup akan mengalami kecacatan neurologis kongenital termasuk cerebral palsy (CP).
Metode: Analitik korelatif dengan desain cross sectional. Subjek penelitian adalah pasien dengan diagnosa cerebral palsy yang melakukan pemeriksaan ke Rumah Sakit Dr. Hasan Sadikin Bandung, dengan riwayat lahir prematur. Pengambilan sampel menggunakan teknik accidental sampling dengan jumlah total sampel 30 pasien. Analisis data secara statistik menggunakan uji Chi-square.  
Hasil: Penelitian menunjukkan 7 (23,3%) pasien anak dengan diagnosa cerebral palsy memiliki riwayat ibu hamil dengan pemberian magnesium sulfat (MgSO4), dan 23 (76,6%) pasien dengan diagnosa cerebral palsy memiliki riwayat ibu hamil tanpa pemberian magnesium sulfat (MgSO4). Hasil analisa data dengan menggunakan uji Chi-square  didapatkan ρ-value 0,001< α = 0,05.
Kesimpulan: Terdapat hubungan yang signifikan dari pemberian magnesium sulfat pada ibu hamil terhadap angka kejadian cerebral palsy pada bayi prematur di Rumah Sakit Hasan Sadikin Bandung.

Kata kunci: magnesium sulfat, persalinan prematur, bayi prematur, cerebral palsy

The Used of Sulfate Magnesium  to Reduce Incidence of Cerebral Palsy
on Preterm Birth

Abstract
Objective: Magnesium Sulfate is a chemical compound that has been widely used in pregnant women and has proven benefits to the condition of pregnancy.  Prematurity is a serious problem because most of the successful neonates will experience congenital neurological disability including cerebral palsy (CP).
Methods: This research is a kind of analytic correlative research with cross sectional design. The research subjects were pediatric patients with a diagnosis of cerebral palsy who performed the examination at Hasan Sadikin Hospital Bandung, with a history of premature birth. Samples were taken by purposive sampling technique with a total number of samples 30 patients. Statistical analysis using Chi-square statistical test.
Result: The result of this research showed 7(23,3%) pediatric patients with a diagnosis of cerebral palsy had a history of pregnant women with administration of magnesium sulfate (MgSO4), and 23(76,6%) patients with a diagnosis of cerebral palsy has a history of pregnant women without administration of magnesium sulphate (MgSO4). The data were analyzed using Chi-square test and obtained ρ-value 0,001 <α = 0,05.
Conclusion: There is a significant relationship between administration of magnesium sulfate in pregnant women and the incidence of cerebral palsy in premature infants at Hasan Sadikin Hospital Bandung.

Keywords: magnesium sulfate, preterm birth, premature infants, cerebral palsy


Keywords


magnesium sulfat; persalinan prematur; bayi prematur; cerebral palsy

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References


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DOI: http://dx.doi.org/10.24198/obgynia.v1n1.44

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Alamat Redaksi

 

KSM/Dep Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran RSUP Dr. Hasan Sadikin

Jl. Pasteur No 38 Bandung 40161 

Telp: 0813-2012-9954

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