Gambaran Karakteristik Klinis dan Histopatologi Kanker Ovarium Anak di RSUP Dr. Hasan Sadikin Bandung

Haifa Tuffahati; Ali Budi Harsono; Muhammad Alamsyah Aziz; Kemala Isnainiasih Mantilidewi; Febia Erfiandi

doi:10.24198/obgynia/v5n1.354

Gambaran Karakteristik Klinis dan Histopatologi Kanker Ovarium Anak di RSUP Dr. Hasan Sadikin Bandung

Haifa Tuffahati,^(1*) Ali Budi Harsono,⁽²⁾ Muhammad Alamsyah Aziz,⁽³⁾ Kemala Isnainiasih Mantilidewi,⁽⁴⁾ Febia Erfiandi,⁽⁵⁾

(1)
(2) Departemen Obstetri dan Ginekologi, Fakultas Kedokteran, Universitas Padjajaran/RSUP Dr. Hasan Sadikin, Bandung
(3) Departemen Obstetri dan Ginekologi, Fakultas Kedokteran, Universitas Padjajaran/RSUP Dr. Hasan Sadikin, Bandung
(4) Departemen Obstetri dan Ginekologi, Fakultas Kedokteran, Universitas Padjajaran/RSUP Dr. Hasan Sadikin, Bandung
(5) Departemen Obstetri dan Ginekologi, Fakultas Kedokteran, Universitas Padjajaran/RSUP Dr. Hasan Sadikin, Bandung
(*) Corresponding Author

Abstract

Tujuan: Untuk mengetahui gambaran karakteristik klinis dan histopatologi kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung.
Metode: Penelitian ini menggunakan desain penelitian deskriptif. Data dikumpulkan dari rekam medis pasien kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung tahun 2017–2020.
Hasil: Terdapat 22 pasien kanker ovarium anak yang sesuai dengan kriteria inklusi dan eksklusi. Ditemukan pasien kanker ovarium anak paling banyak usia 13–18 tahun sebanyak 13 orang (59,1%), stadium klinis I sebanyak 10 orang (45,4%), histopatologi jenis sel germinal sebanyak 17 orang (77%), dan gejala klinis benjolan pada perut sebanyak 16 orang (33%).
Kesimpulan: Kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung Bandung periode 1 Januari 2017 – 31 Desember 2020 paling sering terjadi pada pasien dengan rentang usia 13–18 tahun, terdiagnosis pada stadium I, karakteristik histopatologi tipe sel germinal, dan memiliki gejala klinis berupa benjolan pada perut.

Overview of Clinical Characteristics and Histopathology of Pediatric Ovarian Cancer at RSUP Dr. Hasan Sadikin Bandung

Abstract
Objective: To determine pediatric ovarian cancer’s clinical characteristics and histopathology at RSUP Dr. Hasan Sadikin Bandung.
Methods: This study used a descriptive research design. Data were collected from medical records of pediatric ovarian cancer patients at RSUP Dr. Hasan Sadikin Bandung in 2017 – 2020.
Result: 22 pediatric ovarian cancer patients met the inclusion and exclusion criteria. The majority of pediatric ovarian cancer patients were 13-18 years as many as 13 people (59.1%), clinical stage I as many as 10 people (45.4%), histopathological germ cell types as many as 17 people (77%), and clinical symptoms as lumps in the abdomen as many as 16 people (33%).
Conclusion: Pediatric ovarian cancer at RSUP Dr. Hasan Sadikin Bandung period 1 January 2017 – 31 December 2020 most occurred in patients aged 13–18 years, diagnosed at stage I, histopathological characteristics of germ cell type, and had clinical symptoms in the form of abdominal lump.

Key words: Ovary, Pediatric Ovarian Cancer, Clinical Characteristic, Histopathological Characteristic

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References

Stewart C, Ralyea C, Lockwood S. Ovarian Cancer: An Integrated Review. Semin Oncol Nurs [Internet].

;35(2):151–6. Available from: https://doi.org/10.1016/j.soncn.2019.02.001

Francis JH, Schefler AC, Abramson DH. Cancer Medicine. John Wiley & Sons, Inc. 2017.

