Hubungan Antara Neutrophil Gelatinase Associated Lipocaline (NGAL) dan Kejadian Preeklamsia: Penelitian Potong-Lintang

Edward Chandra Koesuma, Efendi Lukas, Mardiah Tahir, Isharyah Sunarno, Elizabet C Jusuf, Nuraini Abidin


Abstract


Tujuan: Untuk mengetahui hubungan antara kadar Neutrophil Gelatinase Associated Lipocaline (NGAL) pada kehamilan normal, Preeklamsia Berat (PEB) tanpa Komplikasi, dan PEB dengan Komplikasi.
Metode:Desain penelitian cross sectional dilakukan pada ibu hamil dengan usia kehamilan lebih dari 20 minggu di RSUP Dr. Wahidin Sudirohusodo dan rumah sakit jejaring pendidikan lainnya sejak bulan Januari hingga Juni tahun 2022. Data dikumpulkan menggunakan sampel darah dan diperiksa lebih lanjut dengan metode ELISA. Uji Chi-Square digunakan untuk menganalisis hubungan antara kadar NGAL dan derajat keparahan PEB.
Hasil: Pada penelitian ini mencakup 156 sampel, yang terdiri atas wanita hamil normal (n=53), wanita hamil dengan PEB tanpa komplikasi (n=50), dan wanita hamil dengan PEB dan komplikasi (n=53). Penelitian ini menemukan bahwa semakin  berat derajat preeklamsia, maka  semakin rendah kadar NGAL-nya yaitu kadar NGAL diamati pada 58% wanita PEB dengan komplikasi dan 32,1% wanita PEB tanpa komplikasi dan 9,8% pada kehamilan normal (p <0,05). Hasil penelitian ini  tidak sesuai dengan teori yang menemukan peningkatan kadar NGAL pada pasien PEB. Penurunan kadar NGAL ini mungkin dapat disebabkan oleh prevalensi obesitas yang banyak pada kelompok PEB dengan dan tanpa komplikasi. Obesitas merupakan  kondisi inflamasi sistemik dan NGAL dapat bertindak sebagai regulator negatif terhadap aktivitas inflamasi yang dimediasi oleh disfungsi adiposit. Pada kelompok PEB juga didapatkan pemberian MgSO4, yang  memiliki peran untuk menghambat kadar IL-6 sehingga dapat menurunkan kadar NGAL
Kesimpulan: Penurunan kadar NGAL berpotensi untuk menjadi biomarker dalam menilai derajat keparahan preeklamsia.

Correlation Between Neutrophil Gelatinase Associated Lipocaline (NGAL) and Preeclampsia: A Cross-sectional Study

Abstract    
Objective: to observe the correlation between level of Neutrophil Gelatinase Associated Lipocaline (NGAL) on normal pregnancy, severe preeclampsia (SPE) without complication, & SPE with complication.
Method: Cross-sectional Study Design method is performed on pregnant women with gestational age of more than 20 weeks at Dr. Wahidin Sudirohusodo hospital & the other educational networking hospitals from January to June 2022. Data were collected using blood samples & further examined with ELISA method. Chi-Square test   is used to analyze the correlation between NGAL level & degree of severity of the severe preeclampsia.
Results: this study includes 156 samples consisting of normal pregnant women (n=53), pregnant women with SPE without complication (n= 50), & pregnant women with SPE with complication (n= 53), we found out that the more severe the degree of preeclampsia, the lower the level of NGAL where the level of NGAL is observed on 58% of pregnant women with complication & 32.1% pregnant women without complication, & 9.8% on women with normal pregnancy (p<0.05). This study result is irrelevant with the theory which  found the rising level of NGAL on patients with SPE, this decreasing level of NGAL might be caused by obesity prevalence mostly found on pregnant with & without complication since obesity is a systemic  inflammatory condition & NGAL can act as negative regulator against inflammatory activity mediated by adipocyte disfunction. On SPE group there is also MgSO4 administration functioning as a hindrance for IL6 level thus may lessen the NGAL level.
Conclusion: the decreasing level of NGAL  is potential to become a biomarker in evaluating the severity of preeclampsia.

Key words: degree of severity, Neutrophil Gelatinase Associated Lipocaline, preeclampsia


Keywords


Derajat keparahan; neutrophil gelatinase associated lipocalin; preeklamsia

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References


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DOI: http://dx.doi.org/10.24198/obgynia/v6.n3.567

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