Tatalaksana Kehamilan G5P1A3 Gravida 10–11 Minggu dengan Riwayat Keguguran Berulang

Rena Nurita, Ruswana Anwar


Abstract


Keguguran berulang merupakan kejadian keguguran paling tidak sebanyak dua kali atau lebih berturut-turut pada usia kehamilan kurang dari 20 minggu dan/atau berat janin kurang dari 500 gram. Kejadian keguguran tiga kali atau lebih terjadi pada 1% pasangan. Analisis penyebab dan faktor risiko pada tiap pasien bersifat individu dan perlu dipelajari agar dapat dilakukan penatalaksanaan yang sesuai. Penatalaksanaan yang diberikan perlu memerhatikan kondisi sebelum kehamilan berikutnya dan mempertahankan kehamilan berikutnya yang terjadi.  Kami membahas mengenai G5P1A3 gravida 10–11 minggu dengan riwayat keguguran berulang. Pada skrining faktor risiko dan analisis penyebab keguguran berulang pada pasien ini disebabkan oleh hiperagregasi trombosit, yang belum dapat ditentukan apakah diturunkan atau didapat. Diperlukan pemeriksaan lanjutan untuk menegakkan diagnosis tersebut. Terapi kombinasi aspirin dan heparin merupakan terapi yang tepat untuk pasien ini.  

Management of G5P1A3 10–11 Weeks of Pregnancy with History of Recurrent Miscarriage

Abstract
Recurrent miscarriage is the occurrence of miscarriage at least two or more consecutive times at gestational age less than 20 weeks and/or fetal weight less than 500 grams. Three or more miscarriages occur in 1% couples. The analysis of causes and risk factors for each patient is individualized, so that appropriate management can be carried out. Management is focused on condition before pregnancy and maintenance of the following pregnancy. We discuss about G5P1A3 10-11 weeks of pregnancy with history of recurrent miscarriages. Platelet hyperaggregation, which cannot be determined whether it is inherited or acquired suspected as the etiology of recurrent miscarriage in this patient. Further examination is needed to determine the diagnosis. Combination of aspirin and heparin is the appropriate management for this patient.

Key word: aspirin, heparin, platelet hyperaggregation, recurrent miscarriage, thrombophilia




Keywords


aspirin, heparin, hiperagregasi trombosit, keguguran berulang, trombofilia

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References


Taylor HS, Pal L, Seli E. Speroff’s Clinical Gynecologic Endocrinology and Infertility. 9 ed. Philadelphia Wolters Kluwer; 2020.

Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ. Recurrent Pregnancy Loss. Nature Reviews Disease Primers. 2020;6(1):98.

Baziad A, Sumapraja K, Santoso B. Panduan Tata Laksana Keguguran Berulang Jakarta: HIFERI - POGI 2011.

Hendarto H, Santodo B, Harzif AK. Konsensus Keguguran Berulang Jakarta: HIFERI - POGI 2018.

Halvorson LM. First Trimester Abortion In: Hoffman B. L., Schorge J. O., Bradshaw K. D., Halvorson L. M., Schaffer J. I., Corton M. M., editors. Williams Gynecology. 3 ed. New York: McGraw-Hill; 2016. p. 137-60.

Hannah W, Stovall DW, Schust DJ. Immunology and Reproduction In: Strauss J. F., Barbieri R. L., Garguilo A. R., editors. Yen & Jaffe's Reproductive Endocrinology E-Book: Physiology, Pathophysiology, and Clinical Management. 8th ed. Philadelphia: Elsevier 2019. p. 287-307.

Balen AH. Polycystic Ovary Syndrome (Pcos). The Obstetrician & Gynaecologist. 2017;19(2):119-29.

De Jong PG, Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S. Aspirin and/or Heparin for Women with Unexplained Recurrent Miscarriage with or without Inherited Thrombophilia. Cochrane Database of Systematic Reviews. 2014(7).

Regan L, Backos M, Rai R. The Investigation and Treatment of Couples with Recurrent First-Trimester and Second-Trimester Miscarriage. RCOG: London, UK. 2011.

Hamulyák EN, Scheres LJJ, Marijnen MC, Goddijn M, Middeldorp S. Aspirin or Heparin or Both for Improving Pregnancy Outcomes in Women with Persistent Antiphospholipid Antibodies and Recurrent Pregnancy Loss. Cochrane Database of Systematic Reviews. 2020(5).




DOI: http://dx.doi.org/10.24198/obgynia.v4i1.238

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