Defisiensi Mikronutrisi (Zat Besi, Magnesium, Zinc, Kalsium, Vitamin D, Asam Folat, Vitamin C, Vitamin E, dan Omega 3) pada Preeklamsia

Muhammad Ilham Aldika Akbar, Bayu Agung Sangkara Putra


Abstract


Preeklamsia masih menjadi penyebab utama mortalitas dan morbiditas maternal neonatal di Indonesia. Preeklamsia disebabkan oleh multifaktorial yang ujungnya akan berakhir dengan terjadinya disfungsi endotel vaskular dan manifestasi klinis sistemik. Indonesia merupakan salah satu negara berkembang dengan masalah besar yang terkait dengan nutrisi. Tingginya angka stunting dan malnutrisi pada anak-anak, remaja, dan ibu hamil merupakan masalah nasional yang menjadi perhatian utama. Defisiensi nutrisi khususnya mikronutrisi ditunjukkan dari berbagai penelitian memiliki kaitan dengan terjadinya hipertensi dalam kehamilan. Pada artikel ini kami akan membahas mengenai peran dan keterkaitan mikronutrisi (Zat besi, magnesium, zinc, kalsium, vitamin C, D, E, dan DHA) dengan terjadinya preeklamsia.

Abstract
In Indonesia, preeclampsia continues to be the leading cause of maternal and infant morbidity and mortality. A complex etiology for preeclampsia led to vascular endothelial dysfunction and a widespread clinical presentation. Indonesia is a developing nation with significant nutrition-related issues. The key cause for concern is the high rate of stunting and malnutrition in children, adolescents, and pregnant women. Micronutrient deficits in particular have been linked to the development of hypertensive disorders in pregnancy. In this post, we will discuss about how micronutrients like iron, magnesium, zinc, calcium, and the vitamins C, D, E, and DHA might affect in the development of preeclampsia.


Keywords


Preeklampsia; Nutrisi; Kesehatan Maternal

Full Text:

PDF

References


Espinoza J, Vidaeff A, Pettker christian m, Simhan H. Gestational Hypertension and Preeclampsia - Clinical Management Guidelines for Obstetrician – Gynecologists. Obstetrics & Gynecology. 2019;133(76):168–86.

Rah JH, Melse-Boonstra A, Agustina R, van Zutphen KG, Kraemer K. The Triple Burden of Malnutrition Among Adolescents in Indonesia. Food Nutr Bull. 2021 Jun 20;42(1_suppl):S4–8.

Endeshaw M, Ambaw F, Aragaw A, Ayalew A. Effect of Maternal Nutrition and Dietary Habits on Preeclampsia: A Case-Control Study. Int J Clin Med. 2014;05(21):1405–16.

Brannon PM, Taylor CL. Iron Supplementation during Pregnancy and Infancy: Uncertainties and Implications for Research and Policy. Nutrients [Internet]. 2017 Dec 6 [cited 2022 Aug 31];9(12). Available from: https://pubmed.ncbi.nlm.nih.gov/29210994/

Sultana R, Ahmed S, Sultana N, Karim SF. Iron Status in Pre-Eclampsia: A Case-Comparison Study. Bangladesh Journal of Medical Biochemistry. 2013;5(2):53–5.

Sultana R, Ahmed S, Sultana N, Karim SF. Iron Status in Pre-Eclampsia: A Case-Comparison Study. Bangladesh Journal of Medical Biochemistry. 2013;5(2):53–5.

Ani LS, Weta IW, Utami NWA, Suranadi W, Suwiyoga K. Program Pencegahan Anemia Bagi Wanita Masa Prakonsepsi Di Wilayah Kerja Puskesmas Sidemen Kabupaten Karangasem. Buletin Udayana Mengabdi. 2018;17(3):145–51.

