2026-05-28T16:52:50Z https://www.obgynia.com/obgyn/index.php/obgynia/oai

oai:ojs.obgynia.com:article/329 2024-03-19T02:46:16Z obgynia:AR

Antiviral Treatment on Pregnancy with COVID-19 Infection : A Systematic Review Simanjuntak, Tigor Peniel Kakerissa, Angela Putri Kurniawan, Grady Ivan Antiviral, pregnant, covid-19 Objective to evaluate antiviral treatment, duration, and side effects on pregnant women based on gestational age and severity of COVID-19 infection. Method: a systematic review of antiviral treatment, duration, and side effects on pregnant women based on gestational age and severity of COVID-19 infection. Systematic review was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) Statement.  Result 948 papers accessed through Pubmed, Scopus, Science Direct, Cohcrane, and other with keywords “Antiviral”, “Pregnancy” “Pregnant” “Coronavirus” “COVID-19” “SARS-CoV-2”. Duplicate papers were excluded (n=302),  topics and abstracts that do not meet the criteria (n=612), and 25 papers that did not meet the inclusion criteria. 9 papers that meet the inclusion criteria (case reports and cohort retrospective case study) discussed 20 pregnant women with COVID-19 infection (16 moderate and severe cases received Remdesivir, 3 moderate and mild cases received Lopinavir-ritonavir combination, and 1 moderate case received Arbidol). Conclusion, remdesivir is an antiviral frequently used in pregnancy on trimester II and III with severe COVID-19 infection with a duration of treatment of 5-10 days. Remdesivir should be monitored because some show side effects of increasing liver function.Pengobatan Ibu Hamil yang Terinfeksi  COVID−19 dengan AntivirusAbstrakTujuan untuk mengevaluasi penggunaan obat antivirus, lama pengobatan, dan efek samping pada wanita hamil dengan infeksi COVID-19 berdasarkan usia kehamilan dan derajat keparahan. Metode tinjauan literatur sistematis tentang penggunaan obat antivirus, lama pengobatan, dan efek samping pada wanita hamil dengan infeksi COVID-19 berdasarkan usia kehamilan dan tingkat keparahan. Tinjauan sistematis mengikuti pedoman dari Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Hasil terdapat 948 jurnal yang diakses melalui Pubmed, Scopus, Science Direct, Cohcrane dan lainya dengan kata kunci : Antiviral, Pregnancy, Pregnant, Coronavirus, COVID-19, SARS-CoV-2. Terdapat jurnal yang terduplikasi (n=302), topik dan abstrak yang tidak sesuai kriteria (n=612), dan 25 jurnal yang tidak sesuai kriteria inklusi. Terdapat 9 jurnal yang memenuhi kriteria inklusi (laporan kasus dan studi retrosepktif kohort) yang membahas 20 wanita hamil dengan infeksi COVID-19 (16 kasus dengan derajat sedang dan berat menerima Remdesivir, 3 kasus derajat sedang dan ringan menerima kombinasi Lopinavir-ritonavir, dan 1 kasus derajat sedang menerima Arbidol). Kesimpulan, remdesivir adalah antivirus yang sering digunakan pada wanita hamil trisemester II dan III dengan infeksi COVID-19 derajat berat, lama pengobatan 5-10 hari. Remdesivir harus diwaspadai karena dapat menimbulkan efek samping seperti peningkatan fungsi hati. Kata kunci: Antivirus, Hamil, COVID-19 Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran none 2021-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/329 10.24198/obgynia.v4i2s.329 Obgynia; Special Issue: Article Review; 78-85 Indonesian Journal of Obstetrics & Gynecology Science; Special Issue: Article Review; 78-85 2615-496X 10.24198/obgynia.v4i2s eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/329/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/329/192 Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/639 2024-04-29T04:12:24Z obgynia:RA

Kejadian Ballooning dan Avulsi Otot Levator Ani Pada Persalinan Spontan Primipara Non OASIS di Fasilitas Kesehatan Tingkat Pertama Rahman, Muhammad Nurhadi Sukarsa, Mochamad Rizkar Arev Rinaldi, Andi Rinaldi Achmad, Eppy Darmadi Sasotya, Raden Mas Sonny Armawan3, Edwin avulsi otot levator ani, ballooning otot levator ani, primipara, robekan perineum derajat ringan Pendahuluan: Kerusakan otot levator ani, seperti Ballooning dan Avulsi, sering terjadi pada Obstetric Anal Sphincter Injuries (OASIS) saat persalinan, yang menyebabkan masalah jangka panjang seperti inkontinensia dan prolaps uteri. Namun, hubungan antara kerusakan ini dengan robekan perineum derajat ringan atau Non-OASIS masih kurang dipahami. Penelitian ini bertujuan untuk mengeksplorasi prevalensi Ballooning dan Avulsi pada persalinan spontan primipara Non-OASIS tanpa episiotomi di fasilitas kesehatan tingkat pertamaMetode: Studi cross-sectional dilakukan di Rumah Sakit Umum Pusat Dr. Sardjito Yogyakarta dan praktik mandiri bidan di Sleman, Yogyakarta, melibatkan 69 pasien. Penggunaan USG 3D melalui pendekatan translabial digunakan untuk mengidentifikasi Ballooning dan Avulsi.Hasil: Dari 69 pasien yang mengalami persalinan spontan primipara Non-OASIS tanpa episiotomi yang terlibat dalam penelitian ini, 66,67% pasien mengalami robekan perineum derajat ringan, sementara 33,3% memiliki perineum intak. Prevalensi Ballooning adalah 26,1% dan Avulsi adalah 17,4%. Ballooning lebih umum terjadi pada pasien dengan robekan perineum derajat ringan (32,6%) daripada yang memiliki perineum intak (13,0%). Avulsi juga lebih sering terjadi pada pasien dengan robekan perineum derajat ringan (21,7%) dibandingkan dengan yang memiliki perineum intak (8,7%).Kesimpulan: Avulsi terjadi pada satu dari empat persalinan spontan primipara Non-OASIS tanpa episiotomi, sementara Ballooning terjadi pada satu dari enam persalinan. Studi ini memberikan wawasan tentang karakteristik kerusakan otot levator ani dalam setting praktik kebidanan mandiri yang berjejaring dengan fasilitas kesehatan tingkat pertama.The occurance of Ballooning and Avulsion of The Levator Ani Muscles in First Spontaneous Vaginal Birth Non-OASIS without Episiotomy at Primary Health FacilitiesAbstract Introduction: Damage to the levator ani muscles, such as Ballooning and Avulsion, often occurs during Obstetric Anal Sphincter Injuries (OASIS) during childbirth, leading to long-term issues like incontinence and uterine prolapse. However, the relationship between this damage and mild perineal tears or Non-OASIS is not fully understood. This study aims to explore the prevalence of Ballooning and Avulsion in spontaneous primiparous deliveries without episiotomy in primary healthcare facilities.Method: A cross-sectional study was conducted at Dr. Sardjito General Hospital in Yogyakarta and midwifery practices in Sleman, Yogyakarta, involving 69 patients. 3D ultrasound via translabial approach was used to identify Ballooning and Avulsion.Results: Out of 69 patients undergoing spontaneous primiparous deliveries without episiotomy, 66.67% experienced mild perineal tears, while 33.3% had intact perineum. The prevalence of Ballooning was 26.1% and Avulsion was 17.4%. Ballooning was more common in patients with mild perineal tears (32.6%) compared to those with intact perineum (13.0%). Avulsion also occurred more frequently in patients with mild perineal tears (21.7%) compared to those with intact perineum (8.7%).Conclusion: Avulsion occurs in one out of four spontaneous primiparous deliveries without episiotomy, while Ballooning occurs in one out of six deliveries. This study provides insights into the characteristics of levator ani muscle damage in the setting of primary healthcare facilities connected to independent midwifery practices.Key words: levator ani muscle avulsion, levator ani muscle ballooning, primipara, mild perineal tear. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/639 10.24198/obgynia.v7i1.639 Obgynia; Volume 7 Nomor 1 Maret 2024; 92-102 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 1 Maret 2024; 92-102 2615-496X 10.24198/obgynia.v7i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/639/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/639/405 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/1003 2026-01-23T07:42:49Z obgynia:RA

Survival Outcomes at Three Years After Primary vs Interval Debulking in Advanced Ovarian Cancer: A Retrospective Study from Hasan Sadikin Hospital (2021) Everdien, Alce Kurniadi, Andi Pusianawati, Dini Nisa, Aisyah Shofiatun Subhan, Dadang Hawari ovarian cancer; primary debulking surgery; interval debulking surgery; overall survival Objective: Ovarian cancer is the third most prevalent malignancy among women in Indonesia. The 5-year survival rate is approximately 49%, with 68% of patients diagnosed at an advanced stage. Standard treatment involves debulking surgery, which is categorized into primary debulking surgery (PDS) and interval debulking surgery (IDS). This study aims to compare the survival outcomes of ovarian cancer patients treated with PDS versus IDS at Dr. Hasan Sadikin General Hospital (RSHS) during 2021.Methods: A retrospective review of medical records was performed for ovarian cancer patients who underwent surgery at RSHS in 2021. Patients were classified according to the type of surgical management (PDS or IDS), and survival data were analyzed accordingly.Result: A total of 46 patients were included, with 38 undergoing PDS and 8 undergoing IDS. The mean overall survival was 34.1 months for the PDS group and 27.5 months for the IDS group. Bivariate analysis showed no significant difference in survival between the two groups (HR: 1.810, p = 0.341; 95% CI: 0.53–6.13). However, age (HR: 0.950, p = 0.014; 95% CI: 0.91–0.99) and progression-free survival duration (HR: 0.788, p = 0.0001; 95% CI: 0.71–0.86) were identified as significant prognostic factors for overall survival.Conclusion: The mean overall survival for patients undergoing primary debulking surgery (PDS) was higher than for those undergoing interval debulking surgery (IDS), although this difference was not statistically significant.Angka Kelangsungan Hidup Tiga Tahun Setelah Debulking Primer vs Interval pada Kanker Ovarium Stadium Lanjut: Sebuah Studi Retrospektif di RSUP Hasan Sadikin (2021)AbstrakTujuan: Kanker ovarium merupakan keganasan ketiga terbanyak pada wanita di Indonesia. Angka kelangsungan hidup 5 tahun sekira 49%, dengan 68% pasien datang pada stadium lanjut. Tatalaksana standar melibatkan operasi debulking yang diklasifikasikan menjadi operasi debulking primer (PDS) dan operasi debulking interval (IDS). Penelitian ini bertujuan untuk membandingkan hasil kelangsungan hidup pasien kanker ovarium yang diobati dengan PDS versus IDS di RSUP Dr. Hasan Sadikin (RSHS) selama tahun 2021.Metode: Sebuah studi retrospektif dilakukan melalui tinjauan rekam medis pasien kanker ovarium yang menjalani tatalaksana bedah di RSHS pada tahun 2021. Pasien dikategorikan berdasarkan jenis tatalaksana bedah (PDS atau IDS), dan data kelangsungan hidup dianalisis.Hasil: Sebanyak 46 subjek diikutsertakan, dengan 38 pasien menjalani PDS dan 8 pasien menjalani IDS. Rerata kelangsungan hidup keseluruhan adalah 34,1 bulan pada kelompok PDS dan 27,5 bulan pada kelompok IDS. Analisis bivariat tidak menunjukkan perbedaan signifikan dalam kelangsungan hidup antara kedua kelompok (HR: 1,810, p = 0,341; 95% CI: 0,53–6,13). Namun, usia (HR: 0,950, p = 0,014; 95% CI: 0,91–0,99) dan durasi kelangsungan hidup bebas progresi (HR: 0,788, p = 0,0001; 95% CI: 0,71–0,86) diidentifikasi sebagai faktor prognostik yang signifikan terhadap kelangsungan hidup keseluruhan.Kesimpulan: Rata-rata kelangsungan hidup keseluruhan pasien yang menjalani operasi debulking primer (PDS) lebih tinggi daripada rata-rata kelangsungan hidup keseluruhan pasien yang menjalani operasi debulking interval (IDS), meskipun tidak signifikan secara statistik.Kata kunci: Angka kelangsungan hidup; kanker ovarium; pembedahan debulking interval; pembedahan debulking primer Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1003 10.24198/obgynia.v8i3.1003 Obgynia; Volume 8 Nomor 3 November 2025; 503-511 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 3 November 2025; 503-511 2615-496X 10.24198/obgynia.v8i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1003/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1003/853 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1003/865 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1003/866 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/425 2022-09-27T01:54:49Z obgynia:ED

Infeksi Luka Operasi pada Kanker Ginekologi Salima, Siti Mantilidewi, Kemala Isnainiasih Harsono, Ali Budi infeksi, operasi Infeksi luka operasi (ILO) merupakan infeksi pada area operasi yang terjadi dalam waktu 30 hari setelah intervensi bedah. Menurut World Health Organization (WHO), ILO merupakan jenis infeksi nosokomial yang paling sering terjadi pada negara berpenghasilan rendah dan menengah dengan insidensi 11,8 episode per 100 prosedur bedah.1 Infeksi luka operasi dilaporkan terjadi pada 2.6-4.3% pasien yang menjalani operasi.2 Insidensi ILO setelah histerektomi bervariasi mulai dari 1.7-11% tergantung pendekatan operasi, indikasi operasi, dan penggunaan antibiotik profilaksis Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2022-09-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/425 10.24198/obgynia.v5i2.425 Obgynia; Volume 5 Nomor 2 September 2022; 158-160 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 2 September 2022; 158-160 2615-496X 10.24198/obgynia.v5i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/425/pdf Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/736 2024-08-01T02:17:57Z obgynia:FBM

Front Cover, Editorial Team, Table of Contents, and Back Cover Jurnal, Obgynia Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-07-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/736 10.24198/obgynia.v7i2.736 Obgynia; Volume 7 Nomor 2 Juli 2024 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 2 Juli 2024 2615-496X 10.24198/obgynia.v7i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/736/311 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/478 2023-07-17T03:12:46Z obgynia:RA

Hubungan Ekspresi Cyclooxygenase-2 (Cox-2) dengan Invasi Limfovaskuler, Infiltrasi Sel Radang dan Stadium Kanker Serviks Onterio, Andi Ahmed Rauf, Syahrul Pelupessy, Nugraha Utama Masadah, Rina Sunarno, Isharyah Mappaware, Nasrudin Andi Arifuddin, Sharvianty Cyclooxygenase-2, kanker serviks, stadium Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan Ekspresi COX-2 dengan Lymphovascular Space Invasion (LVSI), Infiltrasi sel radang dan stadium kanker serviks. Metode: Penelitian ini menggunakan desain cross sectional di Rumah Sakit Pendidikan Tinggi Negeri Universitas Hasanuddin. Pengambilan sampel menggunakan teknik total sampling dengan data pemeriksaan kadar COX-2 pada 50 hasil biopsi dan hasil operasi pada kasus kasus kanker serviks melalui pemeriksaan immunohistokimia. Data dianalisis dengan uji chi-square dengan tingkat kepercayaan 95%. Hasil: Hasil penelitian diperoleh ada hubungan signifikan antara eskpresi COX-2 dan stadium kanker serviks dengan nilai p<0,05. Ekspresi COX-2 tidak berhubungan signifikan dengan Lymphovascular Space Invasion dan infiltrasi sel radang dengan nilai p>0,05. Ekspresi COX-2 juga tidak berhubungan signifikan dengan paritas, pendidikan, pekerjaan, penggunaan kontrasepsi oral kombinasi ≥5 tahun, mitra seksual, dan riwayat merokok dengan nilai p>0,05. Kesimpulan: Berdasarkan hasil penelitian dapat disimpulkan bahwa semakin tinggi stadium kanker serviks maka semakin tinggi ekspresi COX-2, sehingga pemeriksaan ekspresi COX-2 dapat dijadikan sebagai pertanda keganasan pada serviks, selain itu ditemukan LVSI dan infiltrasi sel radang tidak memiliki pengaruh terhadap ekspresi COX-2.The Correlation Cyclooxygenase-2 (Cox-2) Expression and Lymphovascular Invasion, Inflammatory Cell Infiltration and Cervical Cancer StageAbstractObjective: This study is objected to find out the correlation between COX-2 expression and Lymphovascular Space Invasion, inflammatory cell inflation and cervical cancer stage. Method: This study uses cross sectional design at educational hospital of Hasanuddin University. COX-2 level examination was performed on 50 biopsy and surgery result on cervical cancer cases through immunohistochemistry. Data were analyzed using chi-square test with significant level of 95%. Results: Study result indicated that significant correlation is found between COX-2 expression and cervical cancer stage with p value < 0.05. No significant correlation is found between COX-2 expression and Lymphovascular Space Invasion and inflammatory cell inflation with p value > 0.05. No correlation also is found between COX-2 expression and parity, education, profession, combination oral contraception uses  5 years, sexual partner and smoking history with p value > 0.05. Conclusion: Based on our results it can be concluded that the higher the stage of cervical cancer in line with the expression of COX-2 and examination of COX-2 expression can be used as a marker of cervical malignancy, besides that LVSI and inflammatory cell infiltration not affected on COX-2 expression.Key words: Cyclooxygenase-2, Cervical Cancer, Stage. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran Andi Ahmed Onterio, Universitas Hasanuddin, Fakultas Kedokteran, Departemen Obstetri dan Ginekologi 2023-07-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/478 10.24198/obgynia.v6i2.478 Obgynia; Volume 6 Nomor 2 Juli 2023; 194-202 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 2 Juli 2023; 194-202 2615-496X 10.24198/obgynia.v6i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/478/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/478/277 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/478/279 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/478/280 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/478/281 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/478/321 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/776 2025-03-20T03:00:51Z obgynia:CR

Surgical Approach for Uterine Perforation due to Gestational Trophoblastic Neoplasia: A Case Report Susilo, Sulaeman Andrianto Homenta, Christian Mawardinata, Phindo Sinaga, Ferry Iskandar Kharisma Suardi, Dodi Uterine perforation, Trophoblastic neoplasia, and Hysterectomy Introduction: The most common life-threatening complication of gestational trophoblastic neoplasia (GTN) is uterine perforation. In several cases, a surgical approach becomes inevitable. However, there are numerous considerations regarding the technique of hysterectomy.Case Presentation: A 37-year-old (P1A2) woman came to the ER with severe abdominal pain 12 h before admission. The patient had been previously diagnosed with GTN and was scheduled to undergo methotrexate chemotherapy. However, due to the development of an acute abdomen, accompanied by low hemoglobin levels and free fluid showing signs of uterine perforation, an emergency total abdominal hysterectomy was performed. The intra-operative findings revealed intra-abdominal bleeding and uterine perforation at the right fundal side of the uterus. The patient underwent postoperative chemotherapy and showed significant improvement. Conclusion: Regardless of the efficacy of chemotherapy in GTN, abdominal hysterectomy proved to be beneficial for treating uterine perforation in an emergency setting.Pendekatan Pembedahan pada Perforasi Uterus Akibat Tumor Trofoblastik Gestasional : Sebuah Laporan KasusAbstrakPendahuluan: Komplikasi paling umum yang mengancam jiwa dari Tumor Trofoblastik Gestasional (TTG) adalah perforasi uterus. Pendekatan pembedahan tidak dapat dihindari dalam beberapa kasus. Namun, ada banyak pertimbangan mengenai teknik pembedahan dalam setiap kasus.Laporan Kasus: Seorang wanita berusia 37 tahun (P1A2) datang ke UGD dengan nyeri perut hebat 12 jam sebelum masuk rumah sakit. Pasien didiagnosis dengan neoplasia trofoblastik gestasional dan dijadwalkan untuk kemoterapi metotreksat. Abdomen akut, kadar hemoglobin rendah, cairan bebas menunjukkan tanda perforasi uterus. Temuan intraoperatif adalah perdarahan intra-abdomen dan perforasi uterus di sisi fundus kanan uterus. Histerektomi abdomen total darurat dilakukan. Pasien menjalani kemoterapi pasca-operasi dengan kondisi yang membaik.Kesimpulan:Terlepas dari efektivitas kemoterapi pada TTG, histerektomi abdominal bermanfaat untuk mengobati perforasi uterus dalam keadaan darurat.Kata kunci: Histerektomi, perforasi uterus, trofoblastik neoplasia  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/776 10.24198/obgynia.v8i1.776 Obgynia; Volume 8 Nomor 1 Maret 2025; 163-168 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 1 Maret 2025; 163-168 2615-496X 10.24198/obgynia.v8i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/776/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/776/572 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/776/573 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/776/575 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/776/577 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/776/628 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/205 2021-03-25T19:35:04Z obgynia:RA

Perbandingan Kadar Testosteron dan Lemak Viseral Pasien Sindrom Ovarium Polikistik di Poliklinik Aster RSUP Dr. Hasan Sadikin Bandung Sebelum dan Setelah Pemberian Terapi Metformin Siagian, Imelda Rosmaida Ritonga, Mulyanusa Amarullah Tobing, Maringan D.L. Sukarsa, M. Rizkar Arev Sindrom ovarian polikistik, testosterone, lemak visceral, metformin Tujuan: Terdapat 50-70% kasus sindrom ovarium polikistik yang berkaitan dengan adanya resistensi insulin. Peran agen sensitisasi insulin seperti metformin diharapkan dapat memperbaiki kondisi lemak dan testosteron bebas yang tinggi sehingga memperbaiki gejala klinis pasien dengan sindrom ovarium polikistik. Penelitian ini bertujuan mengetahui perbedaan indeks androgen bebas (sebagai representasi kadar testosteron) dan lemak viseral pasien sindrom ovarium polikistik sebelum dan sesudah diberi pengobatan metformin. Metode: Populasi penelitian didapatkan dari data penelitian DLBS (Dexa Laboratories of Biomolecular Sciences) 3233 yaitu 29 kasus wanita sindrom ovarium polikistik yang datang untuk berobat di Klinik Aster RSUP Dr. Hasan Sadikin Bandung periode Januari 2013 - Desember 2017, dengan menggunakan metode experimental design dengan pendekatan one group pretest-posttest design. Pengambilan sampel penelitian dilakukan secara purposing sampling yang diambil secara retrospektif pada data sekunder yang terdapat dalam rekam medik. Hasil: Didapatkan rata-rata indeks androgen bebas sebelum pemberian terapi metformin 2.67 ± 0.43 dan sesudah pemberian terapi 1.88 ± 0.37. Rata-rata kadar lemak visceral sebelum pemberian terapi metformin 10.27±2.589% dan sesudah pemberian terapi 8.00±1.488%. Kesimpulan: Sehingga disimpulkan terdapat perbedaan signifikan kadar indeks androgen bebas (p:0.008) dan lemak visceral (p:0,0001) pada pasien sindrom ovarium polikistik sebelum dan sesudah pemberian terapi metformin.Comparasion of free Androgen Index and Viseral Fat in Polycystic Ovary Syndrome Patients in Aster Polyclinic Dr. Hasan Sadikin Bandung Before and After Giving Metformin TherapyAbstractObjective: There are 50-70% of cases of polycystic ovary syndrome associated with insulin resistance. The role of insulin sensitizing agents such as metformin is expected to improve the condition of high fat and free testosteron, thereby improving the clinical symptoms of patients with polycystic ovary syndrome. This study aims to determine differences in free androgen index (represent the value of free testosteron) and visceral fat levels of polycystic ovary syndrome patients before and after being given metformin treatment. Method: The study population was obtained from DLBS (Dexa Laboratories of Biomolecular Sciences) 3233 research data, namely 29 cases of polycystic ovary syndrome women who came for treatment at the Aster Clinic Dr. Hasan Sadikin Bandung from January 2013 - December 2017, using the experimental design method with the one group pretest-posttest design approach. Sampling was done by purposing sampling taken retrospectively on secondary data contained in the medical record. Result: The average free androgen index levels were obtained before the administration of metformin therapy 2.67 ± 0.43 and after the administration of therapy 1.88 ± 0.37 Average visceral fat levels before administration of metformin therapy 10.27 ± 2.589% and after administration of 8.00 ± 1,488%. Conclusion : It was concluded that there were significant differences in free androgen index (p: 0.008) and visceral fat (p: 0.0001) in patients with polycystic ovary syndrome before and after metformin therapy.Key word: Polycystic ovary syndrome, free androgen index, viseral fat, metformin Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2021-03-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/205 10.24198/obgynia.v4i1.205 Obgynia; Volume 4 Nomor 1 Maret 2021; 28-33 Indonesian Journal of Obstetrics & Gynecology Science; Volume 4 Nomor 1 Maret 2021; 28-33 2615-496X 10.24198/obgynia.v4i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/205/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/205/148 Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/574 2023-11-22T03:42:22Z obgynia:AR

The Efficacy of Emergency Contraception to Prevent Pregnancy: A Systematic Review and Meta-Analysis Simanjuntak, Tigor Peniel Sihaloho, Resilia Sirait, Batara Imanuel Effectiveness; Emergency Contraception Objective: A systematic review and meta-analysis to determine the effectiveness of various emergency contraceptive methods to prevent pregnancy.Method: This study followed the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) protocol. Data search used four databases, namely Pubmed, Google Scholar, Science Direct, and Wiley. Data that met the inclusion criteria were subjected to meta-analysis to analyze the combined proportion of data using MedCalc 20.012 software, calculation of a percentage of 95% Confidence Intervals (CI) and P<0.05, and heterogeneity test between studies.Results: There were 6 journals that met the criteria. Some of the contraceptives used as emergency contraception are: the copper IUD (CuIUD) with effectiveness reaching 100% in preventing pregnancy, levonorgestrel (LNG) 52-mg IUS with effectiveness reaching 99.95%, the levonorgestrel (LNG) 52-mg IUD with effectiveness reaching 99.7%, mifepristone 10 mg with effectiveness reaching 99.3%, mifepristone 5 mg with effectiveness reaching 98.8%, ulipristal acetate (UPA) 30 mg in pre-ovulatory women with effectiveness reaching 98.6%, levonorgestrel (LNG) 0.75 mg with effectiveness reaching 98.3%, yuzpe regimen with effectiveness reaching 98.2%, and ulipristal acetate (UPA) 30 mg in post-ovulatory women with effectiveness reaching 97.9%. The results of the proportion meta-analysis showed the proportion of pregnancies after the use of emergency contraceptive, which was 0.231% (95% CI 0.116–0.384) from 4,927 samples in 6 studies, and the results of the heterogeneity test between studies were found to be not meaningful (I2 = 0%). Conclusion: The emergency contraception used to prevent pregnancy is very effective with the results of a meta-analysis of the proportion of 0.231% (95% CI 0.116–0.384). This suggests that the percentage of pregnancies after emergency contraceptive use is quite low.Efektivitas Kontrasepsi Darurat untuk Mencegah Kehamilan: Tinjauan Sistematis dan Meta-AnalisisAbstrakTujuan: Tinjauan sistematis dan meta-analisis untuk mengetahui efektivitas berbagai metode kontrasepsi darurat untuk mencegah kehamilan.Metode: Penelitian ini mengikuti protokol Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA). Pencarian data menggunakan empat database yaitu Pubmed, Google Scholar, Science Direct, dan Wiley. Data yang memenuhi kriteria inklusi dilakukan meta analisis dengan analisis proporsi gabungan data menggunakan software MeldCalc 20.012, dilakukan perhitungan persentase 95% CI dan P<0.05, serta dilakukan uji heterogenitas antar studi.Hasil: Terdapat 6 jurnal yang memenuhi kriteria. Beberapa alat kontrasepsi yang digunakan sebagai kontrasepsi darurat yaitu: AKDR tembaga (CuIUD) dengan efektivitas mencapai 100% dalam mencegah kehamilan, levonorgestrel (LNG) 52-mg IUS dengan efektivitas mencapai 99,95%, levonorgestrel (LNG) 52-mg IUD dengan efektivitas mencapai 99,7%, mifepristone 10 mg dengan efektivitas mencapai 99,3%, mifepristone 5 mg dengan efektivitas mencapai 98,8%, ulipristal asetat (UPA) 30 mg pada wanita pre-ovulasi dengan efektivitas mencapai 98,6%, levonorgestrel (LNG) 0,75 mg dengan efektivitas mencapai 98,3%, yuzpe regimen dengan efektivitas mencapai 98,2%, dan ulipristal asetat (UPA) 30 mg pada wanita post-ovulasi dengan efektivitas mencapai 97,9%. Hasil meta analisis proporsi menunjukkan proporsi kehamilan setelah penggunaan kontrasepsi darurat yaitu 0,231% (95% CI 0,116–0,384) dari 4.927 sampel, serta hasil uji heterogenitas antar studi ditemukan tidak bermakna (I2 = 0%).Kesimpulan: Penggunaan kontrasepsi darurat sangat efektif dalam mencegah kehamilan dengan hasil meta analisis proporsi yaitu 0,231% (95%CI 0,116–0,384). Hasil tersebut menunjukkan bahwa persentase kehamilan setelah penggunaan kontrasepsi darurat cukup rendah.Kata kunci: Efektivitas, Kontrasepsi Darurat Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-11-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/574 10.24198/obgynia.v6i3.574 Obgynia; Volume 6 Nomor 3 November 2023; 346-354 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 3 November 2023; 346-354 2615-496X 10.24198/obgynia.v6i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/574/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/574/362 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/893 2025-07-24T00:43:19Z obgynia:RA

Association Between Maternal Random Blood Glucose Level and Prematurity at Margono Soekardjo Hospital Purwokerto Rachmayanti, Erma Priyanto, Edy Priyanto Winarno, Gatot Nyarumenteng Adhipurnawan Suhartomo, Dalri Muhammad Hyperglycemia; random blood glucose; prematurity Objective: Hyperglycemia is among the most common medical conditions encountered during pregnancy. Its prevalence continues to rise in line with two other global epidemics, obesity and diabetes. Studies have shown that hyperglycemia during pregnancy can induce negative impacts on maternal-fetal well-being, one of which is premature birth. This study aims to investigate the association between maternal random blood glucose (RBG) level and prematurity.Methods: This is an observational analytical study with a cross-sectional approach. The data used in the study were obtained from the medical records of patients who gave birth at Margono Soekarjo Hospital, Purwokerto, from January 2023 to February 2024.Result: This study found an association between high maternal RBG levels and prematurity (P-value < 0.005).Conclusion: High maternal RBG level is a risk factor for prematurity. The result of this study shows that RBG may be used as a practical and efficient alternative method to rule out hyperglycemia in pregnancy when OGTT is difficult to perform.Hubungan antara Kadar Glukosa Darah Sewaktu Maternal dan Kejadian Prematuritas di RS. Margono Soekardjo PurwokertoAbstrakTujuan: Hiperglikemia merupakan salah satu kondisi medis yang paling umum dijumpai selama kehamilan. Prevalensinya terus meningkat seiring dengan dua epidemi global lainnya, yaitu obesitas dan diabetes. Berbagai penelitian telah menunjukkan bahwa hiperglikemia selama kehamilan dapat memberikan dampak negatif terhadap kesejahteraan ibu dan janin, salah satunya adalah kelahiran prematur. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara kadar glukosa darah sewaktu (GDS) maternal dan kejadian prematuritas.Metode: Penelitian ini merupakan studi observasional analitik dengan pendekatan potong lintang. Data yang digunakan berasal dari rekam medis pasien yang melahirkan di RSUD Margono Soekarjo, Purwokerto, pada periode Januari 2023 hingga Februari 2024.Hasil: Dalam penelitian ini ditemukan adanya hubungan yang signifikan antara kadar GDS maternal yang tinggi dan prematuritas (nilai P<0,005).Kesimpulan: Kadar GDS maternal yang tinggi merupakan salah satu faktor risiko terjadinya prematuritas. Berdasarkan hasil penelitian ini, GDS dapat dipertimbangkan sebagai metode alternatif yang praktis dan efisien untuk mendeteksi hiperglikemia dalam kehamilan, terutama ketika pemeriksaan OGTT sulit dilakukan Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-07-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/893 10.24198/obgynia.v8i2.893 Obgynia; Volume 8 Nomor 2 July 2025; 278-283 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 2 July 2025; 278-283 2615-496X 10.24198/obgynia.v8i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/893/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/893/700 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/893/701 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/893/719 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/633 2024-04-29T04:12:24Z obgynia:SI

Leiomioma Uteri Besar pada Wanita dengan Grande Multipara dan Pasca-Menopause di Rumah Sakit Umum Daerah Ciamis : Sebuah Laporan Kasus Azhari, Fiqhul Rasas, Budi Ahmad Wibowo, Nanang Giant Leiomyoma; Post Menopause Pendahuluan: Leiomyoma uteri, merupakan neoplasma jinak yang berasal dari otot rahim. Leiomyoma uteri biasanya tumbuh selama usia 30 - 50 tahun, dan kemudian stabil atau menurun setelah menopause. Namun, terdapat beberapa laporan mengenai sejumlah besar pasien yang telah menjalani operasi leiomyoma uteri selama periode pasca-menopause.Presentasi Kasus: Kami melaporkan kasus wanita dengan grande multipara berusia 58 tahun dan pasca-menopause dengan keluhan utama perut terasa membesar sejak 1 tahun. Pasien termasuk kedalam kategori obesitas tipe 2 dengan pemeriksaan tanda vital dalam batas normal dan Pemeriksaan abdomen di dapatkan massa yang mobile dengan ukuran uterus sebesar usia kehamilan 8 bulan yang terbentang di garis tengah tubuh area abdomen. Pada pemeriksaan USG di temukan adanya massa hipoekoik pada uterus. Dilakukan tatalaksana operatif pada pasien dengan giant leiomyoma uteri dengan berat 5 kg tanpa keluhan kompresi yaitu potongan beku, dan total abdominal histerektomi dengan bilateral salpingo-oophorectomy. Hasil pemeriksaan patologi anatomi yaitu tumor jinak leiomyoma uteri intramural.Kesimpulan: Leiomioma sangat umum dan diasumsikan akan hilang seiring dengan di mulainya menopause. Penyebab terjadinya leiomyoma uteri di sebabkan karena interaksi berbagai variasi faktor risiko di antaranya usia, paritas, obesitas, merokok, hipertensi, diet, stress, riwayat kontrasepsi oral yang dapat menstimulasi peningkatan hormon estrogen dan progesterone yang meningkatkan pertumbuhan leiomyoma uteri secara definitif masih belum dapat di simpulkan.Giant Uterine Leiomyoma in Grand Multiparity and Post Menopause Woman at Ciamis Regional General Hospital : A Case ReportAbstractIntroduction: Leiomyoma Uterine, are benign neoplasms originating from the uterus. Uterine leiomyomas typically grow during the age 30 to 50 years of age, and then stabilize or regress after menopause. However, there have been several reports of a considerable number of patients who have undergone surgery for uterine leiomyomas during the postmenpause period. Case Presentation: We report the case of 58 year old female grand multiparity and post menopause with chief complaining of a fast expanding lump in her belly over the past year. Patient categorized a type two obesity, her vital sign was normal and during the abdominal examination a moveable mass that could have been an 8 month pregnancy was felt in the midline of the abdominal area. On ultrasound examination, it was found that there was a hypoechoic mass in uterine. A frozen section, a bilateral salpingo-oophorectomy, and total abdominal hysterectomy were performed for giant uterine leiomyoma weighing 5 kg without compression symptoms. The results of the histology suggested a benign intramural uterine leiomyoma. Conclusion: Leiomyomas are very common and the assumption that they will resolve with the onset of the menopause. The occurrence of uterine leiomyomas was the result of mutual interaction among various factors including age, parity, obesity, smoking, blood pressure, diet, stress, oral contraceptive but whether some of the risk factors can promote estrogen and progesterone to induce uterine leiomyomas has no definitive conclusion.Key words: Giant Leiomyoma; Post Menopause  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran a person 2024-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/633 10.24198/obgynia.v7i1.633 Obgynia; Volume 7 Nomor 1 Maret 2024; 55-62 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 1 Maret 2024; 55-62 2615-496X 10.24198/obgynia.v7i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/633/pdf Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/956 2026-01-23T07:42:49Z obgynia:RA

Association between Serum Cotinine Levels, Fetal Biometry, and Umbilical Artery Flow in Pregnant Women Exposed to Secondhand Smoke Diana, Margaret Riu, Deviana Soraya Madya, Fatmawati Chalid, St. Maisuri T. AM, Nasrudin Tessy, Telly secondhand smoke exposure; cotinine; fetal biometry; umbilical arterial flow Objective: This study aimed to investigate the impact of SHS exposure on fetal biometry and umbilical artery flow at 24 – 28 weeks of gestation.Methods: This cross-sectional study included 110 pregnant women, divided into a study group (55 passive) smokers and a control group (55 non-passive smokers). Serum cotinine levels were measured using ELISA. Fetal biometry (biparietal diameter, head circumference, abdominal circumference, and femur length) and umbilical artery flow (pulsatility and resistance indices) were assessed via ultrasound and Doppler ultrasonography. Group comparisons were conducted using Chi-square and independent t-tests.Results: The passive smoker group had significantly higher mean serum cotinine levels compared with the control group (10.97 ng/mL vs. 4.53 ng/mL; p = 0.01). However, no statistically significant differences (p > 0.05) were found in any of the fetal biometric parameters or umbilical artery flow indices between the groups. Correlation analyses also showed no significant association between cotinine levels and the measured fetal outcomes.Conclusion: In this second-trimester study, SHS exposure, confirmed by elevated cotinine levels, was not associated with measurable adverse effects on fetal biometry or umbilical artery flow. These non-significant findings underscore the need for longitudinal research to evaluate the cumulative impact of SHS, particularly in the third trimester and on final birth outcomes.Hubungan antara Kadar Kotinin Serum, Biometri Janin, dan Aliran Arteri Umbilikalis pada Ibu Hamil yang Terpapar Asap Rokok PasifAbstrakTujuan: Penelitian ini bertujuan untuk menelaah dampak paparan asap rokok pasif terhadap biometri janin dan aliran arteri umbilikalis pada usia kehamilan 24 – 28 minggu.Metode: Penelitian potong lintang ini melibatkan 110 ibu hamil yang dibagi menjadi kelompok studi (55 perokok pasif) dan kelompok kontrol (55 bukan perokok pasif). Kadar kotinin serum diukur menggunakan metode ELISA. Biometri janin (meliputi diameter biparietal, lingkar kepala, lingkar perut, dan panjang femur) serta aliran arteri umbilikalis (indeks pulsasi dan indeks resistensi) dinilai melalui ultrasonografi (USG) dan USG Doppler. Perbandingan antarkelompok dianalisis menggunakan uji Chi-square dan uji t independen.Hasil: Kelompok perokok pasif memiliki rerata kadar kotinin serum yang secara signifikan lebih tinggi dibandingkan kelompok kontrol (10,97 ng/mL vs. 4,53 ng/mL; p = 0,01). Namun, tidak ditemukan perbedaan bermakna secara statistik (p > 0,05) pada parameter biometri janin maupun indeks aliran arteri umbilikalis antara kedua kelompok. Analisis korelasi juga tidak menunjukkan adanya hubungan bermakna antara kadar kotinin dengan luaran janin yang diukur.Kesimpulan: Pada penelitian trimester kedua ini, paparan asap rokok pasif yang dikonfirmasi dengan peningkatan kadar kotinin tidak berhubungan dengan efek merugikan yang terdeteksi pada biometri janin maupun aliran arteri umbilikalis. Temuan yang tidak signifikan ini menekankan pentingnya penelitian longitudinal untuk menilai dampak kumulatif paparan asap rokok pasif, terutama pada trimester ketiga dan luaran kelahiran akhir.Kata kunci: Aliran arteri umbilikalis; biometri janin; kotinin; paparan asap rokok pasif Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran None 2025-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/956 10.24198/obgynia.v8i3.956 Obgynia; Volume 8 Nomor 3 November 2025; 471-477 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 3 November 2025; 471-477 2615-496X 10.24198/obgynia.v8i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/956/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/956/757 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/956/816 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/956/817 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/956/834 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/381 2022-09-28T00:58:31Z obgynia:RA

