Korelasi Asupan Vitamin C dan vitamin D dengan Kadar Timbal Ibu Hamil Preeklamsia
(1) Magister of Midwifery Andalas University
(2) Divisi Fetomaternal Departement Obstetri dan Ginekologi Universitas Andalas
(3) 
(*) Corresponding Author
Abstract
Tujuan: Untuk mengetahui korelasi asupan vitamin C dan vitamin D dengan kadar timbal ibu hamil preeklampsia.
Metode: Studi analitik korelatif dengan pendekatan cross sectional. Sampel penelitian ini yaitu 33 orang ibu hamil preeklampsia bertempat tinggal radius ≤10 km, dan 33 orang ibu hamil preeklampsia bertempat tinggal radius >10 km dari PT. Semen Padang. Penelitian dilakukan di RSUD Rasidin, RSPTM Unand, RS. Hermina, RS. Tentara Reksodiwiryo, RS. Ibnu Sina, dan RSUP Dr. M. Djamil Padang pada bulan Mei 2021-Februari 2022.
Hasil: Penelitian menunjukkan bahwa asupan vitamin C memiliki korelasi negatif yang sangat kuat dengan kadar timbal ibu hamil preeklamsia yang bertempat tinggal radius ≤10 km dari pabrik PT. Semen Padang (r=-0,872, p=0,000), sedangkan asupan vitamin C tidak berkorelasi dengan kadar timbal ibu hamil preeklamsia yang bertempat tinggal radius >10 km dari pabrik PT. Semen Padang (r=-0,049, p=0,785). Asupan vitamin D dengan kadar timbal ibu hamil preeklamsia yang bertempat tinggal radius ≤10 km dan >10 km dari pabrik PT. Semen Padang masing-masing memiliki korelasi negatif yang kuat dan sedang (r=- 0,696, r=-512, p=0,000, p=0,002).
Kesimpulan: Terdapat korelasi asupan vitamin C dan vitamin D dengan kadar timbal ibu hamil preeklampsia setelah dikontrol variabel cofounding (radius tempat tinggal, status merokok, dan lingkungan tempat tinggal).
Correlation of Vitamin C and Vitamin D Intake with Lead Levels in Pregnant Women with Preeclampsia
Abstract
Objective: This study aims to determine the correlation between the intake of vitamin C and vitamin D with lead levels in pregnant women with preeclampsia.
Method: This research is a correlative analytic study with a cross-sectional. The sample of this study was 33 preeclampsia pregnant women living in a radius of ≤10 km, and 33 preeclampsia pregnant women residing in a radius of >10 km from PT. The research was conducted at Rasidin Hospital, RSPTM Unand, RS. Hermina, RS. Tentara Reksodiwiryo, RS. Ibnu Sina, and RSUP Dr. M. Djamil Padang in May 2021-February 2022.
Results: Vitamin C intake has a very strong negative correlation with lead levels of preeclampsia pregnant women who live within a radius of ≤10 km from the Semen Padang Factory (r=-0.872, p=0.000), while vitamin C intake is not correlated with the lead levels of preeclampsia pregnant women who live in a radius of >10 km from the Semen Padang Factory (r=-0.049, p=0.785). Vitamin D intake with lead levels of preeclampsia pregnant women who live in a radius of ≤10 km and >10 km from the Semen Padang Factory each has a strong and moderate negative correlation (r=- 0.696, r=-512, p=0.000, p=0.002).
Conclusion: There is a correlation between vitamin C and vitamin D intake and lead levels of preeclampsia in pregnant women after controlling for confounding variables (radius of residence, smoking status, and living environment).
Key words : Lead, Vitamin C intake, Vitamin D intake, Preeclampsia.
Keywords
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World Health Organization. (2019). Maternal mortality. World Health Organization
Mifbakhuddin. (2013). Gambaran Status Gizi dan Profil darah Petugas Operator SPBU yang Terpapar Gas Buang (Pb) Kendaraan Bermotor di Kota Semarang. Jurnal Ekologi Kesehatan . vol. 12, no. 2.
Poropat, A. Laidlaw, M. Lanphear, B. Ball, A. Mielke, H. (2018). Blood lead and preeclampsia: A meta-analysis and review of implications . Enviromental Research. vol. 160, pp. 12-19.
Bayat, F. Akbari, S. A. Dabirioskoei, A. Nasiri, M. Mellati, A. (2016). The Relationship Between Blood Lead Level and Preeclampsia. electronic Physician : Excellence in Constructive Peer Review. vol. 8, Issue 12, pp. 3450-3455.
Taylor, R. r. (2010). Fact sheet: Nutrients that reduce lead poisoning. Global lead advice& support service .
Bachnas, M. (2020). Neuroproteksi Otak Janin Pada Persalinan Preterm dan Pertumbuhan Janin Terhambat. Divisi Fetomaternal, Bagian Obstetri dan Ginekologi. vol.33, Issue 2.
Zahra, N. Johan, A. Ngestiningsih, D. (2019). Hubungan Antara Kadar Vitamin D Dengan Kadar Malondialdehid (MDA) Plasma Pada Lansia. Jurnal Kedokteran Diponegoro. vol. 8, no.
Wimalawansa, S. J. (2019). Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging. Biology. vol. 8, no. 2, pp. 30
Ettinger, A. Wengrovitz, A. G. (2010). Guidelines For The Identification And Management Of Lead Exposure In Pregnant And Lactating Women. Division of Emergency and Environmental Health Services
Luz, Z. Rondo, P. Duran, M. Oliveira, J. (2008). Relationships of blood lead to calcium, iron, and vitamin C intakes in Brazilian pregnant women. Elsevier. vol. 27, Issue 1, pp. 100-104.