Mohamed ahmed Tayrab E, Adel Sama M, Tayrab E, Abd El Halim Abdullah S. Assessment of iron status in pre-eclamptic pregnant ladies attending Omdurman midwives hospital. International Journal of Medical Science and Clinical Research [Internet]. 2020; Available from: https://www.researchgate.net/publication/344328554

Paul R, Moonajilin MS, Sarker SK, Paul H, Pal S, Paul S, et al. Association between Serum Ferritin and Pre-eclampsia. Bangladesh Med J [Internet]. 2018 Oct 10 [cited 2022 Aug 30];47(3):18–24. Available from: https://www.banglajol.info/index.php/BMJ/article/view/43494

Taeubert MJ, Wiertsema CJ, Vermeulen MJ, Quezada-Pinedo HG, Reiss IK, Muckenthaler MU, et al. Maternal Iron Status in Early Pregnancy and Blood Pressure Throughout Pregnancy, Placental Hemodynamics, and the Risk of Gestational Hypertensive Disorders. J Nutr [Internet]. 2022 Feb 8 [cited 2022 Aug 30];152(2):525–34. Available from: https://academic.oup.com/jn/article/152/2/525/6396755

Smith C, Teng F, Branch E, Chu S, Joseph KS. Maternal and Perinatal Morbidity and Mortality Associated with Anemia in Pregnancy. Obstetrics and Gynecology [Internet]. 2019 Dec 1 [cited 2022 Aug 30];134(6):1234–44. Available from: https://journals.lww.com/greenjournal/Fulltext/2019/12000/Maternal_and_Perinatal_Morbidity_and_Mortality.15.aspx

Ali AA, Rayis DA, Abdallah TM, Elbashir MI, Adam I. Severe anaemia is associated with a higher risk for preeclampsia and poor perinatal outcomes in Kassala hospital, eastern Sudan. BMC Res Notes [Internet]. 2011 [cited 2022 Aug 30];4:311. Available from: /pmc/articles/PMC3224576/

Akhter S, Ali T, Begum S, Ferdousi S. Micronutrient Deficiency in Severe Preeclampsia. Journal of Bangladesh Society of Physiologist [Internet]. 2013 Oct 25 [cited 2022 Aug 30];8(1):26–32. Available from: https://www.banglajol.info/index.php/JBSP/article/view/16644

Ande ABA, Okpere EE, Enaruna NO. Clinical significance of low serum magnesium in pregnant women attending the University of Benin Teaching Hospital. Niger J Clin Pract [Internet]. 2013 Oct [cited 2022 Aug 30];16(4):448–53. Available from: https://pubmed.ncbi.nlm.nih.gov/23974737/

Al-Jameil N, Tabassum H, Ali MN, Qadeer MA, Khan FA, Al-Rashed M. Correlation between serum trace elements and risk of preeclampsia: A case controlled study in Riyadh, Saudi Arabia. Saudi J Biol Sci. 2017 Sep;24(6):1142–8.

Saputri CA, Sunarno I, Usman AN, Arsyad A, Idris I. Serum magnesium levels in normal pregnant women, severe preeclampsia, and severe preeclampsia with complications; a consideration for early supplementation? Enferm Clin. 2020 Jun 1;30:532–5.

Bahadoran P, Zendehdel M, Movahedian A, Zahraee RH. The relationship between serum zinc level and preeclampsia. Iran J Nurs Midwifery Res. 2010;15(3):120–4.

Nugraheni A, Prihatini M, Arifin AY, Retiaty F, Ernawati F. PROFIL ZAT GIZI MIKRO (ZAT BESI, ZINK, VITAMIN A) DAN KADAR HEMOGLOBIN PADA IBU HAMIL. Media Gizi Mikro Indonesia. 2021 Jul 30;12(2):119–30.

Ermawati, Adam B, Bachtiar H. PERBEDAAN KADAR ZINC SERUM PENDERITA PREEKLAMPSIA BERAT DENGAN KEHAMILAN NORMAL. OBGIN EMAS [Internet]. 2015 [cited 2022 Aug 30];1. Available from: https://adoc.pub/queue/perbedaan-kadar-zinc-serum-penderita-preeklampsia-berat-deng.html

Martadiansyah A, Peby Maulina, Putri Mirani, Tia Kaprianti, Theodorus. Zinc Serum Maternal Levels as a Risk Factor for Preeclampsia. Bioscientia Medicina : Journal of Biomedicine and Translational Research. 2021;5(7):693–701.

