Effectiveness of Vitamin D Suplementation in Pregnant Women with Vitamin D Deficiency to Improved Fetal Biometry

Donel S.; Ruza Prima Rustam; Inayah Inayah; M. Yulis Hamidy; Ratu Astuti Dwi Putri; Machyuddin T.M Pangaribuan; Ahmad Fahruddin; Maya Savira

doi:10.24198/obgynia.v6i1.461

Effectiveness of Vitamin D Suplementation in Pregnant Women with Vitamin D Deficiency to Improved Fetal Biometry

Donel S., Ruza Prima Rustam, Inayah Inayah, M. Yulis Hamidy, Ratu Astuti Dwi Putri, Machyuddin T.M Pangaribuan, Ahmad Fahruddin, Maya Savira

Abstract

Objective: The aim of this study was to determine the effect and effectiveness of vitamin D on fetal biometry.
Method: This study was a Quantitative Study of two quasi-experimental groups. The research was conducted in Rupat District, Bengkalis Regency, Riau Province from June 2022 to August 2022. The research sample was pregnant women with vitamin D deficiency who were divided into an intervention group of 20 subjects and a control group of 20 subjects.
Results: Examination of vitamin D levels in pregnant women and examination of fetal biometry was carried out. Then given a 1000 IU vitamin D supplement to pregnant women with vitamin D deficiency levels, re-evaluated after 3 months vitamin D levels in pregnant women and re-measured fetal biometry. There were significant differences in Fetal Biometrics between the pre-Intervention and post-Intervention studies in the intervention group with p=0.001. The intervention group also showed that there was an increase in the proportion of Normal Biometrics from 8 subjects before the intervention compared to 13 subjects after 3 months of vitamin D supplementation intervention
Conclusion: Vitamin D supplementation for 3 months in pregnant women with Vitamin D deficiency is proven to improve fetal health through Fetal Biometry examination.

Efektivitas Suplemen Vitamin D dalam Meningkatkan Biometri Janin pada Wanita Hamil dengan Defisiensi Vitamin D

Abstrak
Tujuan: Studi ini bertujuan mengetahui dampak dan efektivitas vitamin D terhadap biometri janin.
Metode: Studi kuantitatif ini mengunakan dua grup dengan pendekatan kuasi-eksperimental. Penelitian ini dilaksanakan di Rupat, Kabupaten Bengkalis, Provinsi Riau dari Juni 2022 hingga Agustus 2022. Sampel penelitian ini adalah Wanita hamil dengan defisiensi vitamin D yang dibagi menjadi grup intervensi sebanyak 20 orang dan grup kontrol sebanyak 20 orang.
Hasil: Dilakukan pengukuran kadar vitamin D pada Wanita hamil dan biometri janin. Pada grup intervensi diberikan suplementasi vitamin D 1000IU dan dievaluasi kembali kadar vitamin D setelah tiga bulan dan dilakukan kembali biometri janin. Terdapat perbedaan signifikan pada biometri janin sebelum dan sesudah intervensi dengan p=0.001. Grup intervensi juga menunjukkan peningkatan proprorsi biometri normal dari 8 orang menjadi 13 orang setelah tiga bulan suplementasi vitamin D
Kesimpulan: Suplementasi vitamin D selama tiga bulan pada Wanita hamil dengan defisiensi vitamin D terbukti membantu kesehatan janin melalui pemeriksaan biometri janin.

Key words: Biometri, Defisiensi Vitamin D, Kehamilan

Keywords

biometry; Pregnancy; Vitamin D Deficiency

Full Text:

PDF

References

Almatsier S. Pedoman Ilmu Gizi. Jakarta: Gramedia Pustaka; 2012.

Nix S. William’s Basic Nutrition & Diet Therapy. New York: Elsevier Mosby; 2012.

Ioannou C, Javaid MK, Mahon P, Yaqub MK, Harvey NC, Godfrey KM, et al. The Effect of Maternal Vitamin D Concentration on Fetal Bone. J Clin Endocrinol Metab. 1 November 2012;97(11):E2070–7.

