Profil Penderita Kanker Endometrium di RSUP Dr. Hasan Sadikin Bandung Periode Tahun 2017-2020

Siti Salima; Andi Kurniadi; Gatot N.A. Winarno; Dodi Suardi; Hanifah Nurisa Putri

doi:10.24198/obgynia/v5n2.386

Profil Penderita Kanker Endometrium di RSUP Dr. Hasan Sadikin Bandung Periode Tahun 2017-2020

Siti Salima, Andi Kurniadi, Gatot N.A. Winarno, Dodi Suardi, Hanifah Nurisa Putri

Abstract

Tujuan: Mengetahui profil penderita kanker endometrium.
Metode: Penelitian metode deskriptif dengan menggunakan data sekunder. Kriteria inklusi penelitian yaitu pasien dengan diagnosis kanker endometrium dilihat berdasarkan hasil histopatologi.
Hasil: Distribusi pasien mayoritas berusia >50 tahun (62,0%), berasal dari Kota/Kabupaten Bandung (32,5%), memiliki indeks massa tubuh 18,5-22,9 kg/m2 (27,0%), multipara (36,5%), status postmenopause (59,0%), memiliki usia menarche ≥12 tahun (88,0%), tidak memiliki riwayat diabetes mellitus (66,0%) dan hipertensi (27,0%), terdiagnosis ketika stadium I (47,5%), dengan derajat diferensiasi baik/grade I (31,0%) dan tipe I endometrioid adenocarcinoma (82,5%). Terapi yang paling sering adalah tindakan operasi (50,0%) dengan tipe pembedahan histerektomi total dan salfingooforektomi bilateral (44,21%).
Kesimpulan: Pasien kanker endometrium di RSUP Dr. Hasan Sadikin Bandung periode tahun 2017-2020 ditemukan paling banyak berusia >50 tahun, dari Kota/Kabupaten Bandung, indeks massa tubuh normal, multipara, postmenopause, usia menarche ≥12 tahun, tidak ada riwayat DM dan hipertensi, terdiagnosis pada stadium I dengan tipe I endometrioid adenocarcinoma dan derajat diferensiasi baik (grade I), serta dilakukan tindakan operasi dengan tipe pembedahan histerektomi total dan salfingooforektomi bilateral.

Profile of Endometrial Cancer Patients in Dr. Hasan Sadikin Central General Hospital Bandung in 2017–2020

Abstract
Objective: Identifying the profile of endometrial cancer patients
Methods: This research used descriptive method by collecting secondary data. The inclusion criteria was patients with endometrial cancer diagnosis based on the histopathological results.
Results: In this research, the majority of patients were aged >50 years (62,0%), came from Bandung City/Regency (32,5%), with body mass index of 18,5-22,9 kg/m2 (27,0%), multiparous (36,5%), postmenopause (59,0%), menarcge age of ≥12 years (88,0%), no history of diabetes mellitus (66,0%) and hypertension (27,0%), diagnosed at stage I (47,5%), with histopathological results well differentiated/grade I (31,0%) and type I endometrioid adenocarcinoma (82,5%). Surgery (50,0%) with the type of total hysterectomy and bilateral salpingoophorectomy (44,21%) was the most common treatment.
Conclusion: In 2017-2020, endometrial cancer patient in Dr. Hasan Sadikin Central General Hospital Bandung were mostly found in the aged of >50 years, came from Bandung City/Regency, normal body mass index, multiparous, postmenopause, menarche age of ≥12 years, no history of diabetes mellitus and hypertension, diagnosed at stage I with histopathological result type I endometrioid adenocarcinoma and well differentiated (grade I), and the treatment was surgery with the type of total hysterectomy and bilateral salpingoophorectomy.

Key words: Endometrial cancer, profile, risk factor

Keywords

Kanker endometrium; profil; faktor risiko

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References

Cooper GM. The Cell A Molecular Approach. 8th ed. New York: Oxford University Press; 2019. 670 p.

Global Cancer Observatory. Cancer Today [Internet]. 2020 [cited 2021 Jan 25]. Available from: https://gco.iarc.fr/today/online-analysis-table

DeVita, Vincent T. J, Lawrence TS, Rosenberg SA, editors. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 11th ed. Philadelphia: Wolters Kluwer; 2019. 1211–1216 p.

Mehta Sumita, Gupta Bindiya, editors. Recent Advances in Endometrial Cancer. Recent Advances in Endometrial Cancer. Springer Singapore; 2020. 5–25 p.

Amant F, Mirza MR, Koskas M, Creutzberg CL. Cancer of the corpus uteri. Int J Gynecol Obstet. 2018 Oct 1;143:37–50.

