Hubungan Nilai PCI Intraoperatif dengan Resektabilitas Kanker Ovarium di RSUP Dr. M. Djamil Padang

Syamel Muhammad, Fajriman Fajriman


Abstract


Tujuan: Ukuran luas massa sebelum operasi berperan dalam keberhasilan sitoreduksi komplit. Peritonial Carcinomatosis Index (PCI) adalah sistem yang paling umum digunakan untuk peritoneal carcinomatosis, dan indikator prognostik independen untuk hasil jangka panjang. Resektabilitas kanker ovarium ditandai dengan residu kanker berpengaruh terhadap prognosis. Penggunaan PCI pada kanker ovarium sebagai faktor prediktor resektabilitas akan meniadakan sebagian faktor perancu terkait tim bedah. Penelitian ini bertujuan mengetahui hubungan nilai PCI metastasis intraoperatif terhadap resektabilitas massa pada kanker ovarium stadium lanjut di RSUP Dr. M. Djamil Padang.
Metode: Penelitian analitik observasional dengan desain cross sectional study. Kriteria inklusi berupa pasien kanker ovarium stadium lanjut 1C yang akan dilakukan operasi dan bersedia menandatangani informed consent sejak Oktober 2021.
Hasil: Sebanyak 52.5% memiliki riwayat genetik, 72.5% berusia 40 – 70 tahun. Pasien rawatan kanker ovarium stadium lanjut di RSUP Dr. M. Djamil Padang sebanyak 95% IOTA SR malignant, sebanyak 100% memiliki nilai CA-125 > 35, 60% ukuran massa >1 cm. PCI tinggi (skor > 15-39) memiliki frekuensi lebih tinggi dibandingkan nilai PCI Rendah (62,5%). Persentase resektabel lebih tinggi pada nilai PCI rendah dibandingkan nilai PCI tinggi sebanyak 100% (<0.001).
Kesimpulan: Terdapat hubungan signifikan antara nilai Peritoneal Carcinomatosis Index intraoperatif dan resektabilitas massa.

Relationship between Intraoperative PCI Score with Resectability Ovarian Cancer at Dr. M. Djamil Hospital Padang

Abstract
Objective: Peritoneal Carcinomatosis Index (PCI) is the most commonly used peritoneal carcinomatosis system, also an independent prognostic indicator for long-term outcomes. The resectability of ovarian cancer characterized by cancer residue affects prognosis. The use of PCI in ovarian cancer as a predictor of resectability will negate some of the confounding factors related to the surgical team. This research to determine the relationship of intraoperative PCI value to mass resectability in advanced ovarian cancer at Dr. M. Djamil Padang Hospital.
Method: observational analytic research with cross-sectional study design. The inclusion criteria were advanced stage 1C ovarian cancer patients who will undergo surgery and are willing to sign informed consent since October 2021.
Results: 52.5% have a genetic history, 72.5% are 40 – 70 years. For patients with advanced ovarian cancer treatment at Dr. M. Djamil Padang Hospital 95% of malignant SR IOTA,  100% have CA-125 values> 35, 60% of mass size >1 cm. High PCI (score > 15-39) has a higher frequency than a Low PCI value (62.5%). The percentage of resectable is higher in low PCI scores than in high PCI scores, about 100% (<0.001).
Conclusion: There is a significant relationship between intraoperative peritoneal carcinomatosis index and mass resectability.

Key word: Peritonial Carcinomatosis Index, resectability, ovarian cancer




Keywords


Peritonial Carcinomatosis Index, resektabilitas, kanker ovarium

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DOI: http://dx.doi.org/10.24198/obgynia/v6.n3.532

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