Profil Klinikopatologi Pasien Tumor Trofoblas Gestasional yang Dilakukan Operasi di RSUP DR. Hasan Sadikin Bandung Tahun 2017-2020 Ali, Aviscena Fahmi Suardi, Dodi Usman, Hermin Aminah Winarno, Gatot Nyarumenteng Adhipurnawan Kurniadi, Andi Tujuan: Mengetahui proporsi klinis dan histopatologi pasien tumor trofoblas gestasional yang dilakukan operasiMetode: Penelitian ini menggunakan desain studi deskriptif, dengan pengambilan data menggunakan total sampling. Kriteria inklusi adalah Pasien tumor trofoblas gestasional yang dilakukan operasi dengan data lengkap.Hasil: Total 27 kasus, didapatkan bahwa pasien tumor trofoblas gestasional yang dilakukan operasi sebagian besar memiliki kategori usia ≥40 tahun (59,26%), paritas multipara (66,67%), kehamilan sebelumnya mola (66,67%), interval dengan kehamilan sebelumnya >12 bulan (55,56%), kadar β-hCG sebelum operasi 103 -<104 mIU/ml (40,74%), ukuran tumor terbesar ≥5 cm (88,89%), lokasi metastasis tidak ada (74,07%), jumlah metastasis 0 (74,07%), kegagalan kemoterapi agen multipel (74,07%), jenis operasi histerektomi (96,30%), kadar β-hCG setelah operasi <103 mIU/ml (77,78%),  dan gambaran histopatologi koriokarsinoma (88,89%). Diskusi: Penelitian ini didapatkan bahwa seluruh pasien tumor trofoblas gestasional yang dilakukan operasi memiliki skor FIGO/WHO ≥7 yang berarti berisiko tinggi.Kesimpulan: Kasus-kasus tumor trofoblas gestasional yang dilakukan operasi pada penelitian ini sebagian besar memberikan profil klinis berupa multipara, jenis kehamilan sebelumnya mola, dan kegagalan kemoterapi agen multipel dengan jenis histopatologi koriokarsinoma.Profile Clicopathological of Gestational Trophoblastic Neoplasia Patients Who Underwent Surgery at Dr. Hasan Sadikin General Hospital Bandung in 2017–2020AbstractObjective: Knowing the clinical and histopathological proportion of gestational trophoblastic neoplasia patients who underwent surgery.Methods: This study uses a descriptive study design and the data collection using total sampling. The inclusion criteria gestational trophoblastic neoplasia patients who underwent surgery with complete data.Result: : A total of 27 cases, it was found that the most GTN patients who underwent surgery had an age category of 40 years (59.26%), multiparity (66.67%), previous molar pregnancies (66.67%), intervals with previous pregnancies >12 months (55.56%), β-hCG levels before surgery 103 -<104 mIU/ml (40.74%), the largest tumour size 5 cm (88.89%), no metastatic site (74.07 %), failure of multiple agent chemotherapy (74,07%), hysterectomy surgery (96.30%), β-hCG level after surgery <103 mIU/ml (77.78% ), and histopathological features of choriocarcinoma (88.89%).Discussion: In this study, it was found that all gestational trophoblastic neoplasia patients who underwent surgery had a FIGO/WHO score ≥7 which means high risk.Conclusion: The gestational trophoblastic neoplasia cases that underwent surgery in this study presented a clinical profile of multiparity, previous molar pregnancy, and failure of multiple agent chemotherapy with histopathological type of choriocarcinoma.Key words: Profile, gestational trophoblastic neoplasia, operation Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2022-09-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/381 10.24198/obgynia.v5i2.381 Obgynia; Volume 5 Nomor 2 September 2022; 193-200 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 2 September 2022; 193-200 2615-496X 10.24198/obgynia.v5i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/381/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/381/215 Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/694 2024-11-19T11:53:19Z obgynia:CR

Rare Case: Tetra-Amelia Syndrome Alifa, Dhara Aziz, Muhammad Alamsyah Ritonga, Mulyanusa Amarullah Pribadi, Adhi Introduction: Congenital abnormalities are anomalies that become a fear for a family, when a mother experiences pregnancy. Some abnormalities are temporary and can be corrected, while some are permanent and cannot be corrected, so screening at antenatal time is very important.Objective: To explain and analyze a rare case of Tetra-amelia syndrome and how to diagnose it.Case: A 32-year-old woman with a 32-week-old G3P0A2 pregnancy visited the maternal-fetal clinic. According to ultrasound data, a single fetus with a gestational age of 31-32 weeks and a fetal weight of 1837 grams is in breech presentation. Only the proximal components of the arm and leg are formed, leaving the radius bones, ulna, tibia, and fibula unformed. The femur has a length that corresponds to 16 weeks, while the humerus has a length that corresponds to 20 weeks. These findings also revealed a discrepancy in pregnancy age. A tetra-amelia abnormality was discovered at the end of the ultrasound scan. Caesarean section performed on August 6, 2021, at the age of 39 weeks, a baby girl has been born baby girl a baby girl weighing 2300 grams, a body length of 31 cm, with mild asphyxia.Conclusion: During antenatal care, ultrasound on the unidentified distal part of the entire extremity can detect Tetra-amelia syndrome.Kasus Langka: Sindrom Tetra-ameliaAbstrak Pendahuluan: Kelainan bawaan adalah anomali yang menjadi trauma bagi keluarga, ketika seorang ibu mengalami kehamilan. Beberapa kelainan bersifat sementara dan dapat diobati, sementara beberapa bersifat permanen dan tidak dapat diperbaiki sehingga skrining pada waktu antenatal sangat penting.Tujuan: Artikel ini untuk menjelaskan dan menganalisis kasus langka sindrom Tetra-amelia dan cara mendiagnosisnya.Kasus: Seorang wanita berusia 32 tahun dengan kehamilan G3P0A2 berusia 32 minggu mengunjungi klinik fetomaternal. Hasil pemeriksaan ultrasonografi menunjukan janin tunggal dengan usia kehamilan 31 - 32 minggu dan berat janin 1837 gram dalam letak sungsang. Hanya komponen proksimal lengan dan kaki yang terbentuk, sedangkan tulang jari-jari, ulna, tibia, dan fibula tidak terbentuk. Femur memiliki panjang yang sesuai dengan 16 minggu, sedangkan humerus memiliki panjang yang sesuai dengan 20 minggu. Kelainan tetra-amelia dapat dideteksi dengan pemindaian ultrasonografi. Pada tanggal 6 Agustus 2021 presentasi sungsang, dilakukan operasi caesar, lahir bayi perempuan pada usia 39 minggu, berat 2300 gram, panjang 31 cm, disertai asfiksia ringan.Kesimpulan: Pemeriksaan ultrasonografi pada perawatan antenatal dapat mendeteksi sindrom Tetra-amelia, bila bagian distal ekstremitas tidak teridentifikasi.Kata kunci:Sindrom Tetra-amelia, Ultrasonografi, Kelainan Kongenital Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/694 10.24198/obgynia.v7i3.694 Obgynia; Volume 7 Nomor 3 November 2024; 420-423 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 3 November 2024; 420-423 2615-496X 10.24198/obgynia.v7i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/694/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/694/514 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/1076 2026-03-13T02:36:41Z obgynia:RA

The Association Between Obesity and Endometriosis: A Case-Control Study at Margono Soekarjo Hospital Rizal, Rivaldi Sumawan, Herman Erfiandi, Febia Association; body mass index; case control; endometriosis; obesity Objective: To investigate the association between obesity and the risk of endometriosis.Methods: A retrospective case-control study was conducted at Prof. Dr. Margono Soekarjo General Hospital from January 2022 to May 2024. Cases were defined as patients with suspected endometriosis that was histopathologically confirmed, while controls were patients with suspected endometriosis who had negative histopathology results. Body mass index (BMI) was calculated using the Asia-Pacific classification. Data were analyzed using chi-square tests and multivariate logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs).Results: A total of 100 participants were included, with 50 cases and 50 controls. Obesity was more prevalent among women with endometriosis (54%) compared to the control group (26%). Bivariate analysis revealed a significant association between obesity and endometriosis (OR = 3.34; 95% CI: 1.44–7.75; p = 0.004). Multivariate logistic regression confirmed that obesity remained significantly associated with endometriosis after adjusting for age and parity (adjusted OR = 1.66; 95% CI: 1.36–7.24; p = 0.042).Conclusion: Obesity is strongly linked to a higher risk of endometriosis. These findings indicate that metabolic factors, especially obesity, could play a role in the development of the disease. AbstrakTujuan: Penelitian ini bertujuan menginvestigasi asosiasi antara obesitas dan kejadian endometriosis.Metode: Penelitian ini menggunakan desain studi kasus-kontrol retrospektif yang dilakukan di RSUD Prof. Dr. Margono Soekarjo pada periode Januari 2022 hingga Mei 2024. Kelompok kasus didefinisikan sebagai pasien dengan dugaan endometriosis yang terkonfirmasi melalui pemeriksaan histopatologi, sedangkan kelompok kontrol merupakan pasien dengan dugaan endometriosis namun dengan hasil histopatologi negatif. Indeks massa tubuh (IMT) dihitung menggunakan klasifikasi Asia-Pasifik. Analisis data dilakukan menggunakan uji chi-square dan regresi logistik multivariat untuk menghitung odds ratio (OR) dengan interval kepercayaan 95%.Hasil: Sebanyak 100 subjek dilibatkan dalam penelitian ini, terdiri atas 50 kasus dan 50 kontrol. Obesitas lebih banyak ditemukan pada wanita dengan endometriosis (54%) dibandingkan dengan kelompok kontrol (26%). Analisis bivariat menunjukkan adanya hubungan yang signifikan antara obesitas dan kejadian endometriosis (OR = 3,34; IK 95%: 1,44–7,75; p = 0.004). Analisis regresi logistik multivariat menunjukkan bahwa obesitas tetap berhubungan secara signifikan dengan endometriosis setelah dilakukan penyesuaian terhadap usia dan paritas (adjusted OR = 1,66; IK 95%: 1,36–7,24; p = 0.042).Kesimpulan: Hasil penelitian ini menunjukkan bahwa terdapat hubungan yang signifikan antara obesitas dengan kejadian endometriosis. Temuan ini menunjukkan bahwa faktor metabolik seperti obesitas dapat berkontribusi terhadap perkembangan endometriosis.Kata kunci: Asosiasi; endometriosis; indeks massa tubuh; kasus kontrol; obesitas  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2026-03-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1076 10.24198/obgynia.v9i1.1076 Obgynia; Volume 9 Number 1 March 2026; 77-84 Indonesian Journal of Obstetrics & Gynecology Science; Volume 9 Number 1 March 2026; 77-84 2615-496X 10.24198/obgynia.v9i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1076/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1076/948 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1076/952 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1076/953 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1076/954 Copyright (c) 2026 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/468 2023-03-27T01:50:09Z obgynia:RA

Pengaruh Spektrum Plasenta Akreta terhadap Luaran Maternal di RSUP Dr. Hasan Sadikin Bandung Puspitasari, Wati Susiarno, Hadi Pramatirta, Akhmad Yogi infeksi daerah operasi, lama hari rawat, perdarahan, spektrum plasenta akreta Tujuan: Penelitian bertujuan untuk menganalisis pengaruh spektrum plasenta akreta terhadap volume perdarahan, infeksi daerah operasi, dan lama hari rawat.Metode: Metode yang digunakan adalah analitik observasional dengan desain kohor retrospektif. Data diambil dengan meninjau rekam medis. Pengambilan sampel untuk kedua kelompok diambil dengan menggunakan teknik purposive sampling melalui penetapan kriteria inklusi dan ekslusi. Kelompok pertama subjek dengan spektrum plasenta akreta yang tercatat di dalam rekam medik dalam kurun waktu dari tahun 2016 – 2021, dan kelompok kedua subjek dengan non spektrum plasenta akreta diambil dengan perbandingan 1:2 terhadap kelompok pertama. Data dianalisis menggunakan uji Fisher Exact dan Regresi Logistik Ganda dengan nilai p<0,05 dianggap bermakna secara statistik.Hasil: Hasil penelitian menunjukkan bahwa terdapat pengaruh yang signifikan (p<α) terhadap volume perdarahan (p=0,025), infeksi daerah operasi (p=0,025), dan lama hari rawat (p<0,001). Peluang spektrum plasenta akreta terhadap terjadinya volume perdarahan sebesar 3,58 kali, infeksi daerah operasi 4,03 kali, dan lama hari rawat 50,09 kali. Meskipun pengaruh spektrum plasenta akreta secara multivariat tidak dominan terhadap volume perdarahan dan infeksi daerah operasi namun berpengaruh secara bermakna terhadap lama hari rawat.Kesimpulan: Terdapat pengaruh spektrum plasenta akreta terhadap volume perdarahan, infeksi daerah operasi, dan lama hari rawat.The Effect of Placenta Accreta Spectrum on Maternal Outcomes at Hasan Sadikin Bandung General HospitalAbstractObjective: The aim of this study was to analyze the effect of placenta accreta spectrum on bleeding volume, surgical site infection, and length of stay.Methods: This was an observational analytic study with a retrospective cohort design. Data were taken by reviewing medical records with samples divided into two groups. Sampling for both groups was taken using a purposive sampling technique, the samples were selected by establishing inclusion and exclusion criteria. The first group of subjects with the placenta accreta spectrum recorded in the medical record in the period from 2016 – 2021, and the second group of subjects with non-spectrum placenta accreta was taken in a ratio of 1:2 to the first group. Data were analyzed using the Fisher Exact test and Multiple Logistic Regression with a value of p <0.05 which was considered statistically significant.Result: The results showed there was a significant effect (p<α) on bleeding volume (p=0.025), surgical site infection (p=0.025), and length of stay (p<0.001). The probability of placenta accreta spectrum for the occurrence of bleeding volume is 3.58 times, 4.03 times for surgical site infection, and 50.09 times for length of stay. Even though the placenta accreta spectrum multivariate test did not show a significant effect on bleeding volume and surgical site infection, but has a significant effect on length of stay.Conclusion: There was an effect of placenta accreta spectrum on bleeding volume, surgical site infection, and length of stay.Key words: bleeding, length of stay, maternal outcome, surgical site infection, placenta accreta spectrum. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-03-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/468 10.24198/obgynia.v6i1.468 Obgynia; Volume 6 Nomor 1 Maret 2023; 105-114 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 1 Maret 2023; 105-114 2615-496X 10.24198/obgynia.v6i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/468/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/468/282 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/724 2024-12-01T02:34:16Z obgynia:RA

Comparison of Pregnancy Outcomes with Autoimmune Rheumatic Disease and Without Autoimmune Rheumatic Disease Sulaiman, Aina Zakia Pribadi, Adhi Hamijoyo, Laniyati Irianti, Setyorini Rahmadi, Andri Reza Maternal outcome, Neonatal outcome, Autoimmune Introduction: It is known that pregnancies with autoimmunity have a higher risk of complications in the mother and fetus compared to pregnancies without autoimmunity. The purpose of this study was to determine the comparison between pregnancy outcomes with autoimmune rheumatic disease and without autoimmune rheumatic disease.Methods: This study is an observational analytic with a retrospective cross-sectional design. Data were obtained from all patients with pregnancy outcomes with autoimmune rheumatic disease and without autoimmune rheumatic disease at Hasan Sadikin Hospital Bandung 1 January - 31 December 2021-2023.Results: During this period, 71 pregnant women were found to be accompanied by autoimmune rheumatic diseases and then data on pregnant women without autoimmune rheumatic diseases were randomly taken as controls. In this study, it was found that pregnant women with autoimmune diseases experienced more neonatal outcomes of stunted fetal growth, namely 11(15.5%) compared to pregnant women without autoimmune rheumatic diseases, namely 2(2.8%) with a p-value of 0.009.Conclusion: This study found that pregnant women with autoimmune rheumatic disease experienced more neonatal outcomes of FGR compared to pregnant women without autoimmune rheumatism.Perbandingan Antara Luaran Kehamilan Dengan Penyakit Rhematik Autoimun Dan Tanpa Penyakit Rematik AutoimunAbstrakPendahuluan: Diketahui bahwa kehamilan dengan autoimun memiliki risiko komplikasi pada ibu maupun janin lebih tinggi dibandingkan dengan kehamilan tanpa autoimun. Tujuan penelitian ini untuk mengetahui perbandingan antara luaran kehamilan dengan penyakit rematik autoimun dan tanpa penyakit rematik autoimunMetode: Penelitian ini bersifat analitik observasional dengan desain potong lintang retrospektif. Data diperoleh dari seluruh pasien luaran kehamilan dengan penyakit rematik autoimun dan tanpa penyakit rematik autoimun di Rumah Sakit Hasan Sadikin Bandung 1 Januari – 31 Desember 2021-2023Hasil: Dalam periode tersebut ditemukan 71 orang ibu hamil yang disertai dengan penyakit rematik autoimun kemudian diambil data ibu hamil tanpa penyakit rematik autoimun secara random sebagai kontrol. Pada penelitian ini didapatkan ibu hamil dengan penyakit autoimun lebih banyak mengalami luaran neonatal pertumbuhan janin terhambat yaitu 11(15.5%) dibandingkan ibu hamil tanpa penyakit rematik autoimun yaitu 2(2.8%) dengan p- value0.009.Kesimpulan : Penelitian ini menemukan bahwa ibu hamil dengan penyakit rematik autoimun lebih banyak mengalami luaran neonatal pertumbuhan janin terhambat dibandingkan dengan ibu hamil tanpa rematik autoimun.Kata kunci : Luaran Maternal, Luaran Neonatal, Autoimun  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/724 10.24198/obgynia.v7i3.724 Obgynia; Volume 7 Nomor 3 November 2024; 405-411 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 3 November 2024; 405-411 2615-496X 10.24198/obgynia.v7i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/724/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/724/532 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/42 2022-01-05T14:03:37Z obgynia:RA

Analisis Faktor yang Memengaruhi Keberhasilan Kehamilan pada Inseminasi Intrauterin Rachmiawaty, Angghea Djuwantono, Tono Sasotya, R. M. Sonny AbstrakTujuan: Inseminasi intrauterin (IIU) merupakan prosedur yang umum digunakan dan menjadi pilihan terapi pertama dalam tatalaksana infertilitas, karena dampak risiko yang rendah, implementasi yang mudah, dan harga yang murah. Metode: Penelitian cross-sectional ini dilakukan pada seluruh pasangan yang melakukan prosedur IIU di Poliklinik Aster Rumah Sakit dr. Hasan Sadikin Bandung pada periode 1 Januari 2016 sampai dengan 31 Desember 2016, yang tercatat dalam rekam medik. Variabel penelitian berupa Umur Istri, Umur Suami, Jumlah Sperma, Konsentrasi Sperma, dan Motilitas Sperma, Ketebalan Endometrium, Jumlah Folikel preovulasi, Jenis Stimulasi dan Output. Data dikelola dengan SPSS 24.00. Hasilnya disajikan secara analitik melalui angka dan tabel.Hasil: Diantara 159 pasangan yang melakukan prosedur IIU, terdapat 194 prosedur. Namun hanya 98 subjek yang dapat dievaluasi. Angka kehamilan sebesar 23.5%. Faktor yang mempengaruhi hanya jenis stimulasi ovarium dan jumlah ovum preovulasi yang berhubungan secara signifikan dengan angka kehamilan (p<0,05), umur pasangan, jumlah, konsentrasi, dan motilitas sperma tidak berbeda bermakna.Kesimpulan: Berbagai variabel mempengaruhi keberhasilan dari IIU. Jenis stimulasi ovarium dan jumlah ovum preovulasi berhubungan secara signifikan dengan angka kehamilan (p<0,05). Factors Analizyng of Influencing for Succeses Pregnancy Rate on Intrauterina InseminationAbstractObjective: intrauterine insemination (IUI) is a procedure widely used in fertility management. However, the effectiveness of IUI treatment is not consistent, and the role of multiple factor affecting successes in IUI has not been clarified.Methods: Cross sectional study was conducted on infertile couples performing IUI. Data from medical record at Aster Clinique Dr. Hasan Sadikin General Hospital at January 1st- December 12th, 2016. Spouse Ages, Sperm Count, Concentration, and Motility, Endometrial Thickness, Number of Preovulatory Follicles, Type of Stimulation and Output are research variables. Data was analyzed by SPSS 24.00. Result: Among 159 couples, there were 194 procedures of IUI. Only 98 subject was evaluated. The pregnancy rate was 23.5%. Only type of ovarian stimulation and number of  preovulatory follicle related significantly  to the pregnancy rate (p < 0.05), spouse age, sperm count, concentration and motility, endometrial thickness did not significantly related to the pregnancy rate (p>0,05)Conclusion: There were many variables may influence success rates of IUI. Type of ovarian stimulation and number of  preovulatory follicle related significantly  to the pregnancy rate (p<0.05). More cohort trials and randomized trials investigating the multiple factors affecting successes in IUI are urgently needed.Key words: Intrauterine insemination, infertility, ovarian stimulation Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2018-03-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/42 10.24198/obgynia.v1i1.42 Obgynia; Volume 1 Nomor 1 Maret 2018; 24-30 Indonesian Journal of Obstetrics & Gynecology Science; Volume 1 Nomor 1 Maret 2018; 24-30 2615-496X 10.24198/obgynia.v1i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/42/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/42/11 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/42/57 Copyright (c) 2018 Journal Obstetric & Gynecology of Indonesia

oai:ojs.obgynia.com:article/540 2023-11-22T03:42:22Z obgynia:RA

Faktor-Faktor Risiko dan Status Kecemasan Ibu dengan Kehamilan Tidak Diinginkan Hairunnisa, Hairunnisa Tahir, Andi Mardiah Lisal, Lenny M. Sunarno, Isharyah Chalid, St. Maisuri T. Leonardy, Rudy B. Kehamilan Tidak Diinginkan; Kecemasan; Faktor Risiko; Hamilton Anxiety Rating Scale Tujuan: Untuk mengetahui hubungan faktor-faktor risiko dan status kecemasan pada ibu dengan kehamilan tidak diinginkan.Metode: Metode  kasus kontrol terhadap 62 sampel perempuan dengan kehamilan tidak diinginkan di RSUP Dr. Wahidin Sudirohusodo, RSKDIA Fatimah, RSIA Sitti Khadijah 1, RSKDIA Pertiwi, RS Syekh Yusuf dan RSUD Lapalaloi periode Januari 2022–Juni 2022. Data diperoleh menggunakan kuesioner dan status kecemasan dihitung berdasarkan Hamilton  Anxiety Rating Scale.Hasil: Kehamilan tidak diinginkan dihubungkan dengan paritas (16.500; CI 95%=3.675–74.081; p=0,001), penghasilan (OR 3.818; CI 95% = 1.398–10.429; p=0.012), unmet needs (OR 4.444; CI 95% = 2.087–9.464; p=0.001) dan penggunaan kontrasepsi (OR 2.722; CI 95%=1.309–5.659; p=0.011).Kesimpulan: Faktor risiko multiparitas, penghasilan, status unmet need, dan penggunaan kontrasepsi berhubungan dengan tingkat kecemasan pada ibu dengan kehamilan tidak diinginkan.Risk Factors and Anxiety Status in Women with Unwanted PregnancyAbstract Objective: To determine the relationship between risk factors and anxiety status in women with unwanted pregnancies.Method: Case control method of 62 samples of women with unwanted pregnancies at Dr. Wahidin Sudirohusodo, RSKDIA Fatimah, RSIA Sitti Khadijah 1, RSKDIA Pertiwi, Syekh Yusuf Hospital and Lapalaloi Hospital for the period January 2022 - June 2022. Data were obtained using a questionnaire and anxiety status was calculated based on the Hamilton Anxiety Rating Scale.Results: Unwanted pregnancy was associated with parity (16,500; 95% CI = 3,675–74,081; p=0.001), income (OR 3,818; 95% CI = 1,398–10,429; p=0,012), unmet needs (OR 4,444; 95% CI = 2.087–9.464; p=0.001) and contraceptive use (OR 2.722; 95% CI=1.309–5.659; p=0.011).Conclusion: Multiparity risk factors, income, unmet need status and contraceptive use are associated with the level of anxiety in mothers with unwanted pregnancies.Key words: Unwanted Pregnancy, Anxiety, Risk Factors, Hamilton Anxiety Rating Scale Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-11-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/540 10.24198/obgynia.v6i3.540 Obgynia; Volume 6 Nomor 3 November 2023; 355-364 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 3 November 2023; 355-364 2615-496X 10.24198/obgynia.v6i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/540/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/540/333 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/540/346 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/540/351 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/852 2025-07-24T00:43:19Z obgynia:CR

A Clinical Case of Thoracopagus Conjoined Twins Nofiandi, Riki Febriani, Febriani Conjoined twins; Thoracopagus; Prenatal diagnosis; Ethical challenges; Perinatal management Introduction: Conjoined twins result from the incomplete division of a single fertilized egg, with an incidence of approximately 1 in 200,000 live births. This rare congenital anomaly presents significant anatomical and physiological challenges, necessitating a multidisciplinary approach for diagnosis, management, and ethical considerations. Case Presentation: A pair of thoracopagus conjoined twins was delivered at Arifin Achmad General Hospital following preterm labor complicated by premature rupture of membranes (PROM). Prenatal ultrasound identified shared thoracic and abdominal structures, including cardiac and vascular abnormalities. The twins exhibited severe congenital anomalies, such as cardiomegaly and ventriculomegaly. Despite immediate resuscitation efforts, both infants succumbed due to extensive anatomical complications.Conclusion: The prognosis of thoracopagus twins remains poor, particularly in cases with extensive organ fusion. Advances in prenatal imaging and fetal surgery may improve outcomes in select cases; however, a multidisciplinaryand compassionate approach remains essential for optimal perinatal care. Keywords: Conjoined twins, Thoracopagus, Prenatal diagnosis, Ethical challenges, Perinatal managementKasus Klinis Bayi Kembar Siam Tipe ThoracopagusAbstrakPendahuluan: Kembar siam terjadi akibat pembelahan zigot yang tidak sempurna, dengan insiden 1 dari 200.000 kelahiran hidup. Anomali kongenital langka ini menimbulkan tantangan kompleks dalam aspek anatomi, fisiologi,serta etika sehingga memerlukan pendekatan multidisiplin dalam diagnosis dan penatalaksanaan. Laporan Kasus: Sepasang kembar siam thoracopagus lahir prematur di RSUD Arifin Achmad akibat persalinan preterm yang disertai ketuban pecah dini (KPD). Pemeriksaan ultrasonografi prenatal mendeteksi fusi struktur torako-abdominal, termasuk keterlibatan organ jantung dan pembuluh darah utama. Bayi mengalami kelainan kongenital berat kardiomegali dan ventrikulomegali. Meskipun dilakukan resusitasi segera, keduanya tidak bertahan hidup akibat komplikasi anatomi yang luas. Kesimpulan: Prognosis kembar siam thoracopagus tetap buruk, terutama pada kasus dengan keterlibatan organ yang luas. Kemajuan dalam pencitraan prenatal dan pembedahan janin dapat meningkatkan harapan hidup dalam kondisi tertentu; namun, pendekatan multidisiplin yang komprehensif dan penuh empati tetap menjadi kuncidalam perawatan perinatal. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran - 2025-07-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/852 10.24198/obgynia.v8i2.852 Obgynia; Volume 8 Nomor 2 July 2025; 420-427 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 2 July 2025; 420-427 2615-496X 10.24198/obgynia.v8i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/852/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/852/615 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/852/616 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/852/667 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/852/674 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/852/724 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/282 2022-03-15T05:52:25Z obgynia:RA

Hubungan antara Kadar Hemoglobin dan Jumlah Leukosit dengan Kejadian Prematuritas di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung Saleh, Idham Rizali Mose, Johanes C. Handono, Budi Hemoglobin, Prematuritas, Leukosit Tujuan: Untuk mengetahui adanya hubungan antara kadar hemoglobin dan kadar leukosit maternal dengan kejadian prematuritas di Rumah Sakit Umum Pendidikan Dr. Hasan Sadikin Bandung. Metode: Rancangan penelitian ini adalah observasional analitik dengan desain studi potong-lintang. Subjek penelitian adalah pasien dengan persalinan pada kehamilan usia 24–42 minggu di Rumah Sakit Umum Pendidikan Dr. Hasan Sadikin Bandung periode Januari – Desember 2019 yang berjumlah 82 pasien. Dilakukan pengumpulan data dari rekam medis pasien berupa usia kehamilan, kadar hemoglobin, kadar leukosit, dan faktor perancu berupa usia, tingkat pendidikan, dan tingkat paritas. Hubungan antara kadar hemoglobin dan jumlah leukosit dengan persalinan prematur dianalisis statistik dengan uji Chi-square. Variabel-variabel perancu akan dikendalikan melalui analisis multivariat dengan regresi logistik. Hasil: Terdapat hubungan yang signifikan antara kadar hemoglobin dan kadar leukosit dengan terjadinya persalinan prematur (p<0,05). Hasil analisis dengan uji regresi logstik menunjukkan bahwa tetap terdapat hubungan bermakna antara kadar hemoglobin (OR 0,27; p<0,05) dan kadar leukosit (OR 3,60; p<0,05) dengan persalinan prematur setelah dilakukan pengendalian faktor perancu. Kesimpulan: Kadar hemoglobin dan kadar leukosit memiliki hubungan yang signifikan dengan kejadian persalinan prematur tanpa dipengaruhi oleh usia, tingkat pendidikan, dan tingkat paritas. Associated Between Hemoglobin and Leukocytes Levels with the Incidence of Prematurity in Dr. Hasan Sadikin General Hospital BandungAbstract Objective: To examine whether an association exists between maternal hemoglobin and leukocyte level and the risk of preterm delivery in Rumah Sakit Umum Pendidikan Dr. Hasan Sadikin Bandung. Method: An analytical cross-sectional study involving 82 pregnant women who delivered at 24 – 42 weeks gestation at Rumah Sakit Umum Pendidikan Dr. Hasan Sadikin Bandung in January – December 2019 was conducted. Gestational age, maternal hemoglobin level, maternal leukocyte level, and confounding factors including age, education level, and parity data were collected from patients’ medical records. The association between maternal hemoglobin and leukocyte level with the risk of preterm delivery was analyzed using Chi-Square test. Multiple logistic regression models were used to control for confounding variables. Result: Maternal hemoglobin and leukocyte level were significantly associated with the risk of preterm delivery (p<0.05). Multiple logistic regression models showed that the associations between maternal hemoglobin level (OR 0.27; p<0.05) and maternal leukocyte level (OR 3.60; p<0.05) with the risk of preterm delivery were still significant after adjusting for confounding variables. Conclusion: Maternal hemoglobin and leukocyte level were significantly associated with the risk of preterm delivery after adjusting for age, education level, and parity. Key word: Hemoglobin, Prematuritas, Leukocyte. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2021-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/282 10.24198/obgynia.v4i2.282 Obgynia; Volume 4 Nomor 2 September 2021; 118-124 Indonesian Journal of Obstetrics & Gynecology Science; Volume 4 Nomor 2 September 2021; 118-124 2615-496X 10.24198/obgynia.v4i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/282/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/282/199 Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/932 2026-01-23T07:42:49Z obgynia:RA

Urinary Complications after Radical Hysterectomy in Cervical Cancer: A Retrospective Cohort Study Pradoto, Muhammad Edo Antariksa Sutrisno, Sutrisno Tjahyadi, Dian Urinary dysfunction, radical hysterectomy, urinary tract infection. Objective: Radical hysterectomy and pelvic lymphadenectomy are standard treatments for cervical cancer. A common long-term complication is lower urinary tract dysfunction (LUTD), which can lead to urinary tract infections (UTIs) due to urinary stasis. Incontinence may also increase UTI risk by allowing bacteria to enter through the urethra. This study aims to determine the incidence of LUTD and UTI in cervical cancer patients after radical hysterectomy and to analyze their relationship.Methods: A retrospective cohort study was conducted on patients with stage IA2–IIA2 cervical cancer who underwent radical hysterectomy at Margono Soekarjo General Hospital. Urinary catheters were placed postoperatively, and bladder training was initiated on postoperative day three. Urine samples were collected on day fourteen or upon the return of bladder sensation to assess for urinary tract infection (UTI). The relationship between lower urinary tract dysfunction (LUTD) and UTI was analyzed using.Result: LUTD incidence was 13.8%. UTI incidence was significantly higher in patients with LUTD than in those without (7.7% vs. 1.5%, p < 0.001). The relative risk of UTI in patients with LUTD was 31.1 (95% CI: 6.396–739.029), likely due to the limited sample size.Conclusion: There is a significant association between LUTD and UTI in cervical cancer patients after radical hysterectomy. Early detection and monitoring of bladder function are essential in postoperative care.Keywords: Lower urinary tract dysfunction; radical hysterectomy; urinary tract infection.Komplikasi Urinaria Setelah Histerektomi Radikal pada Kanker Serviks: Studi Kohort RetrospektifAbstrak Tujuan: Histerektomi radikal dan limfadenektomi pelvik merupakan terapi standar untuk kanker serviks. Salah satu komplikasi jangka panjang yang umum adalah disfungsi saluran kemih bagian bawah (Lower Urinary Tract Dysfunction/LUTD), yang dapat menyebabkan infeksi saluran kemih (ISK) akibat stasis urin. Inkontinensia urin juga dapat meningkatkan risiko ISK melalui masuknya bakteri melalui uretra. Penelitian ini bertujuan untuk mengevaluasi insidensi LUTD dan ISK pada pasien kanker serviks pasca-histerektomi radikal tipe II serta hubungan antara keduanya.Metode: Sebuah studi kohort retrospektif dilakukan pada pasien kanker serviks stadium IA2–IIA2 yang menjalani histerektomi radikal di RSUD Margono Soekarjo. Setelah operasi kateter urin dipasang dan melatih kandung kemih dimulai pada hari ketiga pascaoperasi. Sampel urin dikumpulkan pada hari keempat belas atau saat sensasi kandung kemih kembali untuk menilai adanya infeksi saluran kemih (ISK). Hubungan antara disfungsi traktus urinarius bawah (LUTD) dan ISK dianalisis menggunakan uji Fisher’s exact.Hasil: Penelitian ini menunjukan insidensi LUTD adalah 13,8%. Insidensi ISK secara signifikan lebih tinggi pada pasien dengan LUTD dibandingkan yang tidak mengalami LUTD (7.7% vs. 1.5%, p < 0.001). Risiko relatif ISK pada pasien dengan LUTD adalah 31.1 (CI 95%: 6.396–739.029) karena jumlah subjek penelitian sedikit.Kesimpulan: Terdapat hubungan yang signifikan antara LUTD dan kejadian ISK pada pasien kanker serviks pasca-histerektomi radikal. Deteksi dini dan pemantauan fungsi kandung kemih sangat penting dalam perawatan pascaoperasi.Kata kunci: Disfungsi urin; histerektomi radikal; infeksi saluran kemih Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran Muhammad Edo Antariksa Pradoto, Department obstetric and Gynecology Padjadjaran University Dian Tjahyadi, Department obstetric and Gynecology Padjadjaran University Sutrisno, Department Obgyn Jend Soedirman Universi 2025-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/932 10.24198/obgynia.v8i3.932 Obgynia; Volume 8 Nomor 3 November 2025; 433-440 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 3 November 2025; 433-440 2615-496X 10.24198/obgynia.v8i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/932/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/932/709 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/932/781 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/932/783 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/932/784 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/932/799 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/932/861 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/374 2022-09-23T03:08:24Z obgynia:AR

Fetal Programming pada Gangguan Mental Emosional: Tantangan Generasi Emas 2045 Mose, Johanes C. Gangguan Mental Pada hari-hari terakhir ini media sosial kita dibanjiri oleh banyak berita tentang pelbagai tindakan kekerasan baik verbal maupun fisik yang membuat kegaduhan dan kecemasan, baik di ruang publik antar anggota masyarakat, diruang privat instansi swasta atau pemerintah, maupun antar elit masyarakat. Fenomena ini menjurus pada pembenaran hipotesis tentang ‘masyarakat kita sedang sakit’. Hal ini sejalan dengan data Profil Kesehatan Indonesia Tahun 2020 yang di sampaikan oleh Kementrian Kesehatan RI 2021, yaitu tentang ‘Gangguan Mental Emosional’. Kelainan ini adalah suatu kondisi yang mengindikasikan seseorang mengalami perubahan psikologis yang mungkin merupakan sebuah kondisi normal, tetapi dapat juga merupakan kondisi patologis.Berdasarkan laporan hasil Riskesdas 2018 diketahui prevalensi gangguan mental emosional pada penduduk Indonesia sebesar 9,8%. Hal tersebut menunjukkan masih tingginya masalah gangguan mental emosional di Indonesia. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2022-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/374 10.24198/obgynia.v5i1.374 Obgynia; Volume 5 Nomor 1 Maret 2022; 4-8 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 1 Maret 2022; 4-8 2615-496X 10.24198/obgynia.v5i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/374/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/374/231 Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/613 2024-08-01T02:16:47Z obgynia:CR

Congenital Diaphragmatic Hernia Anomaly in Multigravida at 36 Weeks Gestation with One Previous Cesarean Section, Single Live Fetus, Cephalic Presentation: Case Report Putri, Asri Indriyani Martadiansyah, Abarham Bernolian, Nuswil Al Farisi Sutrisno, Muhammad Nisfita, Rizania Raudhah Maharsi, Rahma Congenital Diaphragmatic Hernia, Prior Cesarean Section Background: Case of a multigravida at 36 weeks of gestation with one previous cesarean section carrying a single fetus was diagnosed with diaphragmatic hernia. This case aims to address the challenges posed by this complex scenario of diaphragmatic hernia and the importance of specialized care to ensure optimal maternal and fetal outcomes.Case Report: Referred from Muhammadiyah Hospital Palembang, the patient at 36 weeks of gestation with G3P2A0 status present a single live fetus and was diagnosed with diaphragmatic hernia. Following prior midwife care where fetal heartbeats were not detected, the patient was referred to Dr. Mohammad Hoesin Central General Hospital Palembang. The management plan includes a one-week follow-up and folic acid, calcium carbonate, and iron supplementation.Discussion: Congenital diaphragmatic hernia (CDH) is a developmental defect causing diaphragmatic discontinuity, diagnosed prenatally with 40% to 90% accuracy via ultrasound. The treatment aims to minimize lung hypoplasia and reduce mortality, typically performed at 26-28 weeks for severe cases and 30-32 weeks for moderate ones. The optimal delivery timing for CDH remains controversial, with lung-to-head ratio as a widely used prognostic indicator.Conclusion: Congenital diaphragmatic hernia (CDH) exhibits lower survival rates on the right side (50% vs. 75%), with lung area to head circumference ratio (LHR) as a common prognostic parameter. Recent minimally invasive techniques like FETO aim to improve prognosis by reducing pulmonary hypoplasia and mortality.Laporan Kasus: Multigravida Hamil 36 Minggu Belum Inpartu Bekas Seksio Sesarea Satu Kali Janin Tunggal Hidup Presentasi Kepala Dengan Anomali Kongenital Hernia DiafragmatikAbstrakLatar Belakang: Kasus multigravida hamil 36 minggu dengan riwayat operasi caesar janin tunggal hidup yang didiagnosis hernia diafragma. Tujuan laporan kasus ini untuk mengatasi tantangan yang ditimbulkan oleh skenario kompleks hernia diafragma dan menunjukkan pentingnya perawatan khusus untuk memastikan hasil akhir ibu dan janin yang optimal.Laporan Kasus: Pasien usia kehamilan 36 minggu dengan status G3P2A0 janin hidup tunggal dengan diagnosis hernia diafragma dirujuk dari RS Muhammadiyah Palembang setelah sebelumnya diperiksa oleh bidan dan tidak terdeteksi detak jantung janinnya sehingga memerlukan rujukan ke RSUP Dr. Mohammad Hoesin Palembang. Rencana penatalaksanaannya mencakup tindak lanjut selama satu minggu, bersamaan dengan suplementasi asam folat, kalsium karbonat, dan zat besi.Diskusi: Hernia diafragma kongenital (CDH) merupakan kelainan perkembangan yang menyebabkan diskontinuitas diafragma dan didiagnosis sebelum lahir dengan akurasi 40% hingga 90% melalui ultrasonografi. Tatalaksana bertujuan untuk meminimalkan hipoplasia paru-paru dan mengurangi angka kematian, biasanya dilakukan pada minggu ke 26 sampai 28 untuk kasus yang parah dan 30 - 32 minggu untuk kasus yang sedang. Waktu persalinan yang optimal untuk CDH masih kontroversial, dengan rasio paru-paru sebagai indikator prognosis yang banyak digunakan.Kesimpulan: Hernia diafragmatika kongenital (CDH) menunjukkan tingkat kelangsungan hidup yang lebih rendah pada sisi kanan (50% vs. 75%), dengan rasio area paru terhadap lingkar kepala (LHR) sebagai parameter prognosis yang umum; teknik invasif minimal terkini bertujuan untuk meningkatkan prognosis dengan mengurangi hipoplasia paru dan kematian.Kata kunci: Hernia Diafragma Kongenital, Riwayat Operasi Caesar Sebelumnya, Multigravida  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-07-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/613 10.24198/obgynia.v7i2.613 Obgynia; Volume 7 Nomor 2 Juli 2024; 282-290 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 2 Juli 2024; 282-290 2615-496X 10.24198/obgynia.v7i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/613/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/613/428 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/965 2026-03-13T03:51:12Z obgynia:AR

