Characteristics of Infertility Causes in Patients Undergoing in Vitro Fertilization (IVF)

Ida Bagus Putra Adnyana, Ida Bagus Rendra Kurniawan Artha, Anton Tanjung, Luthfi Rahman


Tujuan: Penelitian dilakukan dengan tujuan untuk mengetahui karakteristik faktor penyebab infertilitas pada pasangan yang menjalani in-vitro fertilization (IVF) di Klinik Bayi Tabung Rumah Sakit Umum Bali Royal Hospital periode Januari Desember 2019.

Metode: Penelitian ini adalah penelitian deskriptif observasional dengan populasi target penelitian adalah pasangan infertil yang datang ke Klinik Bayi Tabung Rumah Sakit Umum (RSU) Bali Royal Hospital dengan tindakan IVF pada tahun 2019. Data selanjutnya diolah berdasarkan karakteristik sampel, faktor istri, faktor suami, serta faktor lainnya. 

Hasil: Pada periode 1 Januari–31 Desember 2019, tercatat sebanyak 174 kasus pasien infertilitas. Pada penelitian ini diperoleh bahwa 60,23% terjadi gangguan pada tuba yang merupakan penyebab tertinggi pada kelompok istri, sedangkan gangguan sperma berupa oligoasthenoteratozoospermia (81,82%) merupakan hasil paling tinggi pada kelompok suami. kelainan lainnya yang mengganggu proses fertilisasi pada penelitian ini adalah terdapatnya kelainan uterus pada 23,36% pasangan.

Kesimpulan: Faktor kelainan tuba dan oligoastenoteratozoospermia merupakan karakteristik penyebab terbanyak
infertilitas pada pasangan yang dilakukan IVF

Kata kunci: Infertilitas, IVF,Kelainan tuba, Oligoasthenoteratozoospermia

Characteristics of Infertility Causes in Patients Undergoing in Vitro Fertilization (IVF)

Objective: The study was done to determine the characteristics of infertility cause in couples undergoing in-vitro
fertilization in in-vitro fertilization clinic Bali Royal Hospital Denpasar on January–December 2019.
Method: This was an observational descriptive study with study population of infertile couples that went to in-vitro fertilization clinic at Bali Royal Hospital Denpasar for IVF on 2019. The data obtained will be described based on
sample characteristics, female factor, male factor and other factors.
Result: In one-year period of 1 January–31 December 2019, there were 174 infertile cases included in this study. In this study, we concluded that the most common cause for female factor was tubal problems (60.23%), and for male factor was oligoasthenoteratozoosperm (81.82%), another abnormalities that affect couples fertility were uterus abnormalities (23.26%)
Conclusion: Fallopian tube abnormalities and oligoastenoteratozoospermia were the most common causes of infertility in couples with IVF

Full Text:



Krisnadi SR, Anwar AD. Persalinan Kurang Bulan (Prematur). Dalam: Martaadisoebrata D, Wirakusumah FF, Effendi JS, penyunting. Obstetri Patologi. Edisi. Bandung: EGC; 2013. hlm. 112−5.

Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals. The Lancet. 2016;388(10063):3027−35.

Glass HC, Costarino AT, Stayer SA, Brett C, Cladis F, Davis PJ. Outcomes for Extremely Premature Infants. Anesthesia and analgesia. 2015;120(6):1337−51.

NICE. Preterm labour and birth. NICE guideline. [Guideline]. 2015 20 November 2015:27.

Nadeau HCG, Subramaniam A, Andrews WW. Infection and preterm birth. Seminars in Fetal and Neonatal Medicine. 2016 2016/04/01/;21(2):100−5.

Pradyuman V, Mekhla G. A comparative study of two tocolytic agents for inhibition of preterm labour. Gujarat Medical Journal. 2014;69(1):28−31.

Chiossi G, Saade GR, Sibai B, Berghella V. Using Cervical Length Measurement for Lower Spontaneous Preterm Birth Rates Among Women With Threatened Preterm Labor. Obstetrics & Gynecology. 2018;132(1):102−6.