Ma Y, Shen X, Zhang D. The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis. Nutrients. 2015 Sep 15;7(9):7806–20.

WHO. WHO antenatal care recommendations for a positive pregnancy experience Nutritional interventions update: zinc supplements during pregnancy [Internet]. 1st ed. Geneva: World Health Organization; 2021 [cited 2022 Sep 10]. Available from: file:///Users/aldi/Downloads/9789240030466-eng%20(1).pdf

Anasiru MA. Pengaturan Gizi Pada Penanganan Preeklampsia. Health and Nutritions Journal. 2019;I(1):62–72.

Anasiru MA. Pengaturan Gizi Pada Penanganan Preeklampsia. Health and Nutritions Journal. 2019;I(1):62–72.

Hartini TNS, Winkvist A, Lindholm L, Stenlund H, Persson V, Nurdiati DS, et al. Nutrient intake and iron status of urban poor and rural poor without access to rice fields are affected by the emerging economic crisis: the case of pregnant Indonesian women. Eur J Clin Nutr [Internet]. 2003 May 1 [cited 2022 Aug 31];57(5):654–66. Available from: https://pubmed.ncbi.nlm.nih.gov/12771966/

Purnasari G, Briawan D, Dwiriani CM. Asupan Kalsium dan Tingkat Kecukupan Kalsium Pada Ibu Hamil di Kabupaten Jember. MKMI. 2016;12(4).

Harahap N, Fitriani WN. Kepatuhan Mengonsumsi Suplemen Kalsium Pada Ibu Primipara dan Multipara dengan Kejadian Preeklampsia. Jurnal Ilmu Kesehatan Masyarakat. 2021;10(02):110–7.

Suryono DW. The Correlation between Calcium Serum and Calcium Urine Level with the Blood Pressure in Preeclampsia. Indonesian Journal of Obstetrics and Gynecology. 2016 Dec 16;

Ilham M, Akbar A, Alkaff FF, Adrian A, Harsono H. Serum Calcium and 25-Hydroxy Vitamin D Level in Normal and Early Onset Pre-eclamptic Pregnant Women : A Study from Indonesia. Journal of Clinical and Diagnostic Research. 2019;13(3):4–7.

Handayani E. Faktor Faktor Yang Mempengaruhi Kejadian Preeklampsia di RSUD Wates Kabupaten Kulon Progo DIY Tahun 2019. Poltekkes Kemenkes Yogyakarta. 2019;1(2):1–35.

Nema J, Sundrani D, Joshi S. Role of vitamin D in influencing angiogenesis in preeclampsia. Hypertens Pregnancy. 2019 Oct 2;38(4):201–7.

Poniedziałek-Czajkowska E, Mierzyński R. Could Vitamin D Be Effective in Prevention of Preeclampsia? Nutrients. 2021 Oct 28;13(11):3854.

Baker AM, Haeri S, Camargo CA, Espinola JA, Stuebe AM. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab [Internet]. 2010 [cited 2022 Aug 31];95(11):5105–9. Available from: https://pubmed.ncbi.nlm.nih.gov/20719829/

Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab [Internet]. 2007 [cited 2022 Aug 31];92(9):3517–22. Available from: https://pubmed.ncbi.nlm.nih.gov/17535985/

Haugen M, Brantsæter AL, Trogstad L, Alexander J, Roth C, Magnus P, et al. Vitamin D Supplementation and Reduced Risk of Preeclampsia in Nulliparous Women. Epidemiology. 2009 Sep;20(5):720–6.

Wen SW, Champagne J, Rennicks White R, Coyle D, Fraser W, Smith G, et al. Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia: The Folic Acid Clinical Trial Study. J Pregnancy. 2013;2013:1–9.