Laird E, Thurston SW, van Wijngaarden E, Shamlaye CF, Myers GJ, Davidson PW, et al. Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study. Nutrients. November 2017;9(11).

Arisman MB. Buku Ajar Ilmu Gizi: Gizi Dalam Daur Kehidupan. Jakarta: EGC; 2009.

Cunningham FG; Leveno KJ; Bloom SL; et al, Cunningham FG; et al, Cunningham FG; Leveno KJ; Bloom SL; et al, F. Gary Cunningham, Kenneth J. Leveno, Steven L. Bloom, Catherine Y. Spong, Jodi S. Dashe BLH. Williams Obstetri. 25 ed. New York: The McGraw-Hill Companies; 2020.

Panfiili FM, Roversi M, Argenio P, et al. Possible role of vitamin D in Covid 19 infection in pediatric population. J Endocrinol Invest. 2020;1–9.

Judistiani T, Madjid T, Irianti S, Natalia Y, Indrati A, Ghozali M, et al. Association of first trimester maternal vitamin D, ferritin and hemoglobin level with third trimester fetal biometry: Result from cohort study on vitamin D status and its impact during pregnancy and childhood in Indonesia. BMC Pregnancy Childbirth. 2 April 2019;19.

Sarma D, Saikia UK, Das D V. Fetal Skeletal Size and Growth are Relevant Biometric Markers in Vitamin D Deficient Mothers: A North East India Prospective Cohort Study. Indian J Endocrinol Metab. 2018;22(2):212–6.

Viljakainen HT, Saarnio E, Hytinantti T, Miettinen M, Surcel H, Mäkitie O, et al. Maternal vitamin D status determines bone variables in the newborn. J Clin Endocrinol Metab. April 2010;95(4):1749–57.

Morley R, Carlin JB, Pasco JA, Wark JD. Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. J Clin Endocrinol Metab. Maret 2006;91(3):906–12.

Morales E, Rodriguez A, Valvi D, Iñiguez C, Esplugues A, Vioque J, et al. Deficit of vitamin D in pregnancy and growth and overweight in the offspring. Int J Obes. 2015;39(1):61–8.

Kecamatan Rupat Utara. Homepage on internet, available at https://camatrupatutara.bengkaliskab.go.id/

Lawlor DA, Wills AK, Fraser A, Sayers A, Fraser WD, Tobias JH. Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: A prospective cohort study. Lancet. 2013;381:2176–83. [PMC free article] [PubMed] [Google Scholar]

Sørensen IM, Joner G, Jenum PA, Eskild A, Torjesen PA, Stene LC. Maternal serum levels of 25-hydroxy-vitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes. 2012;61:175–8. [PMC free article] [PubMed] [Google Scholar]

Marjamäki L, Niinistö S, Kenward MG, Uusitalo L, Uusitalo U, Ovaskainen ML, et al. Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring. Diabetologia. 2010;53:1599–607. [PubMed] [Google Scholar]

Zosky GR, Hart PH, Whitehouse AJ, Kusel MM, Ang W, Foong RE, et al. Vitamin D deficiency at 16-20 weeks gestation is associated with impaired lung function and asthma at 6 years of age. Ann Am Thorac Soc. 2014;11:571–7. [PubMed] [Google Scholar]

Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011;26:2341–57. [PMC free article] [PubMed] [Google Scholar]

Dawodu A, Saadi HF, Bekdache G, Javed Y, Altaye M, Hollis BW. Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency. J Clin Endocrinol Metab. 2013;98:2337–46. [PubMed] [Google Scholar]

Grant CC, Stewart AW, Scragg R, Milne T, Rowden J, Ekeroma A, et al. Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration. Pediatrics. 2014;133:e143–53. [PubMed] [Google Scholar]

DOI: http://dx.doi.org/10.24198/obgynia.v6i1.461