Efektivitas Pil Oral Kombinasi Dosis Rendah dalam Pengelolaan Perdarahan Uterus Abnormal pada akseptor DMPA

Rabiah Adawiyah, Inu Mulyantoro

Abstract


Abstrak
Tujuan: Untuk mengeksplorasi Efektivitas Pil Oral Kombinasi (POK) dalam Pengobatan Perdarahan Uterus Abnormal pada akseptor DMPA.
Metode: Kami melakukan percobaan untuk menyelidiki efek pil oral kombinasi dosis rendah dalam pengelolaan PUA pada akseptor DMPA. Penelitian ini dilakukan di Rumah Sakit Dr. Kariadi Semarang, Indonesia. Desain penelitian yang digunakan adalah pra eksperimental. Dua puluh dua  akseptor DMPA diberikan terapi POK dosis rendah sekali sehari selama 28 hari (satu siklus), kemudian subjek dievaluasi untuk durasi perdarahan selama perawatan. Variabel bebas dalam penelitian ini adalah pemberian POK dosis rendah dan variabel dependen adalah jumlah hari perdarahan.
Hasil: Terdapat penurunan bermakna rata-rata hari perdarahan  pada akseptor DMPA dengan PUA antara sebelum dan sesudah terapi POK dosis rendah dari 22,2(4,48) menjadi  9,2 (6,16) hari  (p=0,0001). Persentase dari subjek penelitian yang pendarahannya berhenti dalam minggu pertama setelah pengobatan adalah sebesar 45,5 %. Hanya terdapat satu orang yang mengeluhkan efek samping berupa pusing dan mual selama pengobatan
Kesimpulan: Pil Oral Kombinasi Dosis rendah  dapat mengurangi hari perdarahan pada akseptor DMPA

Kata kunci: POK, PUA, DMPA, hari perdarahan



Abstract
Objective: To explore the effectivity of  Low Dose Oral Contraceptive Pills (LDOCP) in managing AUB in DMPA users.
Methods: We performed the study to investigate the effect of LDOCP in managing AUB in DMPA users. This study was performed in Dr. Kariadi Hospital Semarang, Indonesia. The study design is pre experimental. Twenty two subjects received LDOCP once a day for 28 day (one menstrual cycle). Subjects then evaluated for bleeding length during treatment. Independent variable in this study is LDOCP treatment and the dependent variable is the bleeding days.
Results: The mean bleeding days in DMPA users with AUB were significantly reduced after LDOCP therapy from 22,2(4,48) days to  9,2 (6,16) days (p=0,0001). The precentage of subjects in whom bleeding was stopped during the first week initial treatment was 45,5 %. The mild side effects, such as dizziness and nausea, were experienced by only one subject.
Conclusion : LDOCP significantly reduced  bleeding days in DMPA users with AUB

Key words : OCP, PUA, DMPA, bleeding days


Keywords


POK, PUA, DMPA, hari perdarahan

Full Text:

PDF

References


WHO. From MDGs to SDGs : A new erav for global public health 2016-2030. Worl Heal. Organ. 2015.

Shabaan, M.M., et al., Levonorgestrel-releasing intrauterine system compared to low dose combined oral contraceptive pills for idiopathic menorrhagia : a randomized clinical trial. Contraception Journal, 2011. 83: p. 48-54.

HIFERI. Konsensus Tatalaksana Pendarahan Uterus Abnormal karena Efek Samping Kontrasepsi. 2013.

Aleem, H.A., et al., A Treatment of Vaginal Bleeding Irregularities Induced by Progestin Only Contraceptives (Reviews). The Cochrane Collaboration, 2007: p. 1-91.

Hassanzadeh, R., et al., Comparison of Continuation Rates and Reasons of Discontinuation for Cyclofem and Depot-medroxyprogesterone acetate in Rural Areas of East Azerbaijan Province. J Fam Plann Reprod Health Care, 2012. 6: p. 23-7.

Shafaie, F.S., et al., Compare of Continuation Rate and Reasons for Discontinuation of DMPA Contraceptive among Iranian Women Referred to Tabriz and Ardebil Health Centers. Int J Womens Health, 2014. 4: p. 240-4.

Vincent, A. and L. Salamonsen, The Role of Matrix Metalloproteinase and Leukocytes in Abnormal Uterine Bleeding Associated with Progestin-Only Contraceptives. Hum Reprod, 2000. 15: p. 135-43.

Vincent, A., et al., Decreased tissue inhibitor of metalloproteinase in the endometrium of women using depot medroxyprogesterone acetate: a role for altered endometrial matrix metalloproteinase/tissue inhibitor of metalloproteinase balance in the pathogenesis of abnormal uterine bleeding? . Hum Reprod 2002. 17: p. 1189-98.

M Hickey and Fraser, A functional model for progestogen-induced breakthrough bleeding. Hum Reprod, 2000. 15: p. 1-6.

Alvarez-Sanchez, F., Brache, V., Thevenin, F., Cochon, L. & Faundes, A. Hormonal treatment for bleeding irregularities in Norplant implant users. Am. J. Obstet. Gynecol. 1996;174: 919–22

RCOG, Management of Unscheduled Bleeding in Women Using Hormonal Contraception. Faculty of Sexual & Reproductive Healthcare Clinical Guidance, 2009.

Arab, M. and S. Nasrolahi, Health Approach in the control of Irregular Bleeding due to Depomedroxy Progesterone Acetate. Journal of Research in Health Sciences, 2005. 5(2): p. 32-36.




DOI: http://dx.doi.org/10.24198/obgynia.v2n2.161

Refbacks

  • There are currently no refbacks.


Alamat Redaksi

 

KSM/Dep Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran RSUP Dr. Hasan Sadikin

Jl. Pasteur No 38 Bandung 40161 

Telp: 0813-2012-9954

Email: obgyniajurnal@gmail.com

 

 

 




Indexed By
         



Web Analytics
View My Stats

Indonesian Journal of Obstetrics & Gynecology Science @2017