Precision Chromosomal Surgery before Birth: Allele-Specific CRISPR-Cas9 Editing for Trisomy 21 in Perinatal Medicine Sanjaya, I Nyoman Hariyasa Andonotopo, Wiku Bachnas, Muhammad Adrianes Prabowo, Wisnu Yuliantara, Eric Edwin Lukas, Efendi Dewantiningrum, Julian Pramono, Mochammad Besari Adi Wiradnyana, Anak Agung Gede Putra Mulyana, Ryan Saktika Kusuma, Anak Agung Ngurah Jaya Pangkahila, Evert Solomon Gumilar, Khanisyah Erza Darmawan, Ernawati Akbar, Muhammad Ilham Aldika Yeni, Cut Meurah Aldiansyah, Dudy Bernolian, Nuswil Pribadi, Adhi Anwar, Anita Deborah Suryawan, Aloysius Putra, Ridwan Abdullah Gondo, Harry Kurniawan Nugraha, Laksmana Adi Krista Andanaputra, Waskita Ekamaheswara Kasumba Dharma, Wibisana Andika Krista Djanas, Dovy Stanojevic, Milan Trisomy 21; CRISPR-Cas9; Perinatal gene editing; Chromosome therapy; Fetal genome surgery Objective: Trisomy 21 remains the most common live-born aneuploidy and a major contributor to perinatal morbidity. Although prenatal screening, particularly non-invasive prenatal testing (NIPT), has advanced substantially, clinical management offers no corrective options. Emerging allele-specific genome-editing approaches propose targeted removal or silencing of the extra chromosome 21. This review summarizes current evidence and evaluates the translational relevance of these technologies in perinatal medicine.Methods: A narrative review was conducted following PRISMA-aligned procedures. A structured search of PubMed, Scopus, and Web of Science (January 2000–July 2025) identified 1,242 records. After duplicate removal, title/abstract screening, and full-text assessment based on predefined inclusion criteria, 54 studies met eligibility requirements. Data were synthesized across four domains: mechanistic strategies, developmental applicability, translational feasibility, and ethical–regulatory considerations.Results: Allele-specific CRISPR-Cas9 studies demonstrated selective cleavage of the supernumerary chromosome 21 in cellular models, with partial restoration of near-euploid transcriptional patterns. Additional approaches—XIST-mediated silencing and centromere destabilization—provided alternative mechanisms with varying stability and specificity. Evidence remains limited to in vitro systems, with no validated embryo or fetal applications. Key challenges include mosaicism, delivery barriers, individualized SNP targeting, and ethical governance.Conclusions: Allele-specific chromosome editing represents a promising but still experimental direction for future perinatal therapeutics. Current findings justify continued multidisciplinary investigation while emphasizing cautious interpretation and rigorous ethical oversight prior to any clinical translation. Abstrak Tujuan: Trisomi 21 tetap menjadi aneuploidi yang paling sering ditemukan pada kelahiran hidup dan merupakan kontributor utama terhadap morbiditas perinatal. Meskipun skrining prenatal—khususnya non-invasive prenatal testing (NIPT)—telah mengalami kemajuan yang signifikan, penatalaksanaan klinis hingga kini belum menawarkan opsi korektif. Pendekatan pengeditan genom spesifik alel yang mulai berkembang mengusulkan penghilangan atau penghambatan terarah terhadap salinan ekstra kromosom 21. Tinjauan ini merangkum bukti terkini serta mengevaluasi relevansi translasional teknologi tersebut dalam kedokteran perinatal.Metode: Tinjauan naratif dilakukan dengan mengikuti prosedur yang selaras dengan PRISMA. Pencarian terstruktur terhadap PubMed, Scopus, dan Web of Science (Januari 2000–Juli 2025) mengidentifikasi 1.242 rekaman. Setelah penghapusan duplikasi, penyaringan judul/abstrak, dan penilaian teks lengkap berdasarkan kriteria inklusi yang telah ditentukan, sebanyak 54 studi memenuhi persyaratan kelayakan. Data disintesis ke dalam empat domain: strategi mekanistik, aplikabilitas perkembangan, kelayakan translasional, serta pertimbangan etika dan regulasi.Hasil: Studi CRISPR-Cas9 spesifik alel menunjukkan pemotongan selektif terhadap kromosom 21 supernumerari pada model seluler, dengan pemulihan parsial pola transkripsi menuju profil ekspresi gen yang menyerupai kondisi euploid. Pendekatan lain—seperti penghambatan berbasis XIST dan destabilisasi sentromer—menyediakan mekanisme alternatif dengan tingkat kestabilan dan spesifisitas yang bervariasi. Bukti saat ini terbatas pada sistem in vitro, tanpa aplikasi yang tervalidasi pada embrio maupun janin. Tantangan utama meliputi mosaikisme, hambatan pengantaran, kebutuhan penargetan SNP individual, serta tata kelola etis.Kesimpulan: Pengeditan kromosom spesifik alel merupakan arah yang menjanjikan, namun masih bersifat eksperimental bagi terapi perinatal di masa mendatang. Temuan saat ini mendukung keberlanjutan penelitian multidisipliner, sekaligus menekankan perlunya interpretasi yang hati-hati dan pengawasan etika yang ketat sebelum penerapannya dalam praktik klinis.Kata Kunci: Bedah genom janin; CRISPR-Cas9; Penyuntingan gen perinatal; Terapi kromosom; Trisomi 21 Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2026-03-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/965 10.24198/obgynia.v9i1.965 Obgynia; Volume 9 Number 1 March 2026; 98-117 Indonesian Journal of Obstetrics & Gynecology Science; Volume 9 Number 1 March 2026; 98-117 2615-496X 10.24198/obgynia.v9i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/965/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/965/898 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/965/917 Copyright (c) 2026 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/338 2023-03-27T01:50:09Z obgynia:CR

Hernia Umbilikalis Post Sectio Sesarea pada Kehamilan Ganda: Sebuah Laporan Kasus Christyani, Fenyta Diptoadi, Sigit Pradono Hernia umbilikal, sectio sesarea, kehamilan ganda Tujuan: Mengetahui faktor risiko dan mekanisme terjadinya hernia umbilikalis pada pasien wanita post partumMetode:Teknik pengumpulan data melalui wawancara, pemeriksaan, observasi, serta dokumentasiKasus: Perempuan G2P1A0 hamil 35-36 minggu, bekas sectio sesarea, janin ganda intrauterine dengan rencana sectio sesarea. Riwayat ANC rutin dan tidak ditemukan kelainan. Dua hari setelah operasi section sesarea pasien mengeluhkan mual, muntah, dan ditemukan massa pada regio umbilikalis dengan konsistensi keras, immobile, terdapat nyeri tekan dan suara bising usus. Luka operasi baik. Pada pemeriksaan USG abdomen tampak gambaran hernia ventralis paramedian kanan abdomen. Pasien kemudian dilakukan operasi laparotomi hernioraphyDiskusi: Hernia umbilikal merupakan penonjolan usus yang berlokasi dekat umbilikus. Hal ini disebabkan oleh peningkatan tekanan intraabdominal dan kelemahan dari dinding perut. Terdapat beberapa faktor risiko yang mencetuskan. Faktor risiko pada kasus ini adalah obesitas, riwayat operasi sectio sesarea, dan kehamilan. Obesitas menyebabkan peningkatan tekanan intraabdominal, terjadi stress mekanik yang mengakibatkan gangguan dari metabolisme kolagen. Kesimpulan: Pada wanita dengan kehamilan ganda, obesitas dan riwayat operasi sebelumnya menjadi faktor risiko terjadinya kejadian hernia umbilikal. Umbilical Hernia Post Sectio Caesarea in Multiple Pregnancies: A Case ReportAbstractObjective: To know the risk factors and mechanism of umbilical hernia in post partum female patientsMethods:Techniques through interviews, examinations, observations, and documentationCase: G2P1A0 woman 35-36 weeks, former cesarean section with intrauterine multiple fetus with planned cesarean section. A history of routine ANC and no abnormalities were found. Two days after cesarean section the patient complained of nausea, vomiting, and found a mass in the umbilical region with a firm consistency, immobile, tenderness and bowel sounds. The surgical wound is good. On ultrasound examination of the abdomen showed a picture of the right paramedian ventral hernia of the abdomen. The patient then underwent laparotomy for hernioraphyDiscussion: Umbilical hernia is a protrusion of the intestine that is located near the umbilicus. It is caused by increased intraabdominal pressure and weakness of the abdominal wall. There are several risk factors that trigger it. The risk factors in this case were obesity, history of cesarean section, and pregnancy. Obesity causes an increase in intraabdominal pressure, mechanical stress occurs which results in disruption of collagen metabolism. Conclusion: In women with multiple pregnancies, obesity and a history of previous surgery are risk factors for the occurrence of umbilical herniaKey words: Umbilical hernia, cesarean section, multiple pregnancies Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran Fenyta Christyani1, Sigit Pradono Diptoadi2 1 Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atmajaya 2 Departemen Obstetri Ginekologi, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atmajaya, Jakarta, Indonesi 2023-03-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/338 10.24198/obgynia.v6i1.338 Obgynia; Volume 6 Nomor 1 Maret 2023; 145-148 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 1 Maret 2023; 145-148 2615-496X 10.24198/obgynia.v6i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/338/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/338/273 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/757 2024-12-07T01:19:06Z obgynia:ED

Calcium Paradox, Vitamin D and Vitamin K2 Mose, Johanes C. Calcium, Vitamin D, Vitamin K2 Calsium supplementation during pregnancy is a routine standard practice for antenatal care recommended by WHO, FIGO, POGI as well as Indonesia Ministry of Health. Calcium is one of essential micronutrients needed in human life, especially during pregnancy known for bone and teeth development, prevent osteoporosis, involved in blood coagulation, prevent haemorrhages during pregnancy and post partum periods, muscle contraction, prevent hypertension, preeclampsia, prematurity, IUGR, LBW, stunting, increase immunity, etc.Prevalence of hypocalcemia varies from 60 % to 70.5 % in low-medium income countries (LMIC) and 30 % to 60 % in high income countries (HIC).A systematic review study conducted in 2019 reported a prevalence of low calcium consumption less than 800 mg/day (normal consumption is around 1000-1200 mg/day) was 29 % in HIC and 82 % in LMIC, including Malaysia 377 mg/day and Indonesia < 400 mg/day.Calcium metabolism in human body is very much depend on the normal level of vitamin D, magnesium and parathyroid hormone in blood. Vitamin D is mainly needed for the absorption of calcium in intestine. The combination of vitamin D and calcium supplementation is very much recommended. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/757 10.24198/obgynia.v7i3.757 Obgynia; Volume 7 Nomor 3 November 2024; 291-294 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 3 November 2024; 291-294 2615-496X 10.24198/obgynia.v7i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/757/pdf Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/665 2024-03-22T01:17:15Z obgynia:FBM

oai:ojs.obgynia.com:article/529 2023-07-17T03:12:46Z obgynia:RA

Perbandingan Kadar Reactive Oxygen Species (ROS) sebagai Penanda Stres Oksidatif pada Ibu Hamil Dengan dan Tanpa Vaginosis Bakterial Aries, Dwicky Limbersia Chalid, Maisuri T. Amiruddin, Rina Previana Sjahril, Rizalinda Lukas, Efendi Mustafa, Susiawaty vaginosis bakterial, ibu hamil, reactive oxygen species Tujuan: Menganalisis perbandingan antara kadar reactive oxygen species pada ibu hamil dengan dan tanpa vaginosis bakterial.Metode: Penelitian cross sectional dilakukan pada ibu hamil yang datang berobat ke Poliklinik RSUP Dr. Wahidin Sudirohusodo, Rumah Sakit jejaring serta Puskesmas di Makassar, Indonesia, pada Juli 2021 sampai Juli 2022. Pengambilan sampel dilakukan dengan consecutive sampling. Subjek penelitian dengan dan tanpa vaginosis bakterial dikelompokkan berdasarkan hasil dari kriteria Amsel kemudian  kadar reactive oxygen species diukur dengan ROS ELISA Kit. Data dianalisis dengan uji chi-square, uji Mann-Whitney dan uji Kruskal Wallis.Hasil: Diperoleh 85 subyek penelitian yang terdiri dari 41 ibu hamil dengan vaginosis bakterial positif dan 44 ibu hamil dengan vaginosis bakterial negatif. Ibu hamil dengan vaginosis bakterial positif mempunyai kadar reactive oxygen species lebih rendah dibandingkan ibu hamil dengan vaginosis bakterial negatif (p=0.001*). Faktor lain yang berhubungan signifikan dengan kadar reactive oxygen species adalah lama keputihan >1 bulan. Umur, paritas, status gizi, diet fast food dan usia kehamilan tidak berhubungan signifikan dengan kadar reactive oxygen species (p>0,05).Kesimpulan: Kadar reactive oxygen species pada ibu hamil dengan vaginosis bakterial lebih rendah dari pada ibu hamil tanpa vaginosis bakterial. Diperlukan studi lanjut dengan skala penelitian yang lebih besar dengan lebih mengendalikan faktor-faktor yang dapat memengaruhi bias penelitian serta penelitian lebih lanjut mengenai kadar ROS dengan pendekatan sampel cairan vaginaComparison of Reactive Oxygen Species (ROS) Levels as Marker Of Oxidative Stress in Pregnant Women With and Without Bacterial VaginosisAbstractObjective: To analyze the comparison between levels of reactive oxygen species in pregnant women with and without bacterial vaginosis. Method: This study used a cross-sectional method that was conducted on pregnant women who came for treatment at Dr. Wahidin Sudirohusodo Hospital Polyclinic, a network hospital and public health center in Makassar, Indonesia, in July 2021-July 2022. Sampling was carried out using consecutive sampling. Research subjects with and without bacterial vaginosis were grouped based on the results of Amsel criteria and then ROS levels were measured by ROS ELISA kit. Data were analyzed by chi-square test, Mann-Whitney test, and Kruskal Wallis test. Results: There were 85 research subjects consisting of 41 pregnant women with positive bacterial vaginosis and 44 pregnant women with negative bacterial vaginosis. Pregnant women with positive bacterial vaginosis had lower levels of reactive oxygen species than pregnant women with negative bacterial vaginosis (p=0.001*). Another factor significantly related to reactive oxygen species levels  is vaginal discharge for > 1 month. Age, parity, nutritional status, fast food diet, and gestational age were not significantly related to levels of reactive oxygen species (p>0.05).Conclusion: The level of reactive oxygen species in pregnant women with bacterial vaginosis is lower than in pregnant women without bacterial vaginosis. Further studies are needed with a larger research scale with better control over factors that can influence research bias and further research on ROS levels with a vaginal fluid sample approach.Key words: bacterial vaginosis, pregnant women, reactive oxygen species Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Hasanuddin, Indonesia 2023-07-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/529 10.24198/obgynia.v6i2.529 Obgynia; Volume 6 Nomor 2 Juli 2023; 281-287 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 2 Juli 2023; 281-287 2615-496X 10.24198/obgynia.v6i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/529/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/529/314 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/529/315 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/529/336 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/778 2025-03-20T03:00:51Z obgynia:CR

Management of Ovarian Cancer in the Second Trimester of Pregnancy: A Case Report and Literature Review Syarief, Sri Dewi Rahmawati Ritonga, Mulyanusa Amarullah Anwar, Ruswana Suardi, Dodi ovarian carcinoma, pregnancy, mucinous ovarian carcinoma Introduction: Ovarian carcinoma during pregnancy is a rare but clinically significant condition that requires swift and precise management to optimize maternal and fetal outcomes. This case report highlights the successful conservative surgical management of malignant mucinous ovarian cancer diagnosed in the second trimester. It provides insights into the feasibility and safety of surgical intervention during pregnancy, contributing valuable evidence to the existing literature on oncologic care during pregnancy.Case Illustration: A 21-year-old woman, G1P0A0, presented at 17-18 weeks of gestation with no complaints related to her pregnancy but reported abdominal enlargement over the past three months. At 6 weeks gestation, the patient was diagnosed with an ovarian cyst, later confirmed as a large cystic mass on the right ovary with papillary components through ultrasound. The IOTA simple rules indicate that the mass was suspected to be malignant. The provisional diagnosis was suspected ovarian malignancy with a differential diagnosis of multilocular ovarian cyst. The patient underwent a planned right oophorectomy at 18 weeks gestation. Histopathology revealed a mucinous malignant tumor of the right ovary that had not invaded the right fallopian tube. The pregnancy was continued, and the patient was closely monitored, with plans for further evaluation postpartum.Conclusion: This case highlights the feasibility and safety of conservative surgical management of ovarian cancer in the second trimester, demonstrating that timely intervention can optimize both maternal and fetal outcomes. The successful continuation of pregnancy after surgery reinforces the importance of individualized, multidisciplinary approaches to oncologic care during pregnancy.Penatalaksanaan Kanker Ovarium pada Kehamilan Trimester Kedua: Sebuah Laporan Kasus dan Tinjauan PustakaAbstrakPendahuluan: Karsinoma ovarium pada kehamilan merupakan kondisi yang jarang terjadi tetapi, memiliki implikasi klinis yang signifikan. Penatalaksanaannya memerlukan keputusan yang cepat dan tepat untuk mengoptimalkan hasil bagi ibu dan janin. Laporan kasus ini menyoroti keberhasilan manajemen bedah konservatif pada kanker ovarium mucinous ganas yang terdiagnosis pada trimester kedua kehamilan. Kasus ini memberikan wawasan mengenai kelayakan dan keamanan tindakan bedah selama kehamilan, serta berkontribusi terhadap literatur ilmiah terkait onkologi kehamilan.Ilustrasi Kasus: Seorang wanita berusia 21 tahun, G1P0A0, datang pada usia kehamilan 17 – 18 minggu tanpa keluhan, namun melaporkan pembesaran perut selama tiga bulan terakhir. Pada usia kehamilan 6 minggu, pasien didiagnosis dengan kista ovarium yang kemudian dikonfirmasi sebagai massa kistik besar pada ovarium kanan dengan komponen papiler melalui pemeriksaan ultrasonografi. Berdasarkan IOTA simple rules, massa tersebut dicurigai ganas. Diagnosis sementara adalah dugaan keganasan ovarium dengan diagnosis banding kista ovarium multilokular. Pasien menjalani operasi ooforektomi kanan yang terencana pada usia kehamilan 18 minggu. Hasil histopatologi menunjukkan tumor mukinosa ganas pada ovarium kanan yang tidak menyerang tuba falopi kanan. Kehamilan dilanjutkan, dan pasien dipantau secara ketat dengan rencana evaluasi lebih lanjut setelah persalinan.Kesimpulan: Kasus ini menyoroti kelayakan dan keamanan manajemen bedah konservatif pada kanker ovarium trimester kedua. Intervensi yang tepat dapat mengoptimalkan hasil bagi ibu dan janin. Keberhasilan kelanjutan kehamilan setelah tindakan bedah ini menegaskan pentingnya pendekatan multidisiplin yang disesuaikan dengan kondisi pasien dalam penatalaksanaan kanker pada kehamilan.Kata kunci: kanker ovarium, kehamilan, kanker ovarium musinosum Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/778 10.24198/obgynia.v8i1.778 Obgynia; Volume 8 Nomor 1 Maret 2025; 189-193 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 1 Maret 2025; 189-193 2615-496X 10.24198/obgynia.v8i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/778/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/778/637 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/778/638 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/291 2022-03-15T05:52:25Z obgynia:ED

Cara Vaksin Covid-19 Melindungi Ibu Hamil, Termasuk Pelaksanaan Etikanya Martaadisoebrata, Djamhoer Tujuan: Membicarakan bagaimana cara vaksin COVID-19 bisa mencegah ibu hamil dari penularan Corona Virus, serta pelaksanaan Etikanya.Metoda: Studi Literatur.Hasil: Dengan adanya pandemi COVID-19, maka jumlah ibu hamil yang tertulari corona virus, makin banyak. Hal ini, menimbulkan permasalahan, bagaimana menanganinya, termasuk pelaksanaan Etiknya. Sampai sekarang, belum ada kesepakatan antara para pakar, bagaimana bentuk penangannya. Untuk itu PT POGI, mengajukan rekomendasi, tindakan MATERNAL apa yang harus dilakukan pada ibu hamil dengan COVID-19.Kesimpulan:Ibu hamil dengan COVID-19, merupakan masalah besar bagi negara kita, karena jumlahnya yang banyak, penyebarannya merata dan prognosisnya, dubia ad malam.Dalam melayani ibu hamil dengan COVID-19, Petugas Medis, termasuk Dokter, telah berlaku ETIS kepada pasien. Hal ini terbukti dari :Melakukan Protokol Kesehatan.Didahului dengan pemberian Informed Consent.Selama bertugas, menggunakan Alat Pelindung Diri.Dalam pelaksanaannya, Petugas Medis, menunjukkan sikap yang empati, sabar, jujur dan ikhlas. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran Vaksin COVID-19, Ibu Hamil, Etika 2021-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/291 10.24198/obgynia.v4i2.291 Obgynia; Volume 4 Nomor 2 September 2021; 93-102 Indonesian Journal of Obstetrics & Gynecology Science; Volume 4 Nomor 2 September 2021; 93-102 2615-496X 10.24198/obgynia.v4i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/291/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/291/185 Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/601 2023-11-22T03:42:22Z obgynia:FBM

Front Cover, Editorial Team, Table of Contents, and Back Cover Jurnal, Obgynia Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-11-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/601 10.24198/obgynia.v6i3.601 Obgynia; Volume 6 Nomor 3 November 2023 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 3 November 2023 2615-496X 10.24198/obgynia.v6i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/601/250 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/337 2022-09-29T03:33:47Z obgynia:RA

Absolute Lymphocyte Count and Neutrophil Lymphocyte Ratio in Pregnancy Confirmed Positive for SARS-CoV-2 at Dr. M. Djamil Hospital, Padang Martha, Nanda Tri Utama, Bobby Indra pregnant women, COVID-19, Absolute Lymphocyte Count, Neutrophil Lymphocyte Ratio Objective: To determine the description of ALC and NLR in pregnant women who were confirmed positive for SARS-CoV-2 at Dr. M. Djamil Padang Hospital.Methods: A descriptive study in pregnancy was confirmed positive for COVID-19 on March 2020 to February 2021 at Dr. M. Djamil Padang Hospital.Results: 126 cases of pregnant women with COVID-19 with 25 (20%) patients experiencing a decrease in ALC less than 1500/µL and 101 (80%) patients had ALC values ≥ 1500/µL. NLR values were found to be increased by ≥3.13 in 91(72%) patients and <3.13 in 35(28%) patients.  Conclusion: Most patients’ ALC values were normal, while the NLR values were mainly elevated.Gambaran Absolute Lymphocyte Count dan  Neutrophil Lymphocyte Ratio pada Wanita Hamil yang Terkonfirmasi Positif SARS-Cov2 di RSUP Dr. M. Djamil, Padang AbstrakTujuan: Untuk mengetahui gambaran ALC dan NLR pada ibu hamil yang terkonfirmasi positif SARS-CoV-2 di RSUP Dr. M. Djamil Padang.Metode: Studi deskriptif pada kehamilan terkonfirmasi positif COVID-19 selama Maret 2020 hingga Februari 2021 di RS Dr. M. Djamil Padang.Hasil: 126 kasus ibu hamil dengan COVID-19 dengan 25 (20%) pasien mengalami penurunan ALC yaitu kurang dari 1500/µL dan 101 (80%) pasien memiliki nilai ALC 1500/µL. Nilai NLR ditemukan meningkat 3.13 pada 91 (72%) pasien dan <3.13 pada 35 (28%) pasien.Kesimpulan: Nilai ALC ditemukan normal pada sebagian besar pasien, sedangkan nilai NLR ditemukan sebagian besar meningkat.Kata kunci: kehamilan, COVID-19, Absolute Lymphocyte Count, Neutrophil Lymphocyte Ratio Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2022-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/337 10.24198/obgynia.v5i1.337 Obgynia; Volume 5 Nomor 1 Maret 2022; 49-53 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 1 Maret 2022; 49-53 2615-496X 10.24198/obgynia.v5i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/337/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/337/224 Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/651 2024-08-01T02:16:47Z obgynia:RA

Comparison of Neonates Outcome in Patients with Early and Late Onset of Preeclampsia at Margono Hospital Purwokerto in the Period June-December 2022 Pugar, Hubert Hansel Adityono, Adityono Pusianawati, Dini neonatal outcome; onset of preeclampsia; preeclampsia Introduction: Preeclampsia affects 5% to 7% of pregnant women globally and is responsible for more than 70,000 maternal deaths and 500,000 fetal deaths worldwide each year. Preeclampsia has the highest morbidity and mortality rate. There are two subtypes of preeclampsia based on the onset: early-onset preeclampsia (<34 weeks of gestation) and late-onset preeclampsia (≥34 weeks of gestation). The difference in preeclampsia onset may result in different neonatal outcomes.Objective: This study aims to evaluate the neonate outcomes in patients with early-onset and late-onset preeclampsia and see whether there is a significant difference between those variables.Methods: The research was conducted at Margono Hospital in Purwokerto, Indonesia. The research design used is observational analytic with a cross-sectional method. The research subjects are 106 pregnant women with preeclampsia who gave birth at Margono Hospital from June to December 2022. Data analysis used is the Mann-Whitney and Chi-square statistical test with a 95% confidence level.Results: The study subjects, consisting of 38 subjects with early onset preeclampsia and 68 subjects with late-onset preeclampsia, showed a significant difference between the onset of preeclampsia and neonatal outcomes, as indicated by birth weight, birth length, APGAR scores, NICU admission, and status of the neonate at discharge, with p-values <0.05.Conclusion: The onset of preeclampsia affects the outcome of neonates.Perbandingan Luaran Neonatus pada Pasien dengan Preeklampsia Awitan Dini dan Awitan Lambat di Rumah Sakit Margono Purwokerto pada Periode Juni-Desember 2022Abstrak Pendahuluan: Preeklamsia terjadi pada 5% hingga 7% wanita hamil di seluruh dunia dan bertanggung jawab atas lebih dari 70.000 kematian ibu dan 500.000 kematian janin di seluruh dunia setiap tahunnya. Preeklampsia menempati penyakit dengan angka morbiditas dan mortalitas tertinggi, Terdapat dua subtipe preeklampsia berdasarkan awitannya: preeklamsia awitan dini (usia kehamilan <34 minggu) dan preeklamsia awitan lambat (≥34 minggu kehamilan). Perbedaan awitan preeklampsia dapat mengakibatkan luaran neonatus yang berbeda.Tujuan: Penelitian ini bertujuan untuk mengkaji perbendingan luaran neonatus pada pasien dengan preeklampsia awitan dini dan preeklampsia awitan lambat serta menganalisis perbedaan yang bermakna antara variabel tersebut. Metode: Penelitian dilakukan di RS Margono Purwokerto, Indonesia. Desain penelitian yang digunakan adalah analitik observasional dengan metode cross-sectional. Subjek penelitian ini adalah 106 wanita yang melahirkan di RS Margono Purwokerto dengan diagnosis preeklampsia pada bulan Juni – Desember 2022. Analisis data menggunakan uji statistik Mann Whitney dan Chi-square dengan tingkat kepercayaan 95%. Hasil: Subjek penelitian terdiri atas 38 subjek dengan preeklampsia awitan dini dan 68 subjek dengan preeklampsia awitan lambat. Hasil penelitian menunjukkan adanya perbedaan yang bermakna antara awitan preeklampsia dan luaran neonatus digambarkan dari berat badan lahir, panjang badan lahir, skor APGAR, perawatan NICU, dan kondisi neonatus saat pulang dari rumah sakit dengan nilai p<0.05. Kesimpulan: Awitan preeklampsia berpengaruh terhadap luaran neonatus.Kata kunci: Awitan preeklampsia, luaran neonatus, preeklampsia Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-07-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/651 10.24198/obgynia.v7i2.651 Obgynia; Volume 7 Nomor 2 Juli 2024; 160-168 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 2 Juli 2024; 160-168 2615-496X 10.24198/obgynia.v7i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/651/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/651/416 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/651/417 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/1019 2026-03-13T02:36:41Z obgynia:RA

Outcomes of Total Laparoscopic Hysterectomy Versus Total Abdominal Hysterectomy with Bilateral Salpingo-Oophorectomy in Endometrial Carcinoma Wibowo, Viko Duvadilan Erfiandi, Febia Bayuaji, Hartanto ECOG; endometrial carcinoma; hysterectomy; laparoscopy; laparotomy Objective: Management of endometrial carcinoma may involve total hysterectomy with bilateral salpingo-oophorectomy (TH-BSO), performed either laparoscopically or via laparotomy. This evaluation is crucial for assessing recovery and determining appropriate follow-up care in patients with endometrial cancer based on the ECOG Performance Status.Methods: This retrospective cohort study examined data from patients who underwent THBSO at Dr. Hasan Sadikin Hospital in 2024. The primary outcome measured was ECOG performance status at one month and six months post-surgery. The analysis was conducted using the Mann-Whitney U test to compare ECOG scores between the laparoscopic and laparotomy groups. Result: Of the 47 patients (28 laparotomies and 19 laparoscopies), the Mann-Whitney U test results for the ECOG score one month postoperatively showed no significant difference between patients who underwent THBSO with laparoscopic and laparotomy techniques (p = 0.921). However, the results of the 6-month postoperative ECOG score test indicated a significant difference between the two groups (p = 0.026), with better outcomes in the laparoscopic group. Conclusion: ECOG performance status after laparoscopy in endometrial cancer cases was better than after laparotomy. AbstrakTujuan: Penatalaksanaan karsinoma endometrium dapat dilakukan dengan histerektomi total disertai salpingo-ooforektomi bilateral, yang dilakukan baik secara laparoskopi maupun melalui laparotomi. Penilaian ini penting untuk mengevaluasi proses pemulihan dan menentukan tata laksana tindak lanjut yang tepat pada pasien kanker endometrium berdasarkan ECOG Performance Status.Metode: Studi kohort retrospektif ini menganalisis data pasien yang menjalani HTSOB di RSUP Dr. Hasan Sadikin pada tahun 2024. Luaran utama yang dinilai adalah ECOG performance status satu bulan dan enam bulan postoperatif. Analisis dilakukan menggunakan uji Mann-Whitney U untuk membandingkan skor ECOG antara kelompok laparoskopi dan laparotomi.Hasil: Dari 47 pasien (28 laparotomi dan 19 laparoskopi), hasil uji Mann-Whitney U terhadap skor ECOG satu bulan postoperatif menunjukkan bahwa tidak terdapat perbedaan bermakna antara pasien yang menjalani HTSOB dengan teknik laparoskopi dan laparotomi (p = 0.921). Sedangkan hasil uji skor ECOG 6 bulan postoperatif menunjukkan bahwa terdapat perbedaan signifikan antara kedua kelompok (p = 0.026), dengan hasil lebih baik pada kelompok laparoskopi.Kesimpulan: ECOG performance status pasca laparoskopi pada kasus kanker endometrium lebih baik daripada laparotomi.  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2026-03-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1019 10.24198/obgynia.v9i1.1019 Obgynia; Volume 9 Number 1 March 2026; 14-23 Indonesian Journal of Obstetrics & Gynecology Science; Volume 9 Number 1 March 2026; 14-23 2615-496X 10.24198/obgynia.v9i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1019/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1019/872 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1019/902 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1019/912 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1019/935 Copyright (c) 2026 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/430 2022-09-27T02:51:13Z obgynia:RA

Korelasi Asupan Vitamin C dan vitamin D dengan Kadar Timbal Ibu Hamil Preeklamsia Riska, Anggun Hatika Yusrawati, Yusrawati Efrida, Efrida Timbal, Asupan vitamin C, Asupan vitamin D, SQ-FFQ Tujuan: Untuk mengetahui korelasi asupan vitamin C dan vitamin D dengan kadar timbal ibu hamil preeklampsia.Metode: Studi analitik korelatif dengan pendekatan cross sectional. Sampel penelitian ini yaitu 33 orang ibu hamil preeklampsia bertempat tinggal radius ≤10 km, dan 33 orang ibu hamil preeklampsia bertempat tinggal radius >10 km dari PT. Semen Padang. Penelitian dilakukan di RSUD Rasidin, RSPTM Unand, RS. Hermina, RS. Tentara Reksodiwiryo, RS. Ibnu Sina, dan RSUP Dr. M. Djamil Padang pada bulan Mei 2021-Februari 2022. Hasil: Penelitian menunjukkan bahwa asupan vitamin C memiliki korelasi negatif yang sangat kuat dengan kadar timbal ibu hamil preeklamsia yang bertempat tinggal radius ≤10 km dari pabrik PT. Semen Padang (r=-0,872, p=0,000), sedangkan asupan vitamin C tidak berkorelasi dengan kadar timbal ibu hamil preeklamsia yang bertempat tinggal radius >10 km dari pabrik PT. Semen Padang (r=-0,049, p=0,785). Asupan vitamin D dengan kadar timbal ibu hamil preeklamsia yang bertempat tinggal radius ≤10 km dan >10 km dari pabrik PT. Semen Padang masing-masing memiliki korelasi negatif yang kuat dan sedang (r=- 0,696, r=-512, p=0,000, p=0,002).Kesimpulan: Terdapat korelasi asupan vitamin C dan vitamin D dengan kadar timbal ibu hamil preeklampsia setelah dikontrol variabel cofounding (radius tempat tinggal, status merokok, dan lingkungan tempat tinggal).Correlation of Vitamin C and Vitamin D Intake with Lead Levels in Pregnant Women with PreeclampsiaAbstract Objective: This study aims to determine the correlation between the intake of vitamin C and vitamin D with lead levels in  pregnant women with preeclampsia.Method: This research is a correlative analytic study with a cross-sectional. The sample of this study was 33 preeclampsia pregnant women living in a radius of ≤10 km, and 33 preeclampsia pregnant women residing in a radius of >10 km from PT. The research was conducted at Rasidin Hospital, RSPTM Unand, RS. Hermina, RS. Tentara Reksodiwiryo, RS. Ibnu Sina, and RSUP Dr. M. Djamil Padang in May 2021-February 2022. Results: Vitamin C intake has a very strong negative correlation with lead levels of preeclampsia pregnant women who live within a radius of ≤10 km from the Semen Padang Factory (r=-0.872, p=0.000), while vitamin C intake is not correlated with the lead levels of preeclampsia pregnant women who live in a radius of >10 km from the Semen Padang Factory (r=-0.049, p=0.785). Vitamin D intake with lead levels of preeclampsia pregnant women who live in a radius of ≤10 km and >10 km from the Semen Padang Factory each has a strong and moderate negative correlation (r=- 0.696, r=-512, p=0.000, p=0.002).Conclusion: There is a correlation between vitamin C and vitamin D intake and lead levels of preeclampsia in pregnant women after controlling for confounding variables (radius of residence, smoking status, and living environment).Key words : Lead, Vitamin C intake, Vitamin D intake, Preeclampsia. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2022-09-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/430 10.24198/obgynia.v5i2.430 Obgynia; Volume 5 Nomor 2 September 2022; 284-292 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 2 September 2022; 284-292 2615-496X 10.24198/obgynia.v5i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/430/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/430/258 Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/713 2024-11-19T11:53:19Z obgynia:SI

Alcohol Abuse in Pregnancy (Case Report) Rahmani, Putri Arfiantama, M. Ikhsan Lubis, Ahmad Sofyan Rahman, Luthfi alcohol intoxication, pregnancy, alcohol abuse, abortion Introduction: Alcohol abuse is an uncommon but significant health issue among pregnant women in Indonesia. Even minimal alcohol consumption can cause substantial harm to both individuals and society. However, there are currently no national service standards for screening, recording, or counseling regarding alcohol use during pregnancy in Indonesia.Case Report: A 25-year-old woman, gravida 2 para 1 abortus 0 (G2P1A0), at 20-21 weeks of gestation, presented to the emergency room with decreased consciousness after consuming alcohol suspected to contain ethanol. Clinical assessment and laboratory tests indicated that the patient was suffering from metabolic encephalopathy and severe metabolic acidosis. The patient was promptly intubated and resuscitated. Despite receiving intensive care in the ICU, the patient experienced seizures and intrauterine fetal demise (IUFD), followed by spontaneous labor the next day. Unfortunately, the patient’s condition continued to deteriorate, and she succumbed to multi-organ failure due to high blood alcohol concentration on the ninth day of treatment.Conclusion: From the case we can conclude that alcohol use during pregnancy is closely linked to the patient’s psychological condition. To optimize patient care, obstetricians and gynecologists are encouraged to employ routine screening techniques, clinical laboratory tests, brief interventions, and appropriate treatment referrals, one of them is ASSIST by WHO. Unfortunately, many pregnant women in Indonesia lack access to specialist care. Therefore, it is crucial to disseminate information about the health risks associated with alcohol consumption and abortion within informal community sectors to effectively reach vulnerable groups.Penyalahgunaan Alkohol pada Kehamilan (Laporan Kasus)AbstrakPendahuluan: Penyalahgunaan alkohol merupakan masalah kesehatan yang jarang ditemukan pada ibu hamil di Indonesia, meski konsumsi alkohol dalam jumlah berapa pun dapat menimbulkan kerugian besar bagi individu dan masyarakat. Namun, saat ini belum ada standar layanan nasional untuk skrining, pencatatan, dan konseling mengenai penggunaan alkohol pada ibu hamil di Indonesia.Laporan Kasus: Seorang perempuan berusia 25 tahun, gravida 2 para 1 abortus 0 (G2P1A0), dengan usia kehamilan 20-21 minggu, datang ke IGD dengan kondisi penurunan kesadaran setelah meminum minuman beralkohol yang diduga mengandung etanol. Pemeriksaan klinis dan hasil laboratorium menunjukkan bahwa pasien menderita ensefalopati metabolik dan asidosis metabolik berat. Pasien segera diintubasi dan diresusitasi. Setelah satu hari perawatan di ICU, pasien mengalami kejang dan intrauterine fetal demise (IUFD), yang kemudian disusul dengan persalinan spontan keesokan harinya. Kondisi pasien terus memburuk selama perawatan dan meninggal pada hari kesembilan akibat kegagalan multiorgan karena tingginya kadar alkohol dalam darah. Hasil alloanamnesis dari keluarga pasien menunjukkan bahwa pasien mengalami tekanan psikologis akibat kehamilan yang tidak diinginkan, yang diduga terkait dengan percobaan aborsi.Kesimpulan: Dalam kasus ini dapat disimpulkan bahwa konsumsi alkohol selama kehamilan erat kaitannya dengan kondisi psikologis pasien. Untuk mengoptimalkan perawatan, dokter obstetri dan ginekologi didorong untuk mempelajari dan menggunakan teknik skrining rutin, tes laboratorium klinis, intervensi singkat, dan rujukan pengobatan yang tepat dengan skrining ASSIST dari WHO. Sayangnya, masih banyak ibu hamil di Indonesia yang tidak memiliki akses terhadap dokter spesialis. Oleh karena itu, informasi mengenai risiko kesehatan akibat alkohol dan aborsi penting untuk disebarluaskan kepada masyarakat di sektor informal sehingga kelompok rentan dapat dijangkau dengan baik.Kata kunci: intoksikasi alkohol, kehamilan, penyalahgunaan alkohol, aborsi Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/713 10.24198/obgynia.v7i3.713 Obgynia; Volume 7 Nomor 3 November 2024; 17-24 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 3 November 2024; 17-24 2615-496X 10.24198/obgynia.v7i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/713/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/713/469 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/713/478 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/713/512 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/441 2022-09-22T01:14:44Z obgynia:FBM

oai:ojs.obgynia.com:article/503 2023-07-18T06:12:38Z obgynia:RA

The Correlation Between CYP19 Levels, VAS of Dysmenorrhea, and the Grading Score ASRM of Endometriosis Usman, Fatimah Hakim, Muhammad Komarul Manan, Heriyadi Saleh, Mgs. Irsan Endometriosis, CYP19, ASRM Objective: We aim to assess the correlation between the CYP19 level, the visual analogue scale (VAS) pain and endometriosis American Society for Reproductive Medicine (ASRM)  grading scale.Method: An observational analytic study with a cross–sectional design was conducted at the Obstetrics/Gynecology Department, RSUP Dr. Moh Hoesin Palembang, Laboratory of Biomedical and Biomolecular of the Faculty of Medicine, Universitas Sriwijaya from July–December 2022. Subjects who were diagnosed with endometriosis and met the inclusion and exclusion criteria underwent a histopathological examination to measure the degree of disease according to ASRM. Using the same sample, the CYP19 levels were assessed by enzyme linked immunosorbent assay (ELISA). Univariate and bivariate statistical analyses were performed to see the correlation.Results: This study involved 37 subjects aged 20–48 (Mean: 32 years). We found there was a significant correlation between the degree of VAS score and ASRM grading (p<0.001). In addition, although CYP19 expression was found in ectopic endometrial tissue, there was no significant correlation between the level of CYP19 expression in the tissue and the VAS score dysmenorrhea (p= 0,618) and ASRM grading (p=0.604).Conclusion: There is no significant correlation between CYP19 levels and the degree of pain in VAS or ASRM grading in patients.Hubungan Kadar CYP19, Visual Analogue Score (VAS) Dismenorea, dan Grading Score American Society for Reproductive Medicine (ASRM) Endometriosis Abstrak    Tujuan: Penelitian ini bertujuan untuk menilai hubungan kadar CYP19, skala nyeri visual analogue scale (VAS) dan grading berdasarkan American Society for Reproductive Medicine (ASRM) pada pasien endometriosis.Metode: Sebuah studi analitik observasional dengan rancangan cross–sectional dilakukan di Bagian/KSM Obstetri Ginekologi, RSUP Dr. Moh Hoesin Palembang dan Laboratorium Biomedis dan Biomolekuler Fakultas Kedokteran Universitas Sriwijaya, pada periode Juli–Desember 2022. Subjek penelitian yang terdiagnosis endometriosis dan memenuhi kriteria inklusi dan eksklusi, dilanjutkan pemeriksaan histopatologis untuk mengukur derajat penyakit sesuai rASRM. Dengan menggunakan sampel yang sama dilakukan penilaian kadar CYP19 melalui pemeriksaan enzyme linked immunosorbent assay (ELISA). Analisis statistik univariat dan bivariat dilakukan untuk melihat hubungan tersebut. Hasil: Penelitian ini melibatkan 37 subjek dengan rentang usia 20–48 (Median: 32 tahun). Pada penelitian, terdapat hubungan yang bermakna antara derajat nyeri VAS endometriosis terhadap derajat endometriosis (p<0,001). Selain itu, walaupun ditemukan adanya ekspresi CYP19 pada jaringan endometrium ektopik, namun tidak terdapat hubungan yang bermakna antara tingkat kadar CYP19 pada jaringan dengan derajat VAS score dismenorea (p=0,618) dan derajat ASRM endometriosis (p=0,604).Kesimpulan: Tidak terdapat hubungan bermakna antara kadar CYP19 dengan derajat nyeri VAS maupun derajat ASRM endometriosis pada pasien.Kata kunci: ASRM, Kadar CYP19, Endometriosis Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran Faculty of Medicine Sriwijaya University 2023-07-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/503 10.24198/obgynia.v6i2.503 Obgynia; Volume 6 Nomor 2 Juli 2023; 220-226 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 2 Juli 2023; 220-226 2615-496X 10.24198/obgynia.v6i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/503/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/503/304 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/503/310 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/503/343 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/765 2025-03-20T03:00:51Z obgynia:RA

