Comparison of Nifedipine and Isoxsuprine to Cervical Length in Threatened Preterm Labor

Triyoga Pramadana, Anita Rachmawati, Dini Pusianawati

Abstract


Objective: This study aimed to determine differences in cervical length changes between administration of nifedipine and isoxsuprine.
Method: Subjects of the study were pregnant women who meet the inclusion criteria (n=16). Treatments were given for 48 hours. Parameters measured was the cervical length before and after the administration of nifedipine and isoxsuprine. This study was conducted in Dr. Hasan Sadikin General Hospital from January until April 2020.
Result: Less shortening of the cervical length after administration of tocolytic isoxsuprin for 48 hours compared with tocolytic nifedipine and statistically significant with p value of 0.0001 (p<0.05) using Paired T tests.
Conclusion: Isoxsuprin is more effective to prevent shortening of the cervical length compared to nifedipine in cases of threatened preterm labor.

Perbandingan Efek Nifedipine dan Isoxsuprine terhadap Panjang Serviks pada Persalinan Preterm Terancam

Abstrak
Tujuan: Studi ini bertujuan untuk menelaah perbedaan perubahan panjang serviks antara pemberian nifedipine dan isoxsuprine.
Metode: Studi ini adalah sebuah uji klinis acak dengan metode randomisasi buta ganda. Partisipan studi ini adalah wanita hamil yang memenuhi kriteria inklusi (n=16).  Pengobatan diberikan selama 48 jam. Parameter yang diukur adalah panjang serviks sebelum dan sesudah administrasi nifedipine dan isoxsuprine. Studi ini dilakukan di RSUP Dr. Hasan Sadikin pada Januari sampai April 2020.
Hasil: Terdapat lebih sedikit pemendekan serviks pada pemberian isoxsuprine selama 48 jam dibandingkan dengan nifedipine (p=0.0001).
Kesimpulan: Isoxsuprine lebih efektif untuk mencegah pemendekan serviks dibandingkan dengan nifedipine pada kasus persalinan preterm terancam.

Kata kunci: Nifedipine, Isoxsuprine, Panjang serviks, Persalinan preterm terancam



Keywords


Nifedipine; Isoxsuprine; Preterm labor; Cervical Length

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References


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DOI: http://dx.doi.org/10.24198/obgynia/v4n1.255

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KSM/Dep Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran RSUP Dr. Hasan Sadikin

Jl. Pasteur No 38 Bandung 40161 

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