Hubungan Kadar Vitamin D Serum dengan Konsentrasi, Motilitas dan Morfologi Sperma pada Pria Subfertil di Klinik Teknologi Reproduksi Berbantu Aster Rumah Sakit Dr. Hasan Sadikin Bandung
Abstract
Tujuan: Untuk menganalisis hubungan kadar vitamin D dengan kualitas sperma pada pria subfertil, serta membandingkan kualitas sperma berdasarkan klasifikasi kadar vitamin D serum pada pria normospermia dan pria oligoasthenoteratospermia.
Metode: Penelitian ini merupakan penelitian yang bersifat observasional analitik dengan rancangan studi potong lintang. Subjek penelitian adalah pria subfertil yang berusia 20-50 tahun, dibagi menjadi 2 kelompok, yaitu 30 pasien normospermia dan 16 pasien oligoasthenoteratospermia berdasarkan berdasarkan kriteria World Health Organization 2010. Penelitian dilakukan di Klinik Teknologi Reproduksi Berbantu Aster, RSUP Dr. Hasan Sadikin Bandung. Analisis data menggunakan analisis korelasi rank Spearman
Hasil: Pada penelitian ini didapatkan korelasi positif antara kadar vitamin D dan motilitas sperma ( r = 0,639, p = < 0,001), tetapi tidak didapatkan korelasi pada konsentrasi dan morfologi sperma ( p>0,05). Perbedaan yang bermakna didapatkan antara kadar vitamin D pada kelompok normospermia dan oligoasthenoteratospermia dengan nilai p<0,05. Pada perbandingan kualitas sperma berdasarkan klasifikasi kadar vitamin D hanya motilitas sperma saja yang memiliki perbedaan bermakna dengan nilai p<0,05.
Simpulan: Terdapat hubungan yang bermakna antara kadar vitamin D serum dan motilitas sperma.
Correlation Of Vitamin D Serum Level With Concentration, Motility, And Morphology Of Spermatozoa Subfertil In Assisted Reproductive Technology Aster Clinic Hasan Sadikin Hospital Bandung
Abstract
Objective: This study aims to analyze the relationship of vitamin D levels with sperm quality in subfertile men, as well as comparing sperm quality based on vitamin D serum levels classification in normospermic men and oligoasthenoteratospermia men.
Method: This study is an analytic observasional with cross sectional design. Research subjects were subfertile men aged 20-50 years divided into 2 groups, consisting of 30 patients with normospermic and 16 patients with oligoasthenoteratospermia based on World Health Organization 2010 criteria. The research was conducted at Assisted Reproductive Technology Aster, RSUP Dr. Hasan Sadikin Bandung. Data analysis was using Spearman’s rank correlation analytic.
Result: We found a positive correlation between vitamin D levels and sperm motility (r = 0.639, p = <0.001), but no correlation was found on sperm concentration and morphology (p> 0.05). There was a significant difference between vitamin D levels in normospermic and oligoasthenoteratospermia group with p <0,05. In the sperm quality comparison based on vitamin D serum classification, only sperm motility alone had a significant difference with the value of p <0.05. It was concluded that level of vitamin D serum has positive correlation with sperm motility.
Key word: subfertile, vitamin D, sperm quality
Keywords
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Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, et al. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and The World Health Organization (WHO) Revised Glossary on ART Terminology. 2009. Hum Reprod. 2009: dep343.
Medicine PCotASfR. Definitions of Infertility and Recurrent Pregnancy Loss. Fertil Steril. 2008; 90 (5): S60.
Petraglia F, Serour GI, Chapron C. The Changing Prevalence of Infertility. Int J Gynaecol Obstet. 2013; 123 Suppl 2: S4–8.
Hirsh A. Male Subfertility. BMJ. 2003; 327 (7416): 669–72.
Fields J, Trivedi NJ, Horton E, Mechanick JI. Vitamin D in the Persian Gulf: Integrative Physiology and Socioeconomic Factors. Current Osteoporosis Reports. Hum Reprod. 2011; 9 (4): 243–50.
Jensen MB. Vitamin D and Male Reproduction. Nat Rev Endocrinol. 2014; 10 (3): 175–86.
Yosephin B, Khomsan A, Briawan D, Rimbawan R. Vitamin D plus Calcium Supplementation Increased Serum 25 (OH) D on Reproductive Age Women Workers. Asian Pac J Trop Dis. 2015; 5(11): 877–80.