Relationship Between Severe Preeclampsia, Gestational Hypertension, Impending Eclampsia, Preeclampsia, Superimposed Preeclampsia, and Chronic Hypertension on Fetal Outcomes at Respati Maternal and Child Hospital, Tasikmalaya Utama, Firman Drajat Desyari, Gina Haruman, Kikeu Rizki Perdana, Rikisetya Adhi Fetomaternal, Neonatal outcomes, Preeclampsia, Respati maternity and children’s hospital Objective: This study aims to explore the impact of preeclampsia on fetal outcomes at birth.Methods: This research used a total sampling method with a cross-sectional design. The data were from all pregnant patients and newborns delivered at Respati Maternity and Children’s Hospital, Tasikmalaya, in 2023. Hypertensive disorders included preeclampsia, severe preeclampsia (SPE), superimposed preeclampsia, gestational hypertension (GHT), impending eclampsia, and chronic hypertension, while fetal outcomes included birth weight and prematurity.Results: A total of 1,190 subjects were included. There was an association between birth weight and SPE (p < 0.01, PR = 7.64), GHT (p < 0.01, PR = 13.33), and superimposed preeclampsia (p < 0.05, PR = 5.24). A significant association was found between prematurity and SPE (p < 0.01, PR = 2.79), impending eclampsia (p < 0.05, PR = 3.63), superimposed preeclampsia (p < 0.01, PR = 4.47), and chronic hypertension (p < 0.05, PR = 3.63). No significant associations were found between other variables and low birth weight or prematurity.Conclusion: There is an association between SPE and superimposed preeclampsia with low birth weight and prematurity, between GHT and low birth weight, and between impending eclampsia and prematurity.Hubungan antara Preeklampsia Berat, Hipertensi Gestasional, Impending Eklampsia, Preeklampsia, Superimposed Preeklampsia, dan Hipertensi Kronis terhadap Luaran Janin di RSIA Respati TasikmalayaAbstrakTujuan: Penelitian ini bertujuan untuk mengeksplorasi lebih dalam mengenai dampak preeklampsia terhadap luaran bayi saat lahir.Metode: Penelitian ini dilaksanakan dengan metode total sampling, menggunakan desain potong lintang (cross-sectional) dengan data pasien ibu hamil dan janin yang dilahirkan di RSIA Respati Tasikmalaya pada tahun 2023. Variabel gangguan hipertensi meliputi preeklampsia, preeklampsia berat (PEB), superimposed preeklampsia, hipertensi gestasional (HTG), impending eklampsia, dan hipertensi kronis, sedangkan variabel luaran bayi meliputi berat badan lahir (BBL) dan prematuritas.Hasil: Sebanyak 1.190 subjek dikumpulkan. Terdapat hubungan yang signifikan antara BBL dengan PEB (p < 0,01, PR = 7,64), HTG (p < 0,01, PR = 13,33), dan superimposed preeklampsia (p < 0,05, PR = 5,24). Terdapat hubungan yang signifikan antara prematuritas dengan PEB (p < 0,01, PR = 2,79), impending eklampsia (p < 0,05, PR = 3,63), superimposed preeklampsia (p < 0,01, PR = 4,47), dan hipertensi kronis (p < 0,05, PR = 3,63). Tidak ditemukan hubungan antara variabel lainnya dan BBLR atau prematuritas.Kesimpulan: Terdapat hubungan antara PEB dan superimposed preeklampsia dengan berat badan lahir rendah dan prematuritas, terdapat hubungan antara HTG dan BBLR, dan terdapat hubungan antara impending eklampsia dan prematuritas.Kata kunci: Fetomaternal, Luaran Janin, Preeklampsia, RSIA Respati. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/765 10.24198/obgynia.v8i1.765 Obgynia; Volume 8 Nomor 1 Maret 2025; 26-33 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 1 Maret 2025; 26-33 2615-496X 10.24198/obgynia.v8i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/765/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/765/566 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/765/580 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/765/619 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/245 2021-03-25T20:51:11Z obgynia:RA

Characteristics of Infertility Causes in Patients Undergoing in Vitro Fertilization (IVF) Adnyana, Ida Bagus Putra Artha, Ida Bagus Rendra Kurniawan Tanjung, Anton Rahman, Luthfi Tujuan: Penelitian dilakukan dengan tujuan untuk mengetahui karakteristik faktor penyebab infertilitas pada pasangan yang menjalani in-vitro fertilization (IVF) di Klinik Bayi Tabung Rumah Sakit Umum Bali Royal Hospital periode Januari Desember 2019.Metode: Penelitian ini adalah penelitian deskriptif observasional dengan populasi target penelitian adalah pasangan infertil yang datang ke Klinik Bayi Tabung Rumah Sakit Umum (RSU) Bali Royal Hospital dengan tindakan IVF pada tahun 2019. Data selanjutnya diolah berdasarkan karakteristik sampel, faktor istri, faktor suami, serta faktor lainnya. Hasil: Pada periode 1 Januari–31 Desember 2019, tercatat sebanyak 174 kasus pasien infertilitas. Pada penelitian ini diperoleh bahwa 60,23% terjadi gangguan pada tuba yang merupakan penyebab tertinggi pada kelompok istri, sedangkan gangguan sperma berupa oligoasthenoteratozoospermia (81,82%) merupakan hasil paling tinggi pada kelompok suami. kelainan lainnya yang mengganggu proses fertilisasi pada penelitian ini adalah terdapatnya kelainan uterus pada 23,36% pasangan.Kesimpulan: Faktor kelainan tuba dan oligoastenoteratozoospermia merupakan karakteristik penyebab terbanyak infertilitas pada pasangan yang dilakukan IVFKata kunci: Infertilitas, IVF,Kelainan tuba, OligoasthenoteratozoospermiaCharacteristics of Infertility Causes in Patients Undergoing in Vitro Fertilization (IVF)AbstractObjective: The study was done to determine the characteristics of infertility cause in couples undergoing in-vitro fertilization in in-vitro fertilization clinic Bali Royal Hospital Denpasar on January–December 2019.Method: This was an observational descriptive study with study population of infertile couples that went to in-vitro fertilization clinic at Bali Royal Hospital Denpasar for IVF on 2019. The data obtained will be described based on sample characteristics, female factor, male factor and other factors. Result: In one-year period of 1 January–31 December 2019, there were 174 infertile cases included in this study. In this study, we concluded that the most common cause for female factor was tubal problems (60.23%), and for male factor was oligoasthenoteratozoosperm (81.82%), another abnormalities that affect couples fertility were uterus abnormalities (23.26%)Conclusion: Fallopian tube abnormalities and oligoastenoteratozoospermia were the most common causes of infertility in couples with IVF Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2021-03-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/245 10.24198/obgynia.v4i1.245 Obgynia; Volume 4 Nomor 1 Maret 2021; 49-55 Indonesian Journal of Obstetrics & Gynecology Science; Volume 4 Nomor 1 Maret 2021; 49-55 2615-496X 10.24198/obgynia.v4i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/245/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/245/151 Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/589 2024-04-29T04:12:24Z obgynia:CR

Ruptur Uteri Komplit Disertai Fetal Death pada Pasien Multipara: Sebuah Laporan Kasus Izaak, Revynca Petronella Linasari, Lydia ruptur uteri ; kematian janin ; multipara Pendahuluan : Ruptur uteri adalah suatu kondisi yang mengancam nyawa yaitu terjadi robekan pada rahim baik sebagian atau seluruhnya selama kehamilan atau persalinan.Presentasi kasus: Wanita 43 tahun G3P2002 usia kehamilan 37 - 38 minggu datang ke RSUD Dr. TC. Hillers mengeluh nyeri perut dan perut terasa tegang sejak 4 jam yang lalu. Pemeriksaan fisik didapatkan hipotensi, takikardi, takipnea, konjungtiva anemia, ekspansi dada bilateral, distensi perut, dan nyeri tekan suprapubik. Pemeriksaan dalam belum ada pembukaan dan perdarahan aktif. DJJ tidak terdeteksi dan satu janin dapat dipalpasi. Dilakukan operasi sesar darurat, ditemukan kematian janin di rongga perut dan robekan 10 cm pada segmen bawah rahim juga anterior dinding vagina. Diskusi: Kurangnya ANC yang adekuat, multipara, operasi sesar sebelumnya merupakan faktor risiko ruptur uteri. Ruptur uteri terjadi secara tiba-tiba dengan gejala akut yang bervariasi. Tatalaksana berupa pembedahan yaitu sterilisasi lengkap dengan histerektomi dan pilihan yang konservatif termasuk uterine sparing dengan atau tanpa ligasi tuba.Kesimpulan: Ruptur uteri merupakan suatu kegawatdaruratan obstetri yang berpotensi menimbulkan kematian ibu dan bayi. Diagnosis yang cepat, transportasi dini, transfusi produk darah yang memadai, dan tim bedah berpengalaman sangat penting untuk penatalaksanaan ruptur uteri.Complete Uterine Rupture with Fetal Death in a Multiparous Patient: A Case ReportAbstractIntroduction: Uterine rupture is a life-threatening condition when there is a tearing of the uterus either partially or completely during pregnancy or delivery.Case presentation: A 43 year old pregnant woman visited RSUD Dr. T.C. Hillers with the main complains of abdominal pain and tension since 4 hours prior to the visit. physical examinations showed hypotension, tachycardia, tachypnea, anemic conjunctiva, bilateral chest expansion, abdominal distension, and suprapubic tenderness. However, the results of intravaginal examination showed no dilated cervix or active bleeding. No FHR were detected, and a single fetus can be palpated. An emergency caesarean section was performed, and fetal death was found in the abdominal cavity with 10 cm sized tear in the lower uterine segment and anterior vaginal wall.Discussion: Poor ANC follow up, multiparous women and previous history of caesarean section are the core risk factors for uterine rupture. Uterine rupture often is sudden and may be catastrophic, and the acute signs and symptoms are variable. The treatment is often surgical and limited to two options which are either complete sterilization with hysterectomy and the more conservative option including uterine sparing option of surgical repair with or without tubal ligation.Conclusion: Uterine rupture is an obstetric emergency which could potentially cause of maternal and perinatal mortality. Prompt diagnosis, early transport, adequate blood products transfusion, and an experience surgical team are essential for the management of uterine rupture.Key words: Uterine rupture, fetal death, multiparous  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/589 10.24198/obgynia.v7i1.589 Obgynia; Volume 7 Nomor 1 Maret 2024; 112-121 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 1 Maret 2024; 112-121 2615-496X 10.24198/obgynia.v7i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/589/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/589/390 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/915 2025-07-24T00:43:19Z obgynia:RA

The Influence of Adolescent Pregnancy on Type of Delivery and Birth Weight Egatama, Mohamad ., Sutrisno Pusianawati, Dini Adolescent pregnancy; Type of delivery; Birth weight. Objective: This study aims to analyze the influence of adolescent pregnancy on the type of delivery and birth weight at Margono Soekarjo Hospital during the period 2022–2024.Methods:A cross-sectional study was conducted using secondary data from 198 postpartum mothers—99 adolescents (aged 10–19) and 99 non-adolescents (aged 30–35)—selected through stratified random sampling. Data on maternal age, delivery type, and birth weight were analyzed using chi-square and Mann-Whitney tests, with a significance level of p < 0.05.Results: Significant differences were found between the groups. Vaginal delivery was more common among adolescent mothers (61.5%) compared to non-adolescents (40.4%). Infants of adolescent mothers had lower average birth weights (2516.5 ± 569 g vs. 3031.2 ± 864 g; p = 0.025) and lower APGAR scores at 1, 5, and 10 minutes (p = 0.006). Cesarean indications differed between groups: fetal distress, cephalopelvic disproportion (CPD), and failed induction were common in adolescents, while prior cesarean section was the primary indication among non-adolescents.Conclusion: Adolescent pregnancy significantly affects delivery method and neonatal outcomes. While more likely to result in vaginal delivery, it is associated with lower birth weights, reduced APGAR scores, and higher complication risks, underscoring the need for targeted antenatal care in this population.Pengaruh Kehamilan Remaja Terhadap Jenis Persalinan dan Berat Bayi LahirAbstrakTujuan: Penelitian ini bertujuan untuk menganalisis pengaruh kehamilan remaja terhadap jenis persalinan dan berat bayi lahir di Rumah Sakit Margono Soekarjo selama periode 2022 - 2024.Metode: Desain penelitian yang digunakan adalah studi potong lintang (cross-sectional) dengan total 198 ibu melahirkan, terdiri atas 99 ibu remaja (usia 10 – 19 tahun) dan 99 ibu bukan remaja (usia 30 – 35 tahun), yang dipilih melalui stratified random sampling. Data sekunder diambil dari rekam medis pasien, mencakup usia ibu, jenis persalinan, berat bayi lahir, dan skor APGAR. Analisis data menggunakan uji chi-square untuk variabel kategorik dan uji Mann-Whitney untuk variabel numerik dengan tingkat signifikansi p < 0,05.Hasil: Hasil penelitian menunjukkan bermakna dalam jenis persalinan, persalinan pervaginam lebih banyak terjadi pada ibu remaja (61,5%) dibandingkan dengan ibu bukan remaja (40,4%). Berat bayi lahir juga berbeda signifikan, dengan rata-rata 2516,5 ± 569 gram pada kelompok remaja dan 3031,2 ± 864 gram pada kelompok bukan remaja (p = 0,025). Skor APGAR pada menit pertama, kelima, dan kesepuluh lebih rendah secara signifikan pada bayi dari ibu remaja (p = 0,006). Indikasi seksio pada remaja paling sering disebabkan oleh fetal distress, CPD, dan gagal induksi.Kesimpulan: Kehamilan remaja berpengaruh signifikan terhadap jenis persalinan dan luaran neonatal dengan kecenderungan komplikasi lebih tinggi.Kata kunci: Kehamilan remaja; Jenis persalinan; Berat bayi lahir. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-07-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/915 10.24198/obgynia.v8i2.915 Obgynia; Volume 8 Nomor 2 July 2025; 302-311 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 2 July 2025; 302-311 2615-496X 10.24198/obgynia.v8i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/915/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/915/693 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/915/694 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/915/695 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/915/750 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/915/751 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/642 2024-04-29T04:12:24Z obgynia:SI

Persalinan Prematur pada Pasien dengan Riwayat Keguguran Berulang yang Belum Teridentifikasi Faktor Penyebabnya: Laporan Kasus Pertiwi, Ilonna Putri Rachmawati, Anita Pendahuluan: Persalinan prematur dikaitkan dengan beberapa faktor, antara lain faktor kehamilan, gaya hidup dan perilaku, genetik, dan riwayat obstetrik, termasuk riwayat keguguran berulang. Pada pasien dengan riwayat keguguran berulang investigasi faktor penyebab penting dilakukan sebelum merencanakan kehamilan lagi. Dalam sebuah tinjauan sistematis dan meta-analisis riwayat keguguran berulang secara keseluruhan meningkatkan risiko persalinan prematur sebesar 1,6 kali lipat. Laporan kasus ini akan membahas persalinan prematur pada pasien dengan riwayat keguguran berulang yang belum diketahui faktor penyebabnya.Presentasi kasus: Pasien berusia 32 tahun, G4P1A2 hamil 30 – 31 minggu, datang dengan gejala dan tanda persalinan. Kehamilan pertama cukup bulan dan bersalin normal. Pasien memiliki riwayat dua kali keguguran secara berturut-turut pada kehamilan kedua (usia gestasi 7 minggu) dan ketiga (usia gestasi 10 minggu), tanpa riwayat diabetes melitus ataupun penyakit kronik lain. Pasien tidak mengonsumsi alkohol/obat-obatan tertentu dan tidak merokok. Suami pasien juga bukan seorang perokok. Penyebab keguguran berulang belum dapat diidentifikasi karena pemeriksaan belum dilakukan secara terarah, sehingga tata laksana untuk mencegah risiko persalinan prematur pada kasus ini belum optimal. Kesimpulan: Pada kasus ini risiko persalinan prematur mungkin terkait dengan riwayat keguguran berulang, sehingga investigasi penyebab keguguran berulang harus dilakukan agar dapat diberikan tata laksana medis yang sesuai untuk mencegah keguguran berulang dan persalinan prematur.Preterm Birth In Patient With History Of Unexplained Recurrent Pregnancy Loss: A Case ReportAbstractIntroduction: Premature birth is associated with several factors, including pregnancy factors, lifestyle and behavior, genetics, and obstetric history, including a history of recurrent miscarriage. In patients with a history of recurrent miscarriage, investigation of risk factor is important before planning another pregnancy. In systematic review and meta-analysis a history of recurrent miscarriage increased the risk of preterm birth by 1.6-fold. This case report will discuss premature labor in a patient with a history of recurrent miscarriage whose cause is unknown.Case Presentation: 32 year old patient, G4P1A2 30 – 31 weeks pregnant, presented with symptoms and signs of labor. The first pregnancy was full term and normal. The patient had a history of two consecutive miscarriages in the second (7 weeks' gestation) and third (10 weeks' gestation) pregnancies, without a history of diabetes melitus or other chronic diseases. The patient does not consume alcohol/certain drugs and does not smoke. The patient's husband is also not a smoker. The cause of recurrent miscarriage cannot be identified because examinations have not been carried out in a targeted manner, management to prevent the risk of preterm labor in this case is not optimal.Conclusion: In this case risk of preterm labor may be related to history of recurrent miscarriage, an investigation into the cause of recurrent miscarriage must be carried out, and the appropriate medical treatment can be given to prevent recurrent miscarriage and premature labor.Key words: Recurrent miscarriage, premature labor, management Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/642 10.24198/obgynia.v7i1.642 Obgynia; Volume 7 Nomor 1 Maret 2024; 68-76 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 1 Maret 2024; 68-76 2615-496X 10.24198/obgynia.v7i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/642/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/642/400 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/972 2026-01-23T07:42:49Z obgynia:RA

The Relationship Between Pre-Pregnancy Body Mass Index and the Incidence of Preeclampsia in Primigravida at Cibabat Regional Hospital Utami, Hasri Larasati Gurnadi, Jeffry Iman Pribadi, Adhi Body mass index; Preconception education; Primigravida Objective: This study investigates the association between pre-pregnancy body mass index (BMI) and the incidence of preeclampsia in primigravida women.Methods: This cross-sectional study includes women who delivered at Cibabat General Hospital between 2023 and 2024. Pre-pregnancy BMI (kg/m²) was classified according to WHO categories: underweight (less than 18.5), normal (18.5–22.9), overweight (23.0–24.9), obese class I (25.0–29.9), and obese class II (≥30.0). The Spearman-Rho correlation coefficient was employed to analyze the relationship between pre-pregnancy BMI and the incidence of preeclampsia. Result: Our study demonstrated that, among 217 participants, 159 (73.3%) experienced preeclampsia. The proportion of women with an overweight/obese BMI who have preeclampsia is higher (36%-38%) compared to those with normal BMI (19%) and underweight BMI (15%). The Spearman-Rho correlation coefficient suggested a positive correlation between pre-pregnancy BMI and the incidence of preeclampsia (r = 0.367; p < 0.001), indicating that an increased BMI is statistically associated with an increased risk of preeclampsia.Conclusion: A BMI is associated with an increased risk of preeclampsia in primigravida women.Hubungan antara Indeks Massa Tubuh Sebelum Kehamilan terhadap Kejadian Preeklamsia pada Ibu Primigravida di RSUD CibabatAbstrakTujuan: Penelitian ini bertujuan untuk menilai hubungan antara IMT pra-kehamilan dan insiden preeklamsia pada ibu primigravida.Metode: Penelitian ini menggunakan desain penelitian potong lintang dan melibatkan ibu primigravida yang menjalani persalinan di RSUD Cibabat pada periode 2023 hingga 2024. IMT partisipan sebelum kehamilan dikategorikan berdasarkan standar WHO: berat badan kurang (< 18.5), normal (18.5-22.9), berat badan berlebih (23.0 – 24.9), obesitas tipe 1 (25.0 – 29.9), dan obesitas tipe 2 (≥30.0). Data kemudian dianalisis lebih lanjut menggunakan metode spearman-rho correlation coefficient untuk menetukan korelasi antara IMT pra kehamilan dan kejadian preeklampsia. Hasil: Hasil penelitian menunjukkan, dari 217 partisipan pada penelitian ini, 73,3% diantaranya mengalami kejadian preeklamsia. Proporsi preeklampsia tampak lebih tinggi pada partisipan dengan berat badan berlebih/obesitas (36–38%) dibandingkan dengan partisipan dengan IMT normal (19%) dan IMT kurang berat badan (15%). Hasil uji spearman-Rho correlation coefficient menunjukkan korelasi positif antara IMT pra-kehamilan dan kejadian preeklamsia (r = 0,367; p < 0,001), mengindikasikan peningkatan IMT sebelum kehamilan berhubungan dengan risiko preeklamsia.Kesimpulan: Peningkatan IMT pra-kehamilan berhubungan dengan peningkatan risiko preeklamsia pada wanita primigravida.Kata kunci: Edukasi prakonsepsi; Indeks massa tubuh; Primigravida  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/972 10.24198/obgynia.v8i3.972 Obgynia; Volume 8 Nomor 3 November 2025; 497-502 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 3 November 2025; 497-502 2615-496X 10.24198/obgynia.v8i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/972/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/972/841 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/972/850 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/972/851 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/972/860 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/386 2022-09-27T01:54:49Z obgynia:RA

Profil Penderita Kanker Endometrium di RSUP Dr. Hasan Sadikin Bandung Periode Tahun 2017-2020 Salima, Siti Kurniadi, Andi Winarno, Gatot N.A. Suardi, Dodi Putri, Hanifah Nurisa Kanker endometrium; profil; faktor risiko Tujuan: Mengetahui profil penderita kanker endometrium.Metode: Penelitian metode deskriptif dengan menggunakan data sekunder. Kriteria inklusi penelitian yaitu pasien dengan diagnosis kanker endometrium dilihat berdasarkan hasil histopatologi.Hasil: Distribusi pasien mayoritas berusia >50 tahun (62,0%), berasal dari Kota/Kabupaten Bandung (32,5%), memiliki indeks massa tubuh 18,5-22,9 kg/m2 (27,0%), multipara (36,5%), status postmenopause (59,0%), memiliki usia menarche ≥12 tahun (88,0%), tidak memiliki riwayat diabetes mellitus (66,0%) dan hipertensi (27,0%), terdiagnosis ketika stadium I (47,5%), dengan derajat diferensiasi baik/grade I (31,0%) dan tipe I endometrioid adenocarcinoma (82,5%). Terapi yang paling sering adalah tindakan operasi (50,0%) dengan tipe pembedahan histerektomi total dan salfingooforektomi bilateral (44,21%).Kesimpulan: Pasien kanker endometrium di RSUP Dr. Hasan Sadikin Bandung periode tahun 2017-2020 ditemukan paling banyak berusia >50 tahun, dari Kota/Kabupaten Bandung, indeks massa tubuh normal, multipara, postmenopause, usia menarche ≥12 tahun, tidak ada riwayat DM dan hipertensi, terdiagnosis pada stadium I dengan tipe I endometrioid adenocarcinoma dan derajat diferensiasi baik (grade I), serta dilakukan tindakan operasi dengan tipe pembedahan histerektomi total dan salfingooforektomi bilateral.Profile of Endometrial Cancer Patients in Dr. Hasan Sadikin Central General Hospital Bandung in 2017–2020AbstractObjective: Identifying the profile of endometrial cancer patientsMethods: This research used descriptive method by collecting secondary data. The inclusion criteria was patients with endometrial cancer diagnosis based on the histopathological results.Results: In this research, the majority of patients were aged >50 years (62,0%), came from Bandung City/Regency (32,5%), with body mass index of 18,5-22,9 kg/m2 (27,0%), multiparous (36,5%), postmenopause (59,0%), menarcge age of  ≥12 years (88,0%), no history of diabetes mellitus (66,0%) and hypertension (27,0%), diagnosed at stage I (47,5%), with histopathological results well differentiated/grade I (31,0%) and type I endometrioid adenocarcinoma (82,5%). Surgery (50,0%) with the type of total hysterectomy and bilateral salpingoophorectomy (44,21%) was the most common treatment.Conclusion: In 2017-2020, endometrial cancer patient in Dr. Hasan Sadikin Central General Hospital Bandung were mostly found in the aged of >50 years, came from Bandung City/Regency, normal body mass index, multiparous, postmenopause, menarche age of ≥12 years, no history of diabetes mellitus and hypertension, diagnosed at stage I with histopathological result type I endometrioid adenocarcinoma and well differentiated (grade I), and the treatment was surgery with the type of total hysterectomy and bilateral salpingoophorectomy.Key words: Endometrial cancer, profile, risk factor Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2022-09-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/386 10.24198/obgynia.v5i2.386 Obgynia; Volume 5 Nomor 2 September 2022; 234-243 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 2 September 2022; 234-243 2615-496X 10.24198/obgynia.v5i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/386/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/386/244 Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/740 2024-11-19T11:53:18Z obgynia:AR

Professional Atitude Can Cause to Perch Plagiarism Martaadisoebrata, Djamhoer A calling requiring specialize knowledge and often long and intensive preparation including instruction and skills and methods as well as in the scientific, historical and scholarly principles, underlying such skills and methods, maintaining by force or organization or concern opinion, high standard of achievement and conduct, and committing its members to continue study and to a kind of work which has for prime propose the rendering of public service. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/740 10.24198/obgynia.v7i3.740 Obgynia; Volume 7 Nomor 3 November 2024; 295-297 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 3 November 2024; 295-297 2615-496X 10.24198/obgynia.v7i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/740/pdf Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/480 2023-03-27T01:50:09Z obgynia:AR

The Role of Vitamin D and Vitamin D Receptor in Placenta Accreta Spectrum: A Literature Review Mirani, Putri Lestari, Peby Maulina Murti, Krisna Liberty, Iche Andriyani Kesty, Cindy Andrina, Hana Stevanny, Bella placenta accreta; vitamin D; receptor Objective: This study aims to review the role of vitamin D and vitamin D receptor in Placenta Accreta Spectrum Disorder (PASD)Method: This review used several databases, namely Google Scholar, Science Direct, Elsevier, Medline, PubMed, Proquest, dan Wiley Online Library to search original and review articles in English about placenta accreta spectrum, placenta accreta, vitamin D, and vitamin D receptor in the last 10 years. Other reference sources used were guidelines and textbooks.Results: A total of four articles were included in this review.Discussion: Placenta accreta spectrum disorder is becoming more common around the world, owing to the rise in cesarean deliveries. It is linked to several risk factors, including a lack of vitamin D. Vitamin D and its receptor stimulate endometrial decidualization, which aids implantation. Vitamin D receptors in human placental trophoblasts create and respond to 1,25(OH)2D3, which promotes the conversion of endometrial cells to decidual cells. Women with PASD are mostly suffering from vitamin D deficiency. Conclusion: Vitamin D levels may influence trophoblast invasion in PASD and can be a potential diagnostic marker.Peran Vitamin D dan Reseptor Vitamin D dalam Spektrum Plasenta Akreta: Suatu Tinjauan PustakaAbstrakTujuan: Penelitian ini bertujuan untuk meninjau peran vitamin D dan reseptor vitamin D dalam Spektrum Plasenta Akreta (SPA)Metode: Tinjauan pustaka ini menggunakan beberapa sumber data yaitu Google Scholar, Science Direct, Elsevier, Medline, PubMed, Proquest, dan Wiley Online Library untuk mencari artikel penelitian dan tinjauan pustaka dalam Bahasa Inggris mengenai plasenta akreta, vitamin D, dan reseptor vitamin D dalam 10 tahun terakhir. Sumber referensi lain yang digunakan adalah pedoman dan buku teks.Hasil: Sebanyak empat artikel dimasukkan dalam ulasan ini.Diskusi: Spektrum Plasenta Akreta terjadi lebih sering di seluruh dunia karena meningkatnya persalinan sesar. Plasenta akreta terkait dengan beberapa faktor risiko termasuk kekurangan vitamin D. Vitamin D dan reseptornya merangsang desidualisasi endometrium dan berperan dalam implantasi. Reseptor vitamin D pada trofoblas plasenta membuat dan merespons 1,25(OH)2D3 yang mendorong konversi sel endometrium menjadi sel desidua. Mayoritas wanita dengan SPA mengalami kekurangan vitamin D.Kesimpulan: Kadar vitamin D dapat mempengaruhi invasi trofoblas pada SPA dan berpotensi menjadi penanda diagnostik.Kata kunci: spektrum plasenta akreta, reseptor vitamin D, vitamin D Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-03-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/480 10.24198/obgynia.v6i1.480 Obgynia; Volume 6 Nomor 1 Maret 2023; 20-27 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 1 Maret 2023; 20-27 2615-496X 10.24198/obgynia.v6i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/480/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/480/302 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/766 2025-03-20T03:00:51Z obgynia:CR

Risk of Malposition in a 56-Year-Old Female Lippes Loop IUD User: A Case Report Sepriano, Muhammad Ardi Levrian Susilo, Artha Falentin Putri Sasotya, Raden Mas Sonny Intrauterine device, Embedded, Lippes loop, Embedded Introduction: The intrauterine device (IUD) stands as a widely utilized contraceptive modality globally, renowned for its effectiveness and long-term reliability. However, within the spectrum of potential complications, the occurrence of perforation, though rare, represents a significant concern due to its potential for serious sequelae. Perforation entails the unintended penetration of the uterine wall by the IUD, leading to its migration beyond the uterine cavity. Despite its gravity, perforation often presents as an asymptomatic phenomenon, with some cases remaining undetected for extended durations following insertion. Lippes loop IUD complications are relatively low risk like malposition, embedded, or perforation.Case Report: This study documents a notable case involving a 56-year-old, P1A0, who had been utilizing an intrauterine device for a remarkable 31-year period. Referred from Hermina Arcamanik Hospital, the patient sought intervention for IUD removal, notwithstanding the absence of associated symptoms. Notably, physical examination and laboratory analyses yielded unremarkable findings, highlighting the latent nature of this complication. Further diagnostic elucidation through ultrasound examination confirmed the presence of a Lippes Loop (LL) IUD embedded within the uterine cavity. The intrauterine device (IUD) became embedded, rendering it impossible to remove. The IUD extraction is performed using hysteroscopy. Subsequent peri hysteroscopic extraction of the IUD unveiled partial embedding within the posterior uterine cavity, necessitating precise intervention to mitigate potential complications. Fortunately, postoperative surveillance revealed an absence of pain or hemorrhagic complications, culminating in the patient’s discharge on the first postoperative day. Conclusion: Constituted primarily of plastic material, LL IUDs offer prolonged utility devoid of significant adverse sequelae, underscoring their role as a viable contraceptive option with a slight risk of embedded for women seeking enduring contraception.Risiko Malposisi pada Akseptor Lippes Loop IUD pada Wanita Usia 56 Tahun: Sebuah Laporan KasusAbstrakPendahuluan: Alat Kontrasepsi Dalam Rahim (AKDR) merupakan metode kontrasepsi yang banyak digunakan di seluruh dunia karena efektivitas dan keandalannya dalam jangka panjang. Namun, di antara berbagai potensi komplikasi, perforasi menjadi salah satu kekhawatiran utama meskipun jarang terjadi, mengingat potensi dampak serius yang dapat ditimbulkannya. Perforasi terjadi ketika IUD secara tidak sengaja menembus dinding rahim, menyebabkan migrasi IUD keluar dari kavitas uterus. Meskipun serius, komplikasi ini sering ersifat asimtomatik dan tidak terdeteksi dalam jangka waktu lama setelah pemasangan. Komplikasi IUD tipe lippes loop dapat terjadi seperti malposisi, embedded atau perforasi, tetapi pada kasus yang jarang. Presentasi Kasus: Studi ini melaporkan kasus menarik pada seorang wanita berusia 56 tahun, P1A0, yang telah menggunakan IUD selama 31 tahun. Pasien dirujuk dari RS Hermina Arcamanik untuk menjalani prosedur pengangkatan IUD, meskipun tidak mengalami gejala terkait. Pemeriksaan fisik dan analisis laboratorium tidak menunjukkan kelainan, menekankan sifat laten komplikasi ini. Pemeriksaan ultrasonografi lebih lanjut mengonfirmasi keberadaan IUD jenis Lippes Loop (LL) yang tertanam di dalam kavitas rahim. Prosedur histeroskopi dilakukan karena IUD tertanam di dalam kavitas rahim sehingga membuat IUD sulit untuk diekstraksi secara normal. Saat prosedur histeroskopi, ditemukan bahwa sebagian IUD tertanam di dinding posterior rahim, memerlukan intervensi presisi guna mencegah komplikasi lebih lanjut. Pemantauan pascaoperasi tidak menunjukkan adanya nyeri atau komplikasi perdarahan, dan pasien dipulangkan pada hari pertama setelah operasi.Kesimpulan: Karena terbuat dari bahan dasar plastik, IUD LL menawarkan masa pemakaian yang lama tanpa menimbulkan efek samping yang signifikan, menjadikannya pilihan kontrasepsi yang andal, namun dengan risiko kecil terjadi embedded bagi wanita yang mencari solusi kontrasepsi jangka panjang.Kata kunci: Alat kontrasepsi dalam rahim, embedded, lippes loop, risiko Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/766 10.24198/obgynia.v8i1.766 Obgynia; Volume 8 Nomor 1 Maret 2025; 139-145 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 1 Maret 2025; 139-145 2615-496X 10.24198/obgynia.v8i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/766/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/766/551 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/766/567 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/766/568 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/766/626 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/1 2023-01-30T06:01:55Z obgynia:RA

Apakah Kadar β-hCG Praevakuasi dan Gambaran Proliferasi Sel Trofoblas secara Mikroskopik dapat digunakan untuk Prediksi Transformasi Keganasan pada Mola Hidatidosa? Mantilidewi, Kemala Isnainiasih Zulvayanti, Zulvayanti Permadi, Wiryawan hydatidiform mole, risk factors, remission, malignancy transformation AbstrakTujuan: Meneliti perbedaan karakteristik umur, paritas, besar uterus, kadar β-hCG, dan hiperproliferasi pada mola hidatidosa (MH) dengan regresi spontan dan pada MH dengan transformasi keganasan di RS Dr.Hasan Sadikin Bandung. Metode: Penelitian cross sectional deskriptif restrospektif mengambil data umur, paritas, besar uterus, kadar β-hCG pre-evakuasi, dan hiperproliferasi dari rekam medis pasien MH periode 2007-2016. Data diolah menggunakan program SPSS versi 20.0 for Windows. Nilai p<0,05 dianggap signifikan. Hasil: Dari 400 rekam medis yang dianalisis, 233 dengan data lengkap dapat dianalisis. Mayoritas pasien usia reproduktif 20-35(53,6%) tahun, paritas 1-2 (n=90, 38,6%), dan besar uterus rata-rata 19,12±4,633 (~minggu kehamilan). Kadar β-hCG <100000 mIU/mL sebanyak 78(33,5%), ≥100000 mIU/mL sebanyak 155(66,5%). Pasien dengan hiperproliferasi sebanyak 83(35,6%) sedangkan pasien tanpa hiperproliferasi sebanyak 150(64,4%). Terdapat 219(94,0%) dengan komplit MH, dan 14(6,0%) HM parsial (tidak dipublikasi). Pasien kemudian dikategorikan menjadi kelompok transformasi keganasan dan kelompok remisi spontan. Tidak terdapat perbedaan umur, paritas, dan besar uterus diantara dua kelompok (p>0,05). Perbedaan kadar βhCG (mIU/mL) dan tingkat proliferasi menunjukkan hasil signifikan (p<0.05). Kesimpulan: Kadar β-hCG preevakuasi dan status hiperproliferasi dapat digunakan sebagai prediktor transformasi keganasan pasien MH. Can Preevacuation Level β-hCG and Microscopic Trophoblast Proliferation Predict Malignant Transformation in Hydatidiform Mole?AbstractObjective: To describe differences among age, parity, size of uterus, level of β-hCG, and hyperproliferation state in HM with spontaneous remission and in that with malignancy transformation at dr.Hasan Sadikin General Hospital Bandung. Methods: This a cross sectional descriptive restrospective study of HM cases analyzing data on age, parity, size of uterus, pre-evacuation level of β-hCG, and hyperproliferation state taken from medical record of HM patients between 2007-2016. Data were statistically analyzed using SPSS version 20.0 for Windows. Result p<0.05 was considered significant.  Results: Out of 400 cases, 233 cases were selected. Those with incomplete data were not included in the analysis. Majority of patients were in reproductive age 20-35(53.6%) years old, has parity 1-2(n=90, 38.6%), and the size of uterus has mean 19.12±4.633 (~week of pregnancy). The level of β-hCG <100000 mIU/mL was 78(33.5%), ≥100000 mIU/mL was 155(66.5%). Patients with hyperproliferation were 83(35.6%) while without hyperproliferation were 150(64.4%). There were 219(94.0%) with complete HM, and 14(6.0%) partial HM (unpublished data). There were no significant differences in age, parity, size of uterus between the two groups (p>0.05). Differences on level of βhCG (mIU/mL) and proliferation state showed significant result (p<0.05). Conclusion: Preevacuation level of β-hCG and histopatology (proliferation state) may predict malignancy transformation in HM.Keywords: Hydatidiform mole, risk factors, remission, malignancy transformation Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2018-03-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1 10.24198/obgynia.v1i1.1 Obgynia; Volume 1 Nomor 1 Maret 2018; 52-56 Indonesian Journal of Obstetrics & Gynecology Science; Volume 1 Nomor 1 Maret 2018; 52-56 2615-496X 10.24198/obgynia.v1i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1/7 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1/9 Copyright (c) 2018 Journal Obstetric & Gynecology of Indonesia

oai:ojs.obgynia.com:article/555 2023-11-22T03:42:22Z obgynia:RA

Pengaruh Faktor Risiko terhadap Kejadian Bayi Berat Lahir Rendah di Rumah Sakit Bhayangkara Sartika Asih Bandung Santoso, Herman Budi Susiarno, Hadi Hidayat, Dini Faktor Risiko, Bayi Berat Lahir Rendah Tujuan: Diperlukan identifikasi faktor risiko yang bisa menyebabkan BBLR. Tujuan dalam penelitian ini yaitu mengetahui faktor risiko yang bisa menyebabkan BBLR meliputi faktor sosiodemografi, maternal,  janin, dan lingkungan.Metode: Penelitian menggunakan metode case control. Sampel berjumlah 126 orang. Pengambilan data berupa data rekam medis dengan instrumen menggunakan lembar ceklist mengenai faktor risiko sosiodemografi, maternal janin, dan lingkungan. Data dianalisis menggunakan uji chi square.Hasil: Faktor yang berpengaruh terhadap BBLR di antaranya usia (p-value 0,000), paritas (p-value 0,000), penghasilan (p-value 0,028), perdarahan antepartum (p-value 0,042), ketuban pecah dini (p-value 0,009), hipertensi (p-value 0,000), Kekurangan energi kronis (p-value 0,031), anemia (p-value 0,015), ibu perokok (p-value 0,006), gemeli (p-value 0,0016), hidramnion (p-value 0,042), prematur (p-value 0,000), kelayakan air (p-value 0,016) dan kelayakan sanitas (p-value 0,006). Sementara itu faktor yang tidak berpengaruh terhadap BBLR di antaranya pendidikan (p-value 0, 934), pekerjaan (p-value 0,312), TB paru (p-value 0,257), dan ibu minum alkohol (p-value 0,257). Hasil analisis multivariat didapatkan faktor yang berpengaruh terhadap kejadian BBLR secara berurutan yaitu gemeli (OR 42,218), prematur (OR 17,639), kelayakan air (OR 14,769), perokok (OR 12,462), hipertensi (OR 7,228), anemia  (OR 4,407), paritas (OR 3,116),  ketuban pecah dini (OR 1,674), usia (OR 1,245), dan kelayakan sanitasi (OR 1,230).Kesimpulan:  Faktor risiko yang paling berpengaruh terhadap BBLR yaitu Gemeli.Risk Factors on Low Birth Weight Infants at Hospital Bhayangkara Sartika Asih BandungAbstractObjective: Required identification of risk factors that can cause LBW. So the aim of this research is to know the risk factors that can cause LBW including sociodemographic, maternal, fetal and environmental factors.Method: Research using methods case control. The sample is 126 people. Data collection was in the form of medical record data with instruments using checklist sheets regarding sociodemographic, maternal and environmental risk factors. Data were analyzed using test who squares.Results: Factors that influence LBW include age (p-value 0.000), parity (p-value 0.000), income (p-value 0.028), antepartum hemorrhage (p-value 0.042), premature rupture of membranes (PRM) (p-value 0.009), hypertension (p-value 0.000), Chronic energy deficiency (p-value 0,031), anemia (p-value 0.015), smoking mothers (p-value 0.006), twins (p-value 0.0016), hydramnios (p-value 0.042), premature (p-value 0,000), water qualification (p-value 0.016) and sanitary feasibility (p-value 0.006). While the factors that do not affect LBW include education (p-value 0.934), work (p-value 0.312), pulmonary TB (p-value 0.257), and the mother drinks alcohol (p-value 0.257). The results of the multivariate analysis showed that the factors influencing the incidence of LBW were sequential (OR 42.218), premature (OR 17.639), water adequacy (OR 14.769), smokers (OR 12.462), hypertension (OR 7.228), anemia (OR 4.407), parity (OR 3.116), premature rupture of membranes (OR 1.674), age (OR 1.245) and sanitation feasibility (OR 1.230).Conclusion: The most influential risk factor for LBW is Gemelli.Key words: Gemelli, Low Birth Weight Babies, Risk Factors, Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-11-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/555 10.24198/obgynia.v6i3.555 Obgynia; Volume 6 Nomor 3 November 2023; 397-409 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 3 November 2023; 397-409 2615-496X 10.24198/obgynia.v6i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/555/pdf Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/877 2025-07-24T00:43:19Z obgynia:RA

