Effect of Curcumin towards Metabolic Disturbance Parameters in Patient with PCOS: A Systematic Review and Meta-Analysis of Clinical and Preclinical Randomized Controlled Trials

Angeline Ekafentie,(1*) Nicolas Daniel Widjanarko,(2) Yuliana Yosephine,(3) Mutiara Riani,(4)

(1) School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia
(2) School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia
(3) School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia
(4) Department of Obstetrics and Gynecology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia
(*) Corresponding Author


Objective: Polycystic Ovarian Syndrome (PCOS) is a gynecologic and endocrine disorder with metabolic disturbances and infertility as the most common long-term consequences. Curcumin comes up as one of the alternative herbal remedies in PCOS treatment options. This study aimed to investigate the therapeutic effect of curcumin on metabolic disturbance parameters in PCOS patients and PCOS-modeled rats.
Method: A systematic search of eligible studies was done using PubMed, Google Scholar, EBSCO-Host, and ProQuest according to the PRISMA 2009 guideline. We further assessed for risk of bias using SYRCLE’s risk of bias tool for preclinical studies and The Cochrane risk of bias assessment tool for the clinical studies. We used Review Manager (version 5.4) with random effect model to obtain a pooled mean difference with 95% CIs.
Results: Five preclinical studies and three clinical studies were selected and pooled. The significant decrease in the level of Fasting Plasma Glucose (FPG), Fasting Insulin (FI), lipid profile, and Homeostatic Model of Insulin Resistance (HOMA-IR) value, and a significant increase in Quantitative Insulin-Sensitivity Check Index (QUICKI) value found in preclinical studies. The  result for clinical studies showed  a significantly decreased HOMA-IR values (SMD=-0.36, p=0.001), FPG level (SMD=-3.32, p=0.0001), Serum Insulin level (SMD=-1.47, p=0.002), and increased QUICKI value (SMD=0.01, p=0.006).
Conclusion: Curcumin offers a substantial effect on metabolic disturbance parameters in PCOS patients and could be an alternative promising treatment for PCOS patients in the future.

Pengaruh Kurkuma terhadap Parameter Gangguan Metabolik pada Pasien SOPK: Tinjauan Sistematis dan Meta-Analisis Uji Acak Preklinis dan  Klinis Terkontrol

Tujuan: Sindrom Ovarian Polikistik (PCOS) merupakan suatu kelainan ginekologi dan endokrin dengan gangguan metabolisme dan infertilitas sebagai konsekuensi jangka panjang yang paling umum ditemukan. Kurkumin muncul sebagai salah satu pengobatan herbal alternatif dalam pilihan terapi PCOS. Penelitian ini bertujuan untuk menyelidiki efek terapeutik kurkumin terhadap parameter gangguan metabolik pada pasien PCOS dan model tikus yang mengalami PCOS.
Metode: Penelitian ini dilakukan dengan mencari studi penelitian yang memenuhi syarat menggunakan PubMed, Google Scholar, EBSCO-Host, dan ProQuest mengikuti  PRISMA 2009. Penilaian risiko bias studi menggunakan SYRCLE’s Risk of Bias Tool untuk penelitian preklinis dan The Cochrane Risk of Bias Assessment Tool untuk penelitian klinis. Sintesis kuantitatifmenggunakan Review Manager (versi 5.4) dengan random effect model untuk mendapatkan pooled mean difference dengan interval kepercayaan 95%.
Hasil: Sebanyak lima studi penelitian preklinis dan tiga studi penelitian klinis memenuhi kriteria. Terdapat penurunan signifikan kadar gula darah puasa, insulin puasa, profil lipid, dan nilai HOMA-IR, serta peningkatan nilai QUICKI pada studi preklinis. Pada studi klinis menunjukkan  penurunan nilai HOMA-IR (SMD=-0,36, p=0,001), gula darah puasa (SMD=-3,32, p=0,0001), insulin serum (SMD=-1,47, p=0,002),  dan peningkatan nilai QUICKI (SMD=0,01, p=0,006).
Kesimpulan: Curcumin dapat memberikan efek terapeutik terhadap parameter gangguan metabolik pasien PCOS dan menjadi salah satu tatalaksana alternatif pasien PCOS di masa depan.

Kata kunci: kurkuma; gula darah puasa; sindrom ovarium polikistik.


curcumin; fasting blood glucose; polycystic ovary syndrome

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Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol 2013;6:1–13.

Wekker V, Dammen LV, Koning A, Heida KY, Painter RC, Limpens J, et al. Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis. Human Reproduction Update 2020;26(6):942-960.

Louwers YV, Laven JSE. Characteristics of polycystic ovary syndrome throughout life. Ther Adv Reprod Health 2020;14.

Badawy A, Elnashar A. Treatment options for polycystic ovary syndrome. Int J Womens Health 2011;3:25–35.

Domecq JP, Prutsky G, Mullan RJ, Sundaresh V, Wang AT, Erwin PJ, et al. Adverse Effects of the Common Treatments for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab 2013;98(12):4646–54.

Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 2003;23(1A):363–98.

Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Bio 2007;595:105–25.

Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mendía LE, Majeed M, et al. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed Pharmacother 2016;82:578–82.

Murugan P, Pari L, Rao CA. Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes. J Biosci 2008;33(1):63–72.

Arun N, Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr Dordr Neth 2002;57(1):41–52.

Hewlings SJ, Kalman DS. Curcumin: A Review of Its’ Effects on Human Health. Foods 2017;6(10):92.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009;339:b2700.