Siregar, D. R. (2019). Hubungan Status Vitamin D terhadap Kejadian Early Onset Preeclampsia. Tesis Fakultas Kedokteram USU Departemen Obsetri dan Ginekologi .
Retnosari, E. Permadi, W. Setiawati, E. P. Husin, F. Mose, J. C. Sabaruddin, U. (2015). Korelasi antara Kadar Vitamin D dengan Kejadian Preeklampsi. Indonesian Journal of Education and Midwifery Care. vol. 2, no. 4.
Sakina, N. A. Suhartono, Astorina, N. (2018). Blood Lead Levels in Pregnant Women and the Source of Exposure in Northern Coastal Area of Brebes Regency. Journal Of Public Health For Tropical And Coastal Region (JPHTCR). vol 1. no.1.
Putri, N. B. (2017). Studi Reduksi Particulate Matter 10 (PM10) Udara Ambien oleh Ruang Terbuka Hijau Di Kawasan Pt Petrokimia Gresik. Teknik Sipil dan Perencanaan Institut Teknologi Sepuluh Nopember , Surabaya.
Afdal, dan Yulius, U. (2014). Identifikasi Sebaran Logam Berat Pada Tanah Lapisan Atas dan Hubungannya dengan Suseptibilitas Magnetik di Beberapa Ruas Jalan di Sekitar Pelabuhan Teluk Bayur Padang. Jurnal Fisika Unand. vol.3, no. 4.
Martha, Y., & Budiman, A. (2018). Analisis Suseptibilitas Magnetik dan Kandungan Logam Berat pada Tanah Lapisan Atas di Sekitar Pabrik PT. Semen Padang. Jurnal Fisika Unand. vol. 7, no. 2
Abadin, H. Ashizawa, A. Stevens, Y.W. Liados, F. Diamond, G. Sage, G. et al. (2007). Toxicological Profile for Lead. United States : Agency for Toxic Subtances and Disease Registry.
Al Jameil, N. (2014). Maternal serum lead levels and risk of preeclampsia in pregnant women: a cohort study in a maternity hospital, Riyadh, Saudi Arabia. International Journal of Clinical Experimental Pathology, 7(6): 3182–3189
Marik, P. (2018). Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid. MDPI . vol. 10, no. 11, pp. 1762.
Motawei , Attalla, Gouda, & El-Haro. (2013). Lead level in pregnant women suffering from pre-eclampsia in Dakahlia, Egypt. Int J Occup Environ Med, 36-44
Ghanwat, G. Arun, P. Patil, J. Kshirsagar, M. Sontakke, A. dan Ayachit. (2016). Effect of Vitamin C Supplementation on Blood Lead Level, Oxidative Stress and Antioxidant Status of Battery Manufacturing Workers of Western Maharashtra, India. Journal of Clinical and Diagnostic Research. vol. 10, no. 4
Commite of Opinion. (2012). Lead Screening During Pregnancy and Lactation. The American College of Obstetricians and Gynecologists. Number 533
Kim, H. A. Perrelli, A. Ragni, A. Retta, F. Silva, M. D. Sobey, C. et al. (2020). Vitamin D Deficiency and the Risk of Cerebrovascular Disease. MDPI . vol. 9, Issue 4.
Nassar, K. Rachidi, W. Janani, S. Mkinsi, O. (2016). Vitamin D and Pre-eclampsia. Gynecologics and Obsetrics. vol. 6, no. 6
Agency fo Toxic Substance and Disease Registry. (2019). Lead Toxicity. Case Studies In Environmental Medicine. United States : Agency for Toxic Subtances and Disease Registry
Ballew , & Bowman. (2001). Recommending calcium to reduce lead toxicity in children: a critical review. Nutrition Reviews, Volume 59, Issue 3, Pages 71– 79
Syauqie, M., Machmud, R., Yetti, H., Abdiana, Ilmiawati, C. (2020). Pengaruh emisi debu semen terhadap permukaan okular pada masyarakat di sekitar pabrikl PT. Semen Padang. Majalah Kedokteran Andalas. vol. 43, no. 2.
Bachtiar, V. S, dan Rani, P. S. (2016). Analisis Debu Respirable terhadap Masyarakat di Kawasan Perumahan Sekitar Lokasi Pabrik PT. Semen Padang. Jurnal Teknik Lingkungan UNAND. vol. 3, no. 1, pp. 1-9.
Amalia , N. S., Suhartono , & Dewanti , N. A. (2018). Blood Lead Levels in Pregnant Women and the Soin Northern Coastal Area of Brebes Regency. JOURNAL OF PUBLIC HEALTH FOR TROPICAL AND COASTAL REGION (JPHTCR , Vol. (1) No.1.
Chiarello, D. Abad, C. Rojas, D. Toledo, F. Vazquez, C. Mate, A. et al. (2018). Oxidative astress : Normal Pregnancy versus Preeclampsia. Elsevier. vol. 1866, Issue 2
Yazbeck, C., Thiebaugeorges, O., Moreau, T., Goua, V., Debotte, G., Sahuquillo, J., .. . Huel, G. (2009). Maternal Blood Lead Levels and the Risk of Pregnancy- Induced Hypertension: The EDEN Cohort Study. Environ Health Perspect, 117(10): 1526–1530.
Pasca, A. (2016). Perbedaan Rerata Kadar Resistin Serum Maternal Antara Preeklampsia Awitan Dini (PEAD) dengan Preeklampsia Awitan Lambat (PEAL). Masters Thesis
Nassar, K. Rachidi, W. Janani, S. Mkinsi, O. (2016). Vitamin D and Pre-eclampsia. Gynecologics and Obsetrics. vol. 6, no. 6
DOI: http://dx.doi.org/10.24198/obgynia/v5n2.430
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