Urinary Bladder Injury Among Patients with Placenta Accreta Spectrum: Comparison Between Wedge Resection and Total Hysterectomy Ismayadi, Tedi Pribadi, Adhi Kurniadi, Andi placenta accreta spectrum (PAS); total hysterectomy; wedge resection; urinary bladder injury Objective: This study aims to assess the incidence of urinary bladder injury among pregnant women with placenta accreta spectrum (PAS) who underwent total hysterectomy and wedge resection.Methods: This study employed a cross-sectional design by reviewing secondary data of all pregnant women with PAS who underwent total hysterectomy or wedge resection at Hasan Sadikin General Hospital from January 2021 to December 2023. Statistical analysis for categorical data used the Chi-square test or Fisher’s exact test, and numerical data were analyzed using the unpaired T-test or Mann-Whitney test.Results: The sample consists of 116 patients. A total of 84 patients underwent total hysterectomy, and 32 patients underwent wedge resection. There was no significant difference in mean age between the two groups (p = 0.129). The results showed a significant difference between the two groups for birth weight (p = 0.007) and the incidence of urinary bladder injury (p = 0.018). No urinary bladder injury occurred in the wedge resection group, while 13 (15.50%) patients experienced urinary bladder injury in the total hysterectomy group.Conclusion: Total hysterectomy is associated with a higher incidence of urinary bladder injury compared to wedge resection.Cedera Vesika Urinaria pada Pasien dengan Spektrum Plasenta Akreta:Perbandingan antara Wedge Resection dan Total HisterektomiAbstrak Tujuan: Penelitian ini bertujuan untuk menilai angka kejadian cedera vesika urinaria antara wanita hamil dengan spektrum plasenta akreta (SPA) yang menjalani histerektomi totalis dan wedge resection.Metode: Metode yang digunakan dalam penelitian ini adalah metode potong lintang dengan meninjau data sekunder semua ibu hamil dengan SPA yang menjalani histerektomi totalis atau wedge resection di Rumah Sakit Umum Pusat Hasan Sadikin periode Januari 2021 - Desember 2023. Analisis statistik untuk data kategorik menggunakan uji Chi-square atau uji Fisher dan data numerik diuji menggunakan uji T-tidak berpasangan atau uji Mann-Whitney.Hasil: Sampel penelitian ini terdiri atas 116 pasien. Sebanyak 84 pasien menjalani histerektomi totalis dan 32 pasien menjalani wedge resection. Tidak ada perbedaan rata-rata usia yang bermakna antar kedua kelompok (p = 0,129). Hasil penelitian menunjukkan perbedaan yang signifikan antara kedua kelompok untuk berat badan lahir (p = 0,007) dan kejadian cedera vesika urinaria (p = 0,018). Tidak ada yang mengalami cedera vesika urinaria pada kelompok wedge resection, sedangkan 13 (15,50%) pasien mengalami cedera vesika urinaria pada kelompok histerektomi totalis.Kesimpulan: Histerektomi totalis berhubungan dengan tingkat kejadian cedera vesika urinaria yang lebih tinggi dibandingkan dengan wedge resection. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-07-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/877 10.24198/obgynia.v8i2.877 Obgynia; Volume 8 Nomor 2 July 2025; 259-266 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 2 July 2025; 259-266 2615-496X 10.24198/obgynia.v8i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/877/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/877/705 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/877/706 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/877/721 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/295 2022-03-15T05:52:26Z obgynia:RA

Hubungan Anti-Mullerian Hormone (AMH) pada Long dan Short Protocol Terhadap Fertilization Rate Pasien In Vitro Fertilization (IVF) Wahid, Rizki Amalia Armawan, Edwin Djuwantono, Tono In Vitro Fertilization; Fertilization Rate; Anti-Mullerian Hormone; Protokol Stimulasi Ovarium Tujuan: Untuk mengevaluasi pengaruh kadar anti-mullerian hormone (AMH) dengan fertilization rate (FR) dan menilai perbedaan pengaruh jenis protokol (long protocol (LP) dan short protocol (SP)) pada tiap tingkat cadangan ovarium terhadap FR pada pasien in vitro fertilization (IVF) dengan Intracytoplasmic Sperm Injection. Metode: Data sekunder dari rekam medis pasien yang menjalani IVF di Aster Fertility Clinic Rumah Sakit Umum Pendidikan dr. Hasan Sadikin pada tahun 2016-2020 dan Bandung Fertility Centre Rumah Sakit Ibu Anak Limijati pada tahun 2018-2019. Penelitian ini analitik observational dengan metode Cohort retrospektif. Hubungan antara dua data kategorik diuji dengan uji chi-square dan uji Kruskal-Wallis digunakan pada data numerik dengan distribusi yang tidak rata pada lebih dari 2 kelompok, Hasil: Hasil data diperoleh nilai rerata kadar AMH secara keseluruhan adalah 3.30 ng/ml dengan rerata capaian FR sebesar 71.97%. Berdasarkan metode IVF yang dipilih, mayoritas pasien menjalani pengobatan SP 54.4% (rerata FR 72.80%) dibandingkan dengan LP 45.6% (rerata FR 70.97%). Tidak ditemukan hubungan yang bermakna antara kadar AMH dengan FR, dinyatakan dengan nilai p=0.977. Kadar AMH terhadap FR bila dipisahkan menurut protokol terapi yang diberikan tidak menunjukkan perbedaan yang bermakna pada masing-masing protokol (LP p=0,763; SP p=0,843). Mengenai hubungan antara protokol IVF dengan FR juga tidak diperoleh perbedaan yang signifikan secara statistik dengan nilai p=0,27 (RR 1.17 (0.62-2.15); CI 95%). Penggobatan menggunakan LP (p=0,770) maupun SP (p=0.845) tidak memberikan pengaruh yang bermakna terhadap FR pada setiap kategori AMH.Kesimpulan: Tidak ada pengaruh kadar AMH dan protokol terapi terhadap FR.Relation of Anti-Mullerian Hormone (AMH) in Short and Long Protocol Againts Fertilization Rate of in Vitro Fertilization (IVF) PatientsAbstractObjective:To evaluate the effect of anti-mullerian hormone (AMH) levels on the success of fertilization rate (FR) and assess the effect of different types of protocols (long protocol (LP) and short protocol (SP)) at each level of ovarian reserve on fertilization rate of in-vitro fertilization (IVF) patients using Intracytoplasmic Sperm Injection.Method: Secondary data from the medical records of patients undergoing IVF at the Aster Fertility Clinic, Hasan Sadikin Hospital in 2016-2020 and Bandung Fertility Center Limijati Hospital. This study was an observational analytic study with a retrospective cohort approach. The relationship between two categorical data was analyzed by chi-square and Kruskal-Wallis on numerical data that were not normally distributed in more than 2 groups.Result: The result of obtained data is an average overall AMH level of 3.30 ng/ml with a mean FR achievement of 71.97%. Based on chosen IVF method, more patient underwent short protocol 54.4% (mean FR 72.80%) than long protocol 46.6% (mean FR 70.97%). There was no significant relationship between AMH levels and FR, expressed by the value of p = 0.977.  AMH levels against FR when separated according to the given therapy protocol did not show any significant difference in each protocol (LP p=0.763, SP p=0.843). Regarding the relationship between the IVF protocol and FR, there was also no statistically significant difference with p value =0.27 (RR 1.17 (0.62-2.15) 95% CI), as well as treatment using LP (p=0,770) or SP (p=0.845) did not have a significant effect on FR at each AMH category (p=0.599).Conclusion: There was no significant relationship between AMH levels and therapy protocol on FR.Key word: In Vitro Fertilization, Fertilization Rate, Anti-Mullerian Hormone, Ovarian Stimulation Protocol Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2021-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/295 10.24198/obgynia.v4i2.295 Obgynia; Volume 4 Nomor 2 September 2021; 151-161 Indonesian Journal of Obstetrics & Gynecology Science; Volume 4 Nomor 2 September 2021; 151-161 2615-496X 10.24198/obgynia.v4i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/295/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/295/200 Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/610 2024-04-29T04:12:24Z obgynia:RA

Effect of Methotrexate on Anti-Mullerian Hormone Levels, β-hCG and Tumor Size in Women with Low-Risk Gestational Trophoblast Disease Madjid, Tita Husnitawati Masitoh, Imas Harsono, Ali Budi Purwara, Benny Hasan Rinaldi, Andi Mose, Johannes Cornelius Sunardi, Sunardi Chemotherapy, Methotrexate, Anti-mullerian hormone, ß-hCG, Tumor gestational trophoblast Introduction: This study aimed to evaluate the effect of methotrexate (MTX) chemotherapy on anti-mullerian hormone (AMH) levels, human chorionic gonadotropin (HCG) levels, and tumor size in women with gestational trophoblastic disease (GTD). Method: This study was conducted at Hasan Sadikin General Hospital, Bandung, West Java, from April to October 2020. The AMH level, beta human chorionic gonadotropin (ß-hCG) and tumor size in women with a low risk of GTD prior to and after MTX chemotherapy treatment were measured and compared.Results: Our study found a reduction in mean AMH level to 0.82 ng/ml after the MTX chemotherapy. The mean AMH level after chemotherapy in women with low-risk GTD decreased to 0.82 ng / ml. In addition, ß-hCG level decreased after chemotherapy with MTX. There was a negative relationship between ß-hCG level and tumor size before and after chemotherapy. Higher ß-hCG levels and tumor size before chemotherapy resulted in a further increase in AMH after chemotherapy.Discussion: There was a decrease in AMH and ß-hCG levels after three cycles of MTX chemotherapy in women with low-risk GTD. Tumor size and ß-hCG correlated with post-chemotherapy AMH results.Pengaruh Metotreksat terhadap Kadar Hormon Anti Mullerian, β-hCG dan Ukuran Tumor pada Wanita dengan Penyakit Trofoblas Gestasional Risiko RendahAbstrakPendahuluan: Penelitian ini mengevaluasi efek kemoterapi metotreksat (MTX) terhadap kadar hormon anti-mullerian (AMH), kadar human chorionic gonadotropin (HCG), dan ukuran tumor pada wanita yang didiagnosis penyakit trofoblas gestasional (GTD) risiko rendah.Metode: Penelitian ini dilakukan di Rumah Sakit Umum Pusat Hasan Sadikin, Bandung, Jawa Barat, dari bulan April hingga Oktober 2020. Kadar AMH, beta human chorionic gonadotropin (ß-hCG), dan ukuran tumor pada wanita dengan GTD risiko rendah sebelum dan sesudah pengobatan kemoterapi MTX diukur dan dibandingkan.Hasil: Pada penelitian kami menemukan penurunan kadar AMH rata-rata menjadi 0,82 ng/ml setelah kemoterapi MTX. Rata-rata kadar AMH setelah kemoterapi pada wanita dengan GTD risiko rendah menurun menjadi 0,82 ng/ml. Selain itu, kadar ß-hCG juga menurun setelah kemoterapi dengan MTX. Terdapat hubungan negatif antara kadar ß-hCG dan ukuran tumor sebelum kemoterapi dan AMH setelah kemoterapi. Kadar ß-hCG yang lebih tinggi dan ukuran tumor sebelum kemoterapi menunjukkan peningkatan lebih tinggi pada AMH setelah kemoterapi.Kesimpulan: Terjadi penurunan kadar AMH dan ß-hCG setelah tiga siklus kemoterapi MTX pada wanita dengan GTD risiko rendah. Ukuran tumor dan kadar ß-hCG berkorelasi dengan hasil kadar AMH setelah kemoterapi.Kata kunci: Kemoterapi, Metotreksat, Hormon anti-mullerian, ß-hCG, Tumor trofoblas gestasional Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/610 10.24198/obgynia.v7i1.610 Obgynia; Volume 7 Nomor 1 Maret 2024; 61-68 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 1 Maret 2024; 61-68 2615-496X 10.24198/obgynia.v7i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/610/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/610/392 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/937 2026-01-23T07:42:49Z obgynia:RA

Reevaluating Predictors of Extremely Low Birth Weight: The Dominance of Hemoglobin over Maternal Age and the Discovery of 9.25 g/dL as a New Risk Threshold Normala, Ajeng Susiarno, Hadi Hemoglobin, ELBW, birth weight, maternal anemia, risk screening AbstractObjectives: Extremely Low Birth Weight (ELBW) is a critical factor influencing neonatal morbidity and mortality. Maternal anemia has been linked to negative pregnancy outcomes; the precise hemoglobin threshold for predicting ELBW risk remains poorly defined, especially in low-resource environments.Methods: A cross-sectional observational study was carried out at Ciawi District Hospital between 2019 and 2020. Data from medical records on maternal hemoglobin levels (g/dL) and neonatal birth weights (grams) were extracted for analysis. Statistical methods employed included the Kruskal-Wallis and Mann-Whitney tests, as well as ROC curve analysis.Results: The study comprised 320 cases. The optimal cutoff value for maternal hemoglobin to accurately predict ELBW was identified as 9.25 g/dL (AUC 0.615; p = 0.045). Mothers with hemoglobin levels below this threshold exhibited a 2.1-fold increase in the risk of delivering ELBW infants (p = 0.039). Additionally, the negative predictive value was determined to be 94.05%, indicating that this threshold may serve as a viable screening tool for assessing the risk of ELBW.Conclusion: Maternal hemoglobin levels below 9.25 g/dL are significantly correlated with an elevated risk of ELBW. This threshold may function as an effective early screening parameter for identifying high-risk pregnancies, thereby improving maternal and neonatal health outcomes.Keywords: Birth Weight, ELBW, Hemoglobin, Maternal Anemia, Risk Screening Evaluasi Ulang Prediktor Berat Badan Lahir Sangat Rendah: Dominasi Hemoglobin pada Usia Ibu dan Penemuan 9,25 g/dL sebagai Ambang Risiko Baru AbstrakTujuan: Berat Badan Lahir Sangat Rendah (BBLR) merupakan faktor penting yang memengaruhi morbiditas dan mortalitas neonatal. Anemia ibu telah dikaitkan dengan hasil kehamilan yang negatif. Ambang hemoglobin yang tepat untuk memprediksi risiko BBLR masih belum didefinisikan dengan baik, terutama di lingkungan dengan sumber daya rendah.Metode: Metode yang digunakan dalam penelitian ini adalah studi observasional potong lintang dilakukan di Rumah Sakit Daerah Ciawi antara tahun 2019 dan 2020. Dilakukan analisis data dari catatan medis tentang kadar hemoglobin ibu (g/dL) dan berat badan lahir neonatal (gram). Metode statistik yang digunakan meliputi uji Kruskal-Wallis dan Mann-Whitney, dan analisis kurva ROC.Hasil: Studi ini terdiri atas 320 kasus. Nilai batas optimal hemoglobin ibu untuk memprediksi BBLR secara akurat diidentifikasi sebesar 9,25 g/dL (AUC 0,615; p = 0,045). Ibu dengan kadar hemoglobin di bawah ambang batas ini menunjukkan peningkatan risiko melahirkan bayi ELBW sebanyak 2,1 kali lipat (p = 0,039). Selain itu, nilai prediktif negatif ditetapkan sebesar 94,05%, yang menunjukkan bahwa ambang batas ini dapat berfungsi sebagai alat skrining yang layak untuk menilai risiko ELBW.Kesimpulan: Kadar hemoglobin ibu di bawah 9,25 g/dL berkorelasi signifikan dengan peningkatan risiko ELBW. Ambang batas ini dapat berfungsi sebagai parameter skrining dini yang efektif untuk mengidentifikasi kehamilan berisiko tinggi sehingga meningkatkan hasil kesehatan ibu dan bayi baru lahir. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/937 10.24198/obgynia.v8i3.937 Obgynia; Volume 8 Nomor 3 November 2025; 462-470 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 3 November 2025; 462-470 2615-496X 10.24198/obgynia.v8i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/937/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/937/829 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/937/831 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/363 2022-09-23T03:08:24Z obgynia:RA

Gambaran Klinis dan Histopatologi Kanker Ovarium di RSUP Dr. Hasan Sadikin Bandung Tahun 2019-2020 Aqilla, Salfa Harsono, Ali Budi Agustina, Hasrayati kanker ovarium, gambaran klinis, histopatologi Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran klinis dan histopatologi pasien kanker ovarium di RSHS tahun 2019-2020. Metode: Penelitian deskriptif ini dilaksanakan di RSUP Dr. Hasan Sadikin Bandung dengan menggunakan data rekam medis pasien kanker ovarium yang didiagnosis secara histopatologi tahun 2019-2020. Sampel dipilih menggunakan metode total sampling. Hasil: Penelitian ini menunjukan dari 140 pasien, mayoritas berusia 46-55 tahun (31,4%), multipara (60,7%), dan IMT normal (57,1%). Pasien mayoritas mengeluhkan adanya benjolan pada abdomen (100%) dengan karakteristik kistik sebagian padat (51,4%), berbenjol (57,1%), unilateral (87,4%), dan immobile (35,0%). Kebanyakan pasien memiliki nilai haemoglobin (75,3%) dan albumin (20,7%) rendah. Tumor marker yang paling sering ditemukan adalah CA 125 (37,9%). Mayoritas pasien didiagnosis pada stadium III (47,1%), tipe histopatologi mucinous carcinoma (20,0%) dan dilakukan operasi complete surgical staging (46,8%).Kesimpulan: Pasien kanker ovarium tahun 2019-2020 terbanyak adalah pada usia 46-55, multipara, IMT normal, mengeluhkan massa pada abdomen dengan karakteristik kistik sebagian padat, berbenjol, unilateral. Umumnya pasien mengalami penurunan nilai haemoglobin dan albumin serta berada pada stadium III dengan tipe histopatologi mucinous carcinoma dan dilakukan operasi complete surgical staging.Clinical Features and Histopathology of Ovarian Cancer at RSUP Dr. Hasan Sadikin Bandung 2019-2020AbstractObjective: This study aimed to determine the clinical and histopathological features of ovarian cancer patients at Hasan Sadikin General Hospital Bandung 2019-2020.Method: This descriptive research was conducted at Hasan Sadikin General Hospital Bandung using medical record data for ovarian cancer patients diagnosed histopathologically in 2019-2020. The sample was selected using the total sampling method. Results: This study showed that from 140 patients, the majority were aged 46-55 years (31.4%), multiparous (60.7%), and normal BMI (57.1%). The majority of patients complained of a lump in the abdomen (100%) with the characteristics of a cyst with partially solid (51.4%), uneven surface (57.1%), unilateral (87.4%), and immobile (35.0%). Most patients had low hemoglobin (75.3%) and albumin (20.7%) values. The most common tumor marker found was CA 125 (37.9%). The majority of patients were in stage III (47.1%), the histopathological type of mucinous carcinoma (20.0%), and underwent complete surgical staging (46.8%).Conclusion: Most ovarian cancer patients in 2019-2020 were aged 46-55, multiparous, normal BMI, complained of a mass in the abdomen with the characteristics of a cyst with partially solid,uneven surface, unilateral. Generally, patients have decreased hemoglobin and albumin values were diagnosed as stage III, the histopathological type of mucinous carcinoma and underwent complete surgical staging.Key words: ovarian cancer, clinical features, histopathology Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2022-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/363 10.24198/obgynia.v5i1.363 Obgynia; Volume 5 Nomor 1 Maret 2022; 127-135 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 1 Maret 2022; 127-135 2615-496X 10.24198/obgynia.v5i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/363/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/363/222 Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/692 2024-08-01T02:16:47Z obgynia:RA

Relationship Between Characteristics of Pregnant Women and Incidence of Anemia at I Melaya Health Center, Bali Province Wati, Ni Putu Eka Yadnya Aristasari, Gusti Ayu Putu anemia, pregnant women, risk factor Introduction: Anemia is a condition of low levels of red blood cells (hemoglobin) in the body below normal values. Pregnant women are considered to have anemia if their hemoglobin is less than 11 gr/dl. Data retrieved from the Bali Health Department in 2022 shows obstetric complications due to anemia accounted for 23% of total pregnancies, while data retrieved from the Jembrana Health Department in 2022 shows that 445 out of 3965 pregnant women experienced anemia. This study aims to determine the relationship between the characteristics of pregnant women and the incidence of anemia in the working area of I Melaya Health Center.Method: This descriptive study uses a cross-sectional design based on secondary data with 132 samples.Results: This study shows that the proportion of cases of anemia in pregnant women at I Melaya Health Center in 2022 was 59 cases (44.7%). Most of the anemia occurs in pregnant women aged <20 years, in the third trimester, with grandemultigravida parity and at obese nutritional status.Conclusion: This study shows a significant relationship between maternal age, gestational age, the number of parities, and the incidence of anemia in pregnant women. However, there is an insignificant relationship between maternal nutritional status and the incidence of anemia in pregnant women at I Melaya Health Center.Hubungan antara Karakteristik Ibu Hamil dan Kejadian Anemia di Puskesmas I Melaya Provinsi BaliAbstrakPendahuluan: Anemia merupakan kondisi rendahnya kadar hemoglobin atau sel darah merah dalam tubuh di bawah nilai normal. Untuk kehamilan, dapat dikatakan seorang ibu mengalami anemia jika hemoglobin kurang dari 11 gr/dl. Berdasarkan data profil kesehatan Provinsi Bali tahun 2022, komplikasi kebidanan akibat anemia mencakup 23% dari total kehamilan dan data profil kesehatan Kabupaten Jembrana tahun 2022 menunjukkan 445 dari 3965 ibu hamil mengalami anemia. Penelitian ini bertujuan untuk mengetahui hubungan antara karakteristik ibu hamil dan kejadian anemia di wilayah kerja UPTD Puskesmas I MelayaMetode: Penelitian ini merupakan penelitian deskriptif menggunakan design cross sectional berdasarkan data sekunder dengan sampel yang digunakan sebanyak 132 sampel.Hasil: Penelitian ini menunjukkan proporsi kejadian anemia pada ibu hamil di UPTD Puskesmas I Melaya tahun 2022 adalah sebanyak 59 kasus (44,7%). Mayoritas anemia terjadi pada ibu hamil usia <20 tahun, usia kehamilan trimester III, jumlah anak grandemultigravida, dan status gizi obese.Kesimpulan: Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara usia ibu, usia kehamilan, dan jumlah paritas dan kejadian anemia pada ibu hamil. Namun, terdapat hubungan yang tidak signifikan antara status gizi ibu dan kejadian anemia pada ibu hamil di UPTD Puskesmas I Melaya.Kata kunci : anemia, ibu hamil, faktor risiko. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-07-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/692 10.24198/obgynia.v7i2.692 Obgynia; Volume 7 Nomor 2 Juli 2024; 196-203 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 2 Juli 2024; 196-203 2615-496X 10.24198/obgynia.v7i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/692/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/692/437 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/692/449 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/692/450 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/1057 2026-03-13T02:36:41Z obgynia:RA

Comparison of Maternal and Neonatal Outcomes in Adolescent and Adult Pregnancies in West Java in 2024: A Retrospective Cross-Sectional Study Yulianti, Chiendo Irine Tambunan, Lies Ani Irianti, Setyorini Adolescent pregnancy; maternal outcome; neonatal outcome; preterm delivery; West Java Objective: To identify differences in maternal and neonatal outcomes between adolescent pregnancy (ages 16 – 19 years) and adult pregnancy (ages 20 – 35 years) in West Java in 2024.Methods: A retrospective cross-sectional study analyzed 654 singleton pregnancies (adolescents: 16 – 19 years; adults: 20 – 35 years) at Dr. Hasan Sadikin and Cibabat General Hospitals from January to December 2024. Data were analyzed using Chi-square, Fisher’s exact, and Mann-Whitney U tests.Results: Compared to adults, adolescents showed higher rates of preterm delivery (54.5% vs. 49.8%), premature rupture of membranes (30.3% vs. 14.0%), and unintended pregnancies (12.12% vs. 0.64%). Placental abnormalities were observed in 48.9% of adults, compared with 0% of adolescents (p=0.004). No significant differences in neonatal outcomes were found in birth weight (p=0.674), length (p=0.738), APGAR score at 1 minute (p=0.051), and APGAR score at 5 minutes (p=0.137).Conclusion: Adolescent pregnancies have higher maternal complication risks but do not show significant differences in key neonatal outcomes compared to adults. AbstrakTujuan: Penelitian ini bertujuan untuk mengidentifikasi perbedaan luaran maternal dan neonatal antara kehamilan remaja (usia 16 – 19 tahun) dan kehamilan dewasa (usia 20 - 35 tahun) di Jawa Barat pada tahun 2024.Metode: Metode penelitian ini adalah retrospective cross-sectional yang menganalisis 654 kehamilan tunggal (remaja: 16 – 19 tahun; dewasa: 20 – 35 tahun) di Rumah Sakit Umum Dr. Hasan Sadikin dan RSUD Cibabat, Bandung, pada periode Januari–Desember 2024. Data dianalisis menggunakan uji Chi-square, Fisher’s exact, dan Mann–Whitney.Hasil: Remaja memiliki insiden lebih tinggi untuk preterm delivery (54,5% vs. 49,8%), premature rupture of membranes (30,3% vs. 14,0%), dan unintended pregnancy (12,12% vs. 0,64%). Kelainan plasenta ditemukan pada 48,9% dewasa vs. 0% remaja (p=0,004). Tidak ada perbedaan signifikan pada luaran neonatal: berat lahir (p=0,674), panjang badan (p=0,738), APGAR 1 menit (p=0,051), APGAR 5 menit (p=0,137).Simpulan: Kehamilan remaja memiliki risiko komplikasi maternal lebih tinggi tetapi tidak berbeda signifikan pada hasil neonatal utama dibandingkan kehamilan dewasa.  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2026-03-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1057 10.24198/obgynia.v9i1.1057 Obgynia; Volume 9 Number 1 March 2026; 71-76 Indonesian Journal of Obstetrics & Gynecology Science; Volume 9 Number 1 March 2026; 71-76 2615-496X 10.24198/obgynia.v9i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1057/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1057/921 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1057/949 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1057/950 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1057/951 Copyright (c) 2026 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/461 2023-03-27T01:50:09Z obgynia:RA

Effectiveness of Vitamin D Suplementation in Pregnant Women with Vitamin D Deficiency to Improved Fetal Biometry S., Donel Rustam, Ruza Prima Inayah, Inayah Hamidy, M. Yulis Dwi Putri, Ratu Astuti Pangaribuan, Machyuddin T.M Fahruddin, Ahmad Savira, Maya biometry; Pregnancy; Vitamin D Deficiency Objective: The aim of this study was to determine the effect and effectiveness of vitamin D on fetal biometry.Method: This study was a Quantitative Study of two quasi-experimental groups. The research was conducted in Rupat District, Bengkalis Regency, Riau Province from June 2022 to August 2022. The research sample was pregnant women with vitamin D deficiency who were divided into an intervention group of 20 subjects and a control group of 20 subjects.Results: Examination of vitamin D levels in pregnant women and examination of fetal biometry was carried out. Then given a 1000 IU vitamin D supplement to pregnant women with vitamin D deficiency levels, re-evaluated after 3 months vitamin D levels in pregnant women and re-measured fetal biometry. There were significant differences in Fetal Biometrics between the pre-Intervention and post-Intervention studies in the intervention group with p=0.001. The intervention group also showed that there was an increase in the proportion of Normal Biometrics from 8 subjects before the intervention compared to 13 subjects after 3 months of vitamin D supplementation interventionConclusion: Vitamin D supplementation for 3 months in pregnant women with Vitamin D deficiency is proven to improve fetal health through Fetal Biometry examination.Efektivitas Suplemen Vitamin D dalam Meningkatkan Biometri Janin pada Wanita Hamil dengan Defisiensi Vitamin DAbstrakTujuan: Studi ini bertujuan mengetahui dampak dan efektivitas vitamin D terhadap biometri janin.Metode: Studi kuantitatif ini mengunakan dua grup dengan pendekatan kuasi-eksperimental. Penelitian ini dilaksanakan di Rupat, Kabupaten Bengkalis, Provinsi Riau dari Juni 2022 hingga Agustus 2022. Sampel penelitian ini adalah Wanita hamil dengan defisiensi vitamin D yang dibagi menjadi grup intervensi sebanyak 20 orang dan grup kontrol sebanyak 20 orang.Hasil: Dilakukan pengukuran kadar vitamin D pada Wanita hamil dan biometri janin. Pada grup intervensi diberikan suplementasi vitamin D 1000IU dan dievaluasi kembali kadar vitamin D setelah tiga bulan dan dilakukan kembali biometri janin. Terdapat perbedaan signifikan pada biometri janin sebelum dan sesudah intervensi dengan p=0.001. Grup intervensi juga menunjukkan peningkatan proprorsi biometri normal dari 8 orang menjadi 13 orang setelah tiga bulan suplementasi vitamin DKesimpulan: Suplementasi vitamin D selama tiga bulan pada Wanita hamil dengan defisiensi vitamin D terbukti membantu kesehatan janin melalui pemeriksaan biometri janin.Key words: Biometri, Defisiensi Vitamin D, Kehamilan Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-03-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/461 10.24198/obgynia.v6i1.461 Obgynia; Volume 6 Nomor 1 Maret 2023; 89-95 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 1 Maret 2023; 89-95 2615-496X 10.24198/obgynia.v6i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/461/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/461/276 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/681 2024-11-19T11:53:19Z obgynia:RA

Correlation between Leukocyte Esterase Levels and Pregnancy Latency Interval in Pregnant Women with a History of Preterm Premature Rupture of Membranes Andayani, Aviasti Pratiwi Bayuaji, Hartanto Siddiq, Amillia Ketuban pecah dini; masa latensi; infeksi saluran kemih; leukosit esterase Introduction: Bacterial colonization of the vagina and cervix can lead to intra amniotic infections that increase the risk of chorioamnionitis, premature rupture of membranes, and preterm labor. Leukocyte esterase (LE) is an alternative test that is affordable and easy to perform to predict the risk of preterm labor due to urinary tract infection. We examined the correlation between leukocyte esterase levels and gestational latency interval in pregnant women with preterm premature rupture of membranes.Methods: This study is an observational study with a cross-sectional design from the medical records of singleton pregnancy patients with preterm premature rupture of membranes undergoing conservative treatment at Dr. Hasan Sadikin General Hospital, Bandung. Researchers analyzed the difference in mean latency interval and the correlation between leukocyte esterase levels and latency interval. The data processing results regarding the correlation between variables are presented in tables and graphs.Results: Of 101 patients, 76 patients met the inclusion criteria; 26 patients (34%) had negative results for leukocyte esterase examination, while 50 patients (66%) were positive. The average latency period of all patients was 2.16 days. The latency period ≤2 days occurred in 53% of patients, with the shortest latency period found in patients with leukocyte esterase +4 levels (1.5 days). Moreover, the ANOVA test results show that the correlation between the age latency period and leukocyte esterase levels obtained a value of f-ratio =1.44 with a p-value of 0.65, indicating no significant results at p<0.05.Conclusion: This study found no significant correlation between leukocyte esterase levels and the latency interval after preterm premature membrane rupture.Hubungan antara Kadar Leukosit Esterase dan Interval Masa Latensi Kehamilan pada Ibu Hamil dengan Riwayat Ketuban Pecah Dini pada Kehamilan PrematurAbstrakPendahuluan:Penjalaran infeksi bakteri dari kolonisasi bakteri pada vagina dan serviks menyebabkan infeksi intraamniotik yang meningkatkan risiko korioamnionitis, ketuban pecah dini, serta persalinan prematur. Penapisan infeksi saluran kemih (ISK) melalui pemeriksaan kadar leukosit esterase (LE) merupakan alternatif pemeriksaan yang terjangkau dan mudah dilakukan untuk mencegah persalinan prematur. Penelitian ini meneliti hubungan antara kadar leukosit esterase dan masa latensi kehamilan pada ibu hamil dengan ketuban pecah dini <34 minggu.Metode: Penelitian ini merupakan studi observasional dengan desain cross-sectional dari rekam medik pasien hamil tunggal dengan ketuban pecah dini <34 minggu yang menjalani perawatan konservatif di RSUP Dr.Hasan Sadikin Bandung. Kriteria eksklusi pada penelitian ini ialah penyulit lain pada ibu dan janin dan pemberian tokolitik. Peneliti menganalisis perbedaan rerata masa latensi serta hubungan kadar leukosit esterase dengan masa latensi kehamilan pada ketuban pecah dini <34 minggu. Hasil olah data mengenai hubungan antar variabel disajikan dalam bentuk tabel dan grafik.Hasil: Dari 101 pasien, terdapat 76 pasien yang memenuhi kriteria inklusi, didapatkan hasil pemeriksaan leukosit esterase negatif sebanyak 34% (26 pasien), dan positif pada 66% pasien (50 pasien). Rerata masa latensi dari seluruh pasien ialah 2,16 hari. Masa latensi ≤ 2 hari terjadi pada 53% pasien dengan masa latensi paling singkat didapatkan pada pasien dengan kadar leukosit esterase +4 yaitu 1,5 hari. Pada uji Anova hubungan rerata masa latensi dengan kadar leukosit esterase didapatkan nilai rasio-f = 1,44 dengan nilai p 0.65 yang menunjukkan hasil tidak signifikan pada p<0.05.Kesimpulan: Hasil penelitian menunjukkan tidak ada korelasi signifikan antara kadar leukosit esterase dengan lama masa latensi kehamilan setelah ketuban pecah dini <34 minggu.Kata kunci: Infeksi saluran kemih; leukosit esterase; ketuban pecah dini; masa latensi Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/681 10.24198/obgynia.v7i3.681 Obgynia; Volume 7 Nomor 3 November 2024; 376-381 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 3 November 2024; 376-381 2615-496X 10.24198/obgynia.v7i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/681/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/681/511 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/728 2024-07-23T05:50:51Z obgynia:FBM

oai:ojs.obgynia.com:article/519 2023-11-22T06:21:12Z obgynia:RA

Effects of Combined Laparoscopic Cystectomy and Leuprolide Acetate Therapy on Anti-Mullerian Hormone Level and Antral Follicle Count Profile in Endometriosis Usman, Fatimah Hilmawan, Bagus Yusuf, Kemas Manan, Heriyadi Theodorus, Theodorus Andrina, Hana Endometriosis; Leuprolide Acetate; Cystectomy; Anti-Mullerian Hormone; Antral Follicle Count Objective: This study examines the effectiveness of combined laparoscopic cystectomy and leuprolide acetate therapy on AMH level and AFC profile in endometriosis.Method: This study is a randomized controlled clinical trial with open label form. The subjects were divided into control and therapy groups, with the therapy group receiving leuprolide acetate injection following laparoscopic cystectomy. In both groups, the AMH levels and AFC were examined prior to the surgery and six weeks after before they were compared.Results: There were significant pre-post differences of AMH levels(p = 0.000) and AFC (p = 0.000) in the therapy group but not in the control group. In the therapy group, the mean increases of AMH level and AFC were 0.94 (95% CI: 0.63-1.25) and 9.53 (95% CI: 6.83-12.24), respectively. Linear regression model found that AFC level prior to intervention was a significant predictor of endometriosis ASRM grade (p = 0.001) with an R-value of 0.633, suggesting strong correlation.Conclusion: The combined therapy of laparoscopic cystectomy and leuprolide acetate injection for endometriosis provided better outcome concerning ovarian reserve, as opposed to the therapy with laparoscopic cystectomy alone. Peran Kombinasi Laparoskopi Kistektomi dan Terapi Leuprolide Asetat Terhadap Kadar Hormon Anti-Mullerian dan Profil Jumlah Folikel Antral pada Penderita EndometriosisAbstrakTujuan:Studi ini bertujuan menguji keefektifan kombinasi kistektomi laparoskopi dan terapi leuprolide acetate terhadap kadar AMH dan profil AFC pasien endometriosis.Metode: Penelitian ini merupakan uji klinis terkontrol acak dengan bentuk open label. Subjek dibagi menjadi kelompok kontrol dan terapi, dengan kelompok terapi menerima injeksi leuprolide acetate setelah kistektomi laparoskopi. Pada kedua kelompok, kadar AMH dan AFC diperiksa sebelum pembedahan dan enam minggu setelahnya sebelum kemudian dibandingkan.Hasil: Terdapat perbedaan bermakna kadar AMH (p = 0,000) dan AFC (p = 0,000) sebelum dan sesudah pada kelompok terapi tetapi tidak pada kelompok kontrol. Pada kelompok terapi, rata-rata peningkatan kadar AMH dan AFC adalah masing-masing 0,94 (95% CI: 0,63-1,25) dan 9,53 (95% CI: 6,83-12,24). Model regresi linier menemukan bahwa kadar AFC sebelum intervensi merupakan prediktor signifikan derajat endometriosis sesuai ASRM (p = 0,001) dengan nilai R sebesar 0,633 yang menunjukkan korelasi yang kuat.Kesimpulan: Terapi kombinasi kistektomi laparoskopi dan injeksi leuprolide acetate untuk endometriosis memberikan hasil yang lebih baik terhadap cadangan ovarium, dibandingkan dengan terapi dengan kistektomi laparoskopi saja.Kata kunci: endometriosis; leuprolide acetate; kistektomi; hormon anti-mullerian; jumlah folikel antral Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-11-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/519 10.24198/obgynia.v6i3.519 Obgynia; Volume 6 Nomor 3 November 2023; 410-416 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 3 November 2023; 410-416 2615-496X 10.24198/obgynia.v6i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/519/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/519/363 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/806 2025-07-24T00:43:19Z obgynia:RA

Association between Preeclampsia and Preterm Labor at Raden Mattaher Jambi Hospital from 2021 to 2023 The Relationship of Preeclampsia to the Incidence of Preterm Labor at Raden Mattaher Jambi Hospital in 2021-2023 Quzwain, Suhair Dewi, Hasna Romadiani, Inaya Preeclampsia, Preterm Labor. Preeclampsia, Preterm Labor. Objective: This study aims to determine the association between preeclampsia and preterm labor at Raden Mattaher Jambi Hospital. Methods: This study uses an observational analytic method with a cross-sectional. Data collection techniques using purposive sampling. Data were obtained from the medical records of all laboring mothers who met the inclusion and exclusion criteria. Result: There is an association between preeclampsia and preterm labor at Raden Mattaher Jambi Hospital from 2021 to 2023, with a p-value of Objective: This study aims to determine the relationship of preeclampsia to the incidence of preterm labor at Raden Mattaher Jambi Hospital. Methods: This study used an observational analytic method with a cross-sectional approach. using purposive sampling. Data were obtained from the medical records of all laboring mothers who met the inclusion and exclusion criteria. Result: There is a relationship between preeclampsia and the incidence of preterm labor at Raden Mattaher Jambi Hospital in 2021-2023 with a p-value <0.001 (p<0.05) with an OR of 5.904. Most cases of preeclampsia mothers occur at the age of 20-35 years, with the most recent education of Senior High School (SMA), the most common employment status is not working, and most are first-time mothers (primipara). Conclusion: There is a significant relationship between preeclampsia and the incidence of preterm labor at Raden Mattaher Jambi Hospital in 2021-2023, obtaining an OR value of 5.904. Preeclampsia mothers have a risk of 5.904 of experiencing preterm labor compared to mothers who do not experience preeclampsia. Key words: Preeclampsia, Preterm Labor.Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan preeklampsia terhadap kejadian persalinan preterm di RSUD Raden Mattaher Jambi.Metode: Penelitian ini menggunakan metode analitik observational dengan pendekatan cross-sectional. menggunakan purposive sampling. Data diperoleh dari rekam medis seluruh ibu bersalin yang memenuhi kriteria inklusi dan eksklusi.Hasil: Terdapat hubungan preeklampsia terhadap kejadian persalinan preterm di RSUD Raden Mattaher Jambi tahun 2021-2023 dengan nilai p-value <0,001 (p<0,05) dengan OR 5,904. Kasus ibu preeklampsia sebagian besar terjadi pada usia 20-35 tahun, dengan pendidikan terakhir terbanyak Sekolah Menengah Atas (SMA), status pekerjaan terbanyak tidak bekerja, dan sebagian besar adalah ibu yang pertama kali bersalin (primipara).Kesimpulan: Ada hubungan yang bermakna antara preeklampsia terhadap kejadian persalinan preterm di RSUD Raden Mattaher Jambi tahun 2021-2023 diperoleh nilai OR 5,904. Ibu preeklampsia berisiko 5,904 mengalami persalinan preterm dibandingkan dengan ibu yang tidak mengalami preeklampsia.Kata kunci: Preeklampsia, Persalinan Preterm. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran Jambi University Jambi University 2025-07-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/806 10.24198/obgynia.v8i2.806 Obgynia; Volume 8 Nomor 2 July 2025; 216-223 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 2 July 2025; 216-223 2615-496X 10.24198/obgynia.v8i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/806/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/806/581 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/806/582 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/806/583 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/806/584 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/806/666 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/806/671 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/806/672 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/806/725 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/251 2021-09-30T05:13:02Z obgynia:AR

