Effectiveness of Vitamin D Therapy on the Lipid Profile of Patients with Polycystic Ovary Syndrome

Fatimah Usman, Adnan Abadi, Kms. Yusuf Effendi, Heriyadi Manan, Hana Andrina


Polycystic ovary syndrome (PCOS) is characterized by chronic hyperandrogenism and anovulation that is also associated with various clinical and biochemical features. Vitamin D deficiency is a common problem that affects up to half of the adult population worldwide, including patients with PCOS. Based on these considerations, we are interested in further exploring the effectiveness of vitamin D in improving lipid profiles in PCOS.

Efektivitas Terapi Vitamin D pada Profil Lipid Penderita Sindrom Ovarium Polikistik

Sindrom Ovarium Polikistik (PCOS) ditandai dengan hiperandrogenisme kronis dan anovulasi yang juga berhubungan dengan berbagai gambaran klinis dan biokimia. Kekurangan vitamin D adalah masalah umum yang mempengaruhi setengah populasi orang dewasa di seluruh dunia, termasuk pasien PCOS. Tinjauan literatur ini dilakukan untuk mencari artikel asli dan review mengenai pertanyaan spesifik mengenai efektivitas terapi vitamin D terhadap profil lipid pasien PCOS.

Kata kunci: PCOS, Lipid, Vitamin D


PCOS, Lipids, Vitamin D

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Hoffman BL, Halvorson LM, Schorge JO, Bradshaw KD, Schaffer JI, Corton MM. Williams’s Gynecology. 3rd Edition. New York; 2016.

Escobar-Morreale HF. Polycystic ovary syndrome: Definition, aetiology, diagnosis and treatment. Vol. 14, Nature Reviews Endocrinology. Nature Publishing Group; 2018. p.m. 270–84.

Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Vol. 106, Fertility and Sterility. Elsevier Inc.; 2016. p.m. 6–15.

Abashova EI, Yarmolinskaya MI, Bulgakova OL, Misharina E v. Lipid Profile in Women of Reproductive Age With Various Polycystic Ovary Syndrome Phenotypes. Journal of Obstetrics and Women’s Diseases. 2020 ;69 (6):7–16.

Shi XY, Yao J, Fan SM, Hong PP, Xia YG, Chen Q. Effects of Vitamin D Supplementation on Serum Lipid Profile in Women with Polycystic Ovary Syndrome: A Protocol For A Systematic Review and Meta-analysis. Vol. 99, Medicine (United States). Lippincott Williams and Wilkins; 2020.

Alanouti F, Abboud M, Papandreou D, Mahboub N, Haidar S, Rizk R. Effects of Vitamin D Supplementation on Lipid Profile in Adults with The Metabolic Syndrome: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Vol. 12, Nutrients. MDPI AG; 2020. p.s. 1–25.

Wolf WM, Wattick RA, Kinkade ON, Olfert MD. Geographical Prevalence of Polycystic Ovary Syndrome as Determined by Region and Race/Ethnicity. Vol. 15, International Journal of Environmental Research and Public Health. MDPI AG; 2018.

Sadeghi HM, Adeli I, Calina D, Docea AO, Mousavi T, Daniali M, et al. Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing. Vol. 23, International Journal of Molecular Sciences. MDPI; 2022.

Bakir MB, Abdel-Mageed SM, Mohamed EI. Etiology, Management, and Treatment of Polycystic Ovary Syndrome: A Systematic Review of Pulmonary Function and Body Composition View project Global Mapping of Cancer Odors by E-Nose Technology View project. Journal Of Women’s Health [Internet]. 2021 ;3 (3):39–56. Available from: https://www.researchgate.net/publication/349710089

Mumusoglu S, Yildiz BO. Polycystic Ovary Syndrome Phenotypes and Prevalence: Differential Impact of Diagnostic Criteria and Clinical Versus Unselected Population. Vol. 12, Current Opinion in Endocrine and Metabolic Research. Elsevier Ltd; 2020. p.m. 66–71.

Lentscher JA, Decherney AH. Clinical Presentation and Diagnosis of Polycystic Ovarian Syndrome. Clinical Obstetrics and Gynecology. 2021 Mar ;64 (1):3–11.

Witchel SF, Oberfield SE, Peña AS. Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment with Emphasis on Adolescent Girls. Vol. 3, Journal of the Endocrine Society. Oxford University Press; 2019. p.m. 1545–73.

Taylor HS, Pal L, Seli E. Speroff’s Clinical Gynecologic Endocrinology and Infertility. 9th Edition. Philadelphia; 2020.

Carpentier Y, Sobotka L. Basics In Clinical Nutrition: Lipid Metabolism. Vol. 3, e-SPEN. Elsevier BV; 2008.

Ciavattini A, Serri M, Delli Carpini G, Morini S, Clemente N. Ovarian endometriosis and vitamin D serum levels. Gynecological Endocrinology. 2017 Feb 1 ;33 (2):164–7.

Aziza D Octaviana, Kurniati KI. Vitamin D Supplementation in Women with Polycystic Ovarian Syndrome (PCOS). Sandi Husada Health Scientific Journal. 2019 Dec 30 ;8 (2):169–77.

Wang L, Lv S, Li F, Yu X, Bai E, Yang X. Vitamin D Deficiency Is Associated With Metabolic Risk Factors in Women With Polycystic Ovary Syndrome: A Cross-Sectional Study in Shaanxi China. Frontiers in Endocrinology. Mar 2020 31 ;11

Luo J, Li T, Yuan J. Effectiveness of vitamin d supplementation on lipid profile in polycystic ovary syndrome women: A meta-analysis of randomized controlled trials. Annals of Palliative Medicine. 2021 ;10 (1):114–29.

Dastorani M, Aghadavod E, Mirhosseini N, Foroozanfard F, Zadeh Modarres S, Amiri Siavashani M, et al. The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization. Reproductive Biology and Endocrinology. 2018 Oct 4 ;

DOI: http://dx.doi.org/10.24198/obgynia.v7i1.522


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