Hooijmans CR, Rovers MM, de Vries RBM, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol 2014;14:43.

RoB 2: A revised Cochrane risk-of-bias tool for randomized trials. Available at: https://methods.cochrane.org/bias/resources/rob-2-revised-cochrane-risk-bias-tool-randomized-trials. Cochrane Methods Bias. Accessed January 21, 2021.

Chapter 8: Assessing risk of bias in included studies. Cochrane Handbook for Systematic Reviews of Interventions. Available at: https://handbook-5-1.cochrane.org/chapter_8/8_assessing_risk_of_bias_in_included_studies.htm. Accessed January 21, 2021.

Chapter 10: Analysing data and undertaking meta-analyses. Cochrane Handbook for Systematic Reviews of Interventions Available at: /handbook/current/chapter-10. Accessed January 21, 2021.

Mohammadi A, Sahebkar A, Iranshahi M, Amini M, Khojasteh R, Ghayour-Mobarhan M, et al. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytother Res PTR 2013;27(3):374–9.

Huang J, Qin S, Huang L, Tang Y, Ren H, Hu H. Efficacy and safety of Rhizoma curcumea longae with respect to improving the glucose metabolism of patients at risk for cardiovascular disease: a meta-analysis of randomised controlled trials. J Hum Nutr Diet Off J Br Diet Assoc 2019;32(5):591–606.

Tabrizi R, Vakili S, Lankarani KB, Akbari M, Mirhosseini N, Ghayour-Mobarhan M, et al. The Effects of Curcumin on Glycemic Control and Lipid Profiles Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Metaanalysis of Randomized Controlled Trials. Curr Pharm 2018;24(27):3184–99.

Sahebkar A. A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels. Clin Nutr Edinb Scotl. 2014;33(3):406–14.

Hodaei H, Adibian M, Nikpayam O, Hedayati M, Sohrab G. The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial. Diabetol Metab Syndr 2019;11(1):41.

Na LX, Li Y, Pan HZ, Zhou XL, Sun DJ, Meng M, et al. Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial. Mol Nutr Food Res 2013;57(9):1569–77.

Chougala MB, Bhaskar JJ, Rajan MGR, Salimath PV. Effect of curcumin and quercetin on lysosomal enzyme activities in streptozotocin-induced diabetic rats. Clin Nutr Edinb Scotl 2012;31(5):749–55.

Rivera-Mancía S, Trujillo J, Chaverri JP. Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies. J Nutr Intermed Metab 2018;14:29–41.

Solinas G, Becattini B. JNK at the crossroad of obesity, insulin resistance, and cell stress response. Mol Metab 2016;6(2):174–84.

Kato M, Nishikawa S, Ikehata A, Dochi K, Tani T, Takahashi T, et al. Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion. Mol Nutr Food Res 2017;61(3).

Jamilian M, Foroozanfard F, Kavossian E, Aghadavod E, Shafabakhsh R, Hoseini A, et al. Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Clin Nutr ESPEN 2020;36:128–33.

Song Z, Wang H, Zhu L, Han M, Gao Y, Du Y, et al. Curcumin improves high glucose-induced INS-1 cell insulin resistance via activation of insulin signaling. Food Funct. 2015;6(2):461–9.

Sanoobar M, Eghtesadi S, Azimi A, Khalili M, Jazayeri S, Reza Gohari M. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. Int J Neurosci 2013;123(11):776–82.

Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr 2020;59(2):477–83.

Jin T, Song Z, Weng J, Fantus IG. Curcumin and other dietary polyphenols: potential mechanisms of metabolic actions and therapy for diabetes and obesity. Am J Physiol Endocrinol Metab 2018;314(3):E201–5.

Alsharif FJ, Almuhtadi YA. The Effect of Curcumin Supplementation on Anthropometric Measures among Overweight or Obese Adults. Nutrients [Internet]. 2021 Feb 20 [cited 2021 Mar 14];13(2). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924377/

Shahmoradi MK, Askaripour M, Rajabi S, Dzigandzli G. Beneficial Effects of Curcumin on Rats with Polycystic Ovary Syndrome: Evaluation of the Gene Expression of GLUT4, Erα and Insulin Resistance. GMJ Med 2018;2(1):80–7.

Ferguson JJA, Stojanovski E, MacDonald-Wicks L, Garg ML. Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial. Metabolism 2018;82:22–35.

Zingg J-M, Hasan ST, Meydani M. Molecular mechanisms of hypolipidemic effects of curcumin. BioFactors Oxf Engl 2013;39(1):101–21.

Bachmeier BE, Mirisola V, Romeo F, Generoso L, Esposito A, Dell’eva R, et al. Reference profile correlation reveals estrogen-like trancriptional activity of Curcumin. Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol 2010;26(3):471–82.

Abuelezz NZ, Shabana ME, Abdel-Mageed HM, Rashed L, Morcos GNB. Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: Insights on PI3K/AkT/mTOR and TNF-α modulations. Life Sci 2020;256:118003.

Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin Cancer Res Off J Am Assoc Cancer Res 2007;13(11):3423–30.

Reddy PS, Begum N, Mutha S, Bakshi V. Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome. Asian Pac J Reprod 2016;5(2):116–22.

Lao CD, Ruffin MT, Normolle D, Heath DD, Murray SI, Bailey JM, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 2006;6:10.

Aggarwal BB, Harikumar KB. Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases. Int J Biochem Cell Biol 2009;41(1):40–59.

DOI: http://dx.doi.org/10.24198/obgynia/v6.n2.484


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