Holick MF. The Vitamin D Deficiency Pandemic: a Forgotten Hormone Important for Health. Public Health Reviews (2107-6952). 2010; 32 (1).
Corbett ST, Hill O, Nangia AK. Vitamin D Receptor Found in human Sperm. Int J Urol. 2006; 68 (6):1345–9.
Kwiecinski G, Petrie G, DeLuca H. Vitamin D is Necessary for Reproductive Functions of The Male Rat. J Nutr. 1989; 119 (5): 741–4.
Nangia AK, Hill O, Waterman MD, Schwender CE, Memoli V. Testicular Maturation Arrest to Testis Cancer: Spectrum of Expression of the Vitamin D Receptor and Vitamin D Treatment in Vitro. Int J Urol. 2007; 178 (3): 1092–6.
Bouillon R, Carmeliet G, Verlinden L, Van Etten E, Verstuyf A, Luderer HF, et al. Vitamin D and Human Health: Lessons From Vitamin D Receptor Null Mice. Endocr Rev. 2008; 29 (6): 726–76.
Blomberg Jensen M, Bjerrum PJ, Jessen TE, Nielsen JE, Joensen UN, Olesen IA, et al. Vitamin D is Positively Associated With Sperm Motility and Increases Intracellular Calcium in Human Spermatozoa. Hum Reprod. 2011; 26 (6): 1307–17.
Corbett S, Stern J, Sundaram S, Nangia A. Vitamin D: Is There a Role in Male Infertility? Fertil Steril. 2004; 82: S44.
Ramlau-Hansen CH, Moeller UK, Bonde JP, Olsen J, Thulstrup AM. Are Serum Levels of Vitamin D Associated With Semen Quality? Results from a Cross-Sectional Study in Young Healthy Men. Fertil Steril. 2011; 95 (3): 1000–4.
Rybar R, Kopecka V, Prinosilova P, Markova P, Rubes J. Male Obesity and Age in Relationship to Semen Parameters and Sperm Chromatin Integrity. J Androl. 2011; 43 (4): 286–91.
Kuhnert B, Nieschlag E. Reproductive Functions of the Ageing Male. Hum Reprod Update. 2004; 10 (4): 327–39.
Nguyen RH, Wilcox AJ, Skjaerven R, Baird DD. Men's Body Mass Index and Infertility. Hum Reprod. 2007; 22 (9): 2488–93.
Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, et al. Impact of Body Mass Index Values on Sperm Quantity and Quality. J Androl. 2006; 27 (3): 450–2.
Ammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. Male Obesity and Alteration in Sperm Parameters. Fertil Steril. 2008; 90 (6): 2222–5.
Pauli EM, Legro RS, Demers LM, Kunselman AR, Dodson WC, Lee PA. Diminished Paternity and Gonadal Function with Increasing Obesity in Men. Fertil Steril. 2008; 90 (2): 346–51.
Blomberg Jensen M. Vitamin D and Male Reproduction. Nat Rev Endocr. 2014; 10 (3): 175–86.
Hammoud AO, Meikle AW, Peterson CM, Stanford J, Gibson M, Carrell DT. Association of 25-Hydroxy-Vitamin D Levels with Semen and Hormonal Parameters. Asian J Androl. 2012; 14 (6): 855–9.
Uhland AM, Kwiecinski GG, DeLuca HF. Normalization of Serum Calcium Restores Fertility in Vitamin D-Deficient Male Rats. J Nutr. 1992; 122 (6): 1338–44.
Cornwall GA. New Insights Into Epididymal Biology and Function. Hum Reprod Update. 2009; 15 (2): 213–27.
Menegaz D, Rosso A, Royer C, Leite LD, Santos AR, Silva FR. Role of 1-Alpha, 25-OH)-2 Vitamin D3 on Alpha-[1-(14)C]MeAIB Accumulation in Immature Rat Testis. Steroids. 2009; 74 (2): 264–9.
Kumari KR, Hadalagi NM. Role of Sunshine Vitamin “D” Sufficiency in Male and Female Infertility. Int J Reprod Contracep Obstet Gynecol. 2017; 4 (2): 305–11.
Lee DM, Tajar A, Pye SR, Boonen S, Vanderschueren D, Bouillon R, et al. Association of Hypogonadism With Vitamin D Status: The European Male Ageing Study. Eur J Endocrinol. 2012; 166 (1): 77–85.
DOI: http://dx.doi.org/10.24198/obgynia.v3i1.89
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