Karakteristik Karsinoma Ovarium Pra-Menopause dengan Kadar CA 125 ≤200 U/mL di RSUP Dr. Hasan Sadikin Bandung dari Tahun 2019–2021

Yudi Mulyana Hidayat, Eunike Febe Febriani, Ali Budi Harsono, Gatot N. A. Winarno, Andi Kurniadi


Abstract


Tujuan: Mendeskripsikan karakteristik karsinoma ovarium pra-menopause dengan kadar CA 125 ≤ 200 U/mL di RSUP Dr. Hasan Sadikin Bandung dari tahun 2019 sampai 2021.
Metode: Penelitian deskriptif ini menggunakan metode total sampling dari data sekunder pasien kanker ovarium yang memenuhi kriteria inklusi dan memiliki variabel lengkap.
Hasil: Penelitian yang melibatkan 32 sampel ini, menunjukkan nilai rata-rata CA 125 sebesar 82,63 U/mL dengan interval 3,3–194,8 U/mL. Mayoritas pasien berada pada rentang usia 40–49 tahun (40,6%), sudah menikah (87,5%), berprofesi sebagai ibu rumah tangga (81,3%), dan tinggal di Kawasan Pembangunan Bandung Raya (34,4%). Sebanyak 37,5% pasien adalah nullipara dan memiliki tipe histopatologis tumor epitel mucinous. Stadium tumor terbanyak adalah stadium I (56,3%). Kebanyakan pasien menjalani surgical staging komplit sebagai terapi penyakitnya (46,8%).
Kesimpulan: Sebagian besar pasien karsinoma ovarium pra-menopause dengan kadar CA 125 ≤ 200 U/mL pada tahun 2019–2021 berada pada rentang usia 40–49 tahun, sudah menikah, bekerja sebagai ibu rumah tangga, dan berdomisili di Kawasan Pengembangan Bandung Raya. Kebanyakan pasien berstatus nullipara, memiliki tumor dengan tipe histopatologis epitel mucinous, dan terdiagnosis pada stadium I. Tipe pengobatan yang paling umum ditemui adalah surgical staging komplit.

Characteristics of Pre-Menopausal Ovarian Carcinoma with CA 125 Level ≤ 200 U/mL in Dr. Hasan Sadikin General Hospital Bandung From 2019–2021


Abstract
Objective: To describe the characteristics of pre-menopausal ovarian carcinoma patients with CA 125 Level ≤ 200 U/mL in Dr. Hasan Sadikin General Hospital Bandung from 2019 until 2021.
Method: This descriptive study used the total sampling method of secondary data on ovarian cancer patients that have met the inclusion criterias and have complete variables.
Results: This study involving 32 samples showed the average level of CA 125 was 82,63 U/mL with the interval of 3,3 – 194,8 U/mL. Majority of the patients were in the age range of 40 – 49 years old (40,6%), has been married (87,5%), were housewifes (81,3%), and lived in Development Area of Bandung Raya (34,4%). About 37,5% patients were nullipara and had mucinous epithelial histopatology type of tumor. The most abundant tumor stage were stage I (56,3%). Most patients had undergoing complete surgical staging for their therapy (46,8%).
Conclusion: Most of pre-menopausal ovarian carcinoma patients with CA 125 level ≤ 200 U/mL  in 2019–2021 were in the age range of 40 – 49 years old, has been married, had profession as housewifes, and domiciled in Development Area of Bandung Raya. Majority of patients were nullipara, had tumor with mucinous epithelial histopatology type, and were diagnosed at the stage I. The most found therapy were complete surgical staging.

Key words: ovarian cancer, CA 125, cancer antigen 125, characteristic


Keywords


kanker ovarium, CA 125, cancer antigen 125, karakteristik

Full Text:

PDF

References


CDC. Basic Information About Ovarian Cancer [Internet]. 2021 [cited 2022 Feb 24]. Available from: https://www.cdc.gov/cancer/ovarian/basic_info/

Harsono AB. Kanker Ovarium : “The Silent Killer.” Indonesian Journal of Obstetrics & Gynecology Science. 2020 Mar;3.

Charkhchi P, Cybulski C, Gronwald J, Wong FO, Narod SA, Akbari MR. Ca125 and ovarian cancer: A comprehensive review. Vol. 12, Cancers. MDPI AG; 2020. p. 1–29.

Doubeni CA, Doubeni ARB, Myers AE. Diagnosis and Management of Ovarian Cancer [Internet]. Vol. 93. 2016. Available from: www.aafp.org/afp

Gentry-Maharaj A, Jacobs I, Menon U. Ovarian Cancer-Tumor Markers and Screening. In: Berek JS, Hacker NF, editors. Berek and Hacker’s gynecologic oncology. 6th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2014. p. 443–63.

Metwali M, Ali S, Ahmed Y, Abd El Gaffar H. Level of CA125 in Gynaecologic Masses Necessitating Operative Intervention Prospective cohort study. Sohag Medical Journal. 2019 Apr 1;23(2):135–40.

Aqilla S, Harsono AB, Agustina H. Gambaran Klinis dan Histopatologi Kanker Ovarium di RSUP Dr. Hasan Sadikin Bandung Tahun 2019-2020. Indonesian Journal of Obstetrics & Gynecology Science. 2022 Mar 28;5(1):127–35.

American Cancer Society. Ovarian Cancer Risk Factors [Internet]. 2018 [cited 2022 Feb 28]. Available from: https://www.cancer.org/cancer/ovarian-cancer/causes-risks-prevention.html

Chauhan SC, Singh AP, Ruiz F, Johansson SL, Jain M, Smith LM, et al. Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125). Modern Pathology. 2006 Jan;19(10):1386–94.

Trimbos JB. Surgical treatment of early-stage ovarian cancer. Best Pract Res Clin Obstet Gynaecol. 2017 May;41:60–70.

Kurniadi A, Hidayat YM, Suardi D, Susanto H, N.A.W G, Prayitno H. Peran Serum IL-6 dan CA-125 Prabedah sebagai Prediktor Resektabilitas Tumor pada Kanker Ovarium Tipe Epitel. Indonesian Journal of Cancer. 2018 Jan 9;11(4):151.

WHO. Menopause. WHO Fact Sheets [Internet]. 2022 [cited 2022 Dec 10]; Available from: https://www.who.int/news-room/fact-sheets/detail/menopause

Kementerian Pemberdayaan Perempuan dan Perlindungan Anak. Profil Perempuan Indonesia 2021 [Internet]. 2021 [cited 2022 Dec 18].

Available from: https://www.kemenpppa.go.id/index.php/page/read/26/3813/profil-perempuan-indonesia-tahun-2021

Karpinskyj C, Burnell M, Gonzalez-Izquierdo A, Ryan A, Kalsi J, Jacobs I, et al. Socioeconomic Status and Ovarian Cancer Stage at Diagnosis: A Study Nested Within UKCTOCS. Diagnostics. 2020 Feb 7;10(2):89.

Nyoman Gede Budiana I, Kadek Aditya Prayudi P, Yudi Saspriyana K, Made Darmayasa I, Agung Gede Putra Wiradnyana A, Suwiyoga K.

Characteristics of ovarian malignancy in Bali province, Indonesia. Med J Malaysia. 2021;76(3):326–31.




DOI: http://dx.doi.org/10.24198/obgynia/v6.n2.491

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


     
     

Creative Commons License
Indonesian Journal of Obstetrics & Gynecology Science is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License
  Web Analytics
  View My Stat