Abnormal Uterine Bleeding in Adolescent Theresia, Evelyne Cristopher, Andreas Edelweishia, Melissa Abnormal uterine bleeding, adolescents, heavy menstrual bleeding AbstractAbnormal uterine bleeding (AUB) is a frequent cause of visits to health care provider during adolescent period. Heavy menstrual bleeding is the most frequent clinical presentation of AUB. This condition particularly worrisome in this group not only when it occurs at menarche, but also anytime afterward when bleeding lasts longer than 7 days, blood loss is greater than 80 mL per cycle, or other warning signs that indicate a history of heavy bleeding such as anemia. Careful history and examination can help elucidate the best next steps for workup and management. The primary goal of treatment is prevention of hemodynamic instability. Therefore, assessing the severity and cause of bleeding is important. Therapeutic approach in the acute period should be established according to the degree of anemia and amount of flow. Treatment options for medical care of AUB generally include hormonal, nonhormonal and surgery. Additionally, long-term management with hormonal therapy in patients with severe uterine bleeding is known to be safe for developing HPO axis.Perdarahan Uterus Abnormal pada RemajaAbstrakPerdarahan uterus abnormal (PUA) sering menjadi penyebab kunjungan ke penyedia layanan kesehatan selama masa remaja. Perdarahan menstruasi yang berat adalah gambaran klinis yang paling sering dari AUB. Kondisi ini sangat mengkhawatirkan para remaja yang terjadi bukan hanya saat menarche, tetapi juga bila perdarahan berlangsung lebih dari 7 hari, kehilangan darah lebih dari 80 mL per siklus, atau gejala lain yang menunjukkan riwayat perdarahan berat seperti anemia. Anamnesa dan pemeriksaan yang cermat dapat membantu menentukan langkah selanjutnya untuk pemeriksaan lanjutan dan penatalaksanaan. Tujuan utama penatalaksanaan adalah untuk mencegah ketidakstabilan hemodinamik. Oleh karena itu, menilai tingkat keparahan dan penyebab perdarahan sangat penting. Pendekatan terapeutik pada periode akut harus disesuai dengan derajat anemia dan jumlah perdarahan. Pilihan pengobatan untuk perawatan medis pada PUA  umumnya termasuk hormonal, nonhormonal dan pembedahan. Selain itu, manajemen jangka panjang dengan terapi hormonal pada pasien dengan perdarahan uterus yang parah diketahui aman untuk perkembangan aksis HPO.Kata kunci: Perdarahan uterus abnormal, remaja, menstruasi berat Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2021-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/251 10.24198/obgynia.v4i2s.251 Obgynia; Special Issue: Article Review; 15-22 Indonesian Journal of Obstetrics & Gynecology Science; Special Issue: Article Review; 15-22 2615-496X 10.24198/obgynia.v4i2s eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/251/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/251/189 Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/878 2026-01-23T07:42:49Z obgynia:CR

Pregnancy With Multidrug-Resistant Pulmonary Tuberculosis and Autoimmune Hemolytic Anemia Complicated by Intrauterine Growth Restriction - A Case Report Permata, Putri Indah Aditya, Renny Putri, Ruth Widhiati Raharjo Isa, Mohamad Kurniawan, Sigit Prasetia Nurrasyidah, Ira autoimmune hemolytic anemia, intrauterine growth restriction, multidrug resistance, pregnancy, tuberculosis AbstractIntroductionIntrauterine growth restriction (IUGR) is a major obstetric complication often caused by maternal infections and anemia. We present a case of IUGR in a pregnant woman caused by multidrug-resistant tuberculosis (MDR-TB) and autoimmune hemolytic anemia (AIHA).Case presentationA 37-year-old G5P2A2 woman with confirmed MDR-TB and AIHA was treated with levofloxacin, clofazimine, cycloserine, ethambutol, bedaquiline, and methylprednisolone. Fetal biometry showed estimated fetal weight below the 10th percentile, with a significantly declining growth curve thereafter. After administration of fetal lung maturation at 33 – 34 weeks, she underwent an elective cesarean section at 35 – 36 weeks. A female infant weighing 1,840g was delivered. The treatment for MDR-TB and AIHA in the mother was continued afterward.ConclusionPregnancies complicated by MDR-TB and AIHA require strict monitoring and individualized multidisciplinary treatment. Further research is needed to establish treatment strategies that improve maternal and fetal outcomes in similar cases.Keywords : Autoimmune hemolytic anemia; intrauterine growth restriction; multidrug resistance; pregnancy; tuberculosis. Kehamilan dengan Tuberkulosis Paru Resisten Obat Ganda dan Anemia Hemolitik Autoimun yang Diperberat oleh Pertumbuhan Janin Terhambat – Laporan Kasus AbstrakPendahuluanIUGR adalah komplikasi obstetrik yang dapat disebabkan infeksi dan anemia pada maternal. Pada kasus ini dipresentasikan kasus wanita hamil dengan IUGR yang disebabkan multidrug resistant TB (MDR-TB) dan autoimmune hemolytic anemia (AIHA).Ilustrasi kasusIbu hamil 37 tahun G5P2A2 datang dengan TB-MDR dan AIHA. Pasien menjalani terapi TB-MDR dengan levofloksasin, klofazimin, sikloserin, etambutol, dan bedaquiline, serta metilprednisolon untuk AIHA. Pada fetal biometri ditemukan estimated fetal weight (EFW) di bawah 10 persentil dengan kurva pertumbuhan janin menurun signifikan setelahnya. Setelah dilakukan induksi pematangan paru janin pada usia kehamilan 33 - 34 minggu,  operasi sesar elektif dilakukan pada usia kehamilan 35 – 36 minggu melahirkan bayi perempuan dengan berat janin 1840gram. Pengobatan TB-MDR dan AIHA pada ibu dilanjutkan setelahnya.KesimpulanKehamilan dengan TB dan AIHA memerlukan pemantauan ketat dan terapi multidisiplin yang terindividualisasi. Penelitian lebih lanjut diperlukan.Kata kunci : Hemolitik anemia autoimun; kehamilan; pertumbuhan janin terhambat; resisten obat; tuberkulosis. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/878 10.24198/obgynia.v8i3.878 Obgynia; Volume 8 Nomor 3 November 2025; 606-610 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 3 November 2025; 606-610 2615-496X 10.24198/obgynia.v8i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/878/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/878/777 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/878/778 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/878/779 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/878/801 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/343 2022-09-23T03:08:24Z obgynia:RA

Pola Kuman dan Kepekaan Antibiotik pada Kasus Infeksi Luka Operasi Obstetri Irawan, Iwan Sukarsa, M. Rizkar Arev Aziz, M. Alamsyah Pola kuman, antibiotik, sensitivitas, infeksi luka operasi Tujuan: Mengetahui karakteristik pasien infeksi luka operasi (ILO) bidang Obstetri dan mendeskripsikan gambaran pola kuman serta kepekaan antibiotiknya di Rumah Sakit Umum Pusat (RSUP) Dr. Hasan Sadikin BandungMetode: Penelitian ini merupakan penelitian deskriptif observasional dengan pendekatan cross sectional yang bersifat retrospektif dari rekam medis pasien obstetri yang terdiagnosis infeksi luka operasi di RSUP Dr. Hasan Sadikin Bandung selama periode Juli 2020 - Juni 2021. Karakteristik subjek meliputi usia, berat badan, tinggi badan, body mass index (BMI),  dan paritas. Dalam penelitian ini digunakan tingkat ketelitian (α) 5%, tingkat kepercayaan 95% sehingga diperoleh nilai Z = 1,96. Deskripsi karakteristik dan status pasien ditampilkan dalam bentuk tabel. Data kategorik dideskripsikan dengan jumlah (n) dan persentase (%).Hasil: Hasil penelusuran rekam medis didapatkan sebanyak 20 pasien yang didiagnosis dengan ILO. Seluruh pasien yang mengalami ILO merupakan pasien pasca  seksio sesarea. Tidak didapatkan perbedaan yang bermakna pada rerata umur, berat badan, tinggi badan, BMI, dan sebaran paritas. Kesimpulan: ILO pada bidang obstetri seluruhnya terjadi pasca seksio sesarea. Tidak didapatkan perbedaan bermakna pada karakteristik pasien yang mengalami ILO. Pola kuman yang paling sering dijumpai adalah Escherichia coli dan Acinetobacter baumannii. Antibiotik yang sensitif terhadap mayoritas sampel adalah tigecycline dan meropenem.Antibiotic Susceptibility and Microbial Pattern in Obstetric Surgrical Wound InfectionAbstractObjective: To know the characteristics of surgical site infection (SSI) patients  in obstetrics field and describing the microbial pattern and their antibiotic sensitivity at the Hasan Sadikin General HospitalMethod: This study was a descriptive observational study with a retrospective cross sectional approach from the medical records of obstetric patients diagnosed with surgical wound infections at Dr. Hasan Sadikin Bandung during the period July 2020 - June 2021. Subject characteristics include age, weight, height, body mass index (BMI), and parity. In this study, the level of accuracy (α) 5%, 95% confidence level, so that the value of Z = 1.96 is obtained. Results: The results gained from tracing medical records and obtained as many as 20 patients diagnosed with SSI. All patients who experienced SSI were post-cesarean section patients. There were no significant differences in the mean age, weight, height, BMI, and parity distribution. Conclusion: There was a high prevalence of female sexual dysfunction among health practitioners at Hasan Sadikin General Hospital, accounting to 41.8%. There was no statistically significant difference between various demographic aspects and female sexual dysfunction. Key words: Microbial pattern, antibiotic, sensitivity, surgical site infection Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2022-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/343 10.24198/obgynia.v5i1.343 Obgynia; Volume 5 Nomor 1 Maret 2022; 77-86 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 1 Maret 2022; 77-86 2615-496X 10.24198/obgynia.v5i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/343/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/343/230 Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/678 2024-08-01T02:16:47Z obgynia:CR

Dengue Hemorrhagic Fever and its Effect on the Pregnancy Outcomes: A Case Series Farhanah, Aninda Yasmin Siddiq, Amillia Djuwantono, Tono Adriansyah, Putri Nadhira Adinda Dengue fever; maternal; fetal; outcomes; pregnancy Background: Dengue fever in pregnancy is associated with a more severe presentation and an increased risk of adverse obstetric and neonatal outcomes. We describe three cases of dengue fever in pregnancy with different fetal outcomes (intrauterine fetal death, fetal distress, and healthy neonate). Case Illustration: The first case involves a 23-year-old G1P0A0 at 31-32 weeks of gestation complaining of reduced fetal movement. She presented with a high-grade fever, anaemic, and thrombocytopenic. Her liver function was increased with AST 447 U/L and ALT 403 U/L. The fetal heart rate could not be detected. The second case involves a 26-year-old G3P2A0 at term pregnancy complaining of labor pain. She presented with vaginal bleeding, high-grade fever, and vomiting five days prior. Her liver function was also increased (AST 301 U/L and ALT 298 U/L). At presentation, fetal distress was detected. The third case involves a 19-year-old G2P1A0 presented with high-grade fever and nausea for five days. Her liver function was moderately increased (AST 68 U/L and ALT 76 U/L). She delivered a 3050-gram healthy neonate vaginally. Discussion: Dengue fever causes adverse obstetric outcomes. Endothelial injury exacerbated by plasma loss leads to placental dysfunction and poor fetal conditions. Unfortunately, dengue fever in pregnancy is not yet specifically addressed in our national guidelines. Conclusion: Increased severity of dengue fever in pregnancy may cause poor maternal and fetal outcomes.Demam Berdarah Dengue dan Dampaknya terhadap Luaran Kehamilan: Sebuah Serial KasusAbstrakPendahuluan: Demam berdarah dengue pada kehamilan terkait dengan tingkat keparahan penyakit dengue yang lebih berat dan meningkatnya risiko komplikasi obstetrik dan neonatus. Serial kasus ini menyajikan tiga kasus demam berdarah pada kehamilan dengan luaran janin yang berbeda (kematian janin intrauterine, gawat janin, dan neonatus sehat). Presentasi Kasus: Kasus pertama, G1P0A0 gravida 31 – 32 minggu, berusia 23 tahun, datang dengan keluhan utama berkurangnya gerakan janin. Keluhan demam, nyeri retro-orbital, mual, dan muntah dirasakan sejak 4 hari sebelumnya. Terdapat tanda konjungtiva anemis, trombositopenia, dan fungsi liver meningkat (AST 447 U/L dan ALT 403 U/L). Detak jantung janin tidak terdeteksi. Kasus kedua, G3P2A0 gravida aterm, 26 tahun, datang dengan keluhan mules-mules, perdarahan jalan lahir, demam, mual, dan muntah dirasakan sejak 5 hari sebelumnya. Pasien mengalami trombositopenia dan peningkatan fungsi liver (AST 301 U/L dan ALT 298 U/L). Pemeriksaan janin menunjukkan tanda gawat janin. Kasus ketiga, G2P1A0 gravida aterm, 19 tahun, datang dengan keluhan utama mules-mules. Keluhan demam dan mual dirasakan sejak 5 hari. Pemeriksaan menunjukkan trombositopenia dan fungsi liver sedikit meningkat (AST 68 U/L dan ALT 76 U/L). Pasien melahirkan neonatus sehat secara spontan dengan berat 3050 gram.Diskusi: Kebocoran plasma merupakan pencetus dari kerusakan endotel sehingga dapat mengakibatkan disfungsi plasenta dan kondisi janin memburuk. Namun, belum ada panduan resmi tatalaksana demam berdarah pada kehamilan di Indonesia.Kesimpulan: Meningkatnya tingkat keparahan demam berdarah pada kehamilan menyebabkan luaran maternal dan neonatus yang buruk.Kata kunci: Demam dengue, maternal, fetus, luaran, kehamilan Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-07-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/678 10.24198/obgynia.v7i2.678 Obgynia; Volume 7 Nomor 2 Juli 2024; 252-259 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 2 Juli 2024; 252-259 2615-496X 10.24198/obgynia.v7i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/678/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/678/424 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/898 2026-03-13T02:36:41Z obgynia:AR

OSCS (One Step Conservative Surgery) vs MOSCUS (Modified One Step Conservative Uterine Surgery) for Placenta Accreta Spectrum (PAS) Surgery, Which One Is More Preferred? A Literature Review Anakita, Cantika Simanjuntak, Arya Marganda S., Donel Noviardi, Noviardi Razali, Renardy Reza MOSCUS; OSCS; Placenta Accreta Spectrum (PAS) Surgery, Uterine Conservative Surgery Introduction: Placenta Accreta Spectrum (PAS) is a severe obstetric complication causing hemorrhage, maternal morbidity, and mortality. Two widely adopted approaches to treatment are OSCS and MOSCUS. This literature review compares OSCS and MOSCUS to provide evidence-based insights for optimizing PAS treatment.Objective: This study aims to compare the preferred conservative uterine surgical approaches in the management of Placenta Accreta Spectrum (PAS).Methods: A literature review was undertaken following the scale assessment of narrative review articles (SANRA). We utilized various databases to evaluate current evidence for OSCS and MOSCUS in treating PAS. Relevant articles were reviewed to perform a comparative analysis between OSCS and MOSCUS in order to address the objective.Result: The key difference between OSCS and MOSCUS lies in bleeding control by optimal uterine reconstruction with transverse b-lynch suture and selective vascular ligation. While OSCS is ideal for simpler cases due to its efficiency and practicality, MOSCUS is better suited for complex PAS cases, offering reduced complications and improved outcomes.Conclusion: MOSCUS may be preferable to OSCS in terms of technique with optimal uterine reconstruction by adding several techniques to potentially preserve the uterus. More comparative research between the two required to evaluate the results prospectively. AbstrakPendahuluan: Placenta Accreta Spectrum (PAS) merupakan komplikasi obstetri berat yang menyebabkan perdarahan, morbiditas dan mortalitas ibu. Dua pendekatan yang banyak diadopsi adalah OSCS dan MOSCUS. Tinjauan literatur ini membandingkan OSCS dan MOSCUS untuk memberikan wawasan berbasis bukti untuk mengoptimalkan tatalaksana PASTujuan: Penelitian ini bertujuan untuk membandingkan pilihan tindakan bedah uterus konservatif yang lebih disukai dalam penatalaksanaan Placenta Accreta Spectrum (PAS).Metode: Metode yang digunakan dalam penelitian ini adalah tinjauan literatur yang mengikuti penilaian kualitas SANRA. Kami menggunakan berbagai basis data untuk mengevaluasi bukti terkini OSCS dan MOSCUS dalam tatalaksana PAS. Artikel didiskusikan untuk membuat tinjauan yang komprehensif dan membuat analisis komparatif antara OSCS dan MOSCUS untuk menjawab tujuan penelitian.Hasil: Perbedaan antara OSCS dan MOSCUS bergantung pada kontrol perdarahan dengan rekonstruksi uterus yang optimal dengan jahitan b-lynch melintang dan ligasi pembuluh darah selektif. OSCS ideal untuk kasus-kasus yangKesimpulan: MOSCUS dapat menjadi pilihan dibandingkan dengan OSCS dalam hal teknik dengan rekonstruksi rahim yang optimal dengan menambahkan beberapa teknik yang berpotensi mempertahankan rahim. Penelitian komparatif lebih lanjut antara keduanya diperlukan untuk mengevaluasi hasilnya secara prospektif.  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2026-03-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/898 10.24198/obgynia.v9i1.898 Obgynia; Volume 9 Number 1 March 2026; 118-127 Indonesian Journal of Obstetrics & Gynecology Science; Volume 9 Number 1 March 2026; 118-127 2615-496X 10.24198/obgynia.v9i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/898/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/898/681 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/898/892 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/898/901 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/898/933 Copyright (c) 2026 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/413 2023-03-27T01:50:09Z obgynia:RA

Characteristics of Patients with Morbidly Adherent Placenta at Dr. Hasan Sadikin Hospital Bandung Aziz, Muhammad Alamsyah Wulandari, Dewi Retno morbidly adherent placenta; placenta accreta; placenta increta; placenta percreta AbstractObjective: Morbidly adherent placenta (MAP) is one of the causes of postpartum haemorrhage that impacts morbidity, hysterectomy, and mortality. This study reviewed patient characteristics and disease features in tertiary referral hospital patients with MAP.Methods: This is a quantitative descriptive study conducted on patients with MAP in September 2019–September 2020. Patient data were sourced from medical records. The characteristics described in this study include sociodemographic characteristics, obstetric history (gestation, parity, and abortion), history of caesarean section (CS), history of curettage, comorbidities, and current disease description and outcomes (bleeding, infant outcome, length of stay, death).Result: A total of 24 patients were diagnosed post-operatively as MAP in this study. Most of the patients were multi-parity, had a history of CS or curettage, and had comorbid placenta previa. Most of the patients came for CS plans or went with the chief complaint of bleeding. All patients were managed by hysterectomy. There was one case of maternal death and one case of fetal death.Conclusion: The characteristics of the patients in this study reflect the risk factors and general features of MAP.Karakteristik Pasien MAP di RSUP Dr. Hasan Sadikin BandungAbstrakTujuan: Morbidly adherent placenta (MAP) merupakan salah satu penyebab perdarahan pasca-salin yang berdampak pada morbiditas, tindakan histerektomi, dan mortalitas. Penelitian ini dilakukan untuk meninjau karakteristik pasien dan gambaran penyakit pada pasien dengan MAP di rumah sakit rujukan tersier.Metode: Penelitian ini merupakan deskriptif kuantitatif yang dilakukan pada pasien dengan MAP pada September 2019–September 2020. Data pasien bersumber dari rekam medik. Karakteristik yang dideskripsikan pada penelitian ini meliputi karakteristik sosiodemografi, riwayat obstetrik (gestasi, paritas, dan abortus), riwayat seksio caesarea (SC), riwayat kuretase, komorbid, dan gambaran penyakit terkini serta luarannya (perdarahan, luaran bayi, lama perawatan, kematian).Hasil: Sebanyak 24 pasien yang terdiagnosis pasca-bedah sebagai MAP pada penelitian ini. Sebagian besar pasien multi paritas, memiliki riwayat SC ataupun kuretase, dan memiliki komorbid plasenta previa. Sebagian besar pasien datang untuk rencana SC ataupun datang dengan keluhan utama perdarahan. Semua pasien ditatalaksana dengan histerektomi. Kematian pada ibu terjadi sebanyak satu kasus dan anak terjadi sebanyak satu kasus.Kesimpulan: Karakteristik pasien pada penelitian ini merefleksikan faktor risiko dan gambaran umum MAP.  Kata kunci: morbidly adherent placenta, plasenta akreta, plasenta inkreta, plasenta perkreta. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-03-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/413 10.24198/obgynia.v6i1.413 Obgynia; Volume 6 Nomor 1 Maret 2023; 28-34 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 1 Maret 2023; 28-34 2615-496X 10.24198/obgynia.v6i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/413/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/413/240 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/413/271 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/413/284 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/722 2024-11-19T11:53:19Z obgynia:RA

The Success Rate for Diagnosing Congenital Anomalies During Prenatal Firmansyah, Silva Elifa Pribadi, Adhi Pramatirta, Akhmad Yogi Rachmawati, Anita Rinaldi, Andi diagnosis, congenital malformations, accuracy Introduction: This study aimed to determine the success of prenatal diagnosis in cases of congenital abnormalities at RSHS Bandung.Methods: This study was descriptive and cross-sectional. We collected data from all neonatal patients with congenital abnormalities who received prenatal care at RSHS Bandung between January 1, 2021, and December 31, 2023. Data processing used Microsoft Excel 16.66.1 and IBM SPSS Statistics.Result: The results show that 59 patients, or 93.6%, had appropriate abnormalities diagnosed, while only 4 patients, or 6.3%, had inappropriate abnormalities.Conclusion: Prenatal diagnosis of congenital abnormalities showed a fairly high concordance value, namely 93.6%.Tingkat Keberhasilan Penegakan Diagnosis Kelainan Kongenital pada saat PrenatalAbstrakTujuan: Tujuan penelitian ini untuk mengetahui keberhasilan diagnosis prenatal pada kasus kelainan kongenital di RSHS Bandung.Metode: Penelitian ini bersifat deskriptif cross-sectional. Data diperoleh dari seluruh pasien neonatal yang disertai kelainan kongenital pada saat prenatal di RSHS Bandung 1 Januari 2021 – 31 Desember 2023. Pengolahan data menggunakan Microsoft Excel 16.66.1 dan IBM SPSS Statistics.Hasil: Hasil yang didapatkan yaitu akurasi pasien terdiagnosis sesuai ada kelainan sebanyak 59 atau sebesar 93.6% dan terdiagnosis tidak sesuai ada kelainan sebanyak 4 atau sebesar 6.3%. Kesimpulan: Penegakan diagnosis kelainan kongenital pada saat prenatal menunjukkan nilai kesesuaian yang cukup tinggi, yaitu sebesar 93,6%.Kata kunci: Prenatal, kelanan kongenital, Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/722 10.24198/obgynia.v7i3.722 Obgynia; Volume 7 Nomor 3 November 2024; 369-375 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 3 November 2024; 369-375 2615-496X 10.24198/obgynia.v7i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/722/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/722/533 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/558 2023-07-17T03:12:46Z obgynia:FBM

oai:ojs.obgynia.com:article/266 2023-07-17T03:12:46Z obgynia:RA

CA-125 sebagai Prediktor Sitoreduksi pada Pasien Kanker Ovarium Tipe Epitel Darwizar, Bagja Dumas Winarno, Gatot Nyarumenteng Adipurnawan Effendi, Jusuf Sulaeman CA-125, sitoreduksi, karsinoma ovarium tipe epitel, prediktor Tujuan: Penelitian ini bertujuan untuk mengetahui apakah CA-125 dapat menjadi prediktor yang baik untuk sitoreduksi pada kanker ovarium tipe epitel.Metode: Desain penelitian ini adalah cross sectional dengan pemeriksaan pasien yang diduga memiliki tumor ganas ovarium, pemeriksaan kadar CA-125 pre operasi dan jenis sitoreduksi pasca operasi. Sitoreduksi optimal dipertimbangkan jika sisa tumor terbesar berdiameter <1 cm. Nilai p numerik diuji dengan uji T tidak berpasangan jika data berdistribusi normal dengan uji alternatif Mann Whitney jika data tidak berdistribusi normal. Data kategorik nilai p dihitung berdasarkan uji Chi-Square dengan alternatif Kolmogorov Smirnov dan uji Exact Fisher jika persyaratan Chi-Square tidak terpenuhi. Nilai diagnostik CA-125 dievaluasi dan nilai cut-off optimal ditentukan. Analisis ROC digunakan untuk menentukan nilai cut-off CA-125 yang optimal. Data yang diperoleh direkam dalam bentuk khusus kemudian diolah dengan SPSS versi 25.0 for windows. Pasien yang dikumpulkan sesuai dengan kriteria selama masa penelitian adalah 109 pasien.Hasil: Ditemukan bahwa nilai rata-rata CA-125 untuk kelompok sitoreduksi suboptimal lebih tinggi dibandingkan dengan kelompok sitoreduksi optimal (1157,63±2105,196 vs 237,53±319,432), yang signifikan secara statistik, p=0,0001 (nilai p<0,05). Cut off point CA-125 dalam penelitian ini adalah 248,55 dengan nilai sensitivitas 73,2%, nilai spesifisitas 73,6%, nilai prediksi positif 74,5%, nilai prediksi negatif 72,2%, dan akurasi 73,3%. Kesimpulan: Data kami menunjukkan bahwa CA-125 pre-operasi adalah prediktor sedang untuk sitoreduksi yang optimal.CA-125 as A Cyoreduction Predictor in Patient with Epithelial Ovarian CarcinomaAbstract Objective: This study aims to determine whether CA-125 can be a good predictor of cytoreduction in epithelial ovarian carcinoma.Method: Cross sectional study by examining patients suspected of ovarian malignancy, checking for their preoperative CA-125 levels and post operative type of cytoreduction. Optimal cytoreduction was considered if the largest residual tumor was <1 cm in diameter. Numerical p value is tested by unpaired T test if the data is normally distributed with the alternative Mann Whitney test if the data is not normally distributed. The p value categorical data is calculated based on the Chi-Square test with the alternative Kolmogorov Smirnov and Exact Fisher tests if the requirements of the Chi-Square are not met. The diagnostic value of the CA-125 is evaluated and the optimal cut-off value is determined. The ROC analysis was plotted to determine the optimal cut-off of CA-125. The data obtained is recorded in a special form and then processed with SPSS version 25.0 for windows. Patients collected during the study period were 109 patients. Results: It was found that mean value of CA-125 for suboptimal cytoreduction group was higher than optimal cytoreduction (1157.63±2105.196 vs 237.53±319.432), which is statistically significant, p = 0.0001 (p value <0.05). CA-125 cut off point in this research was 248.55 with sensitivity value of 73.2%, specificity value of 73.6%, the positive predictive value 74.5%, the negative predictive value 72.2% and its accuracy 73.3%. Conclusion: Our data indicate that preoperative CA-125 is moderate predictor for optimal cytoreduction.Key words: CA-125, cytoreduction, Epithelial Ovarian Carcinoma, Predictor Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-07-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/266 10.24198/obgynia.v6i2.266 Obgynia; Volume 6 Nomor 2 Juli 2023; 255-262 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 2 Juli 2023; 255-262 2615-496X 10.24198/obgynia.v6i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/266/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/266/155 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/266/342 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/845 2025-03-20T03:00:51Z obgynia:ED

Tubal Pathology in Infertility Tjahyadi, Dian Tubal, Pathology, Infertility Infertility is a complex reproductive issue which requires thorough evaluation and targeted intervention. A key cause of female infertility is fallopian tube dysfunction, which plays role in egg transport and fertilization. Structural damage to the tubes, including blockages, adhesions, and deformities, significantly reduces fertility potential. One major cause of tubal disease is sexually transmitted infections, especially Chlamydia trachomatis and Neisseria gonorrhoeae, which can lead to pelvic inflammatory disease (PID). 1 In regions where Mycobacterium tuberculosis infection is still prevalent, genital tuberculosis is another contributor to tubal disease, causing inflammation and eventual obstruction. Chronic infection promotes scarring, narrowing, and complete obstruction of the fallopian tubes. Additionally, endometriosis can also exacerbate tubal dysfunction by creating adhesions and disrupting normal tube anatomy Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/845 10.24198/obgynia.v8i1.845 Obgynia; Volume 8 Nomor 1 Maret 2025; 1-2 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 1 Maret 2025; 1-2 2615-496X 10.24198/obgynia.v8i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/845/pdf Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/253 2021-03-25T21:06:56Z obgynia:RA

Correlation of Serum Vitamin D and Metabolic Disturbances in Polycystic Ovarian Syndrome Santoso, Shasya Aniza Madjid, Tita Husnitawati Rachmawati, Anita polycystic ovarian syndrome, insulin resistance, metabolic syndrome Objective: This study was aimed to determine the correlation between vitamin D and insulin resistance in women with PCOS. Method: This study was correlational analytic with cross-sectional approach to 34 women diagnosed with PCOS based on ultrasonography. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. Women with hormonal therapy and vitamin D supplementation were not included to this study. This study used consecutive sampling method.Result: The average of age was 25.6±6.1 years old. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. The average of waist circumference and FBG were 87.6±12.4 cm and 86.2±27.9 mg/dl, respectively. The mean of vitamin D levels was 11,5±3,6 ng/ml. According to Spearman’s correlation, vitamin D levels were weak negative correlated with waist circumference (r=-0.2; p>0.05) and FBG (r= -0,1; p>0,05), it statistically was not significant.Conclusion: There is weak negative correlation between vitamin D and metabolic syndrome in PCOS patients.Korelasi Kadar Vitamin  D Serum dan Gangguan Metabolik pada Sindrom Ovarium PolikistikAbstrakTujuan: Penelitian ini bertujuan untuk menganalisis korelasi vitamin D dengan resistensi insulin pada pasien dengan SOPK.Metode: Penelitian ini merupakan penelitian analitik korelatif dengan pendekatan potong lintang pada 34 subjek penelitian yang didiagnosis SOPK berdasarkan pemeriksaan ultrasonografi (USG). Lingkar pinggang dan kadar glukosa darah puasa (GDP) diambil sebagai parameter resistensi insulin. Pasien dengan terapi hormon dan suplementasi vitamin D tidak termasuk dalam subjek penelitian. Pengambilan sampel menggunakan teknik consecutive sampling.Hasil: Rerata usia subjek penelitain ini adalah 25,6±6,1 tahun. Lingkar pinggang dan glukosa darah puasa (GDP) diambil sebagai parameter resistensi insulin. Pada penelitian ini subjek memiliki rerata lingkar pinggang 87,6±12,4 dan GDP 86,2±27,9 mg/dl. Rerata kadar vitamin D subjek 11,5±3,6 ng/ml. Berdasarkan uji korelasi Spearman, kadar vitamin D berkorelasi negatif lemah dan tidak signifikan secara statistik baik dengan lingkar pinggang (r= -0,2; p>0,05) maupun dengan GDP (r= -0,1; p>0,05). Kesimpulan: Vitamin D berkorelasi negatif lemah dengan parameter gangguan metabolik resistensi insulin pada pasien SOPK.Kata kunci: sindroma ovarium polikistik, vitamin D, resistensi insulin, sindroma metabolik Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran none 2021-03-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/253 10.24198/obgynia.v4i1.253 Obgynia; Volume 4 Nomor 1 Maret 2021; 64-71 Indonesian Journal of Obstetrics & Gynecology Science; Volume 4 Nomor 1 Maret 2021; 64-71 2615-496X 10.24198/obgynia.v4i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/253/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/253/165 Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/481 2024-04-29T04:12:24Z obgynia:AR

CXC Motif Chemokine Receptor 2: Glimpses into the Molecular Pathogenesis of Placenta Accreta Spectrum Disorder Mirani, Putri Lestari, Peby Maulina Murti, Krisna Liberty, Iche Andriyani Kesty, Cindy Andrina, Hana Stevanny, Bella biomarker; CXCR2; placenta accreta Investigation into the mechanism underlying excessive trophoblast invasion yields further strategies and insights for the diagnosis and treatment of placenta accreta spectrum disorder (PASD). We conducted a comprehensive literature review to analyze the relationship between CXCR2 expression and PASD, as well as the possibility of CXCR2 being used as a therapeutic and diagnostic biomarker for PASD. Chemokines are well-known mediators in the immune system, particularly for cell recruitment, angiogenesis, and tumor infiltration. CXCR2 is an important component of the immune system, particularly in neutrophils. One of the CXCR2 ligands, IL-8, has also been found to be expressed in the decidua and trophoblasts of humans and to promote autocrine or paracrine trophoblast migration and invasion. The potential role of CXCR2 in trophoblast invasion in PASD provides researchers with a glimpse into the molecular pathogenesis of PASD.CXC Motif Chemokine Receptor 2: Sekilas tentang Patogenesis Molekuler Gangguan Spektrum Plasenta AkretaAbstrakInvestigasi mekanisme invasi berlebihan trofoblas pada gangguan Spektrum Plasenta Akreta (SPA) akan memberikan lebih banyak strategi dan ide untuk diagnosis dan pengobatan. Kami melakukan tinjauan literatur yang komprehensif untuk menganalisis hubungan antara ekspresi CXCR2 dan SPA serta potensi CXCR2 sebagai penanda terapeutik dan diagnostik untuk SPA. Kemokin berperan sebagai mediator dalam sistem imun karena perannya dalam perekrutan sel, angiogenesis, dan infiltrasi tumor. CXCR2 mempengaruhi sistem imun, terutama pada neutrofil. Salah satu ligan CXCR2, IL-8, juga telah ditemukan diekspresikan dalam desidua dan trofoblas manusia serta untuk mempromosikan migrasi dan invasi trofoblas autokrin atau parakrin. Peran CXCR2 dalam invasi trofoblas pada SPA memungkinkan para peneliti untuk melihat sekilas patogenesis molekuler SPA.Kata kunci: penanda; CXCR2; plasenta akreta Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/481 10.24198/obgynia.v7i1.481 Obgynia; Volume 7 Nomor 1 Maret 2024; 16-22 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 1 Maret 2024; 16-22 2615-496X 10.24198/obgynia.v7i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/481/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/481/391 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/310 2022-09-29T07:12:43Z obgynia:RA

Korelasi Indeks Massa Tubuh dengan Pertambahan Berat Badan Menurut The Institute of Medicine (IOM) selama Kehamilan terhadap Kejadian Persalinan Ekstraksi Vakum dan Persalinan Normal Komala, Yeni Madjid, Tita Husnitawati Bayuaji, Hartanto Tujuan: Mengetahui korelasi indeks massa tubuh (IMT) dan penambahan berat badan menurut The Institute of Medicine (IOM) beserta besaran risiko terjadinya persalinan dengan ekstraksi vakum.Metode: Desain penelitian menggunakan metode case control dengan menggunakan data sekunder dari rekam medis pasien yang bersalin dengan bantuan ekstraksi vakum dan spontan pada empat rumah sakit di Kota Bandung tahun 2016–2020 secara random sampling sebanyak 460 responden.Hasil: Karakteristik pada persalinan ekstraksi vakum maupun persalinan spontan tidak berbeda. Rerata usia ibu saat bersalin pada kelompok persalinan ekstraksi vakum lebih tinggi dibandingkan dengan persalinan spontan (29 tahun vs 27 tahun). Pada kelompok persalinan ekstraksi vakum, proporsi primigravida lebih tinggi dibandingkan persalinan spontan, namun tidak bermakna secara statistik (p=0,217). Skor APGAR <7 pada menit pertama lebih banyak didapatkan dari bayi yang lahir dengan bantuan ekstraksi vakum (28,1%). Terdapat 3% bayi pada kelompok ekstraksi vakum dengan berat lahir di atas 4000 gram, kondisi ini bermakna secara statistik. Kesimpulan: IMT gemuk saat awal kehamilan bersifat protektif 0,27 kali terhadap persalinan ekstraksi vakum, sedangkan penambahan berat badan diatas rekomendasi IOM selama kehamilan meningkatkan risiko 9,76 kali untuk terjadinya persalinan dengan bantuan ekstraksi vakum.Relationship between Body Mass Index and Gestational Weight Gajn According to the Institute of Medicine on the Incidence of Vacuum ExtractionAbstractObjective: To determine the correlation between body mass index (BMI) and pregnancy weight gain according to the Institute of Medicine (IOM) and the magnitude of the risk of delivery by vacuum extraction.Methods: This was a case control study using secondary data from medical records of 460 patients who gave birth with vacuum extraction and spontaneous delivery at four hospitals in Bandung West Java in 2016–2020.Results: The characteristic were similar in both groups. The mean maternal age at delivery in the vacuum extraction group was higher than in the spontaneous delivery group (29 years vs. 27 years). In the vacuum extraction group, the proportion of primigravida was higher than that of spontaneous labor, but it was not statistically significant (p=0.217). The APGAR score <7 in the first minute was obtained more from babies born with vacuum extraction (28.1%). There were 3% of babies in the vacuum extraction group with birth weight above 4000 grams, this condition was statistically significant. Conclusion: Mothers with obese BMI during early pregnancy are 0.27 times protective against vacuum extraction deliveries, while mothers whose weight gain is above the IOM recommendation during pregnancy have a 9.76 times risk of having vacuum extraction deliveries.      Key words : Body mass index, pregnancy weight gain, the institute of medicine, vacuum extraction delivery Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2022-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/310 10.24198/obgynia.v5i1.310 Obgynia; Volume 5 Nomor 1 Maret 2022; 22-29 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 1 Maret 2022; 22-29 2615-496X 10.24198/obgynia.v5i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/310/pdf Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/654 2024-04-29T04:12:24Z obgynia:RA

Maternal Characteristics of Very Low Birth Weight and Extremely Low Birth Weight Incidence Pajajaran, Badar Muhammad Sumawan, Herman Judistiani, Raden Tina Dewi Handono, Budi Low Birth Weight Introduction: Low birth weight (LBW) infants have the potential for cognitive deficits, motor delays, cerebral palsy, and other behavioral and psychological problems. Household expenses and health care system costs can be reduced by alleviating the burden of LBW. Currently, there are no available data on the maternal characteristics of very low birth weight (VLBW) and extremely low birth weight (ELBW) incidence in Indonesia.Method: This was a retrospective analytical observational study with a cross-sectional design. The sample in this study included all infants born with a birth weight of <1500 grams at Margono Purwokerto Hospital during 2018-2022. Univariate and bivariate analyses were performed using a significance level of p≤0.05.Results: A total of 65 patients in the ELBW group and 59 patients in the VLBW group were included in this study. Statistical test results showed no significant differences in the characteristics of age, parity, birth weight of the infant, criteria for hypertension during pregnancy, criteria for anemia, comorbidities, hospital treatment, postpartum care, and type of delivery. The variables that differed significantly were anemia (Hb VLBW vs Hb ELBW; 9.06 vs 8.21) and neonatal outcomes.Conclusion: There was no difference between the maternal characteristics of the incidence of very low birth weight and extremely low birth weight, except for anemia. Checking hemoglobin levels in patients with ELBW is essential for providing appropriate treatment.Karakteristik Ibu dengan Bayi Berat Badan Lahir Sangat Rendah dan Kejadian Berat Badan Lahir Sangat RendahAbstrakPendahuluan: Bayi dengan berat badan lahir rendah (BBLR) berpotensi mengalami defisit kognitif, keterlambatan motorik, Cerebral Palsy, serta permasalahan perilaku dan psikologis lainnya. Pengeluaran rumah tangga dan biaya sistem pelayanan kesehatan dapat dikurangi dengan meringankan beban BBLR. Saat ini belum tersedia data mengenai karakteristik ibu dengan kejadian berat badan lahir sangat rendah (BBLR) dan berat badan lahir sangat rendah (BBLSR) di Indonesia.Metode:Penelitian ini merupakan penelitian observasional analitik retrospektif dengan desain cross-sectional. Sampel dalam penelitian ini meliputi seluruh bayi yang lahir dengan berat badan lahir <1500 gram di RS Margono Purwokerto selama tahun 2018-2022. Analisis univariat dan bivariat dilakukan dengan tingkat signifikansi p≤0,05.Hasil:Sebanyak 65 pasien pada kelompok BBLR dan 59 pasien pada kelompok BBLSR dilibatkan dalam penelitian ini. Hasil uji statistik menunjukkan tidak terdapat perbedaan bermakna pada karakteristik umur, paritas, berat badan lahir bayi, kriteria hipertensi saat hamil, kriteria anemia, penyakit penyerta, perawatan di rumah sakit, perawatan nifas, dan jenis persalinan. Variabel yang berbeda secara signifikan adalah anemia (Hb BBLSR vs Hb BBLR; 9,06 vs 8,21) dan luaran neonatal.Kesimpulan:Tidak terdapat perbedaan karakteristik ibu terhadap kejadian berat badan lahir sangat rendah dan berat badan lahir sangat rendah, kecuali anemia. Pemeriksaan kadar hemoglobin pada pasien BBLR sangat penting untuk memberikan pengobatan yang tepat.Kata kunci: bayi berat lahir sangat rendah, BBLSR, bayi berat lahir sangat rendah, BBLR Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/654 10.24198/obgynia.v7i1.654 Obgynia; Volume 7 Nomor 1 Maret 2024; 103-111 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 1 Maret 2024; 103-111 2615-496X 10.24198/obgynia.v7i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/654/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/654/409 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/654/410 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/991 2026-01-23T07:42:49Z obgynia:RA

