Calcium Paradox, Vitamin D and Vitamin K2

Johanes C. Mose


Abstract


Calsium supplementation during pregnancy is a routine standard practice for antenatal care recommended by WHO, FIGO, POGI as well as Indonesia Ministry of Health.
Calcium is one of essential micronutrients needed in human life, especially during pregnancy known for bone and teeth development, prevent osteoporosis, involved in blood coagulation, prevent haemorrhages during pregnancy and post partum periods, muscle contraction, prevent hypertension, preeclampsia, prematurity, IUGR, LBW, stunting, increase immunity, etc.
Prevalence of hypocalcemia varies from 60 % to 70.5 % in low-medium income countries (LMIC) and 30 % to 60 % in high income countries (HIC).
A systematic review study conducted in 2019 reported a prevalence of low calcium consumption less than 800 mg/day (normal consumption is around 1000-1200 mg/day) was 29 % in HIC and 82 % in LMIC, including Malaysia 377 mg/day and Indonesia < 400 mg/day.
Calcium metabolism in human body is very much depend on the normal level of vitamin D, magnesium and parathyroid hormone in blood. Vitamin D is mainly needed for the absorption of calcium in intestine. The combination of vitamin D and calcium supplementation is very much recommended.


Keywords


Calcium, Vitamin D, Vitamin K2

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References


Erika Aparecida da Silveira , Letícia de Almeida Nogueira e Moura , Maria Clara Rezende Castro, Gilberto Kac, Maria Claret Costa Monteiro Hadler , Priscilla Rayanne E. Silva Noll, et all. Systematic Review : Prevalence of Vitamin D and Calcium Deficiency and Insufficiency in Women of Childbearing Age and Associated Risk Factors: A Systematic Review and Meta-Analysis. Nutrient 2022 ; 14(20): 4351-6

Julie Shlisky, Rubina Mandlik, Sufia Askari, Steven Abrams, Jose M. Belizan, Megan W. Bourassa, et al. Calcium deficiency worldwide: prevalence of inadequate intakes and associated health outcomes. Ann NY Acad Sci 2022;1512:10-28.

Cormick, G., A.P. Betrán, I.B. Romero, et al. 2019. Global inequities in dietary calcium intake during pregnancy: a systematic review and meta-analysis. BJOG 2019;126: 444–456.

Francisco J. de Abajo, Sara Rodríguez‐Martín, Antonio Rodríguez‐Miguel, Miguel J. Gil, MD. Risk of Ischemic Stroke Associated With Calcium Supplements With or Without Vitamin D: A Nested Case‐Control Study. JAHA 2017;

Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. 2010 Jul 29;341:c3691. doi: 10.1136/bmj.c3691. PMID: 20671013

Kate Rheaume-Bleue. Vitamin K2 and the Calcium Paradox: How a Little-Known Vitamin Could Save Your Life. Canada : Harper Colin Canada Ltd 2013.

Piper HM. The calcium paradox revisited : An artefact of great heuristic value. Cardiovascular Research 2000;45: 123–127

Grzegorz B. Wasilewski. The calcium paradox – the role of vitamin K in the bone-vascular axis. Mastricht, the Netherland 2022. Doctoral Thesis.

Monica Straith. The Calcium Paradox : Its History and What it Really Means. AlgaeCal (https://blog.algaecal.com) 20 Oct 2022.




DOI: http://dx.doi.org/10.24198/obgynia.v7i3.757

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