Bourgin C, Saidani M, Poupon C, Cauchois A, Foucher F, Leveque J, et al. Endometrial cancer in elderly women: Which disease, which surgical management? A systematic review of the literature. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2016 Feb;42(2):166–75.

Dewi PPP, Budiana ING. Profil Pasien Kanker Endometrium Di RSUP Sanglah Denpasar Periode Agustus 2012-Juli 2014. E-Jurnal Med [Internet]. 2017;6(8):1–7. Available from: https://ojs.unud.ac.id/index.php/eum/article/view/33453/20261

A. Sri S. SF, Vinsur EYY, Sutiyarsih E. Analisi Faktor yang Mempengaruhi Lansia datang ke Pelayanan Kesehatan. J Ners dan Kebidanan (Journal Ners Midwifery). 2019;6(2):189–96.20

Gambacorti-Passerini ZM, López-De la Manzanara Cano C, Pérez Parra C, Cespedes Casas MC, Sánchez Hipólito L, Martín Francisco C, et al. Obesity in Patients with Endometrial Cancer: May It Affect the Surgical Outcomes of Laparoscopic Approach? Obes Surg. 2019 Oct;29(10):3285–90.

Aune D, Navarro Rosenblatt DA, Chan DSM, Vingeliene S, Abar L, Vieira AR, et al. Anthropometric factors and endometrial cancer risk: A systematic review and dose-response meta-analysis of prospective studies. Ann Oncol. 2015;26(8):1635– 48.

Onstad MA, Schmandt RE, Lu KH. Addressing the role of obesity in endometrial cancer risk, prevention, and treatment. J Clin Oncol. 2016;34(35):4225–30.

Sofyan N, Sudiana IK, Askandar B. Profile of Endometrial Cancer Patients in the Third Referral Hospital in Surabaya based on Known Risk Factors. Biomol Heal Sci J. 2020;3(2):66.

Chen Q, Tong M, Guo F, Lau S, Zhao M. Parity Correlates with the Timing of Developing Endometrial Cancer, But Not Subtype of Endometrial Cancer. J Cancer. 2015;6(11):1087–92.

Gao Y, Zhao M, Dai X, Tong M, Wei J, Chen Q. The prevalence of endometrial cancer in pre- and postmenopausal Chinese women. Menopause. 2016;23(8):884–7.

Wu Y, Sun W, Liu H, Zhang D. Age at Menopause and Risk of Developing Endometrial Cancer: A Meta-Analysis. Biomed Res Int. 2019;2019:8584130.

Yoo JH. Effects of early menarche on physical and psychosocial health problems in adolescent girls and adult women. Korean J Pediatr. 2016;59(9):357–63.21

Yang X, Wang J. The Role of Metabolic Syndrome in Endometrial Cancer: A Review. Front Oncol. 2019;9:744.

Trabert B, Wentzensen N, Felix AS, Yang HP, Sherman ME, Brinton LA. Metabolic syndrome and risk of endometrial cancer in the United States : a study in the SEERMedicare linked database. Cancer Epidemiol Biomarkers Prev. 2016;24(1):261–7.

Aune D, Sen A, Vatten LJ. Hypertension and the risk of endometrial cancer: a systematic review and meta-analysis of case-control and cohort studies. Sci Rep. 2017 Apr;7:44808.

Matsuo K, Machida H, Blake EA, Holman LL, Rimel BJ, Roman LD, et al. Trends and outcomes of women with synchronous endometrial and ovarian cancer. Oncotarget. 2018;9(47):28757–71.

Clarke MA, Long BJ, Del Mar Morillo A, Arbyn M, Bakkum-Gamez JN, Wentzensen N. Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis. JAMA Intern Med. 2018 Sep;178(9):1210–22.

Braun MM, Overbeek-Wager EA, Grumbo RJ. Diagnosis and Management of Endometrial Cancer. Am Fam Physician. 2016 Mar;93(6):468–74.

Suarez AA, Felix AS, Cohn DE. Bokhman Redux: Endometrial cancer “types” in the 21st century. Gynecol Oncol. 2017 Feb;144(2):243–9.

Luna C, Balcacer P, Castillo P, Huang M, Alessandrino F. Endometrial cancer from early to advanced-stage disease: an update for radiologists. Abdom Radiol [Internet]. 2021;46(11):5325–36. Available from: https://doi.org/10.1007/s00261-021-03220-722

Indriani R, Amarullah Ritonga M, Suardi D. Evaluasi Tindakan Operatif pada Kanker Serviks, Endometrium, dan Ovarium di RSUP Dr. Hasan Sadikin Bandung Tahun 2015-2016. Indones J Obstet Gynecol Sci. 2018;1(2):79–86.

DOI: http://dx.doi.org/10.24198/obgynia/v5n2.386