Comparison of Endometriosis Characteristics in Adolescents and Women of Advanced Reproductive Age Paiki, Ottowgeissler Yabes Melaneson Dewi, Marta Isyana Harsono, Ali Budi Endometriosis; adolescents; advanced reproductive age; dysmenorrhea. ABSTRACT Objective: To compare clinical and pathological characteristics of endometriosis between adolescents (10–19 years) and women of advanced reproductive age (35–45 years) to guide early diagnosis and tailored management. Methods: A retrospective, cross-sectional study of 68 patients (31 adolescents; 37 advanced-age women) with laparoscopically and histopathologically confirmed endometriosis at Dr. Margono Soekarjo Regional General Hospital between January 2022 and December 2024. Statistical analyses included independent t-tests, chi-square tests, and multivariate logistic regression. Results: Adolescents exhibited higher dysmenorrhea prevalence (80.6% vs. 43.2%; p=0.003), more early-stage disease (Stage I–II: 71% vs. 22%; p Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/991 10.24198/obgynia.v8i3.991 Obgynia; Volume 8 Nomor 3 November 2025; 540-549 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 3 November 2025; 540-549 2615-496X 10.24198/obgynia.v8i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/991/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/991/862 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/991/870 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/423 2022-09-27T01:54:49Z obgynia:RA

Relationship between Blood Lead Levels and Nitric Oxide (NO) Levels in Preeclampsia Oktaviana, Rina Yusrawati, Yusrawati Amir, Arni Blood lead levels, Nitric Oxide levels, Preeclampsia Objective: This study aims to determine the relationship between blood lead levels and NO levels in preeclampsia.Methods: This research applied analytical survey research with a cross-sectional design. Moreover, the samples were 99 pregnant women, 33 with normal pregnancies, 33 with preeclampsia living >10km from Semen Padang factory, and 33 with preeclampsia who lived ≤10km from Semen Padang factory. Spearman correlation test and logistic regression analysis is used for data analysis.Result: The result of this study shows that the blood lead level median in preeclampsia ≤10km is 26.23 g/dL, and the lead level median in preeclampsia >10km is 23.52 g/dL. Meanwhile, the NO level median in preeclampsia ≤10km is 22.50µmol/L and NO level median in preeclampsia >10km is 28.00µmol/L. There is a relationship between blood lead levels and NO levels in preeclampsia ≤10km, with r-value = -0.601 and p-value <0.001, in preeclampsia >10km, there is no relationship with p-value >0.500 and the strength of the correlation is fragile. In addition, the results of multivariate analysis of reduced levels of NO in preeclampsia with high blood lead levels are two times compared to preeclampsia with normal blood lead levels with 95% CI (0.652-6.362) after being controlled by distance of residence, smoking status and living environment variables.Conclusion: there is a relationship between blood lead levels and NO levels in preeclampsia.Hubungan Kadar Timbal dengan Kadar Nitric Oxide (NO) pada Ibu Hamil PreeklampsiaAbstrakTujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar timbal dengan kadar Nitric Oxide (NO)  pada ibu hamil preeklampsia. Metode: Penelitian ini merupakan penelitian survei analitik, dengan rancangan cross sectional. Sampel diteliti sebanyak 99 orang ibu hamil, 33 orang ibu hamil normal dan 33 orang preeklampsia yang tinggal yang tinggal radius >10km, dan 33 orang preeklampsia yang tinggal radius ≤10km. Kadar timbal diperiksa menggunakan metode AAS dan Kadar Nitric Oxide (NO)  diperiksa menggunakan metode ELISA. Analisis data menggunakan uji korelasi Spearman dan analisis regresi logistik.Hasil: Hasil penelitian ini median kadar timbal pada preeklampsia ≤10km adalah 26,23 µg/dL, dan median kadar timbal preeklampsia >10km adalah 23,52 µg/dL. Median kadar Nitric Oxide (NO)  preeklampsia ≤10km adalah 22,50µmol/L, median kadar Nitric Oxide (NO) preeklampsia >10km adalah 28,00µmol/L. Terdapat hubungan kadar timbal dengan kadar Nitric Oxide (NO) pada preeklampsia ≤10km, diperoleh nilai r = -0,601 dan nilai p < 0,001, pada preeklampsia  >10km tidak terdapat hubungan dengan nilai p > 0.500 dan kekuatan korelasi sangat lemah. Hasil analisis multivariat penurunan kadar Nitric Oxide (NO) preeclampsia yang memiliki kadar timbal tinggi adalah 2 kali dibandingkan ibu hamil preeclampsia dengan kadar timbal normal dengan 95% CI (0.652-6.362) setelah dikontrol variabel jarak tempat tinggal, status merokok dan lingkungan tempat tinggal.Kesimpulan: Terdapat hubungan kadar timbal dengan kadar Nitric Oxide (NO)  pada ibu hamil preeklampsia.Kata kunci: Timbal, Nitric Oxide, Preeklampsia Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2022-09-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/423 10.24198/obgynia.v5i2.423 Obgynia; Volume 5 Nomor 2 September 2022; 255-262 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 2 September 2022; 255-262 2615-496X 10.24198/obgynia.v5i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/423/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/423/260 Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/701 2024-11-19T11:53:18Z obgynia:RA

Comparison of Clinical Characteristics between Pregnant Women Confirmed with Covid-19 with and Without Severe Preeclampsia Pangaribuan, Roma Berlian Anwar, Anita Deborah Sasotya, RM Sonny Characteristics, COVID-19, Pregnancy, Severe Preeclampsia Background:Several clinical studies have reported that COVID-19 was associated with an increased risk of preeclampsia and preeclampsia-like syndrome in infected pregnant women, but the results are still controversial. This study aims to compare the clinical characteristics of pregnant women with confirmed COVID-19 with and without severe preeclampsia.Methods:This retrospective study of pregnant women confirmed for COVID-19 was carried out at RSUP Dr. Hasan Sadikin from April 1st, 2020 to April 30th, 2022. Epidemiological data, clinical features, and laboratory results of subjects with and without severe preeclampsia in pregnant COVID-19 patients were collected and analyzedResults: Eighty-six subjects were in our study, with 42 subjects with severe preeclampsia and 44 subjects without severe preeclampsia. The average age of mothers in this study was 26 years, with a more significant proportion at term. The proportion of primigravida with severe preeclampsia was significantly more than those without severe preeclampsia (71.42% vs 29.54%, p=0.02). There was no significant difference in clinical severity between patients with or without severe preeclampsia (p>0.05). Comparing laboratory parameters showed significant differences in the laboratory characteristics of hemoglobin (28.57% vs 2.2%, p=0.03) and platelets (33.33% vs 4.54%, p=0.02).Conclusion: Our study showed that the clinical characteristics and disease severity were not significantly different. Laboratory markers correlate significantly with the severity of maternal disease, so they can be used as prognostic indicators.Perbandingan Karakteristik Klinis Ibu Hamil Terkonfirmasi Covid- 19 dengan dan Tanpa Preeklamsia BeratAbstrakLatar Belakang: Beberapa studi klinis telah melaporkan bahwa Infeksi COVID-19 dikaitkan dengan peningkatan risiko preeklamsia dan sindroma yang mirip preeklamsia pada wanita hamil yang terinfeksi, tetapi hasilnya masih kontroversial. Penelitian ini bertujuan untuk mengetahui perbandingan karakteristik klinis ibu hamil yang terkonfirmasi COVID-19 dengan dan tanpa preeklamsia berat.Metode: Penelitian secara retrospektif pada ibu hamil positif COVID-19 ini dilakukan di RSUP Dr. Hasan Sadikin dari tanggal 1 April 2020 sampai dengan 30 April 2022. Data berupa epidemiologi, gambaran klinis, hasil laboratorium subjek dengan dan tanpa preeklamsia berat pasien hamil COVID-19 dikumpulkan dan dianalisisHasil: Data yang berhasil dikumpulkan dalam penelitian ini adalah delapan puluh enam subjek yang terbagi atas 42 subjek dengan preeklamsia berat dan 44 subjek tanpa preeklamsia berat. Usia rata-rata ibu dalam penelitian ini 26 tahun, dengan proporsi yang lebih signifikan pada usia kehamilan cukup bulan. Proporsi primigravida dengan preeklamsia berat lebih signifikan dibandingkan dengan tanpa preeklamsia berat (71.42% vs 29.54%, p=0.02). Tidak ditemukan perbedaan signifikan pada keparahan klinis di antara pasien dengan atau tanpa preeklamsia berat (p>0.05). Perbandingan parameter laboratorium didapatkan perbedaan signifikan pada karakteristik laboratorium hemoglobin (28,57% vs 2.2%, p=0.03) dan trombosit (33.33% vs 4,54%, p=0.02).Kesimpulan: Penelitian ini menunjukkan bahwa karakteristik klinis dan keparahan penyakit tidak berbeda secara signifikan pada kedua pasien. Penanda laboratorium berkorelasi signifikan dengan tingkat keparahan penyakit ibu sehingga dapat digunakan sebagai indikator prognostik.Kata kunci: COVID-19, Karakteristik Klinis , Kehamilan, Preeklamsia Berat Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/701 10.24198/obgynia.v7i3.701 Obgynia; Volume 7 Nomor 3 November 2024; 344-351 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 3 November 2024; 344-351 2615-496X 10.24198/obgynia.v7i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/701/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/701/462 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/701/479 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/489 2023-07-17T03:12:46Z obgynia:RA

Correlation of Leucine-Rich-α-2-Glycoprotein- 1 (LRG-1) Level in Urine with Cervical Cancer Stage, Histology Type and Histology Grading Astari, Prilly Rauf, Syahrul Jusuf, Elizabet C. Chalid, St. Maisuri T Arifuddin, Sharvianty Farid, Retno B Cervical cancer; Histological type; Histopathological grade; LRG-1; Stage Objective: To determine if the level of LRG-1 in urine correlates with cervical cancer stage, histology type and histology gradingMethod: This cross-sectional study using ELISA to test urinary LRG-1 of 59 cervical cancer patients. Data were analyzed using Kruskal-Wallis test.Results: From the total of 59 samples, LRG-1 in urine ranged from 0.48 ng/mL to 170.43 ng/mL, with median value 58.42 ng/mL. A median value of 21.42±52.29 ng/mL was found in the urine at early stage and 115.32±59.36 ng/mL at advanced stage. Most patients had cervical cancer at advanced stage (69.4%), squamous cell carcinoma (66.1%), and grade cannot be assessed (45.8%). Median LRG-1 levels were highest in squamous cell carcinoma (66.42±60.89 ng/mL) and poorly differentiated (127.74 ±54.13 ng/mL). LRG-1 levels were significantly correlated with cervical cancer stage (p-value=0.045) but not histological type (p-value=0.940) or histopathological grade (p-value=0.488).Conclusion: The more advanced the cervical cancer stage, the more elevated urinary LRG-1 levels. LRG-1 contributes to angiogenesis and antiapoptotic processes in cancer. Further studies are required to identify and evaluate LRG-1 in urine as an important biomarker for making clinical decisions and developing potential treatments.Hubungan Kadar Protein Leucine-Rich-α-2-Glycoprotein-1 (LRG-1) Urine dengan Stadium, Tipe Histologis, dan Derajat Diferensiasi Kanker ServiksAbstrakTujuan: Untuk mengetahui hubungan kadar LRG-1 dalam urine dengan stadium, tipe histologis, dan derajat diferensiasi kanker serviks.Metode: Studi ini menggunakan desain penelitian cross-sectional pada 59 perempuan yang telah didiagnosis kanker serviks, kemudian diperiksa kadar protein LRG-1 dalam urine dengan metode ELISA. Uji statistik menggunakan Kruskal Wallis. Hasil: Dari total 59 sampel didapatkan kadar LRG-1 dalam urine terendah 0,48 ng/mL dan tertinggi 170,43 ng/mL, nilai median 58,42 ng/mL. Nilai median pada stadium awal 21,42±52,29 ng/mL dan stadium lanjut 115,32±59,36 ng/mL. Lebih banyak penderita mengalami kanker serviks pada stadium lanjut (69,4%), tipe histopatologis Squamous Cell Carcinoma (66,1%), derajat diferensiasi tidak dapat ditentukan (45,8%). Median tertinggi kadar LRG-1 pada tipe Squamous Cell Carcinoma (66,42±60,89 ng/mL), dan derajat diferensiasi yang buruk (127,74±54,13 ng/mL). Terdapat hubungan yang signifikan antara kadar LRG-1 dan stadium kanker serviks (nilai p = 0,045), tetapi tidak dengan tipe histologis (nilai p=0,940) dan derajat diferensiasi (nilai p=0,488).Kesimpulan: Semakin tinggi stadium maka semakin tinggi kadar protein LRG-1 dalam urine. LRG-1 berperan dalam proses angiogenesis dan antiapoptosis pada kanker. Diperlukan penelitian lebih lanjut agar identifikasi dan evaluasi biomarker LRG-1 urine dapat menjadi penanda penting yang membantu dalam pengambilan keputusan klinis, serta pengembangan terapi.Kata Kunci: Derajat diferensiasi, Kanker serviks, LRG-1, Stadium, Tipe histologis Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-07-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/489 10.24198/obgynia.v6i2.489 Obgynia; Volume 6 Nomor 2 Juli 2023; 203-211 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 2 Juli 2023; 203-211 2615-496X 10.24198/obgynia.v6i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/489/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/489/312 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/725 2025-03-20T03:00:51Z obgynia:RA

Overview of Menstrual Patterns in Female Patients Diagnosed with Tuberculosis with a History of Infertility at DOTS Polyclinic Hasan Sadikin Hospital and Community Health Centers in Bandung City Madjid, Tita Husnitawati Utomo, Suhendro Rahmat Susilo, Artha Falentin Putri Ritonga, Mulyanusa Amarullah Arya, Insi Farisa Desy Menstrual patterns, Infertility, Female TB patient, Bandung City Introduction: Female genital tuberculosis (FGTB) is one of the leading causes of infertility in countries with high cases of tuberculosis. However, there is a lack of data showing the menstrual patterns of FGTB patients in Indonesia. This study was conducted to describe the menstrual patterns of female patients diagnosed with TB and who have a history of infertility at the Directly Observed Treatment Short Course Polyclinic of Hasan Sadikin Hospital and community health centers in Bandung City.Method: This is a descriptive observational study using primary data. The subjects were outpatient TB patients with a history of infertility in the Directly Observed Treatment Short Course polyclinic of Hasan Sadikin Hospital and community health centers in Bandung City from 2018 to 2022. Data collection was conducted through questionnaire-based interviews.Results: Out of 950 TB patients of childbearing age recorded in medical records, 41 patients matched the specified criteria. The menstrual disorders experienced by patients included polymenorrhagia, oligomenorrhea, amenorrhea, prolonged menstrual cycles, irregular cycles, hypomenorrhea, heavy menstrual bleeding, and intermenstrual bleeding.Conclusion: The most common menstrual disorders in TB patients with a history of infertility were irregular cycles (36.6%), hypomenorrhea (31.7%), and oligomenorrhea (19.5%).Gambaran Pola Menstruasi pada Pasien Perempuan dengan Diagnosis Tuberkulosis dan Riwayat Infertilitas di Poli DOTS RSHS dan Puskesmas Kota BandungAbstrakPendahuluan: Female genital tuberculosis merupakan salah satu penyebab utama infertilitas pada negara dengan kasus tuberkulosis yang tinggi. Sebagai salah satu dari gejalanya, belum ada data yang menunjukkan pola menstruasi dari pasien female genital tuberculosis di Indonesia. Penelitian ini bertujuan untuk mengetahui gambaran pola menstruasi pada pasien wanita dengan diagnosis tubekulosis dan memiliki riwayat infertilitas di Poliklinik Directly Observed Treatment Short Course Rumah Sakit Hasan Sadikin dan Puskesmas Kota Bandung.Metode: Penelitian deskriptif dengan menggunakan data primer. Subjek penelitian adalah pasien tuberkulosis wanita dengan riwayat infertilitas yang dirawat jalan di poliklinik Directly Observed Treatment Short Course Rumah Sakit Hasan Sadikin dan 4 Puskesmas di Kota Bandung dari tahun 2018 - 2022. Subjek diperoleh melalui wawancara berbasis kuesioner.Hasil: Dari 950 pasien tuberkulosis wanita usia subur yang terdata di rekam medis, didapatkan 41 data pasien yang sesuai dengan kriteria yang ditentukan. Gangguan menstruasi yang dialami pasien dapat berupa polimenore, oligomenore, amenore, siklus menstruasi yang memanjang, siklus yang irreguler, hipomenore, heavy menstrual bleeding, dan perdarahan intermenstrual.Kesimpulan: Gangguan menstruasi yang paling sering terjadi pada pasien TB dengan riwayat infertilitas adalah siklus yang irreguler (36.6%), hipomenore (31.7%), dan oligomenore (19.5%).Kata Kunci: Infertilitas, Kota Bandung, Pasien TB wanita, Pola Menstruasi. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/725 10.24198/obgynia.v8i1.725 Obgynia; Volume 8 Nomor 1 Maret 2025; 34-41 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 1 Maret 2025; 34-41 2615-496X 10.24198/obgynia.v8i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/725/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/725/459 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/725/460 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/725/574 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/725/593 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/725/622 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/223 2021-03-25T19:57:13Z obgynia:RA

Perbandingan Nilai Prediktif antara Risk-of-Malignancy Index (RMI) dan Klasifikasi IOTA Simple Rules dalam Prediksi Keganasan pada Kasus Tumor Ovarium di RSUP Dr. Hasan Sadikin Bandung Toriq, Huda Hidayat, Yudi Mulyana Suardi, Dodi Karsinoma ovarium, IOTA, RMI, USG, CA125 Tujuan: Penelitian ini bertujuan untuk mengevaluasi dan membandingkan penerapan dua metode diagnostik yang telah digunakan di RSHS, yaitu skor RMI dan Klasifikasi IOTA Rules untuk memprediksi keganasan suatu tumor ovarium selama periode 2017−2018Metode: Penelitian ini merupakan penelitian komparatif dengan pengambilan data secara retrospektif. Sumber data diperoleh dari rekam medis pasien yang menjalani operasi pengangkatan dan pemeriksaan histopalogis tumor ovarium. Dilakukan pengumpulan informasi mengenai data USG, kadar CA125, skor RMI, klasifikasi IOTA Simple Rules, dan membandingkannya dengan luaran histopatologis.Hasil: 190 kasus tumor ovarium diteliti. 156 kasus (82,1%) memiliki luaran histopatologis ganas dan 34 kasus lainnya (17.9%) jinak. 178 kasus (93,68%) memiliki skor RMI ≥200 dan 12 kasus (6,32%) <200. sebanyak 78 kasus diklasifikasikan sebagai Malignant, 42 kasus Benign, dan 70 kasus lainnya Inconclusive dengan kriteria IOTA Simple Rules. Distribusi CA125 dan Skor RMI pada kedua kelompok luaran histopatologis berbeda secara bermakna (P<0,05). Sensitivitas dan spesifisitas klasifikasi IOTA Simple Rules di RSHS masing-masing 94,23% dan 97,06%, dengan menggabungkan kelompok IOTA inkonklusif dengan kelompok ganas.  Penghitungan sensitivitas dan spesifisitas skor RMI memberikan nilai 95,51% dan 14,71% dengan menggunakan cut-off-point skor RMI 200.Kesimpulan: Sensitivitas dan spesifisitas klasifikasi IOTA Simple Rules lebih baik dibandingkan dengan skor RMI dalam memprediksi keganasan suatu tumor ovarium.Predictive Value Comparison of Risk-of-Malignancy Index (RMI) and IOTA Simple Rules in Predicting Ovarian Tumor Malignancy in Dr. Hasan Sadikin Hospital BandungAbstractObjective: This study was done to evaluate and compare the use of RMI score & IOTA Simple Rule which has been routinely used in Hasan Sadikin Hospital to predict ovarian malignancy in 2017-2018Method: This is a comparative study that collects data retrospectively. Data was obtained from medical record of patient who underwent ovarian tumor surgery, including USG report, CA125, RMI score, IOTA Simple Rules, and compared it with histopathological outcome. Result: 190 ovarian tumor cases was studied. 156 cases (82.1%) have malignant histopathological result and the other 34 cases (17.9%) were benign. 178 (93.68%) cases have RMI score ≥ 200 and 12 cases (6.32%) <200. As much 78 cases were classified as malignant, 42 cases (22.11%) were classified benign, and the other 70 cases were classified inconclusive using IOTA Simple Rules. CA125 and RMI Score distribution on both histopathological group differs significantly (P<0.05). IOTA Simple Rules shows sensitivity and specificity of 94.23% and 97.06% respectively, when inconclusive and malignant results were grouped together. RMI Score showed sensitivity  and specificity of 95.51% and 14.71% respectively using cut-off point of 200.Conclusion: IOTA Simple Rules performs better than RMI in predicting ovarian tumor malignancy.Key words: Ovarian cancer, IOTA, RMI, USG, CA125 Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2021-03-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/223 10.24198/obgynia.v4i1.223 Obgynia; Volume 4 Nomor 1 Maret 2021; 11-19 Indonesian Journal of Obstetrics & Gynecology Science; Volume 4 Nomor 1 Maret 2021; 11-19 2615-496X 10.24198/obgynia.v4i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/223/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/223/161 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/223/162 Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/578 2023-11-22T03:42:22Z obgynia:RA

Gambaran Faktor Risiko Kanker Endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022 Erfiandi, Febia Balqis, Shalma Alaika Aurel Salima, Siti Mantilidewi, Kemala Isnainiasih Kurniadi, Andi Wibowo, Viko Duvadilan Kanker endometrium, faktor risiko, penelitian deskriptif Tujuan: Mengetahui faktor risiko pasien kanker endometrium di RSUP Dr. Hasan Sadikin pada Tahun 2020 – 2022.Metode: Penelitian metode deskriptif dengan menggunakan data sekunder. Kriteria inklusi yaitu pasien dengan diagnosis utama kanker endometrium.Hasil: Mayoritas pasien kanker endometrium berusia 50 – 59 tahun (34,8%), multipara (40,9%), Indeks Masa Tubuh ≥25 kg/m2 (33,2%), usia menarche ≥12 tahun (68,8%), tidak memiliki riwayat infertilitas (49,0%), belum menopause (36,4%), tidak memiliki riwayat terapi hormon (74,1%), pasien tidak memiliki riwayat kanker/lynsch syndrome (71,7%), tidak memiliki riwayat keluarga dengan lynch syndrome (75,7%), tidak menggunakan kontrasepsi (42,5%), dan tidak memiliki riwayat hipertensi (72,9%).Kesimpulan: Pasien kanker endometrium di RSUP Dr. Hasan Sadikin Bandung periode tahun 2020 – 2022 ditemukan paling banyak pada rentang usia 50 – 59 tahun, status paritas yaitu multi para (≥2 kelahiran hidup), indeks massa tubuh ≥25 (obesitas), belum menopause, usia menarche ≥12 tahun, tidak memiliki riwayat terapi hormon, tidak terdapat riwayat infertilitas, pasien tanpa riwayat kanker, tidak memiliki riwayat keluarga dengan kanker, tidak menggunakan kontrasepsi, dan tidak memiliki riwayat hipertensi.Overview of Endometrial Cancer Risk Factors at RSUP Dr. Hasan Sadikin in 2020 - 2022AbstractObjective: Indentifying the risk factor of endometrial cancer patients at RSUP Dr. Hasan Sadikin in 2020 - 2022.Method: This research used descriptive method by collecting secondary data. The inclusion criteria was patients with primary diagnosis of endometrial cancerResults: In this research, the majority of endometrial cancer patients were aged 50 - 59 years (34,8%), multiparous (40,9%), with body mass index ≥25 kg/m² (33,2%), menarche age of ≥12 years (68,8%), no history of infertility (49,0%), not menopausal yet (36,4%), no history of hormone therapy (74,1%), no patient history of cancer/Lynch syndrome (71,7%), no family history of lynch syndrome (75,7%), no history of contraceptive use (42,55), and no history of hypertension (72,9%).Conclusion: In 2020 - 2022, endometrial cancer patient in Dr. Hasan Sadikin Central General Hospital Bandung were mostly foung in the aged range 50 - 59 years, multiparous, obesity, not menopausal yet, menarche age of ≥12 years, no history of hormone therapy, no patient and family history of cancer, no history of contraceptive use and hypertension.Key words: Endometrial cancer, risk factor, descriptive study Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-11-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/578 10.24198/obgynia.v6i3.578 Obgynia; Volume 6 Nomor 3 November 2023; 452-459 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 3 November 2023; 452-459 2615-496X 10.24198/obgynia.v6i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/578/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/578/365 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/882 2025-07-24T00:43:19Z obgynia:RA

HALP and SII: Innovative Biomarkers for Diagnosing Ovarian Cancer in Both Epithelial and Non-Epithelial Subtypes Ridwan, Steven Mantilidewi, Kemala Isnainiasih A.W., Gatot Nyarumenteng Kurniadi, Andi Suardi, Dodi Salima, Siti Rauf, Syahrul Hidayat, Yudi Mulyana Haemoglobin-albumin-lymphocyte- platelet (HALP) score, Ovarian cancer, Systemic Immune-Inflammation Index, Systemic Inflammatory Response Index Objective: To evaluate the diagnostic utility of PHAL (Platelet, Hemoglobin, Albumin, and Lymphocyte), SII (Systemic Immune Inflammation Index), and SIRI (Systemic Inflammatory Response Index) for both epithelial and non-epithelial ovarian cancer.Methods: A cross-sectional study of 156 patients with ovarian masses was conducted using preoperative laboratory data to calculate PHAL, SII, and SIRI scores. Histopathology confirmed diagnoses. Population I included all ovarian cancer types and benign tumors, while Population II included only non-epithelial ovarian cancer and benign tumors. Statistical analysis using SPSS 25.0, involved ROC curve and validity testing to assess diagnostic performance.Result: SII showed the best performance in the overall population (AUC 0.738; sensitivity 71.25%; specificity 72.37%; accuracy 71.79%; LR+ 2.58; LR– 0.40). In the subgroup of non-epithelial ovarian cancer versus benign tumors, PHAL had the highest diagnostic accuracy (AUC 0.819; sensitivity 81.81%; specificity 73.68%; accuracy 75.51%; LR+ 3.11; LR– 0.25).Conclusion: PHAL and SII are effective, accessible, and low-cost biomarkers that can support ovarian cancer diagnosis through routine blood tests.PHAL dan SII: Biomarker Inovatif untuk Diagnosis Kanker Ovarium Subtipe Epitel dan Non-Epitel Abstrak Tujuan: Penelitian ini bertujuan untuk mengevaluasi nilai diagnostik dari PHAL (Platelet, Haemoglobin, Albumin, dan Limfosit), SII (Systemic Immune Inflammation Index), dan SIRI (Systemic Inflammatory Response Index) pada kanker ovarium epitelial dan non-epitelial. Metode: Penelitian dengan metode potong lintang ini melibatkan 156 pasien dengan massa ovarium. Data laboratorium pra-operatif digunakan untuk menghitung skor PHAL, SII, dan SIRI. Diagnosis ditegakkan melalui pemeriksaan histopatologi. Populasi I mencakup semua jenis kanker ovarium dan tumor jinak, sedangkan Populasi II hanya mencakup kanker ovarium non-epitelial dan tumor jinak. Analisis statistik dilakukan menggunakan SPSS 25.0, termasuk analisis kurva ROC dan uji validitas untuk menilai kinerja diagnostik. Hasil: Hasil penelitian menyimpulkan bahwa SII memiliki performa terbaik pada seluruh populasi (AUC 0,738; sensitivitas 71,25%; spesifisitas 72,37%; akurasi 71,79%; LR+ 2,58; LR– 0,40). Pada subkelompok kanker ovarium non-epitelial dibandingkan dengan tumor jinak, PHAL menunjukkan akurasi diagnostik tertinggi (AUC 0,819; sensitivitas 81,81%; spesifisitas 73,68%; akurasi 75,51%; LR+ 3,11; LR– 0,25). Kesimpulan: PHAL dan SII merupakan biomarker yang efektif, mudah diakses, dan berbiaya rendah yang dapat mendukung diagnosis kanker ovarium melalui pemeriksaan darah rutin. Kata kunci: Kanker ovarium, Skor PHAL (Platelet-Hemoglobin-Albumin-Limfosit), Systemic Immune-Inflammation Index, Systemic Inflammatory Response Index Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-07-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/882 10.24198/obgynia.v8i2.882 Obgynia; Volume 8 Nomor 2 July 2025; 250-258 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 2 July 2025; 250-258 2615-496X 10.24198/obgynia.v8i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/882/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/882/656 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/882/658 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/882/659 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/882/714 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/882/722 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/882/739 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/655 2024-04-29T04:12:24Z obgynia:SI

Dandy– Walker Malformation in a Multiparous Woman: A Case Report Afdanil, Fitra Suhaimi, Donel Dandy-Walker malformation, congenital anomaly; pregnancy; prenatal diagnosis; DWS Background: Dandy-Walker malformation (DWM) or syndrome is a posterior fossa anomaly characterized by agenesis or hypoplasia of the vermis and cystic enlargement of the fourth ventricle causing upward displacement of the tentorium and torcula characterized by dilated posterior fossa, cystic enlargement of the fourth ventricle, hypoplasia of cerebellar vermis and its upward rotation. Most patients have hydrocephalus at the time of diagnosis.Case presentation: A 36-years-old multiparous woman with 39 weeks’ gestation from obstetrics polyclinic with plan for induction of labor. During an ultrasound examination, the fetomaternal department found congenital abnormalities in the fetus, namely the presence of hydrocephalus accompanied by Dandy-Walker syndrome. The patient denied the consumption of alcohol, usage of cosmetic drugs such as isotretinoin or blood thinning drugs. The patient previously had a sudden fever without reddish rash for 7 days at 6 months of gestation which healed on its own. The patient admitted to keeping a cat at her house since last year. The patient admitted that she had never had her blood checked for TORCH screening. After being done of Cervical ripening with Misoprostol according to FIGO 25 mcg/PV/6 hours, born a live baby girl, BW 2440 gr, BL 46 cm, A/S: 6/8.Conclusions: The patient was admitted to the hospital with the main complaint of G4P3A0L3 Gestational age 39-40 weeks, not in labor and a live single fetus in the womb, the patient’s head presentation from the obstetrics clinic with intermittent episodes of vomiting, headache with plans for induction of labor with ultrasound results of Dandy-Walker Syndrome. Pregnant women with DWS in foetal ultrasonic examination should be offered a careful and comprehensive foetal ultrasound scan and further prenatal genetic testing.Malformasi Dandy-Walker pada Wanita Multipara: Laporan KasusAbstrakLatar Belakang: Malformasi atau sindrom Dandy-Walker (DWM) merupakan anomali fosa posterior yang ditandai dengan agenesis atau hipoplasia vermis dan pembesaran kistik ventrikel keempat yang menyebabkan perpindahan tentorium dan torkula ke atas  yang ditandai dengan melebarnya fosa posterior, pembesaran kistik ventrikel keempat, hipoplasia vermis serebelar, dan rotasinya ke atas. Kebanyakan pasien menderita hidrosefalus pada saat diagnosis.Presentasi kasus: Seorang wanita multipara berusia 36 tahun dengan usia kehamilan 39 minggu, pasien dari poliklinik kebidanan dengan rencana induksi persalinan. Pada pemeriksaan USG oleh bagian fetomaternal ditemukan kelainan kongenital pada janin yaitu adanya hidrosefalus disertai Dandy-Walker syndrome. Pasien menyangkal konsumsi alkohol, penggunaan obat-obatan kosmetik seperti isotretinoin atau obat pengencer darah. Pasien sebelumnya mengalami demam mendadak tanpa ruam kemerahan selama 7 hari pada usia kehamilan 6 bulan dan sembuh dengan sendirinya. Pasien mengaku memelihara kucing di rumahnya sejak tahun lalu. Pasien mengaku belum pernah memeriksakan darahnya untuk pemeriksaan TORCH. Setelah pematangan serviks dengan Misoprostol sesuai FIGO 25 mcg/PV/6 jam. Bayi perempuan lahir hidup, BW 2440 gr, BL 46 cm, A/S : 6/8.Kesimpulan: Pasien masuk RS dengan keluhan utama G4P3A0L3 Usia kehamilan 39-40 minggu, tidak bersalin dan janin hidup tunggal dalam kandungan, presentasi kepala pasien dari klinik kebidanan dengan episode muntah intermiten, sakit kepala dengan rencana induksi persalinan dengan hasil USG Sindrom Dandy-Walker. Keahlian yang cukup diperlukan dalam mendiagnosis dan mengobati malformasi yang disebabkan oleh Dandy Walker. Wanita hamil dengan DWS dalam pemeriksaan USG janin harus ditawarkan pemindaian USG janin yang cermat dan komprehensif serta pengujian genetik prenatal lebih lanjut.Kata kunci: Malformasi Dandy-Walker, kelainan kongenital, kehamilan, diagnosis prenatal Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-03-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/655 10.24198/obgynia.v7i1.655 Obgynia; Volume 7 Nomor 1 Maret 2024; 63-67 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 1 Maret 2024; 63-67 2615-496X 10.24198/obgynia.v7i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/655/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/655/402 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/963 2026-01-23T07:42:49Z obgynia:RA

Relationship between Antenatal Care in Severe Preeclampsia and Maternal and Neonatal Outcomes Iskandarsyah, Teuku Muhammad Nurdiawan, Windi Susiarno, Hadi Objective: This study aims to evaluate the relationship between the frequency of antenatal care (ANC) visits and maternal and infant outcomes in cases of severe preeclampsia.Methods: The collected data were processed using computerized methods to convert them into analyzable information. Data analysis was conducted to describe the proportion of each variable descriptively. Furthermore, the results were elaborated through descriptive analysis and hypothesis testing.Result: Based on medical record data, 91.7% of patients had undergone antenatal care (ANC) visits; however, only about 80% received pre-eclampsia screening services according to the 10T standard.Conclusion: The study concluded that inadequate antenatal care (ANC) visits were significantly associated with an increased risk of eclampsia and acute renal failure. On the other hand, there was no statistically significant association between ANC compliance and the occurrence of complications such as placental abruption, HELLP syndrome, DIC, and maternal death.Hubungan Antenatal Care Pada Preeklampsia Berat terhadap Luaran Maternal dan NeonatalAbstrakTujuan: Penelitian ini bertujuan untuk mengevaluasi hubungan antara frekuensi kunjungan antenatal care (ANC) dan luaran maternal dan infant pada kasus preeklamsia berat.Metode: Data yang telah terkumpul diolah secara komputerisasi untuk mengubah data menjadi informasi. Analisis data dilakukan untuk melihat gambaran proporsi masing-masing variabel yang disajikan secara deskriptif. Selanjutnya, hasil analisis tersebut diuraikan ke dalam analisis deskriptif dan pengujian hipotesis.Hasil: Berdasarkan data rekam medis, ditemukan bahwa 91,7% pasien telah menjalani kunjungan antenatal care (ANC), namun hanya 80% yang mendapatkan pelayanan skrining preeklamsia sesuai standar 10T.Kesimpulan: Kesimpulan menunjukkan bahwa kunjungan Antenatal Care (ANC) yang tidak memadai memiliki hubungan yang signifikan dengan peningkatan risiko eklamsia dan gagal ginjal akut. Sementara di sisi lain, tidak terdapat hubungan yang signifikan secara statistik antara tingkat kepatuhan ANC dengan kejadian komplikasi seperti solusio plasenta, edema paru, Sindrom HELLP, DIC, dan kematian ibu.Kata kunci: Antenatal Care; Preeklamsia; Neonatal Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/963 10.24198/obgynia.v8i3.963 Obgynia; Volume 8 Nomor 3 November 2025; 524-532 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 3 November 2025; 524-532 2615-496X 10.24198/obgynia.v8i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/963/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/963/826 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/963/830 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/963/838 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/385 2022-09-28T00:56:45Z obgynia:RA

Evaluation of Pelvic Floor Muscle Strength and Anal Spinchter Defects in Women Post Repair Obstetric Anal Spinchter Injuries Martiani, Sarnisyah Dwi Asni, St. Nur Rahman, Abdul Kasim, Muh. Firdaus Irianta, Trika Tiro, Eddy Pelvic Floor, OASIS, Wexner score Tujuan: penelitian ini bertujuan untuk mengevaluasi defek sfingter ani dan disfungsi otot dasar panggul pada perempuan pasca repair trauma sfingter ani obstetri.Metode: Analitik observasional yang dikembangkan dengan desain kohort prospektif. Perempuan yang mengalami Repair Trauma Sfingter Ani Obstetri pada Bulan Januari 2020-Juni 2021 di beberapa RS jejaring Makassar dinilai defek pasca repair dan keluhan subjektif menggunakan USG Transperineal (Alpinion cube 5 dengan probe transvaginal), Skor Wexner, Numeric Pain Rating Scale dan Perineometer (Peritron 9300 V) yang dilakukan dalam 3 kali pengukuran yaitu pada bulan 1, 3 dan 6 pasca repair. Data diuji menggunakan Mann-Whitney test, Cochrane dan Independent T test. Data diolah menggunakan SPSS 24.Hasil: Dari 51 sampel yang dilakukan pemeriksaan, didapatkan rata-rata usia 27.82±4.04 tahun dengan rerata IMT 24.52±4.31 kg/m2. Sampel didominasi oleh primipara sebanyak 41(80,4%). Rerata berat bayi 3312.75±424.24 gram. Terdapat 5 (9,8%) Pasien yang mengalami defek pasca repair, rerata skor wexner pada sampel dengan defek sfingter ani 1.60±1.14 pada bulan pertama, terdapat perbedaan yang signifikan pada dispareunia (p<0.05) dengan rerata 3.33±1.15 pada sampel dengan defek sfingter ani pada bulan keenam. Tampak peningkatan rerata skor kekuatan otot panggul pada perempuan tanpa defek sfingter ani. Kesimpulan: Gejala subjektif dapat ditemukan pada perempuan tanpa defek sfingter ani. Peningkatan kekuatan otot dasar panggul dapat terjadi seiring bertambahnya waktu pasca repair.Evaluation of Pelvic Floor Muscle Strength and Anal Sphincter Defects in Post Obstetric Anal Sphincter Injuries Repair WomenAbstractObjectives: The goal of this study was to look at anal sphincter deficiencies and pelvic floor muscle dysfunction in women who had obstetric anal sphincter injuries and had them repaired.Methods: Analytical was created as an observational study with a cohort prospective design. Women who underwent OASIS Repair in multiple Makassar hospitals between January 2020 and June 2021 were assessed subjectively using Transperineal Ultrasound (Alpinion cube 5 ultrasound with transvaginal probe), Wexner Score, Numeric Pain Rating Scale, and Perineometer (Peritron 9300 V) at 1, 3, and 6 months after repairs. The data was analyzed using the Mann-Whitney test, Cochran test, and Independent T test in SPSS 24. Result: The average age of the 51 samples that underwent the assessment was 27.82.04 years, with a mean BMI of 24.524.31 kg/m2. Up to 41 percent of the sample was dominated by primiparas (80.4 percent ). The average infant weighs 3312.75424.24 grams. There were 5 (9.8%) patients who had a defect after repair, with an average score of 1.601.14 on the first month and a significant difference in dyspareunia (p0.05) with a mean of 3.331.15 on the sixth month in the sample with anal sphincter defect. In women who do not have an anal sphincter dysfunction, there is an average increase in look strength of the pelvic muscle.Conclusion: Women without an anal sphincter abnormality had subjective complaints. With more time passed after surgery, the pelvic floor muscle may improve.Key words: pelvic floor, OASIS, Wexner score, Anal Sphincter defect, Transperineal ultrasound Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran Hasanuddin University 2022-09-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/385 10.24198/obgynia.v5i2.385 Obgynia; Volume 5 Nomor 2 September 2022; 184-192 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 2 September 2022; 184-192 2615-496X 10.24198/obgynia.v5i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/385/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/385/219 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/385/249 Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/687 2024-11-19T11:53:19Z obgynia:CR