National Cancer Institute. Cancer Stat Facts: Ovarian Cancer [Internet]. The Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute. 2020. Available from: https://seer.cancer.gov/statfacts/html/ovary.html

GLOBOCAN. Globocan 2020 - Global fact sheet. WHO - Int Agency Res Cancer [Internet]. 2020;419:1–2. Available from: https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf

Mahadik K, Ghorpade K. Childhood ovarian malignancy. J Obstet Gynecol India. 2014;64(2):91–4.

Péroux E, Franchi-Abella S, Sainte-Croix D, Canale S, Gauthier F, Martelli H, et al. Ovarian tumors in children and adolescents: A series of 41 cases. Diagn Interv Imaging [Internet]. 2015;96(3):273–82. Available from: http://dx.doi.org/10.1016/j.diii.2014.07.001

Heo SH, Kim JW, Shin SS, Jeong SI, Lim HS, Choi YD, et al. Review of ovarian tumors in children and adolescents: Radiologic- pathologic correlation. Radiographics. 2014;(7):2039–55.

Lim DJ, Manuaba IF, Putra IGM, Budiana ING. Masalah ginekologi pasien remaja di RSUP Sanglah Denpasar pada April 2016 – Maret 2017. Intisari Sains Medis. 2019;10(1):1–5.

Budiana ING, Angelina M, Pemayun TGA. Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery. J Turkish-German Gynecol Assoc. 2019;20(1):47–54.

Orkin SH, Fisher DE, Ginsburg D, Look AT, Lux SE, Nathan DG. Hematology and Oncology Of Infancy and Childhood. 8th ed. Elsevier Saunders. Elsevier Saunders; 2015.

Oberaigner W, Minicozzi P, Bielska-Lasota M, Allemani C, De Angelis R, Mangone L, et al. Survival for Ovarian Cancer in Europe: The across-country variation did not shrink in the past decade. Acta Oncol (Madr). 2012;51(4):441–53.

Bhattacharyya NK, De A, Bera P, Mongal S, Chakraborty S, Bandopadhyay R. Ovarian tumors in pediatric age group - A clinicopathologic study of 10 years cases in West Bengal, India. Indian J Med Paediatr Oncol. 2010;31(2):54–7.

Baert T, Storme N, Van Nieuwenhuysen E, Uyttebroeck A, Van Damme N, Vergote I, et al. Ovarian cancer in children and adolescents: A rare disease that needs more attention. Maturitas [Internet]. 2016;88:3–8. Available from: http://dx.doi.org/10.1016/j.maturitas.2016.03.003

Yeap ST, Hsiao CC, Hsieh CS, Yu HR, Chen YC, Chuang JH, et al. Pediatric malignant ovarian tumors: 15 years of experience at a single institution. Pediatr Neonatol [Internet]. 2011;52(3):140–4.

Available from: http://dx.doi.org/10.1016/j.pedneo.2011.03.003

Von Allmen D. Malignant lesions of the ovary in childhood. Semin Pediatr Surg. 2005;14(2):100–5.

Madenci AL, Vandewalle RJ, Dieffenbach B V., Laufer MR, Boyd TK, Voss SD, et al. Multicenter pre-operative assessment of pediatric ovarian malignancy. J Pediatr Surg [Internet]. 2019;54(9):1921–5. Available from: https://doi.org/10.1016/j.jpedsurg.2019.02.019

Choudhary V, Kumar R, Pankaj S, Kumari A, Kumari J, Nazneen S, et al. CHILDHOOD AND ADOLESCENCE OVARIAN MALIGNANCY : A STUDY IN A TERTIARY CARE CENTRE IN BIHAR. J Indira Gandhi Inst Med Sci. 2018;

Horta M, Cunha TM. Sex cord-stromal tumors of the ovary: A comprehensive review and update for radiologists. Diagnostic Interv Radiol. 2015;21(4):277–86.

Schultz KAP, Schneider DT, Pashankar F, Ross J, Frazier L. Management of ovarian and testicular sex cord-stromal tumors in children and adolescents. J Pediatr Hematol Oncol. 2012;34(SUPPL. 2):55–63.

Hazard FK, Longacre TA. Ovarian Surface Epithelial Neoplasms in the Pediatric Population. Am J Surg Pathol. 2013;37(4):548–53.

DOI: http://dx.doi.org/10.24198/obgynia/v5n1.354