Faktor Risiko Kejadian Tumor Trofoblas Gestasional Pasca Evakuasi Molahidatidosa di RSUP Dr. Hasan Sadikin Bandung Periode Agustus 2013 – Agustus 2018

Indah Permata Noer Islami, Dodi Suardi, Hanom Husni Syam, Mulyanusa A. Ritonga

Abstract


Tujuan: Penelitian bertujuan mengetahui faktor risiko kejadian TTG pasca evakuasi, untuk memprediksi penderita molahidatidosa yang berkembang menjadi TTG atau kembali normal.
Metode: Menggunakan studi case control retrospektif dalam waktu 1 Agustus 2013 - 1 Agustus 2018. Populasi penelitian, penderita molahidatidosa yang datang dan dirawat pada Obstetri dan Ginekologi RSUP Hasan Sadikin.
Hasil: Terdapat 59 pasien high risk, dan 67 pasien low risk. Probabilitas <0,05 terdapat hubungan signifikan antara usia dengan kejadian TTG. Probabilitas 0,031, terdapat hubungan signifikan antara paritas dengan kejadian TTG. Dengan uji Fisher Exact terdapat hubungan bermakna antara kadar βHCG praevakuasi dengan kejadian TTG
(p value =<0,001), dan hubungan bermakna antara gambaran PA dengan kejadian TTG (p value =<0,001). Dengan uji Spearman Correlation terdapat hubungan yang bermakna antara kadar βHCG Praevakuasi dengan gambaran PA (p value <0, 001).
Kesimpulan: Terdapat hubungan yang bermakna antara usia, paritas, BHCG, Patologi Anatomi, dengan kejadian TTG pasca evakuasi molahidatidosa. Dari analisis multivariat dengan uji regresi logistic didapatkan bahwa BHCG dan PA yang merupakan faktor risiko TTG.

Risk Factors Trofoblas Tumor of Post Evacuation Of Hydatidiform Mole in Dr. Hasan Sadikin General Hospital Bandung Period August 2013−August 2018 Period

Abstract
Objective: This study aims to determine the risk factors for GTT events after HM evacuation, used to predict patients who will develop into GTT or return to normal.
Methods: Case control study (retrospective) was conducted from August 1st 2013 −August 1st 2018. Population of this study was all patients with HM who came and treated at the RSHS Obstetrics and Gynecology Department.
Result: There are 59 high risk, 67 low risk patients. The probability value is 0.015, (<0.05) there is a significant relation between age and the incidence of GTT. The probability value of 0.031, there is a significant relationship between parity and the incidence of GTT. Fisher Exact test, significant relation between pre-evacuated βHCG levels and GTT events (p value = <0,001), and significant relation between Pathology Anatomy result and GTT events (p value =<0,001) was found. Spearman Correlation test, there was significant relation between levels of βHCG pre-evacuation with Pathology Anatomy result (p value <0, 001).
Conclusion: There is a significant relation between age, parity, BHCG, Pathology Anatomic result, and the incidence of GTT after evacuation of HM. From multivariate analysis with logistic regression test, it was found that BHCG and pathology anatomic were risk factors for GTT.

Key words: Molahidatidosa, Gestational Trophoblast Tumor.




Keywords


Molahidatidosa, Gestational Trophoblast Tumor

Full Text:

PDF

References


Martaadisoebrata D. Molahidatidosa dalam Buku Pedoman Pengelolaan Penyakit Trofoblas Gestasional. Jakarta: EGC; 2005: 7–41.

Pradjatmo H, Dasuki D, Dwianingsih EK, Triningsih E. Malignancy risk scoring of hydatidiform moles. Asian Pac J Cancer P. vol 16. 2015:2441-5.

Hidayat YM, Gandamihardja S, Krisnadi SR. Hubungan kadar β HCG Praevakuasi, Gambaran Histopatologi dan Kista Lutein dengan Performa β HCG pada Penderita Molahidatidosa yang Berkembang Menjadi PTG dan kembali Normal. MKB vol 46 No 4. 2014 :247-52.

Andrijono A. Deteksi Dini Penyakit Trofoblas Ganas dalam Deteksi Dini Penyakit Kanker. Jakarta : FKUI ; 2004: 130–3.

Khrismawan, Saleh AZ, Sanif R, Theodorus. Ketepatan Prediksi Penyakit Trofoblas Ganas dengan Menggunakan Skoring Faktor Risiko pada Molahidatidosa. Palembang; Tesis Fakultas Kedokteran Unsri. 2003.

Paradinas FJ, Hancock BW, Newland ES, Berkowitz RS.

Gestasional trophoblastic disease. 1st ed. London : Chapman & Hall Medical; 1997:44-76.

Soper JT. Gestasional trophoblastic disease. Am College Obstet Gynecol. 2006;108(1): 176–87.

Muminhodzic L, Bogdonavic G, Ljuca D, Babovic A. Epidemiological factors and pathomorphologic characteristics of hydatidiform mole. J Health Sci. 2013;3(2): 129–37.

Seckl MJ, Sebire MJ, Berkowitz RS. Gestasional trophoblastic disease. Lancet. 2010;376:717–29.

Lurain JR. Gestasional trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestasional trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010;203(6):531–9.

Deep JP, Sedhai LB, Napit J, Pariyar J. Gestasional trophoblastic disease. J Chitwan Medical College. 2013;3(4):4–11.

Loh KY, Sivalingam N, Suryani MY. Gestasional trophoblastic disease. Med J Malaysia. 2004;59(5):697–703.

Cole LA. Immunoassay of human chorionic gonadotropin, its free subunit and metabolites. Clin Chem. 1997;43:2233-43

Shih IM, Kurman RJ. Molecular basis of gestasional trophoblastic disease. Curr Mol Med 2002;2:1-12




DOI: http://dx.doi.org/10.24198/obgynia/v3n2.201

Refbacks

  • There are currently no refbacks.


Alamat Redaksi

 

KSM/Dep Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran RSUP Dr. Hasan Sadikin

Jl. Pasteur No 38 Bandung 40161 

Telp: 0813-2012-9954

Email: obgyniajurnal@gmail.com

 

 

 




Indexed By
         



Web Analytics
View My Stats

Indonesian Journal of Obstetrics & Gynecology Science @2017