Acute Fatty Liver of Pregnancy: A Rare Case Further Complicated with Disseminated Intravascular Coagulation Junita, Nuria Bernolian, Nuswil acute fatty liver of pregnancy; disseminated intravascular coagulation; pregnancy complications Introduction: An acute fatty liver of pregnancy is a rare and potentially deadly pregnancy complication. A case of acute fatty liver of pregnancy that is complicated with disseminated intravascular coagulation is hereby presented.Case Report: A 27-years old, 36 weeks pregnant female is presented with jaundice, elevated LDH and liver enzymes, and thrombocytopenia. An emergency obstetric ultrasonography examination found an unremarkable pregnancy without a placental abruption. The patient was managed conservatively and she delivered 6 days after the presentation. The neonate was treated in the neonatal intensive care unit due to a meconium aspiration. The patient suffered from a continued uterine bleeding and she was managed with the Sayeba’s technique. The laboratory work-up showed a disseminated intravascular coagulation with anemia and thrombocytopenia. The patient was treated with a packed red cell and fresh frozen plasma transfusion. The patient required an intensive care treatment. Discussion: An acute fatty liver of pregnancy is a potentially deadly complication of pregnancy and it requires a multidisciplinary, intensive support. The acute fatty liver of pregnancy symptoms are similar to those of a HELLP syndrome. An acute fatty liver of pregnancy requires a prompt delivery followed with a intensive support. Complications of an acute fatty liver of pregnancy include a hepatic failure and a disseminated intravascular coagulation which should be managed accordingly.Conclusion: An acute fatty liver of pregnancy requires a prompt diagnosis and treatment to achieve the best possible maternal outcome.Acute Fatty Liver of Pregnancy: Kasus Jarang Dengan Komplikasi Koagulasi Intravaskular DiseminataAbstrak Pendahuluan: Acute fatty liver of pregnancy adalah komplikasi kehamilan yang langka dan dapat mematikan. Laporan ini memaparkan sebuah kasus acute fatty liver of pregnancy dengan komplikasi koagulasi intravascular diseminata.Laporan Kasus: Seorang perempuan berusia 27 tahun, hamil 36 minggu datang dengan icterus, peningkatan kadar LDH dan enzim hati, serta trombositopenia. Pemeriksaan ultrasonografi obstetric di IGD menemukan kehamilan tanpa komplikasi dan tanpa solusio plasenta. Pasien ditatalaksana secara konservatif dan melahirkan 6 hari pasca-perawatan. Neonatus dirawat di ruang rawat intensif karena aspirasi meconium. Pasien mengalami perdarahan uterus dan ditatalaksana dengan kondom Sayeba. Pemeriksaan laboratorium menunjukkan adanya koagulasi intravaskular diseminata dengan anemia dan trombositopenia. Pasien ditatalaksana dengan transfuse packed red cell dan fresh frozen plasma. Pasien memerlukan perawatan intensif. Pembahasan: Acute fatty liver of pregnancy adalah komplikasi kehamilan yang dapat mematikan dan memerlukan tatalaksana intensif multidisipliner. Acute fatty liver of pregnancy memiliki gejala yang menyerupai sindrom HELLP. Acute fatty liver of pregnancy ditatalaksana dengan melakukan persalinan diikuti dengan terapi intensif. Komplikasi acute fatty liver of pregnancy meliputi gagal hepar dan koagulasi intravascular diseminata yang harus ditatalaksana dengan tepat.Kesimpulan: Acute fatty liver of pregnancy memerlukan diagnosis dan tatalaksana yang cepat untuk meningkatkan luaran maternal.Kata kunci: acute fatty liver of pregnancy, koagulasi intravascular diseminata, komplikasi kehamilan  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/687 10.24198/obgynia.v7i3.687 Obgynia; Volume 7 Nomor 3 November 2024; 412-419 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 3 November 2024; 412-419 2615-496X 10.24198/obgynia.v7i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/687/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/687/457 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/687/458 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/687/463 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/1144 2026-04-07T13:56:07Z obgynia:err

Retraction Notice: Comparison of Chondroitin Sulfate-E Expression in Benign and Malignant Epithelial Type Ovarian Tumors Mantilidewi, Kemala Isnainiasih Summary:This article has been formally retracted and the PDF file withdrawn from the journal’s database at the request of the authors.Significant concerns were raised regarding the accuracy and reliability of the dataset, rendering the findings no longer robust or dependable for scientific use. Additionally, it was disclosed that the manuscript was submitted without the explicit consent of all listed co-authors.To preserve the integrity of the medical literature, the Editorial Board has removed the original content. This page remains as a permanent record of the retraction. A replacement notice has been issued in the original volume to inform readers of this retraction.We apologize for any inconvenience caused to our reviewers and readers.Readers are advised not to cite this article. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-12-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1144 10.24198/obgynia.v8i3.1144 Obgynia; Volume 8 Nomor 3 November 2025 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 3 November 2025 2615-496X 10.24198/obgynia.v8i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1144/450 Copyright (c) 2026 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/467 2023-03-27T01:50:09Z obgynia:RA

The Relation Between Prenatal Maternal Stress and Sleep Quality of Pregnant Women in Palembang Nurwany, Raissa Niapulina, Rachellida Hasbi, Alfian Alkaf, Syifa Santoso, Budi Swanny, Swanny Pregnant women, Prenatal Maternal Stress, Sleep Quality Objective: The aim of this research is to know incidence and relationship between prenatal maternal stress and sleep quality in pregnant women in Palembang City. This study also aims to determine the factors that influence prenatal maternal stress.Method: Observational analytic study by collecting questionnaires on October 18 - November 19, 2022 in 6 puskesmas in Palembang City. This study used Pregnancy Stress Rating Scale (PSRS) and Pittsburgh Sleep Quality Index (PSQI), followed by calculating the Prevalence Risk.Results: In this study, the results obtained were that of 56 pregnant women in Palembang City, 57.1% experienced stress (mild stress (51.8%) and moderate stress (5.3%)). There were 39.3% of pregnant women with good sleep quality and 60.7% with poor sleep quality. It was found that there was a significant relationship between prenatal maternal stress and sleep quality of pregnant women (PR=4.350; 95% CI; (1.979 – 9.564; p= 0.000). There was a significant relationship between the age of pregnant women and prenatal maternal stress (PR= 0.323; 95) % CI: (0.168 – 0.612); p=0.000) and a significant relationship between maternal work and prenatal maternal stress (PR= 0.425; 95% CI: (0.198 – 0.913); p = 0.013)Conclusion: 57.1% of pregnant women in Palembang experienced stress and 60.7% have poor sleep quality. There was significant relationship between prenatal maternal stress and sleep quality in pregnant women in Palembang City. Factors that influence prenatal maternal stress, namely age and mother's occupation.Hubungan antara Prenatal Maternal Stress dan Kualitas Tidur Ibu Hamil di Kota PalembangAbstractTujuan: Penelitian ini dilakukan dengan tujuan untuk mengetahui insidensi dan hubungan antara prenatal maternal stress dan kualitas tidur pada ibu hamil di Kota Palembang. Penelitian ini juga bertujuan untuk mengetahui faktor-faktor yang memengaruhi prenatal maternal stress.Metode: Penelitian analitik observasional dengan mengumpulkan kuisioner pada tanggal 18 Oktober - 19 November 2022 di 6 puskesmas di Kota Palembang. Penelitian ini menggunakan Pregnancy Stress Rating Scale (PSRS) dan Pittsburgh Sleep Quality Index (PSQI) yang kemudian dilanjutkan penghitungan Prevalence Risk .Hasil: Pada penelitian ini diperoleh hasil, dari 56 ibu hamil di Kota Palembang sebanyak 57,1% mengalami stres (stres ringan (51,8%) dan stres sedang (5,3%)). Terdapat 39,3% ibu hamil dengan kualitas tidur baik dan 60,7% dengan kualitas tidur buruk. Ditemukan bahwa ada hubungan signifikan antara prenatal maternal stress dan kualitas tidur ibu hamil (PR=4.350; 95% CI; (1.979 – 9.564; p= 0,000). Terdapat hubungan signifikan antara usia ibu hamil dengan prenatal maternal stress (PR= 0,323; 95% CI: (0.168 – 0.612); p=0,000) dan hubungan yang signifikan antara pekerjaan ibu dengan prenatal maternal stress (PR= 0.425; 95% CI: (0.198 – 0.913); p = 0,013)Kesimpulan: Sebanyak 57,1% ibu hamil di kota Palembang mengalami stres dan 60,7% memiliki kualitas tidur buruk. Terdapat hubungan signifikan antara prenatal maternal stress dan kualitas tidur pada ibu hamil di Kota Palembang. Faktor yang mempengaruhi  prenatal maternal stress, yaitu usia dan pekerjaan ibu. Kata kunci: Ibu hamil, Prenatal Maternal Stress, Kualitas Tidur Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-03-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/467 10.24198/obgynia.v6i1.467 Obgynia; Volume 6 Nomor 1 Maret 2023; 115-123 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 1 Maret 2023; 115-123 2615-496X 10.24198/obgynia.v6i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/467/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/467/283 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/756 2024-11-19T11:53:19Z obgynia:SI

Anencephaly with Prior Caesarean Section: A Management Dilemma for Lethal Fetal Condition to Perform Labor Induction Rotinggo, Rico Siddiq, Amillia Hidayat, Yudi Mulyana Anencephaly; Prior Caesarean Section; Management of Delivery, Induction Introduction: A failure of cranial neuropore closure during the third to fourth week of gestation is called anencephaly. It leads to the lack of a significant part of the brain, skull, and scalp. The recommended method of delivery in lethal conditions, such as anencephaly, is vaginal delivery. This case report describes anencephalic pregnancy with a history of prior cesarean section. Labor induction held a dilemma to perform, but cesarean section poses a risk of morbidity to the mother and will not improve fetal outcomes.Case Illustration: A 37-year-old woman, G4P3A0, 26-27 weeks of pregnancy, presented with a planned termination of pregnancy. The patient was known to have congenital malformation and anencephaly. The patient had a history of prior cesarean section. During admission, the patient showed no signs of delivery. The patient was then planned for labor induction with misoprostol 50 mcg on the posterior fornix. The delivery outcome was no uterine rupture or significant bleeding.Conclusion: Vaginal delivery is the first choice for the delivery method in cases with poor prognosis. Avoiding a cesarean section will protect the mother from further morbidity from a cesarean section.Anensefali dengan Riwayat Seksio Sesarea: Dilema Manajemen untuk Kondisi Janin Yang Lethal dalam Melakukan Induksi PersalinanAbstrakPendahuluan: Kegagalan penutupan neuroporus kranial selama minggu ketiga hingga keempat kehamilan disebut anensefali. Kondisi ini menyebabkan hilangnya sebagian besar otak, tengkorak, dan kulit kepala. Metode persalinan yang direkomendasikan dalam kondisi janin yang tidak bisa bertahan hidup, seperti anensefali, adalah persalinan melalui vagina. Laporan kasus ini akan menggambarkan kehamilan dengan anensefali pada pasien dengan riwayat seksio sesarea sebelumnya. Induksi persalinan menimbulkan dilema untuk dilakukan, namun seksio sesarea meningkatkan risiko morbiditas bagi ibu tanpa memperbaiki hasil pada janin.Ilustrasi Kasus: Seorang wanita berusia 37 tahun, G4P3A0, usia kehamilan 26 - 27 minggu, datang dengan rencana terminasi kehamilan. Pasien diketahui memiliki malformasi kongenital dan anensefali. Pasien juga memiliki riwayat seksio sesarea sebelumnya. Saat masuk rumah sakit, pasien tidak menunjukkan tanda-tanda persalinan. Pasien kemudian direncanakan untuk induksi persalinan dengan misoprostol 50 mcg yang dimasukkan ke fornix posterior. Hasil persalinan tidak menunjukkan adanya ruptur uterus atau perdarahan yang signifikan.Kesimpulan: Persalinan melalui vagina adalah pilihan pertama untuk metode persalinan pada kasus dengan prognosis buruk. Menghindari seksio sesarea akan melindungi ibu dari morbiditas lebih lanjut akibat seksio sesarea.Kata kunci: Anensefali; Induksi; Letal; Manajemen Persalinan; Riwayat Seksio Sesarea Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/756 10.24198/obgynia.v7i3.756 Obgynia; Volume 7 Nomor 3 November 2024; 79-84 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 3 November 2024; 79-84 2615-496X 10.24198/obgynia.v7i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/756/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/756/519 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/756/520 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/756/521 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/64 2022-01-05T14:02:12Z obgynia:RA

Hubungan antara Faktor Risiko Demografi dan Klinis terhadap Kejadian Persalinan Preterm Dini dan Lanjut Sasongko, Rahadyan Aji Effendi, Jusuf Sulaeman Sabarudin, Udin Armawan, Edwin Siddiq, Amillia Zulvayanti, Zulvayanti Kata kunci: Faktor demografi, faktor klinik, persalinan spontan preterm dini, persalinan spontan preterm lanjut Tujuan: Persalinan preterm dini dan lanjut masih menjadi penyebab penting morbiditas dan mortalitas perinatal. Penelitian ini bertujuan untuk mengetahui karakteristik pasien, menganalisis hubungan faktor risiko demografi dan klinik dengan persalinan spontan preterm dini dan preterm lanjut periode Januari 2015-Desember 2016. Metode: Penelitian secara potong lintang retrospektif dilaksanakan pada bulan April-Juni 2017 dengan sumber data rekam medis Rumah Sakit Hasan Sadikin. Hasil: penelitian menunjukan insidensi persalinan preterm adalah 38,54%. Diskusi: Terdapat hubungan signifikan dari faktor risiko pendidikan, jumlah perawatan antenatal, riwayat persalinan preterm, dan ketuban pecah dini terhadap kejadian persalinan spontan preterm dini dan preterm lanjut. Pendidikan SD meningkatkan kejadian persalinan preterm dini 2,3 kali, perawatan antenatal kurang dari 4 kali selama kehamilan meningkatkan kejadian persalinan preterm dini 1,6 kali, riwayat persalinan preterm sebelumnya meningkatkan kejadian persalinan preterm dini 1,9 kali. Ketuban pecah dini meningkatkan kejadian persalinan preterm lanjut 2,6 kali (p<0,05). Kesimpulan: Terdapat hubungan antara tingkat pendidikan, jumlah perawatan antenatal, riwayat persalinan preterm, dan ketuban pecah dini, dengan  persalinan spontan preterm dini dan preterm lanjut. Relation between Demographic and Clinical Risk Factors to the Occurrence of Spontaneous Early and Late Preterm Birth Abstract     Objective: Early and late preterm birth remains an important cause of perinatal morbidity and mortality. Various studies indicate the incidence of is influenced by demographic and clinical factors affecting baby’s outcome. This study aims to analyze demographic and clinical factor’s relations of spontaneous early and late preterm birth in Hasan Sadikin General Hospital, from January 2015 until December 2016. Method: Retrospective-cross sectional was conducted in April until June 2017 from Hasan Sadikin General Hospital’s medical record, collected from January 2015 to December 2016. Results: Incidence of preterm birth from January 2015 until December 2016 was 38,54%. There was significant relations of education, times of antenatal care, previous preterm birth, and premature rupture of membrane with spontaneous early and late preterm birth. Education level of elementary school increased the incidence of spontaneous early preterm birth 2.3 times, previous preterm birth increased the incidence of spontaneous early preterm birth 1.6 times, antenatal care less than 4 times increased the incidence of spontaneous early preterm birth 1.9 times. Premature rupture of membrane increased the incidence of spontaneous late preterm birth 2.6 times (p<0.05. Conclusion: there is a relations between education, times of antenatal care, previous preterm birth, and premature rupture of membrane,  with spontaneous early and late preterm birth.Keywords: Demographic factors, clinical factors, preterm spontaneous early delivery, spontaneous late preterm delivery Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2018-03-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/64 10.24198/obgynia.v1i1.64 Obgynia; Volume 1 Nomor 1 Maret 2018; 6-16 Indonesian Journal of Obstetrics & Gynecology Science; Volume 1 Nomor 1 Maret 2018; 6-16 2615-496X 10.24198/obgynia.v1i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/64/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/64/15 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/64/59 Copyright (c) 2018 Journal Obstetric & Gynecology of Indonesia

oai:ojs.obgynia.com:article/403 2023-11-22T03:42:22Z obgynia:AR

Pencegahan Abortus pada Awal Kehamilan Pencegahan Abortus pada Awal Kehamilan Bernolian, Nuswil Pangemanan, Wim T. Syamsuri, Ahmad Kurdi Ansyori, M. Hatta Mirani, Putri Lestari, Peby Maulina Martadiansyah, Abarham Kesty, Cindy abortus, pencegahan, faktor risiko, kehamilan. Kata kunci: abortus, pencegahan, faktor risiko, kehamilan Abortus merupakan suatu kejadian terminasi kehamilan dengan usia kehamilan <20 minggu dan berat janin <500 g. Angka kejadian abortus disebutkan sekitar 15% dari seluruh kehamilan. Terdapat beberapa faktor risiko abortus yaitu faktor risiko yang dapat dimodifikasi dan tidak dapat dimodifikasi. Beberapa faktor risiko yang dapat dimodifikasi yaitu faktor nutrisi, konsumsi kafein, alkohol, kebiasaan merokok, infeksi, paparan radiasi, beban kerja, dan pengaruh obat-obatan. Beberapa faktor risiko yang tidak dapat dimodifikasi, yaitu genetik, kelainan kongenital, dan lain-lain. Dengan mengetahui faktor risiko tersebut, dokter dapat melakukan pencegahan dan intervensi yang sesuai dengan kondisi masing-masing pasien yang mengalami abortus. Metode yang digunakan adalah tinjauan pustaka dengan menggunakan beberapa database seperti Pubmed, Wiley Online Library, dan ScienceDirect dari 10 tahun terakhir.Prevention of Miscarriage in Early PregnancyAbstractMiscarriage is an event of termination of pregnancy with < 20 weeks of gestation and fetal weight < 500 grams. The incidence of miscarriage is around 15% of all pregnancies. There are several risk factors for miscarriage, namely modifiable and non-modifiable risk factors. Some modifiable risk factors are nutritional factors, consumption of caffeine, alcohol, smoking habit, infection, radiation exposure, workload, and the influence of drugs. Several risk factors that can not be modified, namely genetics, congenital abnormalities, and others. By knowing these risk factors, doctors can carry out prevention and intervention according to the conditions of each patient who undergoes miscarriage. The method used is a literature review using several databases such as Pubmed, Wiley Online Library, and ScienceDirect from the last 10 years.Key words: miscarriage, prevention, risk factors, pregnancy. Abortus merupakan suatu kejadian terminasi kehamilan dengan usia kehamilan <20 minggu dan berat janin <500 g. Angka kejadian abortus disebutkan sekitar 15% dari seluruh kehamilan. Terdapat beberapa faktor risiko abortus yaitu faktor risiko yang dapat dimodifikasi dan tidak dapat dimodifikasi. Beberapa faktor risiko yang dapat dimodifikasi yaitu faktor nutrisi, konsumsi kafein, alkohol, kebiasaan merokok, infeksi, paparan radiasi, beban kerja, dan pengaruh obat-obatan. Beberapa faktor risiko yang tidak dapat dimodifikasi, yaitu genetik, kelainan kongenital, dan lain-lain. Dengan mengetahui faktor risiko tersebut, dokter dapat melakukan pencegahan dan intervensi yang sesuai dengan kondisi masing-masing pasien yang mengalami abortus. Metode yang digunakan adalah tinjauan pustaka dengan menggunakan beberapa database seperti Pubmed, Wiley Online Library, dan ScienceDirect dari 10 tahun terakhir.Prevention of Miscarriage in Early PregnancyAbstractMiscarriage is an event of termination of pregnancy with <20 weeks of gestation and fetal weight <500 grams. The incidence of miscarriage is around 15% of all pregnancies. There are several risk factors for miscarriage, namely modifiable and non-modifiable risk factors. Some modifiable risk factors are nutritional factors, consumption of caffeine, alcohol, smoking habit, infection, radiation exposure, workload, and the influence of drugs. Several risk factors that can not be modified, namely genetics, congenital abnormalities, and others. By knowing these risk factors, doctors can carry out prevention and intervention according to the conditions of each patient who undergoes miscarriage. The method used is a literature review using several databases such as Pubmed, Wiley Online Library, and ScienceDirect from the last 10 years.Key words: miscarriage, prevention, risk factors, pregnancy. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2023-11-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/403 10.24198/obgynia.v6i3.403 Obgynia; Volume 6 Nomor 3 November 2023; 327-338 Indonesian Journal of Obstetrics & Gynecology Science; Volume 6 Nomor 3 November 2023; 327-338 2615-496X 10.24198/obgynia.v6i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/403/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/403/354 Copyright (c) 2023 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/858 2025-07-24T00:43:19Z obgynia:RA

Accuracy of Platelet Parameters (PC, MPV, and PDW) as A Predictor of The Severity of Preeclampsia Nababan, Heru Maranatha S, Donel Arfianti, Arfianti Simanjuntak, Arya Marganda Preeclampsia, Platelet Count, Platelet Distribution Width, Mean Platelet Volume, Predictive Biomarkers Objective: To evaluate the accuracy of platelet parameters—platelet count (PC), mean platelet volume (MPV), and platelet distribution width (PDW)—as predictors of preeclampsia severity. Methods:A case-control study was conducted on 153 pregnant women with preeclampsia at Arifin Achmad Hospital from January 2019 to December 2020. Platelet indices (PC, MPV, PDW) were compared between 61 patients with severe preeclampsia and 92 with non-severe preeclampsia. ROC analysis determined predictive accuracy, with sensitivity and specificity calculated for selected cut-off values. Results:Significant differences were found in PC (p=0.000), PDW (p=0.049), and MPV (p=0.012) between groups. ROC analysis showed PDW >12.3% had a sensitivity of 60.7% and specificity of 59.8%, while MPV >10.65 fL had a sensitivity of 62.3% and specificity of 64.1%. AUC values for PDW and MPV were 0.62 and 0.66, respectively, indicating weak predictive accuracy. Conclusion:Although platelet parameters differ significantly between preeclampsia severity groups, their predictive value is limited. They should not be solely relied upon for assessing preeclampsia severity. Akurasi Parameter Trombosit (PC, MPV, dan PDW) sebagai Prediktor Tingkat Keparahan PreeklampsiaAbstrak Tujuan: Penelitian ini dilaksanakan pada pasien preeklampsia untuk mengevaluasi akurasi parameter trombosit—jumlah trombosit (PC), volume trombosit rata-rata (MPV), dan lebar distribusi trombosit (PDW)—sebagai prediktor tingkat keparahan.Metode: Studi kasus-kontrol dilakukan pada 153 ibu hamil dengan preeklamsia di Rumah Sakit Arifin Achmad dari Januari 2019 hingga Desember 2020. Indeks trombosit (PC, MPV, PDW) dibandingkan antara 61 pasien dengan preeklamsia berat dan 92 pasien dengan preeklamsia tanpa gejala berat. Analisis ROC digunakan untuk menentukan akurasi prediktif, dengan perhitungan sensitivitas dan spesifisitas berdasarkan nilai cut-off tertentu. Hasil: Terdapat perbedaan signifikan pada PC (p=0.000), PDW (p=0,049), dan MPV (p=0.012) antara kedua kelompok. Analisis ROC menunjukkan bahwa PDW >12.3% memiliki sensitivitas 60.7% dan spesifisitas 59.8%, sedangkan MPV >10.65 fL memiliki sensitivitas 62.3% dan spesifisitas 64.1%. Nilai AUC untuk PDW dan MPV adalah 0.62 dan 0.66, menunjukkan akurasi prediktif yang lemah. Kesimpulan: Meskipun parameter trombosit menunjukkan perbedaan signifikan antara kelompok preeklamsia berat dan tidak berat, nilai prediktifnya terbatas. Parameter ini tidak dapat digunakan secara mandiri untuk menilai tingkat keparahan preeklamsia. Kata kunci: Preeklamsia, Jumlah Trombosit, Lebar Distribusi Trombosit, Volume Trombosit Rata-rata, Biomarker Prediktif Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran This manuscript doesn't receive any funding from any organization or individuals 2025-07-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/858 10.24198/obgynia.v8i2.858 Obgynia; Volume 8 Nomor 2 July 2025; 224-232 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 2 July 2025; 224-232 2615-496X 10.24198/obgynia.v8i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/858/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/858/634 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/858/635 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/858/678 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/858/682 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/283 2022-03-15T05:52:25Z obgynia:RA

Gambaran Prevalensi dan Faktor Risiko Ibu pada Pasien Intrauterin Growth Restriction di Rumah Sakit Umum Pendidikan Hasan Sadikin Bandung Irwantoro, Giritama Hidayat, Dini Aziz, Muhammad Alamsyah Prevalensi, Intrauterine Growth Restriction, Faktor Risiko Tujuan: Penelitian ini akan dilakukan untuk identifikasi prevalensi dan faktor risiko ibu terhadap angka kejadian IUGR di Rumah Sakit Umum Penidikan (RSUP) Dr. Hasan Sadikin Bandung.Metode: Penelitian ini menggunakan desain deskriptif retrospektif menggunakan data sekunder dengan melihat data rekam medik rawat inap pasien hamil dengan IUGR yang lahir di RSUP Dr. Hasan Sadikin Bandung periode bulan Januari 2018 – Desember 2019 berdasarkan kriteria inklusi dan eksklusi.Hasil: Prevalensi kasus IUGR di RSUP Hasan Sadikin Bandung adalah 76,16 orang per 1000 kehamilan. Karakteristik pasien dengan diagnosis IUGR terbanyak pada usia 21-34 tahun (64,32%), dengan paritas paling banyak pada primipara dengan total 147 kasus (79,45%). Faktor Risiko IUGR terdiri dari nilai BMI terbanyak dengan 86 subjek (46.5%) memiliki nilai BMI di atas batas normal. Tiga puluh lima subjek penelitian (18.9%) memiliki riwayat merokok, sementara 15 pasien (8.1%) memiliki riwayat mengonsumsi alkohol. Penyulit dalam kehamilan dengan PEB sebagai penyakit penyulit terbanyak. 28 pasien (15,1%). Pasien memiliki riwayat penyakit kronis 25 orang (13,5%) di antaranya mempunyai riwayat hipertensi kronis. Mayoritas dari seluruh pasien bersekolah hingga jenjang sekolah menengah. Kesimpulan: Prevalensi kasus IUGR di RSUP Hasan Sadikin Bandung adalah 76,16 orang per 1000 kehamilan. Karakteristik pasien terbanyak pada usia 21-34 tahun (64,32%), dengan paritas paling banyak pada primipara dengan total 147 kasus (79,45%).Description of Maternal Prevalence and Risk Factors in Intrauterine Growth Restriction Patients at Hasan Sadikin General Hospital BandungAbstractObjective: This study will identify the prevalence and risk factors of mothers for the incidence of IUGR in the General Hospital of Dr. Hasan Sadikin Bandung.Method: This research uses a retrospective descriptive design, using secondary data from the medical records of pregnant inpatients with IUGR born in RSUP Dr. Hasan Sadikin Bandung from January 2018 - December 2019 based on inclusion and exclusion criterias.Result: The prevalence of IUGR cases in RSUP Hasan Sadikin Bandung was 76.16 patients per 1000 pregnancies. The majority of patients with IUGR was at the age of 21-34 years (64.32%), with primipara was 147 of the cases (79.45%). The IUGR Risk Factor consists of 86 subjects (46.5%) having a BMI value above the normal limit, 35 study subjects (18.9%) had a history of smoking, and 15 patients (8.1%) had a history of consuming alcohol. Twenty-eight pregnancies (15.1%) complicated with preeclampsia. Patients with chronic diseases were 25 patients (13.5%) with chronic hypertension. The majority of the last education of all patients is in high school.Conclusion: Further research needed to assess the risk factors for the occurrence of intrauterine growth restriction (IUGR). Several components of fetal and uteroplacental risk factors, as well as other welfare level risk factors, may also need to be involved in the assessment of socioeconomic risk factors.Keyword: Prevalence, Intrauterine Growth Restriction. Risk Factor Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran Department of obstetric and gynecology UNPAD 2021-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/283 10.24198/obgynia.v4i2.283 Obgynia; Volume 4 Nomor 2 September 2021; 111-117 Indonesian Journal of Obstetrics & Gynecology Science; Volume 4 Nomor 2 September 2021; 111-117 2615-496X 10.24198/obgynia.v4i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/283/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/283/190 Copyright (c) 2021 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/947 2026-01-23T07:42:49Z obgynia:RA

Non-Severe Preeclampsia and Subclinical Inflammation: A Study of Cyclophilin A, NF-κB, PARP- 1, and Apoptosis in Human Placentas Resistantie, Novi Wibowo, Noroyono Prasmusinto, Damar Jusman, Sri Widia Azraki Yamin, Muhammad Siregar, Nurjati Chairani Prihartono, Joedo Mose, Johannes Cornelius Suhendro, Suhendro Yunita, Ferdiana Rosmanah, Lis Margyaningsih, Nur Ita Qotrunnada, Labibah Roviqoh, Cindy Fawwaz Rauf, Saidah Apoptosis, inflammation, preeclampsia. Objective: To compare the expression of CyP-A, NF-κB, PARP-1, and apoptotic index in Non-Severe Preeclampsia (NS-PE) and Normal Pregnancy (NP) and explore their roles in inflammation during preeclampsia.Methods: Conducted in Depok, Indonesia, the cross-sectional study involved 28 participants divided into NS-PE and NP groups based on ISSHP criteria. NP was defined as uncomplicated pregnancies at 38–40 weeks gestation. Placental weight was measured, and ELISA was used to assess biomolecule levels. Data were analyzed using T-tests or Mann-Whitney tests.Result: Maternal gestational age, body mass index, and leukocyte levels were significantly higher in NS-PE. The apoptotic index, measured by TUNEL assay, was also significantly elevated in NS-PE (41.56 ±24.87) compared to NP (23.96 ±18.79; p = 0.044). While CyP-A, PARP-1, and NF-κB levels were higher in NS-PE eventhough they were not statistically significant. Immunohistochemistry confirmed an overall increase in these molecules, supporting their clinical relevance.Conclusion: Despite the lack of statistical significance, increased inflammation and apoptosis in NS-PE may contribute to placental dysfunction and adverse pregnancy outcomes.Non-Severe Preeclampsia dan Inflamasi Subklinis: Studi CyP-A, NF-κB, PARP-1, dan Apoptosis pada Plasenta ManusiaAbstrak Tujuan: Penelitian ini bertujuan untuk mengetahui perbedaan ekspresi CyP-A, NF-κB, PARP-1, dan indeks apoptosis antara preeklamsia non-severe (NS-PE) dan kehamilan normal (NP), serta perannya dalam proses inflamasi pada preeklamsia.Metode: Metode penelitian yang digunakan dalam penelitian ini adalah cross-sectional. Penelitian ini dilakukan di Depok, Indonesia, dengan 28 partisipan yang dikelompokkan menjadi NS-PE dan NP berdasarkan kriteria ISSHP. Berat plasenta diukur dan kadar biomolekul dianalisis menggunakan ELISA. Uji T dan alternatif Mann-Whitney digunakan untuk analisis statistik.Hasil: Hasil penelitian menunjukkan bahwa usia kehamilan, indeks massa tubuh (IMT), dan kadar leukosit secara signifikan lebih tinggi pada NS-PE. Indeks apoptosis (TUNEL) juga lebih tinggi secara signifikan pada NS-PE (41,56 ±24,87) dibandingkan NP (23,96 ±18,79; p = 0,044). Kadar CyP-A, PARP-1, dan NF-κB lebih tinggi pada NS-PE meskipun tidak signifikan secara statistik, pemeriksaan IHK mengonfirmasi relevansi klinis peningkatan pada keseluruhan biomolekul tersebut. Kesimpulan: Meskipun signifikansi statistik rendah, peningkatan peradangan dan apoptosis pada NS-PE dapat menyebabkan disfungsi plasenta dan dampak buruk pada kehamilan.Kata kunci: Apoptosis; inflamasi; preeklamsia. Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2025-11-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/947 10.24198/obgynia.v8i3.947 Obgynia; Volume 8 Nomor 3 November 2025; 441-451 Indonesian Journal of Obstetrics & Gynecology Science; Volume 8 Nomor 3 November 2025; 441-451 2615-496X 10.24198/obgynia.v8i3 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/947/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/947/754 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/947/785 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/947/806 Copyright (c) 2025 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/348 2022-09-29T07:03:03Z obgynia:RA

Genotip Virus Human Pappiloma Tipe Risiko Rendah pada Wanita Pekerja Seks Komersial di Kota Makassar Chandra Montolalu, Yurike Adeline Susiawaty, Susiawaty Arifuddin, Sharvianty HPV tipe risiko rendah, Genotipe HPV Makassar, Infeksi HPV Makassar Tujuan: Mengetahui genotip HPV risiko rendah melalui pemeriksaan DNA HPV dan mencari hubungan faktor risiko terhadap angka kejadian infeksi HPV pada PSK diMakassar  Metode: Jenis penelitian ini adalah potong lintang dan terlaksana pada bulan Agustus  2019.  Populasi penelitian adalah wanita PSK usia reproduktif dengan total 80 sampel.Hasil: Pemeriksaan genotip HPV menunjukkan tipe HPV risiko rendah didominasi oleh tipe 43 dan 44 serta riwayat coitarche berpengaruh terhadap angka kejadian Infeksi HPV di Makassar (p=0,002)Kesimpulan: Coitarche pada usia <15tahun merupakan faktor predisposisi terhadap infeksi HPV dan genotip terbanyak HPV risiko rendah adalah tipe 43 dan 44 pada PSK di MakassarGenotype of Low Risk Type Human Papilloma Virus in Female Commercial Sex Workers in MakassarAbstractObjective: To investigate low-risk HPV genotype through HPV DNA examination and to determine the correlation between risk factors and incidence of HPV infection in Commercial Sex Workers (CSWs) in Makassar.Method: Cross-sectional study was used and conducted in August 2019. The study population was productive CSWs with a total of 80 samples.Result: HPV genotype examination showed low-risk HPV types were dominated by types 43 and 44.Conclusion: Coitarche before 15 years old is a predisposing factor for HPV infection and the highest low-risk HPV genotype is type 43 and 44 in CSWs in Makassar.Key words : HPV Infection in Makassar, Low risk HPV Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran Sharvianty Arifuddin, Oncology Gynecology Division, Obstetrics and Gynecology Department, Hasanuddin University 2022-03-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/348 10.24198/obgynia.v5i1.348 Obgynia; Volume 5 Nomor 1 Maret 2022; 94-101 Indonesian Journal of Obstetrics & Gynecology Science; Volume 5 Nomor 1 Maret 2022; 94-101 2615-496X 10.24198/obgynia.v5i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/348/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/348/197 Copyright (c) 2022 Indonesian Journal of Obstetrics & Gynecology Science

oai:ojs.obgynia.com:article/671 2024-08-01T02:16:47Z obgynia:RA

Neutrophil- Lymphocyte Ratio (NLR) and Platelet- Lymphocyte Ratio (PLR) as Inflammatory Markers in Preterm Birth Izzah, Muthiah Nurul Sumawan, Herman Achmad, Eppy Darmadi NLR, PLR, preterm birth Introduction: Preterm births make up roughly 16–18% of all live births in Indonesia. One of the factors that contribute to preterm birth is inflammation. The study aimed to assess the role of platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) as inflammatory markers in preterm birth. Method: This is a cross-sectional retrospective Study. Data were collected from medical records at Margono Soekarjo Hospital, January 2022-February 2023. The cohort comprised 150 participants with singleton pregnancies, ranging from 28 to less than 37 weeks of gestation, divided into three groups: preterm birth without preterm premature rupture of membranes (PPROM), preterm birth with PPROM, and threatened preterm labor (TPL). Multivariate ANOVA tests were employed for data analysis. Result: There was a statistically significant difference NLR values , notably in preterm births without PPROM compared to other groups (p value < 0.005), whereas the only difference noted in PLR values was noted between preterm births with and without PPROM. Our finding differs from that of previous studies, which indicated higher NLR values in preterm births with PPROM.Conclusion: NLR and PLR have the potential to be used as inflammatory markers indicative of heightened risk of preterm birth.Rasio Neutrofil-Limfosit (RNL) dan Rasio Platelet-Limfosit (RPL) sebagai Penanda Inflamasi pada Persalinan PrematurAbstrakPendahuluan: Angka kejadian persalinan prematur di Indonesia mencakup 16-18% dari semua kelahiran hidup. Inflamasi atau infeksi dianggap sebagai salah satu penyebab persalinan prematur. Penelitian ini bertujuan untuk menilai peran rasio trombosit/limfosit (PLR) dan rasio neutrofil/limfosit (NLR) sebagai penanda inflamasi pada kelahiran premature.Metode: Penelitian merupakan studi retrospektif cross-sectional. Data dikumpulkan dari rekam medis RSUD Margono Soekarjo periode Januari 2022 - Februari 2023. Didapatkan 150 pasien hamil tunggal dengan rentang usia kehamilan 28 hingga kurang dari 37 minggu yang terbagi dalam tiga kelompok: kelahiran prematur tanpa ketuban pecah dini (KPD), kelahiran prematur dengan KPD, dan ancaman persalinan prematur. Tes ANOVA multivariat digunakan untuk analisis data.Hasil: Terdapat perbedaan nilai NLR yang signifikan secara statistik, terutama pada kelahiran prematur tanpa KPD dibandingkan dengan kelompok lain (nilai p <0,005), sedangkan perbedaan nilai PLR hanya terdapat pada kelahiran prematur dengan dan tanpa KPD. Temuan kami berbeda dengan penelitian sebelumnya yang menunjukkan nilai NLR lebih tinggi pada kelahiran prematur dengan KPD.Kesimpulan: NLR dan PLR berpotensi digunakan sebagai penanda inflamasi yang mengindikasikan peningkatan risiko kelahiran prematur.Kata kunci: NLR, PLR, persalinan prematur Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2024-07-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/671 10.24198/obgynia.v7i2.671 Obgynia; Volume 7 Nomor 2 Juli 2024; 182-188 Indonesian Journal of Obstetrics & Gynecology Science; Volume 7 Nomor 2 Juli 2024; 182-188 2615-496X 10.24198/obgynia.v7i2 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/671/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/671/429 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/671/430 Copyright (c) 2024 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0

oai:ojs.obgynia.com:article/1059 2026-03-13T02:36:41Z obgynia:RA

Association between Maternal Body Mass Index and Neonatal Apgar Scores: A Multicenter Study Darajatun, Ryan Haryana Aditiyono, Aditiyono Aziz, Muhammad Alamsyah Aladawiyah, Nurul Robiah Apgar score; maternal body mass index; mode of delivery; neonatal outcomes; obesity Objective: To determine the association between maternal body mass index (BMI) and neonatal Apgar scores in two tertiary referral hospitals in Indonesia between 2023 and 2024.Methods: This cross-sectional study analyzed the medical records of 200 women who delivered at Dr. Hasan Sadikin Hospital, Bandung, and Prof. Dr. Margono Soekarjo Hospital, Purwokerto, from August 2023 to July 2024. Participants were classified based on maternal BMI. The associations between BMI, mode of delivery, and Apgar scores were analyzed using chi-square tests and logistic regression.Results: Maternal BMI, mode of delivery, age, parity, gestational age, and comorbidities showed no significant association with Apgar scores (p > 0.05). Birth weight was the only significant predictor; infants with low birth weight were associated with Apgar scores <7 (OR 0.219; 95% CI: 0.118–0.407). Regarding mode of delivery, 69.2% of obese mothers underwent cesarean section compared to 52.3% of normoweight mothers. Obese mothers were significantly more likely to have a cesarean delivery, although this did not correlate with lower Apgar scores.Conclusion: Maternal obesity is associated with a higher chance of cesarean delivery but does not significantly affect neonatal Apgar scores. Infant birth weight remains the strongest predictor of Apgar scores in this group. AbstrakTujuan: Penelitian ini bertujuan untuk mengetahui asosiasi antara indeks massa tubuh (IMT) dan skor Apgar dengan obesitas pada kehamilan di Rumah Sakit Margono dan Rumah Sakit Hasan Sadikin selama tahun 2023 – 2024.Metode: Penelitian ini merupakan studi observasional analitik dengan pendekatan potong lintang. Data diperoleh dari rekam medis 200 ibu bersalin periode Agustus 2023 – Juli 2024 di RSUP Dr. Hasan Sadikin Bandung dan RS Prof. Dr. Margono Soekarjo Purwokerto. Subjek diklasifikasikan berdasarkan Indeks Massa Tubuh (IMT). Hubungan antara IMT dengan metode persalinan dan skor Apgar dianalisis menggunakan uji chi-square dan regresi logistik.Hasil: Hasil penelitian menunjukkan bahwa dari seluruh variabel, hanya berat lahir bayi yang berpengaruh signifikan terhadap skor Apgar. Bayi dengan berat lahir rendah berisiko lebih tinggi mendapat skor Apgar rendah (p < 0,05) OR 0,219 (CI 95% 0,118–0,407). Tidak ditemukan hubungan signifikan antara IMT maupun metode persalinan dengan skor Apgar (p > 0,05). Persalinan seksio sesarea terjadi pada 52,3% ibu dengan IMT normoweight dan 69,2% pada kelompok obesitas. Kesimpulan: Obesitas pada ibu hamil meningkatkan risiko persalinan dengan seksio sesarea. Berat lahir bayi merupakan prediktor skor Apgar yang signifikan.  Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran 2026-03-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Back Matter application/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1059 10.24198/obgynia.v9i1.1059 Obgynia; Volume 9 Number 1 March 2026; 41-49 Indonesian Journal of Obstetrics & Gynecology Science; Volume 9 Number 1 March 2026; 41-49 2615-496X 10.24198/obgynia.v9i1 eng https://www.obgynia.com/obgyn/index.php/obgynia/article/view/1059/pdf https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1059/903 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1059/905 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1059/906 https://www.obgynia.com/obgyn/index.php/obgynia/article/downloadSuppFile/1059/919 Copyright (c) 2026 Indonesian Journal of Obstetrics & Gynecology Science http://creativecommons.org/licenses/by-sa/4.0 baae97a2a5b8f804d3abfa4ea697e6fc