Sanin Blair J, Palacio M, Delgado J, Figueras F, Coll O, Cabero L, et al. Impact of ultrasound cervical length assessment on duration of hospital stay in the clinical management of threatened preterm labor. Ultrasound in Obstetrics and Gynecology: The Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2004;24(7):756−60.

WHO. WHO recommendations on interventions to improve preterm birth outcomes: evidence base. 2015.

Chawanpaiboon S, Vogel JP, Moller A-B, Lumbiganon P, Petzold M, Hogan D, et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. The Lancet Global Health. 2019;7(1):e37−e46.

Chawanpaiboon S, Sutantawibul A. Effect of cervical length to the efficacy of nifedipine and bed rest for inhibiting threatened preterm labor. Journal Medical Association of Thai. 2012 May;95(5):636−43.

Vis JY, Kuin RA, Grobman WA, Mol BWJ, Bossuyt PMM, Opmeer BC. Additional effects of the cervical length measurement in women with preterm contractions: a systematic review.Archives of Gynecology and Obstetrics. 2011;284(3):521−6.

King JF, Flenady VJ, Papatsonis DN, Dekker GA, Carbonne B. Calcium channel blockers for inhibiting preterm labour. Cochrane Database System Review. 2003(1):Cd002255.

Gaunekar NN, Crowther CA. Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour. Cochrane Database System Review. 2004(3):Cd004071.

Giorgino FL, Egan CG. Use of isoxsuprine hydrochloride as a tocolytic agent in the treatment of preterm labour: a systematic review of previous literature.Arzneimittelforschung. 2010;60(7):415−20.

Dudenhausen JW, Kunze M, Wittwer-Backofen U, Hagenah HP, Strauss A, Günther V, et al. The relationship between maternal age, body mass index, and the rate of preterm birth. Journal of the Turkish German Gynecological Association. 2018;19(4):182.

Astolfi P, Zonta LA. Risks of preterm delivery and association with maternal age, birth order, and fetal gender. Human Reproduction. 1999;14(11):2891−4.

Cavazos-Rehg PA, Krauss MJ, Spitznagel EL, Bommarito K, Madden T, Olsen MA, et al. Maternal age and risk of labor and delivery complications. Maternal and Child Health Journal. 2015;19(6):1202−11.

Alotaibi M. The physiological mechanism of uterine contraction with emphasis on calcium ion. Calcium signaling. 2014;1(2):101−19.

Aguilar HN, Mitchell B. Physiological pathways and molecular mechanisms regulating uterine contractility. Human reproduction update. 2010;16(6):725−44.

Singh N, Singh U, Seth S. Comparative study of nifedipine and isoxpurine as tocolytics for preterm labor. Journal of Obstetrics Gynaecology of India. 2011;61(5):512−5.

Di Renzo GC, Rosati A, Mattei A, Gojnic M, Gerli S. The changing role of progesterone in preterm labour. BJOG: An International Journal of Obstetrics & Gynaecology. 2005 2005/03/01;112(s1):57−60.

Kwasan S, Paisarntuntiwong R, Charoenchainont P. Cervical length measurement by transvaginal sonography in preterm pregnant women for prediction of preterm birth. Journal-Medical Association of Thailand. 2005;88:S48.

Oktavia N, Yulistiani Y, Markus UH, Mamo HI. Effectiveness And Safety Differences of Isoxsuprine And Nifedipine As Tocolytics In The Risk Of Preterm Labor. Folia Medica Indonesiana. 2017;53(4):242−6.

Raymajhi R, Pratap K. A comparative study between nifedipine and isoxsuprine in the suppression of preterm labour. Kathmandu University Medical Journal (KUMJ). 2003;1(2):85−90.



  • There are currently no refbacks.

Alamat Redaksi


KSM/Dep Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran RSUP Dr. Hasan Sadikin

Jl. Pasteur No 38 Bandung 40161 

Telp: 0813-2012-9954





Indexed By

Web Analytics
View My Stats

Indonesian Journal of Obstetrics & Gynecology Science @2017