Salehi-Pourmehr H, Mohamad-Alizadeh S, Malakouti J, Farshbaf-Khalili A. Association of the folic acid consumption and its serum levels with preeclampsia in pregnant women. Iran J Nurs Midwifery Res. 2012 Sep;17(6):461–6.

Rahat B, Hamid A, Bagga R, Kaur J. Folic Acid Levels During Pregnancy Regulate Trophoblast Invasive Behavior and the Possible Development of Preeclampsia. Front Nutr. 2022 Apr 28;9.

Wen SW, Champagne J, Rennicks White R, Coyle D, Fraser W, Smith G, et al. Effect of folic acid supplementation in pregnancy on preeclampsia: The folic acid clinical trial study. J Pregnancy. 2013;2013.

Fu Z mei, Ma Z zhi, Liu G jie, Wang L ling, Guo Y. Vitamins supplementation affects the onset of preeclampsia. Journal of the Formosan Medical Association. 2018 Jan;117(1):6–13.

Fu Z mei, Ma Z zhi, Liu G jie, Wang L ling, Guo Y. Vitamins supplementation affects the onset of preeclampsia. Journal of the Formosan Medical Association. 2018 Jan;117(1):6–13.

Utami CT, Berawi KN, Karima N, Kedokteran F, Lampung U, Fisiologi B, et al. Hubungan Suplementasi Omega-3 Pada Ibu Hamil dengan Kejadian Preeklampsia Relationship between Omega-3 Supplementation in Pregnant Women with the incidence of preeclampsia. 2018;7:211–6.

Kemse NG, Kale AA, Joshi SR. Supplementation of maternal omega-3 fatty acids to pregnancy induced hypertension Wistar rats improves IL10 and VEGF levels. Prostaglandins Leukot Essent Fatty Acids. 2016;104:25–32.

Kemse NG, Kale AA, Joshi SR. Supplementation of maternal omega-3 fatty acids to pregnancy induced hypertension Wistar rats improves IL10 and VEGF levels. Prostaglandins Leukot Essent Fatty Acids. 2016;104:25–32.

Irwinda R, Hiksas R, Siregar AA, Saroyo YB, Wibowo N. Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study. Sci Rep [Internet]. 2021 Dec 1 [cited 2022 Aug 31];11(1). Available from: https://pubmed.ncbi.nlm.nih.gov/34282168/

Li S na, Liu Y hua, Luo Z yan, Cui Y feng, Cao Y, Fu W jun, et al. The association between dietary fatty acid intake and the risk of developing preeclampsia: a matched case–control study. Scientific Reports 2021 11:1 [Internet]. 2021 Feb 18 [cited 2022 Aug 31];11(1):1–10. Available from: https://www.nature.com/articles/s41598-021-83674-3

Bakouei F, Delavar MA, Mashayekh-Amiri S, Esmailzadeh S, Taheri Z. Efficacy of n-3 fatty acids supplementation on the prevention of pregnancy induced-hypertension or preeclampsia: A systematic review and meta-analysis. Taiwan J Obstet Gynecol [Internet]. 2020 Jan 1 [cited 2022 Aug 31];59(1):8–15. Available from: https://pubmed.ncbi.nlm.nih.gov/32039806/

Abdelrahman MA, Osama H, Saeed H, Madney YM, Harb HS, Abdelrahim MEA. Impact of n-3 polyunsaturated fatty acid intake in pregnancy on maternal health and birth outcomes: systematic review and meta-analysis from randomized controlled trails. Arch Gynecol Obstet [Internet]. 2022 Mar 28 [cited 2022 Aug 31]; Available from: https://pubmed.ncbi.nlm.nih.gov/35348829/

Greenberg JA, Bell SJ, Ausdal W Van. Omega-3 Fatty Acid supplementation during pregnancy. Rev Obstet Gynecol. 2008;1(4):162–9.




DOI: http://dx.doi.org/10.24198/obgynia.v5i2.432

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


     
     

Creative Commons License
Indonesian Journal of Obstetrics & Gynecology Science is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License
  Web Analytics
  View My Stat