Hubungan antara Kadar Hepsidin dan Kadar Hemoglobin pada Kehamilan dengan Obesitas

Andi Sri Ratnaningsih; Isharyah Sunarno; Fatmawati Madya; Firdaus Hamid; Trika Irianta; Susiawaty Susiawaty

doi:10.24198/obgynia.v7i1.583

Hubungan antara Kadar Hepsidin dan Kadar Hemoglobin pada Kehamilan dengan Obesitas

Andi Sri Ratnaningsih, Isharyah Sunarno, Fatmawati Madya, Firdaus Hamid, Trika Irianta, Susiawaty Susiawaty

Abstract

Tujuan: Untuk menilai kadar Hepsidin dan kadar hemoglobin menggunakan sampel darah dan selanjutnya dianalisis dengan metode ELISA.
Metode: Penelitian ini merupakan kohort prospektif pada perempuan hamil dengan obesitas dan pembanding non-obesitas pada trimester pertama dan kedua di RSUP Dr. Wahidin Sudirohusodo dan Rumah Sakit Pendidikan Jejaring pada periode Januari - Agustus 2022.
Hasil: Penelitian dilakukan terhadap 44 sampel yang terdiri atas 22 sampel kelompok ibu hamil dengan obesitas dan 22 sampel ibu hamil dengan IMT normal. Pada pasien obesitas tidak didapatkan korelasi antara kadar Hepsidin dan kadar hemoglobin di trimester pertama dengan nilai p=0.097 sedangkan pada trimester kedua terdapat korelasi dengan nilai p=0.028. Pada pasien non obesitas tidak didapatkan korelasi antara kadar Hepsidin dengan kadar hemoglobin nilai p=0.489 di trimester pertama dan nilai p=0.906 di trimester kedua.
Kesimpulan: Peningkatan kadar Hepsidin dan anemia dapat ditemukan pada wanita obese yang sedang hamil, terutama pada trimester kedua.

The Relationship Between Hepcidin Levels And Hemoglobin Levels In Pregnancy With Obesity

Abstract
Objective: To compare hepcidin levels and hemoglobin levels using blood samples and further analyzed with ELISA method.
Method: This study is a prospective cohort of obese pregnant women and a non-obese comparator in the first and second trimesters at RSUP Dr. Wahidin Sudirohusodo Hospital and Networking Teaching Hospitals in the period January - August 2022.
Results: The study was conducted on 44 samples consisting of 22 samples of obese pregnant women and 22 samples of pregnant women with normal BMI. In obese sample, there was no correlation between hepcidin levels and hemoglobin levels in the first trimester with a value of p=0.097 while in the second trimester there was a correlation with a value of p=0.028. In non-obese patients, there was no correlation between hepcidin levels and hemoglobin levels, p = 0.489 in the first trimester and p= 0.906 in the second trimester.
Conclusion: Increased hepcidin levels and anemia can be found in obese women in the second trimester of pregnancy.

Key words: Hepcidin, Obesity, Hemoglobin

Keywords

Hepcidin; Obesitas; Hemoglobin

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DOI: http://dx.doi.org/10.24198/obgynia.v7i1.583